pyrroles has been researched along with dinoprostone in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.03) | 18.7374 |
| 1990's | 10 (15.15) | 18.2507 |
| 2000's | 28 (42.42) | 29.6817 |
| 2010's | 24 (36.36) | 24.3611 |
| 2020's | 2 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Albus, U; Englert, HC; Fürst, U; Gehring, D; Rosenkranz, B; Schölkens, BA; Scholz, W; Wirth, K | 1 |
| Grose, JH; Lacourcière, Y; Lebel, M | 1 |
| Cenarruzabeitia, E; Lasheras, B; Ucelay, M | 1 |
| Chevalier, RL; Rogol, AD | 1 |
| Iitaka, M; Ishii, J; Kitahama, S | 1 |
| Bouchard, JF; Dumont, E; Lamontagne, D | 1 |
| Morita, I; Murota, S; Nakahama, K | 1 |
| Grimaldi, M; Navarra, P; Pozzoli, G; Preziosi, P; Schettini, G | 1 |
| McGrath, JC; Smith, GC | 1 |
| al-Rashed, S; Hellewell, PG; Rossi, AG; Teixeira, MM | 1 |
| Chabot-Fletcher, M; Jackson, JR; Marshall, LA; Roshak, A | 1 |
| McCarthy, TL; Millet, I; Vignery, A | 1 |
| Belogi, L; Mezzadri, CM; Tubaro, E | 1 |
| Akuzawa, S; Ito, H; Iwaoka, K; Kamato, T; Kiso, T; Miyata, K; Nagakura, Y; Naitoh, Y; Sakai, H; Suzuki, M; Yamaguchi, T; Yamano, M; Yuki, H | 1 |
| Fujita, N; Ishida, A; Kitazawa, R; Tsuruo, T | 1 |
| Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP | 1 |
| Averbeck, B; Reeh, WP; Zimmermann, K | 1 |
| Fernandes, JC; Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Pelletier, JP | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Cai, Y; Chen, P; Duan, S; Fang, X; Wu, S; Zhao, S | 1 |
| Kimura, T; Shimada, K; Ushiyama, S; Wada, Y | 1 |
| Blanco-Colio, LM; Egido, J; Gómez-Hernández, A; Hernández, G; Martín-Ventura, JL; Muñoz-García, B; Ortega, L; Serrano, J; Tuñón, J; Vega, M | 1 |
| Wu, SJ; Zhao, SP | 1 |
| Kimura, T; Shimada, K; Sugimoto, K; Ushiyama, S; Wada, Y | 1 |
| Blanco-Colio, LM; Egido, J; Gómez-Hernández, A; Hernández, G; Martín-Ventura, JL; Ortega, L; Ortego, M; Sánchez-Galán, E; Serrano, J; Tunón, J; Vega, M; Vidal, C | 1 |
| Cunha, FQ; Cunha, TM; Ferreira, SH; Parada, CA; Poole, S; Santodomingo-Garzón, T; Valério, DA; Verri, WA | 1 |
| Kamio, K; Kawasaki, S; Kobayashi, T; Liu, X; Mao, LJ; Rennard, SI; Shen, L; Sugiura, H; Togo, S; Wang, XQ | 1 |
| Egido, J; Gómez-Gerique, JA; Gómez-Hernández, A; González, A; Ortega, L; Sánchez-Galán, E; Tuñón, J; Vidal, C | 1 |
| Gao, Y; Kastrissios, H; Moberly, J; Rohatagi, S; Salazar, D; Takahashi, M; Truitt, K; Wada, R; Xu, J; Yoshihara, K; Zhang, N | 1 |
| Seidler, U; Tuo, BG; Wen, GR | 1 |
| DiGiovanni, J; Franco, E; Fujiwara, K; Hanai, M; Kawamoto, T; Kiguchi, K; Kurakata, S; Ruffino, L; Rumi, M | 1 |
| Jia, Z; Soodvilai, S; Yang, T | 1 |
| Anzellotti, P; Anzini, M; Biava, M; Botta, M; Cappelli, A; Forli, S; Ghelardini, C; Makovec, F; Manetti, F; Patrignani, P; Pergola, C; Poce, G; Porretta, GC; Rossi, A; Rovini, M; Sautebin, L; Supino, S; Vivoli, E | 1 |
| Hashizume, H; Kamio, N; Matsushima, K; Nakao, S; Sugiya, H | 1 |
| Chung, J; Huang, SK; Peters-Golden, M; Wettlaufer, SH | 1 |
| Albrecht, W; Bühring, U; Koeberle, A; Laufer, S; Northoff, H; Siemoneit, U; Werz, O | 1 |
| Blanco-Colio, LM; Egido, J; Gómez-Hernández, A; Jiménez-Nacher, JJ; López-Bescos, L; Martín-Ventura, JL; Ortego, M; Sánchez-Galán, E; Tarín-Vicente, N; Tuñón, J | 1 |
| Hershman, JM; Moatamed, F; Naeim, F; Sugawara, M; Tomoda, C | 1 |
| Alonso, S; Alvarez, Y; Fernández, N; Municio, C; San Román, JA; Sánchez Crespo, M | 1 |
| Chen, CL; Lo, HM; Tsai, YJ; Wu, PH; Wu, WB | 1 |
| Frank, PG; Lanza-Jacoby, S; Laury-Kleintop, L; Raval, M; Yan, G | 1 |
| Kalonia, H; Kumar, A; Kumar, P | 1 |
| Kang, Y; Lee, M; McGeer, E; McGeer, PL; Suk, K | 1 |
| Aoyagi, H; Inagaki, N; Kajiwara, D; Miyoshi, K; Shigeno, K; Tanaka, K; Togawa, M | 1 |
| Bagsby, AL; Freiter, EM; Mandal, PK; McMurray, JS; Robertson, FM | 1 |
| Aritake, K; Hori, M; Matsuoka, T; Michishita, M; Murata, T; Narumiya, S; Ozaki, H; Tajima, T; Urade, Y | 1 |
| Cho, YW; Lee, JY; Lee, KT; Noh, YS; Shin, JS; Yoo, MS | 1 |
| Gao, Y; He, C; He, S; Lai, L; Liu, Y; Wu, Y | 1 |
| Borda, E; Passafaro, D; Reina, S; Sterin-Borda, L | 1 |
| Brekken, RA; Burrows, FJ; Kirane, A; Larsen, JE; Meshaw, KR; Ostapoff, KT; Toombs, JE; Zaknoen, S | 1 |
| Guan, F; Ju, J; Li, G; Liu, AB; Sun, Y; Yang, CS; Yang, Z | 1 |
| Anzini, M; Biava, M; Cappelli, A; Di Capua, A; Fioravanti, A; Galeazzi, M; Giordani, A; Lamboglia, A; Niccolini, S; Pascarelli, NA; Tinti, L | 1 |
| Chen, YC; Cheng, KT; Lee, WR; Shen, SC; Tsai, HH; Wang, PH | 1 |
| Dulin, JN; Grill, RJ; Karoly, ED; Strobel, HW; Wang, Y | 1 |
| Li, X; Li, Y; Tan, L; Tang, T; Wang, J; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z | 1 |
| Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; More, AS; Pathak, NN; Tandan, SK | 1 |
| Dannenberg, AJ; Elchaki, R; Falcone, DJ; Khan, KM; Kothari, P; Mesraoua, R; Pestana, R | 1 |
| Brosh, T; Chechik, O; Dolkart, O; Gabet, Y; Liron, T; Maman, E; Somjen, D | 1 |
| Jin, YH; Jin, Z; Kim, S; Lee, G; Park, CS; Park, YS | 1 |
| Anzini, M; Belmonte, G; Biava, M; Cheleschi, S; Di Capua, A; Fioravanti, A; Giordani, A; Pascarelli, NA; Sticozzi, C; Valacchi, G | 1 |
| Hayashi, Y; Liu, X; Morinaga, S; Nakanishi, H; Wu, Z; Yokoyama, T; Zhang, J | 1 |
| Passeron, T | 1 |
| Choi, HY; Jang, C; Lee, JY; Lee, KT; Park, CS; Youn, I; Yune, TY | 1 |
| Heo, JD; Jeong, EJ; Kim, NH; Kim, YN; Lee, S; Lee, SM; Rho, JR | 1 |
| Danielewski, M; Dzimira, S; Merwid-Ląd, A; Rutkowska, M; Świątek, P; Szandruk-Bender, M; Szczukowski, Ł; Szeląg, A; Wiatrak, B | 1 |
| Horita, M; Takadera, T; Uema, S | 1 |
1 review(s) available for pyrroles and dinoprostone
| Article | Year |
|---|---|
Medical and Maintenance Treatments for Vitiligo.
Topics: Administration, Cutaneous; Adrenal Cortex Hormones; alpha-MSH; Anti-Bacterial Agents; Calcineurin Inhibitors; Dinoprostone; Humans; Immunosuppressive Agents; Low-Level Light Therapy; Methotrexate; Minocycline; Oxytocics; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Ultraviolet Therapy; Vitamin D; Vitiligo | 2017 |
3 trial(s) available for pyrroles and dinoprostone
| Article | Year |
|---|---|
Effect of short-term administration of cromakalim on renal hemodynamics and eicosanoid excretion in essential hypertension.
Topics: Adult; Antihypertensive Agents; Atrial Natriuretic Factor; Benzopyrans; Blood Pressure; Chlorides; Cromakalim; Dinoprost; Dinoprostone; Eicosanoids; Female; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Potassium; Prostaglandins; Pyrroles; Regional Blood Flow; Renin-Angiotensin System; Sodium; Thromboxane B2; Time Factors; Vascular Resistance | 1991 |
Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month.
Topics: Aged; Anti-Inflammatory Agents; Atherosclerosis; Atorvastatin; Blotting, Southern; Blotting, Western; Carotid Arteries; Chemokine CCL2; Cyclooxygenase 2; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Image Processing, Computer-Assisted; Immunohistochemistry; Inflammation; Leukocytes, Mononuclear; Lipids; Male; Middle Aged; NF-kappa B; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Effect of intensive atorvastatin therapy on prostaglandin E2 levels and metalloproteinase-9 activity in the plasma of patients with non-ST-elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Atorvastatin; Dinoprostone; Electrocardiography; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukotriene B4; Male; Matrix Metalloproteinase 9; Middle Aged; NF-kappa B; Pyrroles; Treatment Outcome | 2008 |
62 other study(ies) available for pyrroles and dinoprostone
| Article | Year |
|---|---|
Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies.
Topics: Animals; Benzopyrans; Bronchoconstrictor Agents; Bronchodilator Agents; Carbachol; Chromans; Cromakalim; Dinoprostone; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Pyrrolidines; Trachea | 1992 |
On the mechanism of the pharmacological activity of the new nonsteroidal antiinflammatory agent 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Carrageenan; Cell Migration Inhibition; Dinoprostone; In Vitro Techniques; Leukocytes; Lysosomes; Male; Prostaglandin Antagonists; Pyrroles; Rats; Rats, Inbred Strains; Tolmetin | 1989 |
Tolmetin sodium in the management of nephrogenic diabetes insipidus.
Topics: Child, Preschool; Diabetes Insipidus; Dinoprostone; Humans; Kidney Tubules, Collecting; Male; Prostaglandins E; Pyrroles; Tolmetin | 1982 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Evidence that prostaglandins I2, E2, and D2 may activate ATP sensitive potassium channels in the isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprostone; Dose-Response Relationship, Drug; Glyburide; Iloprost; In Vitro Techniques; Ion Channel Gating; Male; Myocardium; Perfusion; Potassium Channels; Pressure; Prostaglandin D2; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Effects of endogenously produced arachidonic acid metabolites on rat mesangial cell proliferation.
Topics: 1-Methyl-3-isobutylxanthine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Benzeneacetamides; Bucladesine; Carbazoles; Cell Division; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Dinoprostone; DNA Replication; Flavanones; Flavonoids; Glomerular Mesangium; Hydroxamic Acids; Hydroxyeicosatetraenoic Acids; Indoles; Indomethacin; Lipoxygenase Inhibitors; Male; Platelet-Derived Growth Factor; Pyrroles; Rats; Rats, Sprague-Dawley; Umbelliferones | 1994 |
Vasoactive intestinal peptide and forskolin stimulate interleukin 6 production by rat cortical astrocytes in culture via a cyclic AMP-dependent, prostaglandin-independent mechanism.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Bucladesine; Carbazoles; Cells, Cultured; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Dinoprostone; Indoles; Interleukin-6; Prostaglandins; Pyrroles; Radioimmunoassay; Rats; Rats, Wistar; Vasoactive Intestinal Peptide | 1994 |
Characterisation of the effect of oxygen tension on response of fetal rabbit ductus arteriosus to vasodilators.
Topics: Adenosine; Animals; Atrial Natriuretic Factor; Benzopyrans; Colforsin; Cromakalim; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Flurbiprofen; Indomethacin; Nifedipine; Nitroprusside; Norepinephrine; Oxygen; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Characterization of the prostanoid receptors mediating inhibition of PAF-induced aggregation of guinea-pig eosinophils.
Topics: Alprostadil; Analysis of Variance; Animals; Anti-Ulcer Agents; Carbazoles; Cell Aggregation; Dinoprostone; Dose-Response Relationship, Drug; Eosinophils; Female; Guinea Pigs; Indoles; Misoprostol; Oxytocics; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin D2; Prostaglandins E, Synthetic; Prostanoic Acids; Protein Kinase C; Pyrroles; Receptors, Prostaglandin; Structure-Activity Relationship | 1997 |
Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine.
Topics: Adult; Arthritis, Rheumatoid; Azepines; Cells, Cultured; Dinoprostone; Endothelial Growth Factors; Humans; Interleukin-1; Interleukin-8; Lymphokines; NF-kappa B; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrroles; Synovial Membrane; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Regulation of interleukin-6 production by prostaglandin E2 in fetal rat osteoblasts: role of protein kinase A signaling pathway.
Topics: Animals; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Indoles; Interleukin-6; Isoquinolines; Osteoblasts; Promoter Regions, Genetic; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thionucleotides; Transcription, Genetic | 1998 |
The mechanism of action of amtolmetin guacyl, a new gastroprotective nonsteroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Stability; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Pyrroles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug | 2000 |
Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.
Topics: Acetylcholine; Action Potentials; Animals; Anthraquinones; Atrial Function; Biguanides; Binding, Competitive; Colon; Dinoprostone; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Humans; In Vitro Techniques; Muscle Contraction; Myocardial Contraction; Pyrroles; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Receptor Agonists; Thiazoles | 2000 |
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone.
Topics: Animals; Bone and Bones; Carbazoles; Carrier Proteins; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelium, Vascular; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Pyrroles; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; RNA, Messenger; Transforming Growth Factor beta | 2002 |
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides | 2002 |
S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Culture Media, Conditioned; Dinoprostone; Drug Interactions; Dura Mater; Flurbiprofen; Immunoassay; In Vitro Techniques; Indoles; Inflammation Mediators; Male; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Serotonin Receptor Agonists; Time Factors; Tryptamines | 2003 |
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Topics: Acetates; Animals; Antirheumatic Agents; Arthritis, Experimental; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Enzyme Inhibitors; Insulin-Like Growth Factor I; Leukotriene B4; Lipoxygenase Inhibitors; Osteoarthritis; Osteoblasts; Pyrroles; Urokinase-Type Plasminogen Activator | 2004 |
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |
Atorvastatin reduces lipopolysaccharide-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells.
Topics: Atorvastatin; Cell Line; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Membrane Proteins; Metabolic Clearance Rate; Pyrroles; Respiratory Mucosa | 2005 |
Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982.
Topics: Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Dinoprostone; Humans; Interleukin-6; Interleukin-8; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrroles; Sarcoma, Synovial; Spheroids, Cellular | 2005 |
[Effects of atorvastatin on LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells].
Topics: Anticholesteremic Agents; Atorvastatin; Cell Line; Dinoprostone; Epithelial Cells; Heptanoic Acids; Humans; Interleukin-6; Lipopolysaccharides; Lung; Pyrroles | 2004 |
Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes.
Topics: Algorithms; Animals; Blotting, Western; Cartilage; Cattle; Cell Line, Tumor; Chondrocytes; Collagen; Collagenases; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Enzyme Inhibitors; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Nose; Nuclease Protection Assays; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; RNA, Messenger | 2006 |
Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization.
Topics: Aged; Atherosclerosis; Atorvastatin; Carotid Artery Diseases; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Intramolecular Oxidoreductases; Male; Matrix Metalloproteinase 1; Mevalonic Acid; Middle Aged; Monocytes; Prostaglandin-E Synthases; Protein Serine-Threonine Kinases; Pyrroles; Receptors, Prostaglandin E; rho GTP-Binding Proteins; rho-Associated Kinases | 2006 |
Atorvastatin inhibits inflammatory hypernociception.
Topics: Animals; Atorvastatin; Bradykinin; Cholesterol; Cytokines; Dinoprostone; Enzyme Inhibitors; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Inflammation; Interleukin-1; Lipopolysaccharides; Male; Mice; Nitric Oxide Synthase; Pain Measurement; Pyrroles; Skin | 2006 |
Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Apoptosis; Carbazoles; Caspases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dideoxyadenosine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Indoles; Lung; Nicotiana; Pyrroles; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; RNA, Small Interfering; Signal Transduction; Smoke; Thiophenes; Triazoles | 2007 |
Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
Topics: Acetates; Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Macrophages; Male; NF-kappa B; Pyrroles; Rabbits; RNA, Messenger; Thromboxane B2; Tunica Intima | 2007 |
Predictive population pharmacokinetic/pharmacodynamic model for a novel COX-2 inhibitor.
Topics: Administration, Oral; Adult; Algorithms; Asian People; Clinical Trials, Phase I as Topic; Cyclooxygenase 2 Inhibitors; Data Interpretation, Statistical; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Pyrroles; Randomized Controlled Trials as Topic; Software; Sulfonamides; Thromboxane B2; Time Factors; White People | 2007 |
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin | 2007 |
Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice.
Topics: Administration, Oral; Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; ErbB Receptors; Fluorescent Antibody Technique; Gallbladder Neoplasms; Mice; Mice, Transgenic; Pyrroles; Receptor, ErbB-2; Sulfonamides | 2007 |
Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2.
Topics: Amiloride; Animals; Biological Transport; Carbazoles; Cells, Cultured; Chlorides; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Enzyme Inhibitors; Hydrogen Peroxide; Indoles; Intramolecular Oxidoreductases; Isoquinolines; Kidney Medulla; Kidney Tubules, Collecting; Mice; Mice, Knockout; Microsomes; Oxidants; Prostaglandin-E Synthases; Protein Kinase Inhibitors; Pyrroles; Sodium Chloride; Sulfonamides | 2007 |
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.
Topics: Acetates; Adult; Animals; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Edema; Female; Humans; Male; Mice; Models, Molecular; Pain Measurement; Pyrroles; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; T-Box Domain Proteins | 2007 |
Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp.
Topics: Adult; Calcium; Cells, Cultured; Dental Pulp; Dinoprostone; Fibrinolysin; Humans; Inflammation; Interleukin-8; Peptides; Pyrroles; Quinazolines; Receptor, PAR-1; RNA, Messenger | 2008 |
Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1.
Topics: Carbazoles; Catalytic Domain; Cell Line; Cell Proliferation; Collagen Type I; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Fibroblasts; Guanine Nucleotide Exchange Factors; Humans; Lung; Protein Kinase C-delta; Pyrroles; rap1 GTP-Binding Proteins | 2008 |
Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
Topics: Adult; Animals; Cattle; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Humans; Intramolecular Oxidoreductases; Microsomes; Prostaglandin-E Synthases; Pyrroles; Sheep | 2008 |
Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase.
Topics: Antineoplastic Agents; Apoptosis; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Medullary; Cell Cycle; Cell Line; Cell Proliferation; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Humans; Indoles; Indomethacin; Phosphorylation; Pyrroles; Retinoblastoma Protein; S Phase; Sunitinib; Thyroid Neoplasms | 2008 |
Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin.
Topics: Antigens, CD; Arachidonic Acid; Atorvastatin; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Dendritic Cells; Dinoprostone; Gene Expression; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Mevalonic Acid; Peptidoglycan; Phospholipases A2, Cytosolic; Pyrroles; Zymosan | 2009 |
Thrombin induces cyclooxygenase-2 expression and prostaglandin E2 release via PAR1 activation and ERK1/2- and p38 MAPK-dependent pathway in murine macrophages.
Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Imidazoles; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Thrombin; Thromboxane A2 | 2009 |
Celecoxib combined with atorvastatin prevents progression of atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Atorvastatin; Celecoxib; Chemokine CCL2; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Progression; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrroles; Sulfonamides; Vascular Cell Adhesion Molecule-1 | 2010 |
Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats: protective effect of licofelone.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Body Weight; Caspase 3; Corpus Striatum; Dinoprostone; Huntington Disease; Interleukin-6; Lipid Peroxidation; Lipoxygenase; Male; Mitochondria; Motor Activity; Neuroprotective Agents; NF-kappa B; Nitrites; Nitro Compounds; Propionates; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2011 |
Neurotoxic factors released by stimulated human monocytes and THP-1 cells.
Topics: Analysis of Variance; Antibodies; Cell Line, Transformed; Cell Line, Tumor; Cyclic N-Oxides; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Glutamic Acid; Humans; Imidazoles; Interferon-gamma; L-Lactate Dehydrogenase; Leukemia, Monocytic, Acute; Lipopolysaccharides; Molecular Weight; Monocytes; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase Type I; Nitrites; Pyrroles; RNA, Messenger; Teratocarcinoma | 2011 |
Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis.
Topics: Animals; Benzimidazoles; Dinoprostone; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Humans; Intramolecular Oxidoreductases; Leukotrienes; Lipocalins; Male; Nasal Lavage Fluid; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Prostaglandin D2; Pyrroles; Rhinitis; Time Factors | 2011 |
Efficient synthesis of apricoxib, CS-706, a selective cyclooxygenase-2 inhibitor, and evaluation of inhibition of prostaglandin E2 production in inflammatory breast cancer cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Humans; Inflammatory Breast Neoplasms; Pyrroles; Sulfonamides | 2011 |
EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.
Topics: Animals; Carbazoles; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Flavonoids; Gastrointestinal Motility; Ileum; Isoxazoles; Lipopolysaccharides; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Pyrroles; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sulfones; Up-Regulation | 2012 |
Anti-inflammatory and anti-arthritic effects of new synthetic 3-(4-hydroxyphenyl)-4-(4-thiomethoxyphenyl)-1H-pyrrole-2,5-dione.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley | 2012 |
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Cell-Free System; Databases, Factual; Dinoprostone; Humans; Intramolecular Oxidoreductases; Leukotriene B4; Lipoxygenase Inhibitors; Microsomes; Molecular Dynamics Simulation; Prostaglandin-E Synthases; Protein Binding; Protein Conformation; Pyrroles; Recombinant Proteins; Structure-Activity Relationship | 2012 |
Atorvastatin inhibits the inflammatory response caused by anti-M(3) peptide IgG in patients with primary Sjögren's syndrome.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atorvastatin; Autoantibodies; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Heptanoic Acids; Humans; Immunoglobulin G; In Vitro Techniques; Interleukin-1beta; Male; Matrix Metalloproteinase 3; Middle Aged; Peptide Fragments; Pyrroles; Rats; Receptor, Muscarinic M3; Sjogren's Syndrome; Submandibular Gland | 2012 |
Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epithelial-Mesenchymal Transition; Female; HT29 Cells; Humans; Mice; Mice, Nude; Pyrroles; Sulfonamides; Vascular Endothelial Growth Factor A | 2012 |
Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation.
Topics: Animals; Atorvastatin; Azoxymethane; Catechin; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Heptanoic Acids; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pyrroles; Rectum; Weight Loss | 2012 |
In vitro effects of VA441, a new selective cyclooxygenase-2 inhibitor, on human osteoarthritic chondrocytes exposed to IL-1β.
Topics: Aged; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1beta; Matrix Metalloproteinase 3; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis; Pyrroles; Sulfones | 2012 |
Propionibacterium acnes-induced iNOS and COX-2 protein expression via ROS-dependent NF-κB and AP-1 activation in macrophages.
Topics: Allopurinol; Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gram-Positive Bacterial Infections; Imidazoles; Luciferases; Macrophages; MAP Kinase Signaling System; Mice; NADPH Oxidases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Propionibacterium acnes; Pyrroles; Reactive Oxygen Species; Transcription Factor AP-1; Xanthine Oxidase | 2013 |
Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Leukotriene B4; Locomotion; Metabolomics; Oxidative Stress; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2013 |
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones | 2013 |
Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats.
Topics: Analgesia; Animals; Anti-Inflammatory Agents; Atorvastatin; Constriction; Dinoprostone; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1beta; Male; Matrix Metalloproteinase 2; Nerve Growth Factor; Neuralgia; Pain Measurement; Pyrroles; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha | 2013 |
IL-6-mediated induction of matrix metalloproteinase-9 is modulated by JAK-dependent IL-10 expression in macrophages.
Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hydroxyprostaglandin Dehydrogenases; Interleukin-10; Interleukin-6; Intramolecular Oxidoreductases; Janus Kinases; Macrophages; Matrix Metalloproteinase 9; Mice; Models, Biological; Piperidines; Prostaglandin-E Synthases; Pyrimidines; Pyrroles | 2014 |
Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study.
Topics: Animals; Atorvastatin; Biomechanical Phenomena; Celecoxib; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Models, Animal; Pyrazoles; Pyrroles; Random Allocation; Rats, Wistar; Receptors, Prostaglandin E, EP4 Subtype; Rotator Cuff; Sulfonamides; Tendons; Wound Healing | 2014 |
Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.
Topics: Animals; Anti-Inflammatory Agents; Carbazoles; Dinoprostone; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Ileum; Male; Neurons, Afferent; Nodose Ganglion; Ondansetron; Patch-Clamp Techniques; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Sensory Receptor Cells; Serotonin; Signal Transduction; Stomach; Thiophenes; Triazoles; Visceral Afferents; Xanthones | 2015 |
Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression; Humans; Interleukin-1beta; Matrix Metalloproteinases; Middle Aged; Molecular Structure; Naproxen; NF-kappa B; Nitrates; Osteoarthritis, Hip; Pyrroles | 2015 |
An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons.
Topics: Alprostadil; Animals; Carbazoles; Dinoprostone; In Vitro Techniques; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Male; Methyl Ethers; Mice; Mice, Inbred C57BL; Pyrroles; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype | 2016 |
Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats.
Topics: Animals; Cauda Equina; Celecoxib; Chronic Pain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Hyperalgesia; Lumbar Vertebrae; Macrophages; Male; Neuralgia; Pyrroles; Rats, Sprague-Dawley; Spinal Stenosis | 2019 |
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Topics: Animals; Aquatic Organisms; Azepines; Caco-2 Cells; Coculture Techniques; Colitis, Ulcerative; Crohn Disease; Dinoprostone; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Intestines; Porifera; Pyrroles; THP-1 Cells | 2019 |
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-
Topics: Analgesics; Animals; Dinoprostone; Gastric Mucosa; Male; Nociception; Nociceptive Pain; Oxadiazoles; Pain Measurement; Peroxidase; Pyridazines; Pyrroles; Rats; Rats, Wistar | 2020 |
Protective effects of calcium ions via L-type calcium channels and NMDA receptors on prostaglandin E
Topics: Animals; Apoptosis; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Calcium Signaling; Carbazoles; Cells, Cultured; Cerebral Cortex; Dinoprostone; Enzyme Inhibitors; Ions; N-Methylaspartate; Neurons; Protective Agents; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2021 |