pyrroles and farnesyl pyrophosphate

Topics: Animals; Apoptosis; Atorvastatin; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Polyisoprenyl Phosphates; Protein Prenylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Solubility

Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Caspase Inhibitors; Caspases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Muscle, Smooth, Vascular; Polyisoprenyl Phosphates; Protein Prenylation; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Rabbits; Rats; rhoA GTP-Binding Protein; Sesquiterpenes; Simvastatin; Time Factors

Topics: Amides; Atorvastatin; Cell Division; Cells, Cultured; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Peptidyl-Dipeptidase A; Phosphorylation; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; rho-Associated Kinases; RNA, Messenger; Sesquiterpenes; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Atorvastatin; Cell Death; Cell Survival; Cholesterol; Dose-Response Relationship, Drug; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neurites; Neurons; Polyisoprenyl Phosphates; Pyrroles; Rats; Sesquiterpenes; Squalene

Topics: Alkaline Phosphatase; Atorvastatin; Calcinosis; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polyisoprenyl Phosphates; Pyridines; Pyrroles; Sesquiterpenes

Topics: Alkyl and Aryl Transferases; Aryldialkylphosphatase; Atorvastatin; Cell Line; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Farnesyltranstransferase; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Luciferases; Mevalonic Acid; Plasmids; Polyisoprenyl Phosphates; Pyrroles; Quinolines; Sesquiterpenes; Sp1 Transcription Factor; Time Factors; Transcriptional Activation; Transfection

Topics: Animals; Apolipoprotein A-I; Atorvastatin; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cell Line; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Genes, Dominant; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipoproteins; Macrophages; Mevalonic Acid; Mice; Models, Biological; Phosphorylation; Polyisoprenyl Phosphates; PPAR gamma; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Transfection; Up-Regulation

Topics: Adolescent; Adult; Aged; Atorvastatin; Cell Differentiation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Macrophages; Mevalonic Acid; Middle Aged; Peptidyl-Dipeptidase A; Phosphorylation; Polyisoprenyl Phosphates; Protein Kinase C; Pyrroles; RNA, Messenger; Sesquiterpenes; Terpenes; Up-Regulation

Topics: Animals; Atorvastatin; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipase; Lipoprotein Lipase; Liver X Receptors; Macrophages; NF-kappa B; Orphan Nuclear Receptors; Polyisoprenyl Phosphates; Pyrroles; Receptors, Cytoplasmic and Nuclear; Sesquiterpenes; Simvastatin

Topics: Animals; Atorvastatin; Cell Growth Processes; Drug Interactions; Female; Heptanoic Acids; Male; Mice; Monomeric GTP-Binding Proteins; Neuropeptides; Phosphorylation; Polyisoprenyl Phosphates; Prenylation; Protein Kinases; Pyrroles; Ras Homolog Enriched in Brain Protein; Rats; rho GTP-Binding Proteins; Ribosomal Protein S6 Kinases; Sesquiterpenes; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins

Topics: Actins; Amino Acid Motifs; Atorvastatin; Cell Differentiation; Cell Proliferation; Diterpenes; DNA Replication; GATA6 Transcription Factor; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nucleic Acid Synthesis Inhibitors; Polyisoprenyl Phosphates; Pyrroles; Sesquiterpenes; Simvastatin; Transcription, Genetic

Topics: Antigens, CD; Atorvastatin; Cadherins; cdc42 GTP-Binding Protein; Guanosine Triphosphate; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Junctions; Interleukin-6; Interleukin-8; Lipopolysaccharides; Mevalonic Acid; Polyisoprenyl Phosphates; Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyrroles; rho-Associated Kinases; Sesquiterpenes; Thrombin

Topics: Animals; Apicoplasts; Atorvastatin; Diphosphates; Diterpenes; Farnesyltranstransferase; Female; Gene Knockdown Techniques; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Polyisoprenyl Phosphates; Protozoan Proteins; Pyrroles; Sesquiterpenes; Toxoplasma; Toxoplasmosis