pyrroles and endothelin-1

Topics: Androstenes; Androstenols; Angiogenesis Inhibitors; Anilides; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Atrasentan; Benzamides; Bevacizumab; Biomarkers, Tumor; Bone Remodeling; Cancer Vaccines; Clinical Trials as Topic; Clusterin; Dasatinib; Denosumab; Endothelin-1; Humans; Immunotherapy; Indoles; Ipilimumab; Male; Mice; Mice, SCID; Molecular Targeted Therapy; Nitriles; Orchiectomy; Phenylthiohydantoin; Prostate-Specific Antigen; Prostatic Neoplasms; Pyridines; Pyrimidines; Pyrroles; Pyrrolidines; RANK Ligand; Receptor Cross-Talk; Receptors, Androgen; Signal Transduction; Sunitinib; Taxoids; Thiazoles; Tissue Extracts; Treatment Failure; Tumor Microenvironment; Xenograft Model Antitumor Assays

Topics: Adult; Aged; Atorvastatin; Biomarkers; C-Reactive Protein; Cross-Over Studies; Double-Blind Method; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Heart Failure; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Pyrroles; Receptors, Tumor Necrosis Factor, Type I; Treatment Outcome

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Atorvastatin; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyslipidemias; Endothelin-1; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; Middle Aged; Pyrroles

Topics: Adult; Aged; Atorvastatin; Biomarkers; Endothelin-1; Endothelium, Vascular; Female; Fenofibrate; Heptanoic Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Pyrroles

Topics: Aged; Angiotensin II; Animals; Blood Pressure; Bradykinin; Carcinoma, Renal Cell; Cells, Cultured; Coronary Circulation; Endothelial Cells; Endothelin-1; Female; Gastrointestinal Stromal Tumors; Heart; Heart Rate; Humans; Hypertension; In Vitro Techniques; Indoles; Kidney Neoplasms; Male; Middle Aged; Pyrroles; Rats; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Renin; Sunitinib; Vascular Endothelial Growth Factor A

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents

Topics: Animals; Atorvastatin; Cattle; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrroles; RNA, Messenger; Simvastatin

Topics: Adenine; Adenylyl Cyclase Inhibitors; Carbazoles; Cell Movement; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; Enzyme Inhibitors; Humans; Imines; Indoles; Neutrophils; Pyrroles; Thionucleotides

Topics: Animals; Anti-Bacterial Agents; Bradykinin; Cells, Cultured; Cerebral Arteries; Dogs; Dose-Response Relationship, Drug; Endothelin-1; Female; Gentamicins; Indoles; Isometric Contraction; Kanamycin; Male; Muscle, Smooth, Vascular; Neomycin; Peptides, Cyclic; Polyamines; Polyelectrolytes; Protein Kinase C; Pyrroles; Streptomycin; Tetradecanoylphorbol Acetate; Vasoconstriction; Vasospasm, Intracranial

Topics: Animals; Anticholesteremic Agents; Atorvastatin; Calcium; Calcium Signaling; Coronary Artery Disease; Diabetes Complications; Diet; Disease Models, Animal; Endothelin-1; Endothelins; Heptanoic Acids; Hyperlipidemias; Male; Phosphorylation; Pyrroles; Receptor, Endothelin A; Receptors, Endothelin; Swine; Tyrosine

Topics: Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelin-1; Endothelin-3; Indoles; Male; MAP Kinase Signaling System; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A

Topics: Aminoquinolines; Apoptosis; Carbazoles; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagenases; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endothelin-1; Enzyme Induction; Female; Guanylate Cyclase; Humans; Imidazoles; Indoles; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis, Knee; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Pyrroles; Signal Transduction

Topics: Animals; Aorta; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Phosphorylation; Pravastatin; Pyridines; Pyrroles; Quinolines; RNA, Messenger; Swine

Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Arginine Vasopressin; Barium; Calcium Channels, L-Type; Carbazoles; Cell Line; Cyclic AMP-Dependent Protein Kinases; Endothelin-1; Estrenes; GTP-Binding Proteins; Indoles; Myocardium; Protein Kinase C; Pyrroles; Pyrrolidinones; Rats

Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Endothelin-1; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Pyrroles; Rats; Rats, Sprague-Dawley; Up-Regulation

Topics: Animals; Corticosterone; Endothelin-1; Gene Expression Regulation; Hypoxia; Male; Paraventricular Hypothalamic Nucleus; Pyrimidines; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Time Factors

Topics: Antineoplastic Agents, Phytogenic; Carbazoles; Cell Division; Cells, Cultured; Coronary Vessels; Cyclic GMP-Dependent Protein Kinases; Drug Interactions; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogens; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pyrroles; Resveratrol; Stilbenes

Topics: Animals; Atorvastatin; Disease Models, Animal; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Preconditioning; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilation; Vasospasm, Intracranial

Topics: Blood Pressure; Carcinoma, Renal Cell; Endothelin-1; Gastrointestinal Stromal Tumors; Heart Rate; Humans; Hypertension; Indoles; Kidney Neoplasms; Models, Biological; Proteinuria; Pyrroles; Receptor Protein-Tyrosine Kinases; Renin; Sunitinib; Vascular Endothelial Growth Factor A

Topics: Air Pollutants; Anti-Inflammatory Agents; Atorvastatin; Cell Survival; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Malondialdehyde; Nitric Oxide; Oxidative Stress; P-Selectin; Particulate Matter; Pyrroles; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tumor Necrosis Factor-alpha

Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endothelin-1; Hypertension; Indoles; Kidney; Male; Nitric Oxide; Oxidative Stress; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sunitinib; Vascular Endothelial Growth Factor Receptor-1

Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Coronary Circulation; Endothelin-1; Female; Hemodynamics; Indoles; Male; Motor Activity; Nitric Oxide; Oxidative Stress; Pulmonary Circulation; Pyrroles; Reactive Oxygen Species; Rest; Sunitinib; Sus scrofa; Vasoconstriction

Topics: Apoptosis; Atorvastatin; Cell Death; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Gene Expression Regulation; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lysophospholipids; Nitric Oxide Synthase Type III; Oligonucleotide Array Sequence Analysis; Pyrroles; RNA

Topics: Animals; Aorta, Abdominal; Atherosclerosis; Atorvastatin; Diet, High-Fat; Disease Models, Animal; Disease Progression; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iliac Artery; Inflammation Mediators; Lipids; Male; Matrix Metalloproteinase 9; NF-kappa B; Phenylpropionates; Plaque, Atherosclerotic; Pyrimidines; Pyrroles; Rabbits; RNA, Messenger

Topics: Animals; Biomarkers; Body Weight; Cell Hypoxia; Cell Line; Disease Models, Animal; Endothelial Cells; Endothelin-1; Heart Rate; Humans; Hypertension, Pulmonary; Indoles; Inflammation; Interleukin-6; Lung; Male; Mice; Pulmonary Artery; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Up-Regulation

Topics: Blotting, Western; Endothelial Cells; Endothelin-1; Growth Differentiation Factor 2; Humans; Indoles; Lung; Microvessels; Phosphorylation; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A

Topics: Animals; Antithrombin III; Atorvastatin; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Liver; Male; Pyrroles; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha

Topics: 3' Untranslated Regions; Animals; Binding Sites; Cell Proliferation; Cells, Cultured; Endothelial Cells; Endothelin-1; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Hypoxia; Indoles; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; PPAR gamma; Pulmonary Artery; Pyrroles; RNA Interference; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transfection; Vascular Remodeling

Topics: Animals; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Cell Adhesion Molecules; Cell Hypoxia; Cell Movement; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Endothelin-1; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Membrane Glycoproteins; Mice; Myocytes, Smooth Muscle; Protein-Tyrosine Kinases; Pulmonary Artery; Pyrroles; Receptor, trkB; Vascular Endothelial Growth Factor A

Topics: Animals; Antihypertensive Agents; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Hypertrophy, Right Ventricular; Hypoxia; Indoles; Monocrotaline; Predictive Value of Tests; Pulmonary Arterial Hypertension; Pyrimidines; Pyrroles; Rats, Sprague-Dawley; Severity of Illness Index; Sulfonamides; Synchrotrons; Vasodilation; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling