Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and cyclosporine

pyrroles has been researched along with cyclosporine in 55 studies

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (7.27)18.2507
2000's21 (38.18)29.6817
2010's30 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ichikawa, M; Matsuyama, K; Nakashima, M; Ohya, H; Sakurai, M; Sasaki, H; Zhao, MF1
Bastos, CM; Gordon, KA; Granstein, RD; Jenson, JC; Jones, B; McAuliffe, DJ; Newcomb, JR; Ocain, TD1
Hioki, K; Kameshita, I; Mohri, T; Suzuki, S; Takatani, S; Tokunaga, R1
Balog, DL; Cheigh, JS; Maltz, HC1
Stewart, BH; Whitfield, LR; Wu, X1
Böhmig, G; Demetriou, D; Hörl, WH; Schmaldienst, S; Shabpar, A; Watschinger, B1
Burkhardt, K; Hauser, IA; Koch, C; Mayer-Kadner, I; Renders, L; Schärffe, S; Schmieder, RE; Veelken, R1
Behbod, F; Erwin-Cohen, RA; Kahan, BD; Kirken, RA; Nagy, ZS; Qu, X; Stepkowski, SM; Tejpal, N; Wang, ME1
Asberg, A; Bergan, S; Fjeldså, E; Hartmann, A; Holdaas, H1
Ananth, SL; Babu, YS; Banti, S; Horn, LL; Miller, PJ; Parker, CD; Sandhu, JS1
Allen, J; Butler, M; Kubler, PA; Lynch, SV; Pillans, PI; Taylor, PJ1
Chan, KH; Chau, E; Lai, KC; Wai-Hung Shek, T; Wong, WM1
Asberg, A; Christensen, H; Hartmann, A; Hermann, M; Holdaas, H; Reubsaet, JL2
Das, V; Shrivastava, R; Singh, S1
Hess, L; Krähenbühl, S; Krähenbühl-Melcher, A; Rätz Bravo, AE; Schlienger, RG; Tchambaz, L1
Burton, I; Koshman, SL; Lalonde, LD; Pearson, GJ; Tymchak, WJ1
Asberg, A; Hermann, M; Holdaas, H; Lemahieu, WP; Maes, BD; Vanrenterghem, Y; Verbeke, K1
Barsotti, G; Carpi, A; Consani, C; Manca-Rizza, G; Mantuano, E; Marchetti, V; Panichi, V; Paoletti, S; Sbragia, G; Taccola, D1
Anglicheau, D; Beaune, P; Cassinat, B; Legendre, C; Marquet, P; Méria, P; Pallet, N; Rabant, M; Thervet, E1
Gu, M; Liu, M; Wu, Y; Yin, C; Zhang, W; Zhu, P1
Chen, XJ; Dong, J; Sun, YB; Wang, GJ; Wang, L; Yu, X1
de Barros e Silva, MJ; de Paiva, TF; Fanelli, MF; Gimenes, DL; Rinck, JA1
Aliabadi, AZ; Dunkler, D; Grimm, M; Grömmer, M; Mahr, S; Wolner, E; Zimpfer, D; Zuckermann, AO1
Hoskova, L; Kautzner, J; Kubanek, M; Malek, I; Podzimkova, M; Skalicka, B; Vymetalova, Y1
Beerli, C; Bruns, C; Burkhart, C; Metzler, B; Morris, RE; Pally, C; Wagner, J; Weckbecker, G; Wieczorek, G1
Cooper, JE; Wiseman, AC1
Amundsen, R; Asberg, A; Christensen, H; Zabihyan, B1
Grenet, O; Kovarik, JM; Seiberling, M; Sfikas, N; Slade, A; Stitah, S; Straube, F; Vitaliti, A; Winter, S1
Haron, MM; Houssen, ME; Ibrahim, TM; Metwally, SS1
Budde, K; Glander, P; Mashreghi, MF; Matz, M; Naik, M; Neumayer, HH1
Becker, T; Chicano Wust, I; Ciesek, S; Heidrich, B; Helfritz, FA; Manns, MP; Pietschmann, T; Rohrmann, K; Schulze, A; Steinmann, E; Urban, S; von Hahn, T1
Todo, S; Yamashita, K1
Audet, M; Beerli, C; Bigaud, M; Blancher, A; Heusser, C; Morris, RE; Wagner, J; Wieczorek, G1
Foulks, GN; Klamerus, KJ; Li, JZ; Liew, SH; Nichols, KK; Zhang, M1
Cooper, SR; Huang, JF; Liew, SH; McDowell, M; Pickering, EH; Rittenhouse, KD; Sace, F; Yafawi, R; Zhang, M1
Baan, CC; Chan, G; Kho, MM; Mol, WM; Quaedackers, ME; Vafadari, R; Weimar, W1
Klintmalm, GB; Ruiz, R1
Enache, I; Garrouste, C; Heng, AE; Kaysi, S; Philipponnet, C; Tiple, A1
Davidson, SM; Elliot, PM; Harding, SE; Hausenloy, DJ; McGregor, C; Rees, PS; Yellon, DM1
Ali, R; Khanna, N; Kumar, S; Naqvi, RA; Rani, R; Rao, DN1
Baan, C; de Weerd, A; Kho, M; Kraaijeveld, R; Weimar, W; Zuiderwijk, J1
Bossart, W; Etter, A; Fehr, T; Hässig, A; Müller, N; Roos, M; Schiesser, M; Wüthrich, RP1
Ben-Eltriki, M; Brocks, DR; Chaudhary, HR; El-Kadi, AO; Elsherbiny, ME1
Ballmick, A; Cano, M; Cruz-Guilloty, F; Duffort, S; Ebrahimi, KB; Handa, JT; Laird, JM; Perez, VL; Saeed, AM; Salomon, RG; Tan, Y; Wang, H1
Chen, WC; Huang, L; Li, HY; Liu, JS; Wang, J; Yang, WD1
Foley, P; Kelly, JB; Strober, BE1
Budde, K; Busque, S; Chan, G; Lamba, M; Lawendy, N; O'Connell, PJ; Russ, G; Silva, HT; Tortorici, MA; Vincenti, F; Wang, W; Yoshida, A1
Bašić-Jukić, N; Ivandić, E1
Karam, S; Wali, RK1
Day, AS; Eliadou, E; Gearry, RB; Inns, SJ; Rowbotham, DS; Schultz, M; Thompson-Fawcett, MW; Walmsley, R1
Amano, W; Hayashi, M; Kakimoto, K; Katsuda, Y; Kimoto, Y; Konishi, N; Shinozaki, Y; Taniai-Riya, E; Tanimoto, A; Toyoda, K; Yamamoto, Y1
Lacour, JP1
Cho, S; Huh, CH; Kim, MW; Kwon, O; Lee, JS; Park, HS; Shin, JW1
Abe, M; Endo, M; Fukuda, N; Horikoshi, S; Inoue, T; Mineshige, T; Otsuki, M; Otsuki, T1

Reviews

5 review(s) available for pyrroles and cyclosporine

ArticleYear
Novel immunosuppressive agents in kidney transplantation.
    Clinical nephrology, 2010, Volume: 73, Issue:5

    Topics: Abatacept; Alefacept; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cyclosporine; Everolimus; Graft Rejection; Graft Survival; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney Transplantation; Piperidines; Pyrimidines; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Sirolimus

2010
Evaluation of the novel protein kinase C inhibitor sotrastaurin as immunosuppressive therapy after renal transplantation.
    Expert opinion on drug metabolism & toxicology, 2011, Volume: 7, Issue:1

    Topics: Calcineurin Inhibitors; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclosporine; Drug Evaluation; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Sirolimus; Tacrolimus; Treatment Outcome

2011
Renal-sparing regimens employing new agents.
    Current opinion in organ transplantation, 2012, Volume: 17, Issue:6

    Topics: Abatacept; Calcineurin Inhibitors; Cyclosporine; Everolimus; Graft Rejection; Humans; Immunoconjugates; Immunosuppressive Agents; Kidney; Kidney Transplantation; Mycophenolic Acid; Pyrroles; Quinazolines; Sirolimus; TOR Serine-Threonine Kinases

2012
Current and future oral systemic therapies for psoriasis.
    Dermatologic clinics, 2015, Volume: 33, Issue:1

    Topics: Acitretin; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Cyclosporine; Fumarates; Humans; Hydroxyurea; Immunosuppressive Agents; Isoxazoles; Keratolytic Agents; Leflunomide; Methotrexate; Mycophenolic Acid; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Sulfasalazine; Thalidomide; Thioguanine

2015
Current State of Immunosuppression: Past, Present, and Future.
    Critical reviews in eukaryotic gene expression, 2015, Volume: 25, Issue:2

    Topics: Abatacept; Alemtuzumab; Animals; Antibodies, Monoclonal, Humanized; Azathioprine; Bone Marrow Transplantation; Calcineurin Inhibitors; Cyclosporine; Disease Models, Animal; Everolimus; Heart Transplantation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Transplantation; Lung Transplantation; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Sirolimus; Tacrolimus

2015

Trials

12 trial(s) available for pyrroles and cyclosporine

ArticleYear
Beneficial effects of atorvastatin in the treatment of hyperlipidemia after renal transplantation.
    Wiener klinische Wochenschrift, 2000, Apr-21, Volume: 112, Issue:8

    Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Cyclosporine; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Kidney Failure, Chronic; Kidney Function Tests; Kidney Transplantation; Liver Function Tests; Male; Middle Aged; Pyrroles; Treatment Outcome; Triglycerides

2000
Efficacy and drug interactions of the new HMG-CoA reductase inhibitors cerivastatin and atorvastatin in CsA-treated renal transplant recipients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:1

    Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Cyclosporine; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Pyridines; Pyrroles; Safety

2001
Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2001, Volume: 1, Issue:4

    Topics: Adult; Aged; Antibodies, Monoclonal; Area Under Curve; Atorvastatin; Basiliximab; Cyclosporine; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Prednisolone; Pyrroles; Recombinant Fusion Proteins

2001
Effect of atorvastatin on cyclosporine pharmacokinetics in liver transplant recipients.
    The Annals of pharmacotherapy, 2004, Volume: 38, Issue:2

    Topics: Adult; Aged; Area Under Curve; Atorvastatin; Cholesterol; Cyclosporine; Drug Interactions; Female; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Postoperative Complications; Pyrroles; Treatment Outcome

2004
Substantially elevated levels of atorvastatin and metabolites in cyclosporine-treated renal transplant recipients.
    Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:4

    Topics: Adult; Anticholesteremic Agents; Area Under Curve; Atorvastatin; Chromatography, High Pressure Liquid; Cyclosporine; Drug Interactions; Female; Heptanoic Acids; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mass Spectrometry; Middle Aged; Pyrroles

2004
Atorvastatin does not affect the pharmacokinetics of cyclosporine in renal transplant recipients.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:1

    Topics: Anticholesteremic Agents; Area Under Curve; Atorvastatin; Cyclosporine; Drug Interactions; Half-Life; Heptanoic Acids; Humans; Immunosuppressive Agents; Kidney Transplantation; Linear Models; Pyrroles

2005
Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, Volume: 5, Issue:9

    Topics: Area Under Curve; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indoles; Lactones; Liver; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Pravastatin; Pyrroles; Simvastatin; Tacrolimus; Time Factors

2005
Sotrastaurin and cyclosporine drug interaction study in healthy subjects.
    Biopharmaceutics & drug disposition, 2010, Volume: 31, Issue:5-6

    Topics: Adult; Biomarkers, Pharmacological; Cyclosporine; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Humans; Lymphocyte Activation; Male; Pyrroles; Quinazolines; T-Lymphocytes

2010
Tofacitinib (CP-690,550), a Janus kinase inhibitor for dry eye disease: results from a phase 1/2 trial.
    Ophthalmology, 2012, Volume: 119, Issue:7

    Topics: Cyclosporine; Double-Blind Method; Dry Eye Syndromes; Female; Humans; Janus Kinase 3; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Pyrimidines; Pyrroles; Surveys and Questionnaires; Tears; Treatment Outcome

2012
Immunomodulatory effect of the topical ophthalmic Janus kinase inhibitor tofacitinib (CP-690,550) in patients with dry eye disease.
    Ophthalmology, 2012, Volume: 119, Issue:7

    Topics: Administration, Topical; Conjunctiva; Cyclosporine; Cytokines; Dry Eye Syndromes; Female; Flow Cytometry; HLA-DR1 Antigen; Humans; Janus Kinase 3; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Pyrimidines; Pyrroles; Tears

2012
Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients.
    Transplantation, 2012, Sep-15, Volume: 94, Issue:5

    Topics: Antibodies, Monoclonal; Basiliximab; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Interleukin-15; Interleukin-2; Interleukin-7; Janus Kinases; Kidney Transplantation; Lymphocyte Activation; Lymphocyte Count; Lymphocytes; Netherlands; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptors, Interleukin-2; Recombinant Fusion Proteins; Signal Transduction; STAT5 Transcription Factor; Tacrolimus; Time Factors; Treatment Outcome

2012
The protein kinase C inhibitor sotrastaurin allows regulatory T cell function.
    Clinical and experimental immunology, 2014, Volume: 175, Issue:2

    Topics: Adult; CD4 Antigens; Cell Proliferation; Cyclosporine; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Kidney Transplantation; Lymphocyte Count; Lymphocyte Culture Test, Mixed; Male; Middle Aged; NF-kappa B; Phosphorylation; Protein Kinase C; Pyrroles; Quinazolines; Signal Transduction; STAT5 Transcription Factor; T-Lymphocytes, Regulatory

2014

Other Studies

38 other study(ies) available for pyrroles and cyclosporine

ArticleYear
Evaluation of in-vivo transdermal absorption of cyclosporin with absorption enhancer using intradermal microdialysis in rats.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:11

    Topics: Administration, Cutaneous; Animals; Cyclosporine; Dose-Response Relationship, Drug; Drug Carriers; Immunosuppressive Agents; Male; Microdialysis; Pyrroles; Rats; Rats, Wistar; Skin Absorption

1996
A novel series of low molecular weight immunosuppressive agents.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Animals; Antibodies; CD2 Antigens; Cells, Cultured; Cyclosporine; Female; Graft Rejection; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C57BL; Organometallic Compounds; Pyrroles; Skin Transplantation; T-Lymphocytes; Time Factors; Transplantation, Homologous

1996
Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A.
    Cell structure and function, 1998, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Carbazoles; Cell Adhesion; Cell Adhesion Molecules; Colonic Neoplasms; Cyclosporine; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunosuppressive Agents; Indole Alkaloids; Indoles; Integrins; Neoplasm Metastasis; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrroles; Sulfonamides; Tacrolimus; Tumor Cells, Cultured; Tyrosine

1998
Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:11

    Topics: Anticholesteremic Agents; Atorvastatin; Cadaver; Clinical Enzyme Tests; Cyclosporine; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Pyrroles; Rhabdomyolysis

1999
Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter.
    Pharmaceutical research, 2000, Volume: 17, Issue:2

    Topics: Acetic Acid; Anion Transport Proteins; Antineoplastic Agents, Phytogenic; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoic Acid; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Carbon Radioisotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carboxylic Acids; Carrier Proteins; Cell Polarity; Cyclosporine; Drug Interactions; Heptanoic Acids; Humans; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indicators and Reagents; Ionophores; Niacin; Protons; Pyrroles; Verapamil; Vinblastine

2000
Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
    Blood, 2002, Jan-15, Volume: 99, Issue:2

    Topics: Administration, Oral; Animals; Cell Line; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Graft Survival; Heart Transplantation; Humans; Immunosuppressive Agents; Interleukins; Janus Kinase 2; Janus Kinase 3; Jurkat Cells; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Signaling System; Milk Proteins; Phosphorylation; Prodigiosin; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrroles; Rats; Rats, Inbred BUF; Rats, Inbred WF; Sirolimus; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators

2002
Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777.
    International immunopharmacology, 2002, Volume: 2, Issue:7

    Topics: Animals; Cyclosporine; Deoxyguanine Nucleotides; Dogs; Drug Therapy, Combination; Graft vs Host Disease; Growth Inhibitors; Humans; Immunosuppressive Agents; Lymphocytes; Macaca fascicularis; Mice; Mice, Inbred BALB C; Mice, SCID; Purine Nucleosides; Pyrimidinones; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Transplantation, Heterologous

2002
Rhabdomyolysis triggered by cytomegalovirus infection in a heart transplant patient on concomitant cyclosporine and atorvastatin therapy.
    Journal of gastroenterology and hepatology, 2004, Volume: 19, Issue:8

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Colon; Colonoscopy; Cyclosporine; Cytomegalovirus Infections; Drug Interactions; Heart Transplantation; Heptanoic Acids; Humans; Immunosuppressive Agents; Male; Postoperative Complications; Pyrroles; Rhabdomyolysis; Treatment Outcome

2004
Formulary conversion programs: the need for patient-specific risk assessment.
    MedGenMed : Medscape general medicine, 2004, Sep-14, Volume: 6, Issue:3

    Topics: Aged; Atorvastatin; Cyclosporine; Drug Interactions; Female; Formularies as Topic; Heart Transplantation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Postoperative Care; Pyrroles; Rhabdomyolysis; Risk Assessment; Simvastatin

2004
Prevalence of potentially severe drug-drug interactions in ambulatory patients with dyslipidaemia receiving HMG-CoA reductase inhibitor therapy.
    Drug safety, 2005, Volume: 28, Issue:3

    Topics: Aged; Ambulatory Care; Aryl Hydrocarbon Hydroxylases; Atorvastatin; Comorbidity; Cross-Sectional Studies; Cyclosporine; Cytochrome P-450 CYP3A; Digoxin; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Male; Niacin; Oxidoreductases, N-Demethylating; Physicians; Pravastatin; Prevalence; Product Surveillance, Postmarketing; Pyrroles; Simvastatin; Time Factors

2005
Supratherapeutic response to ezetimibe administered with cyclosporine.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:9

    Topics: Anticholesteremic Agents; Atorvastatin; Azetidines; Cyclosporine; Drug Interactions; Ezetimibe; Heart Transplantation; Heptanoic Acids; Humans; Hyperlipidemias; Immunosuppressive Agents; Male; Middle Aged; Postoperative Complications; Pyrroles

2005
Safety and effects on the lipid and C-reactive protein plasma concentration of the association of ezetimibe plus atorvastatin in renal transplant patients treated by cyclosporine-A: a pilot study.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:5

    Topics: Aged; Anticholesteremic Agents; Atorvastatin; Azetidines; C-Reactive Protein; Cyclosporine; Drug Combinations; Ezetimibe; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Function Tests; Kidney Transplantation; Lipids; Male; Middle Aged; Pilot Projects; Pyrroles; Triglycerides

2006
Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction.
    Kidney international, 2006, Volume: 70, Issue:6

    Topics: Acetanilides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Fluorescent Dyes; Humans; Immunosuppressive Agents; Kidney; Pyrroles; Quinine; Quinolines; Rhodamines; Sirolimus; Verapamil

2006
Protective effects of atorvastatin on chronic allograft nephropathy in rats.
    The Journal of surgical research, 2007, Volume: 143, Issue:2

    Topics: Animals; Anticholesteremic Agents; Atorvastatin; Chemokines; Chronic Disease; Cyclosporine; Cytokines; Drug Therapy, Combination; Extracellular Matrix Proteins; Fibrosis; Gene Expression; Graft Rejection; Heptanoic Acids; Immunosuppressive Agents; Kidney Transplantation; Male; Monocytes; Proteinuria; Pyrroles; Rats; Rats, Inbred F344; Rats, Inbred Lew; T-Lymphocytes; Transplantation, Homologous

2007
Effects of cyclosporin A and itraconazole on the pharmacokinetics of atorvastatin in rats.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:10

    Topics: Animals; Antifungal Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Calibration; Cyclosporine; Cytochrome P-450 CYP3A; Drug Interactions; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Injections, Intravenous; Intubation, Gastrointestinal; Itraconazole; Male; Pyrroles; Rats; Rats, Sprague-Dawley

2008
Tuberculosis in a patient on temozolomide: a case report.
    Journal of neuro-oncology, 2009, Volume: 92, Issue:1

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Anticholesteremic Agents; Anticonvulsants; Antineoplastic Agents, Alkylating; Atorvastatin; Brain Neoplasms; Combined Modality Therapy; Cyclosporine; Dacarbazine; Dexamethasone; Female; Fluoxetine; Glioblastoma; Heptanoic Acids; Humans; Immunosuppressive Agents; Isoniazid; Middle Aged; Omeprazole; Phenobarbital; Prednisone; Pyrazinamide; Pyrroles; Radiotherapy; Red-Cell Aplasia, Pure; Rifampin; Temozolomide; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Pulmonary

2009
Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation.
    Transplantation, 2008, Dec-27, Volume: 86, Issue:12

    Topics: Adrenal Cortex Hormones; Aged; Atorvastatin; Cholesterol; Cyclosporine; Dyslipidemias; Female; Heart Transplantation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; Middle Aged; Postoperative Complications; Pravastatin; Pyrroles; Safety; Sirolimus; Treatment Outcome; Triglycerides

2008
Conversion to tacrolimus and atorvastatin in cyclosporine-treated heart transplant recipients with dyslipidemia refractory to fluvastatin.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2009, Volume: 28, Issue:6

    Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cohort Studies; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Dyslipidemias; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heart Transplantation; Heptanoic Acids; Humans; Immunosuppressive Agents; Indoles; Male; Middle Aged; Prospective Studies; Pyrroles; Tacrolimus; Treatment Outcome; Triglycerides

2009
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
    Transplant international : official journal of the European Society for Organ Transplantation, 2010, May-01, Volume: 23, Issue:5

    Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Everolimus; Fingolimod Hydrochloride; Heart Transplantation; Immunosuppressive Agents; Male; Propylene Glycols; Protein Kinase C; Pyrroles; Quinazolines; Rats; Rats, Inbred Lew; Rats, Wistar; Sirolimus; Sphingosine

2010
Cyclosporine A, but not tacrolimus, shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:9

    Topics: Atorvastatin; Cell Line; Cyclosporine; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Organic Anion Transporters; Pyrroles; Tacrolimus

2010
Effects of immunomodulatory drugs on plasma inflammatory markers in a rabbit model of atherosclerosis.
    Journal of physiology and biochemistry, 2011, Volume: 67, Issue:1

    Topics: Animals; Atherosclerosis; Atorvastatin; Biomarkers; C-Reactive Protein; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Cyclosporine; Heptanoic Acids; Immunologic Factors; Inflammation; Interferon-gamma; Interleukin-6; Male; Plasma; Pyrroles; Rabbits; Tacrolimus; Triglycerides

2011
The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Calcineurin; Calcineurin Inhibitors; Cell Line, Tumor; Cyclosporine; Hepacivirus; Hepatitis B virus; Humans; Immunosuppressive Agents; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; RNA, Viral; Virus Internalization; Virus Replication

2011
Sotrastaurin, a new selective protein kinase C inhibitor, on the way.
    Transplantation, 2012, Jan-27, Volume: 93, Issue:2

    Topics: Animals; Cyclosporine; Graft Survival; Humans; Kidney Transplantation; Pyrroles; Quinazolines

2012
Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts.
    Transplantation, 2012, Jan-27, Volume: 93, Issue:2

    Topics: Animals; Cyclosporine; Drug Synergism; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Lymphocyte Activation; Macaca fascicularis; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; T-Lymphocytes; Time Factors; Transplantation, Homologous

2012
Severe colchicine intoxication in a renal transplant recipient on cyclosporine.
    Transplantation proceedings, 2012, Volume: 44, Issue:9

    Topics: Acute Kidney Injury; Atorvastatin; Colchicine; Cyclosporine; Drug Interactions; Gout; Gout Suppressants; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Pyrroles; Quadriplegia; Rhabdomyolysis; Treatment Outcome

2012
The mitochondrial permeability transition pore as a target for cardioprotection in hypertrophic cardiomyopathy.
    Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:3

    Topics: Atorvastatin; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cells, Cultured; Cyclosporine; Heptanoic Acids; Humans; Ion Channel Gating; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Pyrroles; Time Factors

2013
CD4+CD25+ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy.
    Molecular immunology, 2013, Volume: 56, Issue:4

    Topics: Acetylation; Active Transport, Cell Nucleus; Adolescent; Adult; CD4-Positive T-Lymphocytes; Cell Nucleus; Cyclosporine; Female; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Isoquinolines; Leprosy; Leukocyte Common Antigens; Male; Middle Aged; NFATC Transcription Factors; Phosphorylation; Pyridines; Pyrroles; Smad3 Protein; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Ubiquitination; Young Adult

2013
Association of BK viremia with human leukocyte antigen mismatches and acute rejection, but not with type of calcineurin inhibitor.
    Transplant infectious disease : an official journal of the Transplantation Society, 2014, Volume: 16, Issue:1

    Topics: Adult; Aged; Allografts; Antibodies, Monoclonal; Azathioprine; Basiliximab; BK Virus; Cohort Studies; Cyclosporine; Female; Glomerular Filtration Rate; Graft Rejection; Histocompatibility; HLA Antigens; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Transplantation; Logistic Models; Male; Middle Aged; Multivariate Analysis; Mycophenolic Acid; Polyomavirus Infections; Proteinuria; Pyrroles; Quinazolines; Recombinant Fusion Proteins; Tacrolimus; Tumor Virus Infections; Viremia

2014
Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro.
    Canadian journal of physiology and pharmacology, 2014, Volume: 92, Issue:2

    Topics: Animals; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Hepatocytes; Heptanoic Acids; Hypolipidemic Agents; Immunosuppressive Agents; Kidney; Lipoproteins; Pyrroles; Rats; Rats, Sprague-Dawley

2014
T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Biological Transport; Cyclosporine; Disease Models, Animal; Female; Humans; Immunization; Interferon-gamma; Interleukin-7; Macrophages; Macular Degeneration; Male; Mice; Oxidative Stress; Pyrroles; Retinal Pigment Epithelium; Sirolimus; T-Lymphocytes

2014
P-glycoprotein expression in Perna viridis after exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins.
    Fish & shellfish immunology, 2014, Volume: 39, Issue:2

    Topics: Acetanilides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Cloning, Molecular; Cyclosporine; Dinoflagellida; DNA Primers; DNA, Complementary; Gills; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Perna; Pyrroles; Quinolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Verapamil

2014
Evaluation of the effect of tofacitinib exposure on outcomes in kidney transplant patients.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2015, Volume: 15, Issue:6

    Topics: Adult; Biopsy; Cyclosporine; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Lymphoproliferative Disorders; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors

2015
[Liver damage caused by atorvastatin and cyclosporine in patients with renal transplant].
    Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2014, Volume: 68, Issue:2

    Topics: Atorvastatin; Chemical and Drug Induced Liver Injury; Cyclosporine; Graft Rejection; Graft Survival; Heptanoic Acids; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Liver; Male; Middle Aged; Pyrroles

2014
New Zealand Society of Gastroenterology Guidelines for the Management of Refractory Ulcerative Colitis.
    The New Zealand medical journal, 2015, Oct-16, Volume: 128, Issue:1423

    Topics: Adalimumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Appendectomy; Azathioprine; Colitis, Ulcerative; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Fecal Microbiota Transplantation; Gastrointestinal Agents; Humans; Immunosuppressive Agents; Infliximab; Leukapheresis; Mercaptopurine; Mesalamine; Methotrexate; New Zealand; Pediatrics; Piperidines; Proctocolectomy, Restorative; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recurrence; Severity of Illness Index; Tacrolimus; Tumor Necrosis Factor-alpha

2015
A novel JAK inhibitor JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents.
    Experimental dermatology, 2018, Volume: 27, Issue:1

    Topics: Animals; Cyclosporine; Cytokines; Dermatitis, Atopic; Female; Haptens; Humans; Immunoglobulin E; Inflammation; Interleukin-23; Interleukin-23 Subunit p19; Janus Kinase Inhibitors; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrroles; Rats; Rats, Inbred BN; Skin; Thymic Stromal Lymphopoietin

2018
[Current and upcoming treatments of adult atopic dermatitis].
    Annales de dermatologie et de venereologie, 2017, Volume: 144 Suppl 5

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azathioprine; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclosporine; Dermatitis, Atopic; Dermatologic Agents; Glucocorticoids; Humans; Methotrexate; Mycophenolic Acid; Piperidines; Pyrimidines; Pyrroles; Thalidomide; Ustekinumab

2017
Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study.
    Acta dermato-venereologica, 2019, 01-01, Volume: 99, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Alopecia; Cyclopropanes; Cyclosporine; Female; Humans; Immunosuppressive Agents; Janus Kinase Inhibitors; Male; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Retrospective Studies; Steroids; Time Factors; Treatment Outcome; Young Adult

2019
Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset.
    Molecules (Basel, Switzerland), 2019, Sep-01, Volume: 24, Issue:17

    Topics: Animals; Base Sequence; Cadherins; Callithrix; Cyclosporine; DNA; Fibrosis; Humans; Imidazoles; Kidney; Kidney Diseases; Nylons; Peptides; Promoter Regions, Genetic; Pyrroles; RNA, Messenger; Snail Family Transcription Factors; Transforming Growth Factor beta1; Urethral Obstruction

2019