Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and debromohymenialdisine

pyrroles has been researched along with debromohymenialdisine in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's8 (61.54)29.6817
2010's3 (23.08)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
DiMartino, M; Nambi, P; Patil, A; Wolff, C1
Barrios Sosa, AC; Horne, DA; Yakushijin, K1
Andersen, RJ; Block, WD; Cinel, B; Clarke, PR; Curman, D; Goodarzi, AA; Hutchins, JR; Lees-Miller, SP; Roberge, M; Rundle, N; Williams, DE; Zhou, BB1
Clarke, PR; Dikovskaya, D; Hutchins, JR1
Castedo, M; Feunteun, J; Horne, D; Kroemer, G; Lenoir, G; Medema, R; Perfettini, JL; Raslova, H; Roumier, T; Vainchenker, W; Valent, A; Yakushijin, K1
Fisher, LM; Foloppe, N; Francis, G; Howes, R; Kierstan, P; Potter, A1
Borghi, D; Papeo, G; Posteri, H; Varasi, M1
Aherne, GW; Barrie, SE; Boxall, KJ; Garrett, MD; Mittnacht, S; Oliver, AW; Paul, A; Pearl, LH1
Jobson, AG; Lountos, GT; Pommier, Y; Shoemaker, RH; Tropea, JE; Waugh, DS; Zhang, D1
Cao, XP; Qu, Y; Song, YF; Zhang, W1
Lansdell, TA; Saleem, RS; Tepe, JJ1
Heo, JD; Jeong, EJ; Kim, NH; Kim, YN; Lee, S; Lee, SM; Rho, JR1
Cao, X; Linhardt, RJ; Qu, Y; Song, Y; Yang, Q; Zhang, F; Zhang, W1

Other Studies

13 other study(ies) available for pyrroles and debromohymenialdisine

ArticleYear
Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Azepines; Enzyme Inhibitors; Indomethacin; Lymphocyte Activation; Male; Methotrexate; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Lew

1995
A practical synthesis of (Z)-debromohymenialdisine.
    The Journal of organic chemistry, 2000, Jan-28, Volume: 65, Issue:2

    Topics: Azepines; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Pyrroles

2000
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
    The Journal of biological chemistry, 2001, May-25, Volume: 276, Issue:21

    Topics: Alkaloids; Animals; Azepines; Cell Line; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; Enzyme Inhibitors; G2 Phase; Porifera; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; Signal Transduction

2001
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
    Molecular biology of the cell, 2003, Volume: 14, Issue:10

    Topics: Amino Acid Sequence; Animals; Azepines; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; CDC2-CDC28 Kinases; cdc25 Phosphatases; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Cloning, Molecular; Cyclin B; DNA Damage; DNA Replication; Female; G2 Phase; Interphase; Mitosis; Models, Molecular; Molecular Sequence Data; Oocytes; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyrroles; Staurosporine; Xenopus laevis; Xenopus Proteins

2003
Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.
    Oncogene, 2004, May-27, Volume: 23, Issue:25

    Topics: Amino Acid Chloromethyl Ketones; Aneuploidy; Antibiotics, Antineoplastic; Apoptosis; Azepines; Caspase 2; Caspase 3; Caspase Inhibitors; Caspases; CD4 Antigens; Cell Division; Cell Fusion; Cell Line, Tumor; Cell Transformation, Neoplastic; Centrosome; Checkpoint Kinase 2; Colonic Neoplasms; Cysteine Proteinase Inhibitors; DNA Damage; Doxorubicin; Genes, env; Giant Cells; HeLa Cells; Humans; Intracellular Membranes; Metaphase; Mitochondria; Mitosis; Models, Biological; Protein Serine-Threonine Kinases; Pyrroles; RNA Interference; Transfection

2004
Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification.
    Bioorganic & medicinal chemistry, 2006, Mar-15, Volume: 14, Issue:6

    Topics: Adenosine Triphosphate; Azepines; Binding Sites; Checkpoint Kinase 1; Computer Simulation; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Indazoles; Ligands; Models, Molecular; Protein Binding; Protein Kinases; Pyrroles; Structure-Activity Relationship

2006
A new glycociamidine ring precursor: syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (+/-)-endo-2-debromohymenialdisine.
    Organic letters, 2005, Dec-08, Volume: 7, Issue:25

    Topics: Alkaloids; Animals; Azepines; Cyclization; Marine Biology; Molecular Structure; Porifera; Pyrroles; Stereoisomerism

2005
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
    The EMBO journal, 2006, Jul-12, Volume: 25, Issue:13

    Topics: Adenosine Diphosphate; Ataxia Telangiectasia Mutated Proteins; Azepines; Catalytic Domain; Cell Cycle Proteins; Checkpoint Kinase 2; Dimerization; DNA Damage; DNA-Binding Proteins; Enzyme Activation; Humans; Models, Molecular; Phosphorylation; Protein Conformation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyrroles; Signal Transduction; Trans-Activators; Tumor Suppressor Proteins

2006
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
    Protein science : a publication of the Protein Society, 2009, Volume: 18, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Carbanilides; Catalytic Domain; Checkpoint Kinase 2; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Protein Binding; Protein Serine-Threonine Kinases; Pyrroles; Structure-Activity Relationship; Substrate Specificity

2009
Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol.
    Marine biotechnology (New York, N.Y.), 2011, Volume: 13, Issue:5

    Topics: Animals; Azepines; Bacteria; Cell Separation; Porifera; Protein Transport; Pyrroles

2011
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors.
    Bioorganic & medicinal chemistry, 2012, Feb-15, Volume: 20, Issue:4

    Topics: Animals; Azepines; Binding Sites; Checkpoint Kinase 1; Checkpoint Kinase 2; Crystallography, X-Ray; Enzyme Activation; Inhibitory Concentration 50; Molecular Structure; Porifera; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrroles; Substrate Specificity

2012
(10
    Molecules (Basel, Switzerland), 2019, Sep-18, Volume: 24, Issue:18

    Topics: Animals; Aquatic Organisms; Azepines; Caco-2 Cells; Coculture Techniques; Colitis, Ulcerative; Crohn Disease; Dinoprostone; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Intestines; Porifera; Pyrroles; THP-1 Cells

2019
Cultivation of fractionated cells from a bioactive-alkaloid-bearing marine sponge Axinella sp.
    In vitro cellular & developmental biology. Animal, 2021, Volume: 57, Issue:5

    Topics: Animals; Axinella; Azepines; Cell Fractionation; Cells, Cultured; Pyrroles

2021