pyrroles has been researched along with cyclic gmp in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (7.50) | 18.7374 |
| 1990's | 40 (50.00) | 18.2507 |
| 2000's | 23 (28.75) | 29.6817 |
| 2010's | 10 (12.50) | 24.3611 |
| 2020's | 1 (1.25) | 2.80 |
| Authors | Studies |
|---|---|
| Bertelli, A; Schinetti, ML | 1 |
| Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Adams, D; Arch, JR; Challiss, RA; Patel, N | 1 |
| Hong, KW; Kim, CD; Lee, WS; Rhim, BY | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Shikada, K; Tanaka, S | 1 |
| Huang, LJ; Huang, TF; Kuo, SC; Sun, SS; Teng, CM; Yu, SM | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Becker, RH; Busse, R; Schölkens, BA; Wiemer, G | 1 |
| Bray, KM; Brown, BS; Duty, S; Edwards, G; Kay, PB; Longmore, J; McHarg, AD; Newgreen, DT; Southerton, JS; Weston, AH | 1 |
| Kaneko, K; Miyata, N; Otomo, S; Tanaka, M; Tsuchida, K | 1 |
| Coldwell, MC; Howlett, DR | 1 |
| Baker, JR; Southerton, JS; Taylor, SG; Weston, AH | 1 |
| Gillespie, JS; Sheng, H | 1 |
| Hashimoto, H; Taira, N; Yanagisawa, T | 1 |
| Anderson, WB; Pastan, I; Perlman, RL | 1 |
| Satake, N; Shibata, S; Zhou, Q | 1 |
| Maggi, CA; Morbidelli, L; Parenti, A; Santicioli, P; Ziche, M | 1 |
| McKee, M; Nathanson, JA; Scanlon, C; Scavone, C | 1 |
| Hou, YS; Lee, SS; Teng, CM; Yu, SM | 1 |
| Abe, S; Kanaide, H; Nakamura, M; Nishimura, J | 1 |
| Donatucci, CF; Hsu, GL; Lue, TF; Martinez-Piñeiro, L; Tanagho, EA; Trigo-Rocha, F | 1 |
| Kamei, K; Kuriyama, H; Nabata, H | 1 |
| Okamoto, K; Sakuta, H; Watanabe, Y | 1 |
| Ko, FN; Lin, CH; Lu, ST; Teng, CM; Wu, YC | 1 |
| Basson, MD; Hong, F | 1 |
| Andersson, KE; Persson, K; Waldeck, K | 1 |
| Komalavilas, P; Lincoln, TM | 1 |
| Hohn, J; Papp, JG; Pataricza, J; Penke, B; Toth, GK | 1 |
| Karaki, H; Mitsui-Saito, M; Ozaki, H; Trongvanichnam, K | 1 |
| McCulloch, AI; Randall, MD | 1 |
| Brading, AF; Teramoto, N | 1 |
| Norisue, M; Okabe, E; Todoki, K | 1 |
| Armstead, WM | 1 |
| Kamisato, S; Okamoto, K; Takami, N; Uemura, Y | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Endo, K; Nakamura, M; Nakata, K | 1 |
| Asano, Y; Homma, S; Iimura, O; Ikeda, U; Kusano, E; Shimada, K; Takeda, S | 1 |
| May, K; Sisson, JH; Spurzem, JR; Wyatt, TA | 1 |
| Allescher, HD; Franck, H; Huber, A; Ruth, P; Schusdziarra, V; Storr, M; Trudrung, P | 1 |
| Polte, T; Schröder, H | 1 |
| Huang, LJ; Kuo, SC; Raung, SL; Wang, JP | 1 |
| Kubokawa, M; Kubota, T; Mori, Y; Nakamura, K; Nakaya, S; Sato, F; Yoshioka, Y | 1 |
| Amoroso, S; Annunziato, L; Cataldi, M; Colao, AM; D'Alessio, A; Di Renzo, GF; Sarnacchiaro, F; Secondo, A | 1 |
| Shahidullah, M; Wilson, WS | 1 |
| Jo, H; Komalavilas, P; Lincoln, TM; Shah, PK | 1 |
| Dhanakoti, SN; Gao, Y; Nguyen, MQ; Raj, JU | 1 |
| Casadei, B; Musialek, P; Paterson, DJ; Rigg, L; Terrar, DA | 1 |
| Conde, M; Porras, T; Rosado, JA; Sage, SO | 1 |
| Fang, Q; Kim, HJ; Kobayashi, T; Kohyama, T; Liu, X; Rennard, SI; Wen, FQ; Wyatt, TA | 1 |
| Hirano, J; Itazawa, S; Kubokawa, M; Nakamura, K | 1 |
| De Godoy, M; Li, F; Rattan, S | 1 |
| Hirano, J; Kubokawa, M; Nakamura, K | 1 |
| Puggina, E; Sellitti, D | 1 |
| Adams, JM; Forgèt, MA; Sisson, JH; Wyatt, TA | 1 |
| Chan, DC; Dogra, GK; Stanton, K; Watts, GF | 1 |
| Fernandes, JC; Manacu, CA; Martel-Pelletier, J; Mitrovic, DR; Moldovan, F; Pelletier, JP; Roy-Beaudry, M; Shipkolye, FS | 1 |
| Bhattacharjee, S; Guan, J; Haynes-Johnson, D; Jiang, W; John, TM; Kraft, P; Lundeen, S; Macielag, MJ; Qiu, Y; Sui, Z; Zhang, S | 1 |
| Ay, B; Iyanoye, A; Pabelick, CM; Prakash, YS; Sieck, GC | 1 |
| Bem, AF; Metzger, IF; Nagassaki, S; Rocha, JB; Sertório, JT; Tanus-Santos, JE | 1 |
| Das, AK; Dev, S; Fujimoto, K; Fukui, H; Horio, S; Kitamura, Y; Mishima, R; Mizuguchi, H; Takeda, N; Wakayama, Y; Yoshimura, S | 1 |
| Fleischmann, BK; Hescheler, J; Reppel, M; Reuter, H; Sasse, P; Schunkert, H | 1 |
| Earm, YE; Han, J; Jung, ID; Kang, SH; Kim, N; Ko, JH; Park, WS; Park, YM; Son, YK; Warda, M | 1 |
| Choi, S; Lim, I; Roh, S | 1 |
| Caracchini, R; Gresele, P; Guglielmini, G; Guzzetta, M; Impagnatiello, F; Momi, S; Monopoli, A; Olivieri, R | 1 |
| Cai, CY; Cai, ZX; Gu, XY; Guo, HS; Qi, QH; Shan, LJ; Wang, YX; Yin, XZ | 1 |
| Akaike, A; Ito, R; Izumi, Y; Katsuki, H; Kume, T; Niidome, T; Sugimoto, H; Taguchi, R; Takada-Takatori, Y | 1 |
| Cai, ZX; Gu, XY; Guo, HS; Li, J; Wu, TH; Yuan, H | 1 |
| Kloc, R; Luchowska, E; Olajossy, B; Owe-Larsson, B; Urbanska, EM; Wielosz, M; Wnuk, S | 1 |
| Allain, C; Ceyhan, O; Demirbas, D; Francis, SH; Hoffman, CS; Ivey, FD; Sharuk, MN; Wang, L; Wyman, AR | 1 |
| Aubin, MC; Carrier, M; Forcillo, J; Maltais, S; Perrault, LP; Shi, YF; Tardif, JC | 1 |
| Cunha, MP; Dal-Cim, T; Ludka, FK; Rodrigues, AL; Tasca, CI; Zeni, AL; Zomkowski, AD | 1 |
| Ghofrani, HA; Grimminger, F; Kalymbetov, A; Kojonazarov, B; Kretschmer, A; Lang, M; Schermuly, RT; Seeger, W; Stasch, JP; Tian, X; Weissmann, N | 1 |
| Gross, PL; Ni, R; Peleg, T | 1 |
| Amin, A; Badr El-Din, NK; Choi, SK; Kadowitz, P; Kevil, CG; Matrougui, K; Navar, LG; Osman-Elazeik, Y; Trebak, M | 1 |
| Jia, L; Peng, S; Wang, L; Wu, C; Yang, J; Yang, X; Yin, J; Yuan, Z; Zhao, S | 1 |
| Duan, H; Li, N; Liu, H; Pu, F; Xiao, S; Zhang, A; Zhang, G; Zhao, L; Zhou, EM | 1 |
| Abe, K; Hoka, S; Ishikawa, T; McMurtry, IF; Oka, M; Saku, K; Sunagawa, K; Tanaka, M; Tsutsui, H; Yoshida, K | 1 |
| Baker, JE; Barnett, SD; Buxton, ILO; Smith, CR; Ulrich, CC | 1 |
| Bae, H; Kim, T; Lim, I | 1 |
2 trial(s) available for pyrroles and cyclic gmp
| Article | Year |
|---|---|
Statin therapy improves brachial artery vasodilator function in patients with Type 1 diabetes and microalbuminuria.
Topics: Adolescent; Adult; Aged; Albuminuria; Apolipoproteins B; Atorvastatin; Brachial Artery; Cholesterol, LDL; Cross-Over Studies; Cyclic GMP; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Linear Models; Lipoproteins, LDL; Male; Middle Aged; Nitroglycerin; Pyrroles; Regional Blood Flow; Statistics, Nonparametric; Vasodilation; Vasodilator Agents | 2005 |
eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite.
Topics: Adolescent; Adult; Amino Acid Substitution; Atorvastatin; Cyclic GMP; Heptanoic Acids; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide Synthase Type III; Nitrites; Polymorphism, Genetic; Pyrroles; Thiobarbiturates | 2006 |
78 other study(ies) available for pyrroles and cyclic gmp
| Article | Year |
|---|---|
Activity of tolmetin on levels of cyclic nucleotides in experimental pleurisy.
Topics: Acetates; Animals; Cyclic AMP; Cyclic GMP; Indomethacin; Male; Pleurisy; Pyrroles; Rats; Tolmetin | 1979 |
Molecular mechanism of action of nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Nitroprusside; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Inhibitory action of the potassium channel opener BRL 38227 on agonist-stimulated phosphoinositide metabolism in bovine tracheal smooth muscle.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Inositol Phosphates; Muscle, Smooth; Phosphatidylinositols; Phosphodiesterase Inhibitors; Potassium Channels; Pyrroles; Trachea | 1992 |
Similarities between effects of superoxide-mediated endothelium-derived relaxing factor and cromakalim.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic GMP; Female; Hypoxanthine; Hypoxanthines; Male; Mesenteric Arteries; Nitric Oxide; Pyrroles; Rabbits; Rubidium; Superoxides; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents | 1992 |
Vasorelaxation of rat thoracic aorta caused by two Ca(2+)-channel blockers, HA-22 and HA-23.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Caffeine; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; In Vitro Techniques; Male; Nifedipine; Pyrans; Pyrazoles; Pyrroles; Rats; Rats, Inbred Strains; Vasodilation; Verapamil | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Ramiprilat enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Epoprostenol; Humans; Nitric Oxide; Pyrroles; Ramipril | 1991 |
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Diazoxide; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Minoxidil; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1990 |
Mechanisms of inhibitory effects of CD-349 and K(+)-channel activators on noradrenaline-induced contraction and changes in levels of cyclic GMP in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dihydropyridines; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Antihypertensive Agents; Apamin; Benzopyrans; Binding Sites; Cromakalim; Cyclic AMP; Cyclic GMP; Inositol Phosphates; Ion Channels; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrendipine; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Tetraethylammonium Compounds | 1987 |
Endothelium-dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic GMP; Endothelium, Vascular; Ferricyanides; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Microscopy, Electron; Nitroprusside; Norepinephrine; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1988 |
The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915.
Topics: Animals; Antihypertensive Agents; Apamin; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Drug Interactions; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pyrroles; Rabbits | 1988 |
The negative inotropic effect of nicorandil is independent of cyclic GMP changes: a comparison with pinacidil and cromakalim in canine atrial muscle.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanidines; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
Effect of adenosine 3',5'-monophosphate analogues on the activity of the cyclic adenosine 3',5'-monophosphate receptor in Escherichia coli.
Topics: Adenine Nucleotides; Ammonium Sulfate; Arabinose; Bacterial Proteins; Carrier Proteins; Chemical Precipitation; Coliphages; Cyclic AMP; Cyclic GMP; DNA, Viral; Escherichia coli; Galactose; Genetic Code; Inosine Nucleotides; Operon; Protein Binding; Protein Conformation; Pyrimidine Nucleotides; Pyrroles; RNA Nucleotidyltransferases; RNA, Messenger; Structure-Activity Relationship; Thymine Nucleotides; Tritium | 1972 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
Calcitonin gene-related peptide selectively increases cAMP levels in the guinea-pig ureter.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Drug Interactions; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Potassium Channels; Pyrroles; Ureter | 1995 |
Atrial natriuretic peptide modulates sodium and potassium-activated adenosine triphosphatase through a mechanism involving cyclic GMP and cyclic GMP-dependent protein kinase.
Topics: Alkaloids; Amiloride; Animals; Atrial Natriuretic Factor; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Indoles; Kidney Medulla; Male; Nitric Oxide; Ouabain; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase | 1995 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Intracellular mechanism of penile erection in monkeys.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Ethylmaleimide; Macaca nemestrina; Male; Methylene Blue; Nitroprusside; Penile Erection; Penis; Phosphodiesterase Inhibitors; Purinones; Pyrroles; Ultrasonography | 1994 |
Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1994 |
Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Methylene Blue; Niacinamide; Nicorandil; Nitroprusside; Oocytes; Potassium Channels; Pyridines; Pyrroles; Xenopus laevis | 1993 |
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Egtazic Acid; Epithelium; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitroprusside; Phenanthrenes; Plants, Medicinal; Propranolol; Pyrroles; Theophylline; Trachea; Vasodilator Agents | 1993 |
Regulation of human Caco-2 intestinal epithelial brush border enzyme activity by cyclic nucleotides.
Topics: Adenylyl Cyclase Inhibitors; Alkaline Phosphatase; Alkaloids; Bucladesine; Caco-2 Cells; Carbazoles; Cell Line; Colonic Neoplasms; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Synergism; Enzyme Inhibitors; Epithelium; Guanylate Cyclase; Homeostasis; Humans; Indoles; Intestines; Kinetics; Microvilli; Pyrroles | 1996 |
Effects of KRN2391, a novel vasodilator acting as a nitrate and a K+ channel opener, on the rabbit lower urinary tract.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electrophysiology; Female; Hypoglycemic Agents; Molsidomine; Muscle Relaxation; Muscle, Smooth; Pyridines; Pyrroles; Rabbits; Urethra; Vasodilator Agents | 1995 |
Phosphorylation of the inositol 1,4,5-trisphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta.
Topics: Alkaloids; Angiotensin II; Animals; Aorta; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Indoles; Inositol 1,4,5-Trisphosphate Receptors; Male; Nitroprusside; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thionucleotides; Time Factors | 1996 |
Effect of selective inhibition of potassium channels on vasorelaxing response to cromakalim, nitroglycerin and nitric oxide of canine coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Peptides; Potassium Channel Blockers; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents | 1995 |
Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Vasodilator Agents; Verapamil | 1996 |
Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Papaverine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Theophylline; Vasodilation; Vasodilator Agents | 1996 |
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Swine; Urethra | 1997 |
Inhibition by hydroxyl radicals of calcitonin gene-related peptide-mediated neurogenic vasorelaxation in isolated canine lingual artery.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Cyclic GMP; Dogs; Female; Humans; Hydroxyl Radical; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Vasodilation | 1997 |
Role of activation of calcium-sensitive K+ channels in NO- and hypoxia-induced pial artery vasodilation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Arterioles; Benzimidazoles; Benzopyrans; Cerebral Arteries; Cromakalim; Cyclic GMP; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Pia Mater; Potassium Channels; Pyrroles; S-Nitroso-N-Acetylpenicillamine; Swine; Vasodilation; Vasodilator Agents | 1997 |
Involvement of intracellular cyclic GMP and cyclic GMP-dependent protein kinase in alpha-elastin-induced macrophage chemotaxis.
Topics: Alkaloids; Animals; Carbazoles; Cells, Cultured; Chemotaxis; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elastin; Enzyme Inhibitors; Indoles; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase Inhibitors; Protein Kinases; Pyrroles; Rats; Rats, Wistar | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Mucin-like glycoprotein secretion is mediated by cyclic-AMP and protein kinase C signal transduction pathways in rat corneal epithelium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelium, Corneal; Indoles; Male; Mucins; Naphthalenes; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction | 1998 |
Atrial natriuretic peptide enhances IL-1 beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Blotting, Northern; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Indoles; Interleukin-1; Intracellular Fluid; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger | 1998 |
Regulation of ciliary beat frequency by both PKA and PKG in bovine airway epithelial cells.
Topics: Animals; Bronchi; Bucladesine; Carbazoles; Cattle; Chromatography, Ion Exchange; Cilia; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; Indoles; Isoproterenol; Kinetics; Nitroprusside; Pyrroles; Time Factors | 1998 |
Protein kinase G expression in the small intestine and functional importance for smooth muscle relaxation.
Topics: Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Indoles; Intestinal Mucosa; Intestine, Small; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Polymerase Chain Reaction; Pyrroles; Rats; Rats, Wistar; Thionucleotides | 1998 |
Cyclic AMP mediates endothelial protection by nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1998 |
Involvement of cyclic AMP generation in the inhibition of respiratory burst by 2-phenyl-4-quinolone (YT-1) in rat neutrophils.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Bucladesine; Calcium; Carbazoles; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cytosol; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Pyrroles; Quinolones; Rats; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Activation of inwardly rectifying K+ channel in OK proximal tubule cells involves cGMP-dependent phosphorylation process.
Topics: Alkaloids; Animals; Carbazoles; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytosol; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Indoles; Kidney Tubules, Proximal; Opossums; Patch-Clamp Techniques; Potassium Channels; Protein Kinase Inhibitors; Pyrroles | 1998 |
Involvement of phosphodiesterase-cGMP-PKG pathway in intracellular Ca2+ oscillations in pituitary GH3 cells.
Topics: Alkaloids; Animals; Calcium; Carbazoles; Cell Line; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 1; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Indoles; Phosphoric Diester Hydrolases; Pituitary Gland; Protein Kinases; Pyrroles; Vinca Alkaloids | 1999 |
Atriopeptin, sodium azide and cyclic GMP reduce secretion of aqueous humour and inhibit intracellular calcium release in bovine cultured ciliary epithelium.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Aqueous Humor; Atrial Natriuretic Factor; Calcium; Carbazoles; Cattle; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Indoles; Intraocular Pressure; Pigment Epithelium of Eye; Protein Kinase Inhibitors; Pyrroles; Sodium Azide | 1999 |
Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Aorta; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyrroles; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Thionucleotides; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 1999 |
Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP.
Topics: Animals; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Indoles; Male; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Artery; Pyrroles; Sheep; Thionucleotides; Vasodilation | 2000 |
Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.
Topics: Animals; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Hydrazines; Indoles; Isoquinolines; Male; Milrinone; Models, Biological; Molsidomine; Nitric Oxide Donors; Nitrogen Oxides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation Inhibitors; Pyrroles; Quinazolines; Ryanodine; Sarcoplasmic Reticulum; Signal Transduction; Spectrometry, Fluorescence; Sulfonamides; Superoxide Dismutase; Tetrahydroisoquinolines; Thionucleotides; Time Factors; Vasodilator Agents | 2000 |
Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets.
Topics: Actins; Adenosine Diphosphate; Alprostadil; Arsenicals; Blood Platelets; Calcium; Carbazoles; Cyclic AMP; Cyclic GMP; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitroprusside; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Protein Tyrosine Phosphatases; Pyrroles; Thapsigargin; Thrombin; Vanadates | 2001 |
PGD(2) modulates fibroblast-mediated native collagen gel contraction.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cells, Cultured; Collagen; Cyclic GMP; Enzyme Inhibitors; Estrenes; Fatty Acids, Unsaturated; Fibroblasts; Gels; Humans; Hydrazines; Indoles; Lung; Mesylates; Naphthalenes; Prostaglandin Antagonists; Prostaglandin D2; Protein Kinase C; Pyrroles; Pyrrolidinones; Rats; Receptors, Immunologic; Receptors, Prostaglandin; Thionucleotides; Type C Phospholipases; Wound Healing; Xanthenes; Xanthones | 2002 |
Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells.
Topics: Adult; Algorithms; Alkaloids; Atrial Natriuretic Factor; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Guanylate Cyclase; Humans; Indoles; Kidney Tubules, Proximal; Microscopy, Electron, Scanning; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Pyrroles; Stimulation, Chemical | 2002 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
Regulation of an inwardly rectifying K+ channel by nitric oxide in cultured human proximal tubule cells.
Topics: Adult; Carbazoles; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Indoles; Kidney Tubules, Proximal; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Pyrroles | 2004 |
Cyclic adenosine monophosphate (cAMP) increases natriuretic peptide receptor C (NPR-C) expression in human aortic smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Atrial Natriuretic Factor; Bucladesine; Carbazoles; Cell Culture Techniques; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Guanylate Cyclase; Humans; Indoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Binding; Pyrroles; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Signal Transduction | 2004 |
Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Carbazoles; Cattle; Cell-Free System; Cilia; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Indoles; Nucleotides, Cyclic; Pyrroles | 2005 |
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.
Topics: Aminoquinolines; Apoptosis; Carbazoles; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagenases; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endothelin-1; Enzyme Induction; Female; Guanylate Cyclase; Humans; Imidazoles; Indoles; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Osteoarthritis, Knee; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Pyrroles; Signal Transduction | 2005 |
Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Biological Availability; Blood Pressure; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Electric Stimulation; Erectile Dysfunction; Macaca mulatta; Male; Penis; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Solubility; Stereoisomerism; Structure-Activity Relationship | 2005 |
Cyclic nucleotide regulation of store-operated Ca2+ influx in airway smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Indoles; Muscle, Smooth; Pyrroles; Swine; Trachea | 2006 |
Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Cyclic GMP; Enzyme Inhibitors; HeLa Cells; Histamine; Histamine H1 Antagonists; Humans; Indoles; Luciferases; Protein Kinase C; Pyrilamine; Pyrroles; Receptors, Histamine H1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thionucleotides; Transcription, Genetic; Transfection; Tritium; Up-Regulation | 2007 |
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Fetal Development; Gestational Age; Heart; Heart Ventricles; Indoles; Mice; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Pyrroles; Sodium-Calcium Exchanger; Tetradecanoylphorbol Acetate | 2007 |
Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.
Topics: Acute Disease; Adenine; Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Glyburide; Hypoxia; In Vitro Techniques; Indoles; Male; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyrroles; Rabbits; Signal Transduction; Thionucleotides; Vasodilation | 2007 |
Involvement of protein kinase A in nitric oxide stimulating effect on a BK(Ca) channel of human dermal fibroblasts.
Topics: Adenylyl Cyclases; Adolescent; Carbazoles; Cells, Cultured; Child; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dermis; Electrophysiology; Enzyme Inhibitors; Fibroblasts; Humans; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Patch-Clamp Techniques; Pyrroles; Signal Transduction | 2007 |
NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties.
Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Aorta, Thoracic; Atorvastatin; Blood Pressure; Cell Line; Cholesterol; Cyclic GMP; Fibrinolytic Agents; Heptanoic Acids; Hyperlipidemias; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; PC12 Cells; Pulmonary Embolism; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2007 |
Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through the cGMP/cGMP-dependent protein kinase pathway.
Topics: Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elapid Venoms; Female; Guinea Pigs; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Relaxation; Muscle, Smooth; Patch-Clamp Techniques; Peptides; Potassium Channels, Calcium-Activated; Protein Kinase Inhibitors; Pyloric Antrum; Pyrroles; Signal Transduction | 2008 |
Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes.
Topics: Adrenergic beta-Agonists; Amides; Animals; Astrocytes; Bucladesine; Carbazoles; Cell Shape; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Isoproterenol; Neuroprotective Agents; Pyridines; Pyrroles; Rats; Rats, Wistar; rho-Associated Kinases; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Effects of Dendroaspis natriuretic peptide on delayed rectifier potassium currents and its mechanism.
Topics: Aminoquinolines; Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Elapid Venoms; Electrophysiology; Enzyme Inhibitors; Female; Guinea Pigs; Intercellular Signaling Peptides and Proteins; Male; Patch-Clamp Techniques; Peptides; Potassium Channels, Voltage-Gated; Pyrroles; Signal Transduction | 2009 |
beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agents; Animals; Animals, Newborn; Brain; Brain Chemistry; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; In Vitro Techniques; Kynurenic Acid; L-Lactate Dehydrogenase; Male; Neuroglia; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Thionucleotides; Transaminases | 2009 |
Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.
Topics: Animals; Benzimidazoles; Cattle; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Genes, Reporter; Humans; Mice; Phosphodiesterase 5 Inhibitors; Pyrroles; Recombinant Proteins; Schizosaccharomyces | 2011 |
Atorvastatin worsens left ventricular diastolic dysfunction and endothelial dysfunction of epicardial coronary arteries in normocholesterolemic porcine with left ventricular hypertrophy.
Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Coronary Vessels; Cyclic GMP; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Echocardiography; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Male; Nitrates; Nitrites; Pyrroles; Random Allocation; Swine; Vasodilation; Ventricular Dysfunction, Left | 2011 |
Acute atorvastatin treatment exerts antidepressant-like effect in mice via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and increases BDNF levels.
Topics: Animals; Antidepressive Agents; Arginine; Atorvastatin; Brain-Derived Neurotrophic Factor; Cyclic GMP; Depression; Heptanoic Acids; Male; Mice; Nitric Oxide; Pyrroles; Signal Transduction | 2013 |
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
Topics: Animals; Apoptosis; Blood Pressure; Blotting, Western; Caspase 3; Cell Proliferation; Cyclic GMP; Guanylate Cyclase; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Immunohistochemistry; Indoles; Lung; Male; Nitric Oxide Synthase Type III; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrazoles; Pyrimidines; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Time Factors; Treatment Outcome | 2012 |
Atorvastatin delays murine platelet activation in vivo even in the absence of endothelial NO synthase.
Topics: Administration, Oral; Animals; Atorvastatin; Blood Platelets; Cyclic GMP; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Membrane Glycoprotein IIb; Pyrroles; Receptors, Thrombin; Signal Transduction; Thrombin; Time Factors | 2012 |
Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension.
Topics: Allopurinol; Angiotensin II; Animals; Arterial Pressure; Capillaries; Cyclic AMP; Cyclic GMP; Femoral Artery; Hindlimb; Hypertension; Indoles; Ischemia; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Regional Blood Flow; Sodium Nitrite; Xanthine Dehydrogenase | 2012 |
NF-κB Upregulates Type 5 Phosphodiesterase in N9 Microglial Cells: Inhibition by Sildenafil and Yonkenafil.
Topics: Animals; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Humans; Inflammation Mediators; Lipopolysaccharides; Mice; Microglia; Neurotoxins; NF-kappa B; Phosphodiesterase Inhibitors; Pyrimidinones; Pyrroles; RNA Interference; RNA, Messenger; Sildenafil Citrate; Up-Regulation | 2016 |
Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-κB Signaling Pathway.
Topics: Animals; Antiviral Agents; Carbon Monoxide; Cell Line; Chlorocebus aethiops; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytokines; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Host-Pathogen Interactions; Macrophages, Alveolar; NF-kappa B; Organometallic Compounds; Porcine respiratory and reproductive syndrome virus; Pyrazines; Pyrroles; RNA, Messenger; Signal Transduction; Swine; Virus Internalization; Virus Replication | 2017 |
Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension.
Topics: Acetylcholine; Animals; Blood Pressure; Cyclic GMP; Hypertension, Pulmonary; Indoles; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Kinase Inhibitors; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Vascular Endothelial Growth Factor; Vasoconstriction | 2017 |
S-Nitrosoglutathione Reductase Underlies the Dysfunctional Relaxation to Nitric Oxide in Preterm Labor.
Topics: Actins; Aldehyde Oxidoreductases; Benzamides; Cyclic GMP; Female; Guanylate Cyclase; Humans; Muscle, Smooth; Myometrium; Myosins; Nitric Oxide; Nitrosation; Obstetric Labor, Premature; Pregnancy; Pyrroles; S-Nitrosoglutathione; Uterine Contraction | 2018 |
Effects of nitric oxide on apoptosis and voltage-gated calcium channels in human cardiac myofibroblasts.
Topics: Apoptosis; Calcium Channels; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fibroblasts; Guanylate Cyclase; Humans; Myofibroblasts; Nitric Oxide; Nitric Oxide Donors; Pyrroles; Signal Transduction | 2020 |