pyrroles has been researched along with cromakalim in 830 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 104 (12.53) | 18.7374 |
| 1990's | 726 (87.47) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Richard, V | 1 |
| Kreye, VA; Lenz, T; Pfründer, D; Theiss, U | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH | 2 |
| Griffith, TM; Randall, MD | 3 |
| Bray, K; Quast, U | 4 |
| Chen, XJ; Liu, KQ; Liu, TF | 1 |
| de Hemptinne, A; Vanheel, B | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Parham, CS | 2 |
| Galiñanes, M; Hearse, DJ; Shattock, MJ | 1 |
| Wilde, AA | 1 |
| Adams, D; Arch, JR; Challiss, RA; Patel, N | 1 |
| Berry, JL; Burka, JF; Cook, SJ; Foster, RW; Green, KA; Murray, MA; Small, RC | 1 |
| Kamata, K; Kasuya, Y; Miyata, N; Otomo, S; Tsuchida, K; Yamaura, H | 1 |
| Hong, KW; Kim, CD; Lee, WS; Rhim, BY | 1 |
| Downing, SJ; Hollingsworth, M | 4 |
| Fang, D; Wu, Y | 1 |
| Arch, JR; Challiss, RA; Patel, N | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Aaronson, PI; Russell, SN; Smirnov, SV | 2 |
| Okamoto, K; Sakai, Y; Sakuta, H; Sekiguchi, M | 1 |
| Shikada, K; Tanaka, S | 3 |
| Berry, JL; Foster, RW; Small, RC | 2 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Amalric, M; Heurteaux, C; Lazdunski, M; Nieoullon, A | 1 |
| Illiano, S; Nagao, T; Vanhoutte, PM | 2 |
| Huang, LJ; Huang, TF; Kuo, SC; Sun, SS; Teng, CM; Yu, SM | 1 |
| Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
| Aitken, S; De Jonckheere, B; McCaig, DJ | 1 |
| Bayguinov, O; Boev, K; Kortezova, N; Papasova, M | 1 |
| Edwards, G; Henshaw, M; Miller, M; Weston, AH | 1 |
| Asano, M; Ito, K; Kanno, T; Masuzawa-Ito, K; Ohashi, H; Suzuki, H; Suzuki, K; Takewaki, T | 1 |
| Akima, M; Imagawa, J; Nabata, H; Taira, N | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Aikawa, T; Itabashi, S; Morikawa, M; Sasaki, H; Sekizawa, K; Takishima, T | 1 |
| McLeod, JD; Piper, PJ | 2 |
| Edvinsson, L; Jansen, I; Nilsson, L | 1 |
| Bourreau, JP; Daniel, EE; Kwan, CY | 2 |
| Barnes, PJ; Kuo, HP; Rogers, DF; Rohde, JA | 1 |
| Deitmer, P; Golenhofen, K; Noack, T | 1 |
| Broadley, KJ; Urquhart, RA | 1 |
| Nielsen-Kudsk, JE; Thirstrup, S | 3 |
| Ichihara, K; Nagasaka, M; Okumura, K | 1 |
| Messing, MW; Struijker Boudier, HA; van Essen, H | 1 |
| Taira, N; Yamagishi, T; Yanagisawa, T | 3 |
| Fraser, R; Kenyon, CJ; Shepherd, RM | 1 |
| Benton, DC; Haylett, DG | 1 |
| Armstrong, JM; Barras, M; Hicks, PE; Lawson, K; Martin, DJ; Zazzi-Sudriez, E | 1 |
| Berry, JL; Edwards, G; Hollingsworth, M; Hughes, SJ; Miller, AJ; Small, RC; Smith, RD; Weston, AH | 1 |
| Alexander, LD; Lamp, ST; Stuart, JS; Venkatesh, N; Weiss, JN | 1 |
| Downing, SJ; Hollingsworth, M; Piper, I | 1 |
| Hillaire-Buys, D; Loubatières-Mariani, MM; Mir, AK; Petit, P | 1 |
| Akiba, Y; Matsumoto, H; Nakano, H; Onodera, S; Osanai, S; Tobise, K | 1 |
| Cortijo, J; Morcillo, E; Paris, F; Pedrós, C; Perpiñá, M; Sarriá, B | 1 |
| Henderson, G; Hicks, GA | 1 |
| Racagni, G; Salvaggio, A; Tromba, C; Volterra, A | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Abman, SH; Cornfield, DN; McMurtry, IF; McQueston, JA; Rodman, DM | 1 |
| Malik, AB; Pinheiro, JM | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Alibhai, KN; Huizinga, JD; Richardson, D | 1 |
| Filer, CW; Ramji, JV; Tomlinson, PW | 1 |
| Aghi, M; Balani, DK; Husain, Z; Imran, M; Pillai, KK; Qadry, JS | 1 |
| Auger, P; Bardou, A; Bril, A; Cardinal, R; Rochette, L | 1 |
| Ashford, ML; Boden, PR; Sellers, AJ | 1 |
| Bennett, T; Gardiner, SM | 1 |
| Duty, S; Weston, AH | 1 |
| Deitmer, P; Edwards, G; Noack, T; Weston, AH | 3 |
| Arch, JR; Foster, KA; Newson, PN; Shaw, D; Taylor, SG | 1 |
| Berdeaux, A; Dubois-Randé, JL; Giudicelli, JF; Hittinger, L; la Rochelle, CD; Richard, V; Roupie, E | 1 |
| Gadwood, RC; Groppi, VE; Lee, KS; Norman, NR; Shebuski, RJ; Toombs, CF | 1 |
| Kato, H; Shimada, F; Takata, Y | 1 |
| Adachi, H; Kodama, K; Ogawa, T; Ohhara, H | 1 |
| Adams, DJ; Rusko, J; Tanzi, F; van Breemen, C | 1 |
| Quast, U | 3 |
| Bott, A; Eltze, M; Illes, P | 1 |
| Li, YQ; Triggle, CR; Wyse, DG | 1 |
| Fernandes, LB; Goldie, RG; Hay, DW; Muccitelli, RM; Page, CP; Preuss, JM; Spina, D | 1 |
| Clapham, JC; Good, DM; Hamilton, TC | 1 |
| Andersson, PO; Criddle, D; Deitmer, P; Edwards, G; Greengrass, P; Morita, T; Noack, T; Weston, AH; Wyllie, MG | 1 |
| Eckman, DM; Frankovich, JD; Keef, KD | 1 |
| Trezise, DJ; Weston, AH | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 3 |
| Hong, KW; Lee, WS; Rhim, BY | 1 |
| Lau, WM | 1 |
| Brayden, JE; Uusitalo, H; Zschauer, A | 1 |
| Colatsky, TJ; Harvey, C; Kitzen, JM; McCallum, JD; Morin, ME; Oshiro, GT | 1 |
| Barbieri, A; Botta, L; Grana, E; Valli, P; Zucca, G | 1 |
| Berdeaux, A; Drieu la Rochelle, C; Giudicelli, JF; Richard, V; Roupie, E | 1 |
| McPherson, GA; Stork, AP | 1 |
| Andersson, KE | 1 |
| Hamilton, TC; Longman, SD | 1 |
| Brunden, MN; Buhl, AE; Conrad, SJ; Johnson, GA; Kubicek, MF; Mulholland, MJ; Shull, KL; Stefanski, KJ; Stehle, RG; Waldon, DJ | 1 |
| Zucker, JR | 1 |
| Bishop, BE; Doggrell, SA | 2 |
| Silberberg, SD; van Breemen, C | 1 |
| Clapp, LH; Gurney, AM | 1 |
| Chopra, LC; Twort, CH; Ward, JP | 1 |
| Kreye, VA; Pfründer, D; Theiss, U | 1 |
| Antoine, MH; Herchuelz, A; Lebrun, P | 1 |
| Arch, JR; Bond, J; Buckle, DR; Shaw, DJ; Taylor, JF; Taylor, SG; Ward, JS | 1 |
| Aoki, K; Fukunari, A; Katoh, A; Nakajima, T; Setoguchi, M; Shinagawa, K; Shinohara, T; Tahara, T; Yamanaka, T; Yaoka, O | 1 |
| Horacek, J; Lefebvre, RA | 1 |
| Albus, U; Englert, HC; Fürst, U; Gehring, D; Rosenkranz, B; Schölkens, BA; Scholz, W; Wirth, K | 1 |
| Colatsky, TJ; Cullinan, CA; Follmer, CH; Lodge, NJ | 1 |
| Dockrell, ME; Haynes, WG; Olverman, HJ; Waugh, CJ; Webb, DJ; Williams, BC | 2 |
| Bang, L; Nielsen-Kudsk, JE | 1 |
| Bowen, S; Carl, A; Gelband, CH; Hume, JR; Sanders, KM | 1 |
| Lewis, MJ; Shah, AM; Shattock, MJ | 1 |
| Honoré, E; Lazdunski, M | 2 |
| Berry, JL; Boyle, JP; Chapman, ID; Elliott, KR; Foster, RW; Small, RC; Watt, AJ | 1 |
| Angel, I; Bidet, S | 1 |
| Adeagbo, AS; Malik, KU | 2 |
| Ashford, ML; Ben-Ari, Y; Zini, S | 1 |
| Ashwood, VA; Cassidy, F; Evans, JM; Gagliardi, S; Stemp, G | 1 |
| Berry, JL; Burka, JF; Foster, RW; Small, RC; Watt, AJ | 1 |
| Berry, JL; Elliott, KR; Foster, RW; Green, KA; Murray, MA; Small, RC | 1 |
| Pezzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A; Zeng, YC | 1 |
| Ito, K; Nishimura, K; Ota, M | 1 |
| Fukushima, H; Izawa, T; Kashiwabara, T; Nakajima, S; Nishikori, K | 1 |
| Armstrong, SJ; Grimes, D; Rimele, TJ; Sturm, RJ | 1 |
| Iwakami, N; Kojima, K; Sugai, T; Suzuki, Y | 1 |
| Burden, DT; Burke, YM; Cowlrick, IS; Paciorek, PM; Perkins, RS; Taylor, JC; Waterfall, JF | 1 |
| Kajioka, S; Kitamura, K; Kuriyama, H; Nakao, K; Okabe, K; Weston, AH | 1 |
| Criddle, DN; Dewar, GH; Wathey, WB; Woodward, B | 1 |
| Grover, GJ; Parham, CS; Sleph, PG | 1 |
| Ehring, T; Rademacher, C; Thämer, V | 1 |
| Fish, FA; Prakash, C; Roden, DM | 1 |
| Busse, R; Lückhoff, A | 2 |
| Bray, KM; Duty, S; Edwards, G; Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Charette, L; Garcia, ML; Jones, TR; Kaczorowski, GJ | 1 |
| Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL | 1 |
| Dzwonczyk, S; Grover, GJ; Sleph, PG | 1 |
| Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Abe, Y; Fukui, K; Hasui, K; Iwao, H; Shoji, T; Tamaki, T | 1 |
| Bertrand, JP; Gautier, P; Guiraudou, P | 1 |
| Politi, DM; Rogawski, MA | 1 |
| Kovacs, RJ; Nelson, MT | 1 |
| Arakawa, C; Masuda, Y; Shigenobu, K; Tanaka, S; Yokoyama, T | 1 |
| Oliet, SH; Randle, JC; Renaud, JF | 1 |
| Berry, JL; Cook, SJ; Foster, RW; Green, KA; Murray, MA; Small, RC | 1 |
| Grant, TL; Zuzack, JS | 1 |
| Davis, A; Holliwell, DL; Leenen, FH; Tasker, TC; von Nguyen, P | 1 |
| Corrêa, DS; Rabetti, AC; Rae, GA | 1 |
| Cohen, RA; Cowan, CL | 1 |
| Dwyer, TM; Farley, JM; Petrini, MF; Shieh, CC | 1 |
| Aronson, JK | 1 |
| de Moura, RS; Jasbik, W | 1 |
| Calixto, JB; Guimarães, CL; Rae, GA | 1 |
| Erne, P; Hermsmeyer, K | 1 |
| Baumlin, Y; Quast, U | 2 |
| Ito, S; Itoh, T; Kajikuri, J; Kuriyama, H | 1 |
| Hood, JS; Kadowitz, PJ; McMahon, TJ | 2 |
| Barbieri, A; Grana, E; Zonta, F | 2 |
| Buckle, DR; Taylor, JF | 1 |
| Chapman, ID; Mazzoni, L; Morley, J | 1 |
| Cooper, J; Maclagan, J | 1 |
| Balwierczak, JL | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA | 1 |
| Kageyama, C; Shigenobu, K; Watanabe, M | 1 |
| Cox, RH | 3 |
| Arch, JR; Bowring, NE; Buckle, DR; Clarke, GD; Taylor, JF | 1 |
| Daniel, EE; Jury, J | 1 |
| Collins, P; Jiang, CW; Poole-Wilson, PA | 1 |
| Berdeaux, A; Giudicelli, JF; Richer, C | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 2 |
| Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T | 1 |
| Goto, S; Kitagaki, K; Koda, A; Nagai, H; Suda, H | 1 |
| Grose, JH; Lacourcière, Y; Lebel, M | 2 |
| Kurachi, Y; Machulda, MM; Shen, WK; Tung, RT | 1 |
| Cavero, I; Mondot, S; Pratz, J | 1 |
| Stockbridge, N; Weir, B; Zhang, H | 2 |
| Bray, KM; Longmore, J; Weston, AH | 1 |
| Mundy, AR; Nurse, DE; Restorick, JM | 1 |
| Arch, JR; Buckle, DR; Carey, C; Faller, A; Foster, KA; Houge-Frydrych, CS; Parr-Dobrzanski, H; Pinto, IL; Smith, DG; Taylor, SG | 1 |
| Asano, M; Masuzawa, K; Matsuda, T | 2 |
| Grant, TL; Grimwood, S; Todd, MH; Wickenden, AD | 1 |
| Fox, JS; Shanks, RG; Whitehead, EM | 1 |
| Kinnaird, AA; Man, RY | 1 |
| de Weille, JR; Häusser, MA; Lazdunski, M | 1 |
| Brown, TJ; Raeburn, D | 1 |
| Jones, AW; Post, JM | 1 |
| Huang, Y; Langton, PD; Nelson, MT; Standen, NB | 1 |
| Farraway, L; Huizinga, JD | 1 |
| Hirano, K; Kanaide, H; Yoshitake, K | 1 |
| Cavero, I; Mondot, S; Montier, F; Pratz, J | 1 |
| Chapnick, BM; Pawloski, JR | 1 |
| Buckingham, RE; Campbell, CA; Clapham, JC; Gout, B; Hamilton, TC; Ilsley, GL; Longman, SD | 1 |
| Dunn, A; Sylvester, JT; Wiener, CM | 1 |
| Halpern, W; McCarron, JG; Nelson, MT; Quayle, JM | 1 |
| Angus, JA; McPherson, GA | 3 |
| Angus, JA; Keily, SG; McPherson, GA | 1 |
| Dzwonczyk, S; Grover, GJ; Sargent, CA; Sleph, PG; Smith, MA | 1 |
| Heurteaux, C; Lazdunski, M | 1 |
| Conder, ML; Dzwonczyk, S; Grover, GJ; McCullough, JR; Normandin, DE; Sleph, PG | 1 |
| Chang, CC; Hong, SJ | 1 |
| Greger, R; Kunzelmann, K; Lindeman, S; Lindeman, V; Pavenstädt, H; Späth, M | 1 |
| Chiew, F; Cochrane, GM; Hopkirk, A; Lavender, E; Lee, TH; Owen, S; Richards, DH; Stone, P; Vyse, T; Williams, AJ | 1 |
| Attwood, MR; Jones, PS; Kay, PB; Paciorek, PM; Redshaw, S | 1 |
| Hume, JR; Post, JM; Sanders, KM; Stevens, RJ | 1 |
| Arch, JR; Buckle, DR; Edge, C; Foster, KA; Houge-Frydrych, CS; Pinto, IL; Smith, DG; Taylor, JF; Taylor, SG; Tedder, JM | 1 |
| Fujishima, M; Kamouchi, M; Nagao, T; Sadoshima, S | 1 |
| Bray, KM; Brown, TJ; Duty, S; Edwards, G; Longmore, J; Newgreen, DT; Weston, AH | 1 |
| Ahmed, SZ; Atwal, KS; Dzwonczyk, S; Grover, GJ; Newburger, J; Sleph, PG; Taylor, SC | 1 |
| Fromm-Freeck, S; Hayes, L; Howe, BB; Kau, ST; Kitada, S; Levin, RM; Wein, AJ | 1 |
| Armstrong, JM; Gellotte, M; Hicks, PE; Martin, DJ | 1 |
| Haeusler, G | 1 |
| de Weille, JR; Lazdunski, M | 1 |
| Daut, J; Goedel-Meinen, L; Günther, K; Maier-Rudolph, W; Mehrke, G; von Beckerath, N | 1 |
| Barnes, PJ; Ichinose, M | 1 |
| Hayashi, K; Hisaki, K; Matsumura, Y; Morimoto, S; Ohyama, T; Suzuki, Y; Yoshida, Y | 1 |
| Hu, SL; Kim, HS; Okolie, P; Weiss, GB | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Blaustein, MP; Rubin, LJ; Tod, ML; Yuan, XJ | 1 |
| Pilsudski, R; Rougier, O; Tourneur, Y | 1 |
| Miyata, N; Otomo, S; Tsuchida, K | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Asano, M; Imaizumi, Y; Masuzawa, K; Matsuda, T; Watanabe, M | 2 |
| Alouan, LA; Armour, CL; Barnes, PJ; Black, JL; Johnson, PR | 1 |
| McHarg, AD; Southerton, JS; Weston, AH | 1 |
| Antoine, MH; Devreux, V; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Franke, C; Hatt, H; Quasthoff, S; Richter-Turtur, M | 1 |
| Downing, SJ; Hollingsworth, M; Minshall, E; Piper, I; Sadraei, H | 1 |
| Sanguinetti, MC | 1 |
| Colatsky, T; Follmer, C; Parsons, R; Spinelli, W | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Satoh, K; Taira, N; Yoneyama, F | 1 |
| MacLeod, KM; Ray, A | 1 |
| Bray, KM; Brown, BS; Duty, S; Edwards, G; Kay, PB; Longmore, J; McHarg, AD; Newgreen, DT; Southerton, JS; Weston, AH | 1 |
| Berdeaux, A; Giudicelli, JF; la Rochelle, CD | 1 |
| Kaneko, K; Miyata, N; Otomo, S; Tanaka, M; Tsuchida, K | 1 |
| Dunne, MJ; Gallacher, DV; Petersen, OH; Yule, DI | 2 |
| Aspinall, RJ; Dunne, MJ; Petersen, OH | 1 |
| Duty, S; Paciorek, PM; Waterfall, JF; Weston, AH | 1 |
| Burrell, G; Cassidy, F; Evans, JM; Lightowler, D; Stemp, G | 1 |
| Arch, JR; Buckle, DR; Fenwick, AE; Houge-Frydrych, CS; Pinto, IL; Smith, DG; Taylor, SG; Tedder, JM | 1 |
| Abele, AE; Miller, RJ | 1 |
| Lederer, WJ; Nichols, CG; Ripoll, C | 1 |
| Koch, P; Peters, T; Wilffert, B; Wilhelm, D | 1 |
| Baeyens, JM; Barrios, M; Del Pozo, E | 1 |
| Kadlec, O; Masek, K; Seferna, I; Sevcík, J | 1 |
| Neumcke, B; Weik, R | 1 |
| Abe, Y; Aki, Y; Fukui, K; Iwao, H; Shoji, T; Tamaki, T | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Spittelmeister, W; Spuler, A | 1 |
| Kudoh, S; Nakamura, H | 1 |
| Dzwonczyk, S; Grover, GJ; Parham, CS; Sleph, PG | 1 |
| Dixon, MS; Sheridan, DJ; Thomas, P; Winterton, SJ | 1 |
| Andersson, KE; Andersson, PO; Fovaeus, M; Malmgren, A; Sjögren, C | 1 |
| Amoroso, S; Fosset, M; Lazdunski, M; Schmid-Antomarchi, H | 1 |
| Higashida, H; Ito, Y; Matsubara, T; Miyamori, I; Takeda, R | 1 |
| Grafe, P; Lehmann-Horn, F; Quasthoff, S; Strupp, M | 1 |
| Bril, A; Man, RY | 1 |
| Andersson, KE; Fovaeus, M; Hedlund, H; Holmquist, F | 1 |
| Brading, AF; Foster, CD; Fujii, K; Parekh, AB | 1 |
| Arányi, P; Kovács, A; Rabloczky, G; Singer, J | 1 |
| Cowlrick, IS; Paciorek, PM; Perkins, RS; Taylor, JC; Waterfall, JF; Wilkinson, GF | 1 |
| Doussau, MP; Gautier, P; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Cavero, I; Hyman, A; Le Monnier de Gouville, AC; Lippton, H; Mondot, S | 1 |
| Weir, SW; Weston, AH | 2 |
| Allen, SL; Boyle, JP; Cortijo, J; Foster, RW; Morgan, GP; Small, RC | 1 |
| Scholtysik, G | 1 |
| Amédée, T; Edwards, D; Hollingsworth, M; Mironneau, J; Savineau, JP; Small, RC; Weston, AH | 1 |
| Coldwell, MC; Howlett, DR | 2 |
| Cook, NS; Quast, U | 2 |
| Baumlin, Y; Cook, NS; Hof, RP; Pally, C; Quast, U | 1 |
| Blarer, S; Cook, NS; Hof, RP; Quast, U | 1 |
| Cook, NS; Quast, U; Scholtysik, G; Weir, SW | 1 |
| Cavero, I; Escande, D; Leguern, S; Thuringer, D | 1 |
| Gotanda, K; Satoh, K; Taira, N | 1 |
| Sanguinetti, MC; Scott, AL; Siegl, PK; Zingaro, GJ | 1 |
| Baskin, EP; Garcia, ML; Heaney, LA; Kaczorowski, GJ; Stein, RB; Wallace, AA; Winquist, RJ | 1 |
| Clapham, JC; Hamilton, TC; Longman, SD; Wilson, C | 1 |
| Buckingham, RE; Clapham, JC | 1 |
| Bühler, FR; Cauvin, C; Weir, SW | 1 |
| Eltze, M | 2 |
| Dollery, CT; Turner, NC; Williams, AJ | 1 |
| Golenhofen, K; Mandrek, K; Noack, T | 1 |
| Clark, KL; Drew, GM; Hilditch, A | 1 |
| Gotanda, K; Satoh, K; Taira, N; Yokoyama, H | 1 |
| Cavero, I; Mestre, M; Mondot, S | 1 |
| Buckingham, RE; Hamilton, TC; Howlett, DR; Mootoo, S; Wilson, C | 1 |
| Wilson, C | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Bidard, JN; Coenen, A; Gandolfo, G; Gottesmann, C; Lazdunski, M; Romettino, S; van Luijtelaar, G | 1 |
| Sanguinetti, MC; Siegl, PK; Wolleben, CD | 1 |
| BoSmith, RE; Briggs, I; Grant, TL; Grimwood, S; Russell, NJ; Stone, MA; Wickenden, AD | 1 |
| Conder, ML; Grover, GJ; Henry, DE; McCullough, JR; Sleph, PG | 1 |
| Cavero, I; Courteix, J; Escande, D; Laville, M; Le Guern, S; Thuringer, D | 1 |
| Doussau, MP; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Kim, S; Koh, E; Miyashita, Y; Morimoto, S; Ogihara, T | 1 |
| Boyle, JP; Murray, MA; Small, RC | 1 |
| Longmore, J; Weston, AH | 1 |
| Bray, KM; Duty, S; Weston, AH | 1 |
| Hollingsworth, M; Piper, I | 1 |
| den Hertog, A; Nelemans, A; Van den Akker, J | 1 |
| Hironaka, T; Kim, S; Koh, E; Morimoto, S; Morita, R; Nabata, T; Ogihara, T; Onishi, T; Takamoto, S | 1 |
| Garrino, MG; Henquin, JC; Plant, TD | 2 |
| Kamata, K; Kasuya, Y; Miyata, N | 1 |
| Beech, DJ; Hiestand, P; Kocher, HP; Strong, PN; Weir, SW | 1 |
| Cooper, SM; Wilson, C | 1 |
| Politi, DM; Rogawski, MA; Suzuki, S | 1 |
| Alzheimer, C; Sutor, B; ten Bruggencate, G | 2 |
| Beech, DJ; Bolton, TB | 1 |
| Gelband, CH; Lodge, NJ; Van Breemen, C | 1 |
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| Bellan, JA; Kadowitz, PJ; Longenecker, LL; McNamara, DB | 1 |
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| Creed, KE; Malmgren, A | 1 |
| Quast, U; Villhauer, EB | 1 |
| Barnes, PJ; Chung, KF; Fuller, RW; Kidney, JC; Lavender, EA; Worsdell, YM | 1 |
| Gu, H; Hagiwara, N; Momma, K; Nakanishi, T | 1 |
| Shen, YT; Vatner, SF | 1 |
| Chiba, S; Furukawa, Y; Inoue, Y; Sawaki, S; Takayama, S | 1 |
| Dubray, LA; Gadwood, RC; Groppi, VE; Kamdar, BV; Mizsak, SA; Smith, MP; Watt, W; Wolfe, ML | 1 |
| Gelband, GH; McCullough, JR | 1 |
| Jacoby, HI; Lee, DK; Steffler, C; Tomko, KA | 1 |
| Halaka, NN; Lodge, NJ | 1 |
| Okada, Y; Taira, N; Yanagisawa, T | 1 |
| Das, DK; Engelman, DT; Engelman, RM; Tosaki, A | 1 |
| Liu, J; Luo, Y; Zhou, L | 1 |
| Griffin, A | 1 |
| Balderrama, DS; Eichinger, MR; Herrera, GM; Resta, JM; Resta, TC; Richardson, LA; Walker, BR | 1 |
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| Bonasso, CL; Lewis, AI; Rapoport, RM; Sperelakis, N; Zuccarello, M | 1 |
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| Brotchie, JM; Crossman, AR; Duty, S; Hille, CJ; Maneuf, YP | 1 |
| Grover, GJ; Sleph, PG | 1 |
| Abe, I; Fujii, K; Fujishima, M; Nagao, T; Ohya, Y; Setoguchi, M | 1 |
| de Lemos Neto, M; de Moura, RS | 1 |
| Hara, Y; Kimura, S; Kobayashi, S; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| Hollingsworth, M; Hughes, SJ | 2 |
| Randall, MD | 1 |
| Baird, AJ; Grover, GJ; Sleph, PG | 1 |
| Andersson, KE; Persson, K; Waldeck, K | 1 |
| Hohn, J; Papp, JG; Pataricza, J; Penke, B; Toth, GK | 1 |
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| Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Poggioli, R | 1 |
| Endoh, N; Ichinose, M; Kageyama, N; Miura, M; Sakurai, E; Shirato, K; Takahashi, T; Tomaki, M; Watanabe, T; Yamauchi, H | 1 |
| Baumlin, Y; Loffler, C; Quast, U | 1 |
| Brading, AF; Teramoto, N | 2 |
| Bányász, T; Nánási, PP; Pankucsi, C; Szigligeti, P; Varró, A | 1 |
| Dzwonczyk, S; Grover, GJ; Monticello, TM | 1 |
| Hong, KW; Lee, JY; Rhim, BY; Yoo, SE; Yu, SS | 1 |
| Brasch, H | 1 |
| Baeyens, JM; Barrios, M; Ocaña, M | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Grover, GJ; Hess, TA; Lodge, NJ; Normandin, DE; Sewter, JC; Sleph, PG | 1 |
| Morice, AH; Woodmansey, PA; Zhang, F | 1 |
| Kelly, E; Kumar, P; Poucher, SM; Prior, H; Russell, K; Wickenden, AD | 1 |
| Del Prete, E; Lutz, TA; Scharrer, E | 1 |
| Lawson, K | 2 |
| Karaki, H; Mitsui-Saito, M; Ozaki, H; Trongvanichnam, K | 1 |
| O'Brien, E; Wanstall, JC | 1 |
| Davis, SC; Edwards, G; Högestätt, ED; Weston, AH; Zygmunt, PM | 1 |
| French, RJ; Giles, WR; Han, X; Light, PE | 1 |
| Bennett, T; Fallgren, B; Gardiner, SM; Kemp, PA; March, JE | 1 |
| Fulton, D; McGiff, JC; Mieyal, P; Quilley, J; Rapacon, M | 1 |
| Bertelsen, DL; Chun, A; Kau, S; Levin, RM; Murphy, J | 1 |
| Boev, KK; Duridanova, DB | 1 |
| Mizoguchi, K; Tanaka, M; Tanaka, T; Yokoo, H; Yoshida, M | 1 |
| McCulloch, AI; Randall, MD | 1 |
| D'Alonzo, AJ; Darbenzio, RB; Dzwonczyk, S; Grover, GJ; Hess, TA; Sewter, JC; Sleph, PG | 1 |
| Kaneto, H; Nakao, K; Takahashi, M | 1 |
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| Hashii, M; Higashida, H; Ito, Y; Katsumori, H; Minabe, Y | 1 |
| Asano, M; Ito, K; Kuwako, M; Nomura, Y; Shibuya, M; Sugita, K; Suzuki, Y | 1 |
| Izawa, T; Izumi, H; Kawahara, J; Okada, Y | 1 |
| Ausina, P; Candenas, ML; D'Ocón, MP; Hernandez, JS; Martín, JD; Savineau, JP | 1 |
| Dobashi, K; Houjou, S; Iizuka, K; Nakazawa, T | 1 |
| Das, DK; Engelman, RM; Tosaki, A | 1 |
| Cheung, WM; Damiano, BP; Falotico, R; Mitchell, JA | 1 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Coirault, C; Ducros, L; Joseph, T; Lecarpentier, Y | 1 |
| Bonev, A; Heppner, TJ; Kau, ST; Li, JH; Nelson, MT | 1 |
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| Calixto, JB; Cechinel-Filho, V; Paulino, N; Yunes, RA | 1 |
| Gidday, JM; Maceren, RG; Meier, JA; Shah, AR; Zhu, Y | 1 |
| Angus, JA; Fujiwara, T | 1 |
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| Hüsken, BC; Pfaffendorf, M; Timmenga, EJ; Van Zwieten, PA; Vroom, MB | 1 |
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| Fujii, K; Fujikawa, M; Fujishima, M; Ibayashi, S; Kitazono, T; Nagao, T; Takata, Y; Toyoda, K | 1 |
| Kim, KH; Ro, JY; Yim, YN | 1 |
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| Batra, S; Kostrzewska, A; Laudański, T | 1 |
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| Aya, G; de La Coussaye, JE; Delye, B; Eledjam, JJ; Juan, JM; Péray, P; Robert, E; Sassine, A | 1 |
| Hüsken, BC; Pfaffendorf, M; van Zwieten, PA | 1 |
| Fulton, D; Kaminski, P; McGiff, JC; Quilley, J; Wolin, MS | 1 |
| Bianchi, L; Boselli, C; Grana, E | 1 |
| Allard, B; Rougier, O | 1 |
| Biggs, CS; Fowler, LJ; Maione, S; Rossi, F; Whitton, PS | 1 |
| Adler-Graschinsky, E; Feleder, EC | 1 |
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| Goswami, S; Jain, S; Santani, D | 1 |
| Fleck, E; Henning, B; Hildebrandt, AG; Ott, T; Zünkler, BJ | 1 |
| Bizub, DM; Gauthier-Rein, KM; Lombard, JH; Rusch, NJ | 1 |
| Aguggini, G; Dimori, M; Hussain, SN; Vanelli, G | 1 |
| Katoh, I; Kitagawa, T; Masuda, Y; Shimoe, Y; Yoshizumi, M | 1 |
| Murray, PA; Nakayama, M; Sato, K; Seki, S | 1 |
| Brading, AF; McMurray, G; Teramoto, N | 1 |
| Babenko, A; Vassort, G | 1 |
| Lavallée, M; Ming, Z; Parent, R | 1 |
| Haddad, GG; Jiang, C | 1 |
| Aisaka, K; Hirata, Y | 1 |
| Anthony, DM; Buckett, WR; Dickinson, K; Jones, RB; Kaul, CL; Marita, AR | 1 |
| Baczkó, I; Leprán, I; Papp, JG | 1 |
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| Choi, RT; Iskander, MN; Kong, DC; McPherson, GA | 1 |
| Ballejo, G; Corrado, AP; Cruz-Höfling, MA; Heluany, NF; Leite, GB; Prado-Franceschi, J; Rodrigues-Simioni, L; Silva-Carvalho, I | 1 |
| Elliott, KR; Hollingsworth, M; Hughes, SJ | 1 |
| Huang, Y; Kwok, KH | 1 |
| Burton, FL; Smith, GL | 1 |
| Barberá, M; Cortijo, J; Higueras, J; Maruenda, A; Morcillo, EJ; Ortiz, JL; Sarría, B | 1 |
| Dahl, R; Nielsen-Kudsk, F; Thirstrup, S | 1 |
| Matsumura, K; Mochizuki-Oda, N; Oosawa, Y; Takeuchi, Y; Watanabe, Y | 1 |
| Ando, T; Kume, H; Takagi, K; Urata, Y | 1 |
| Deslauriers, R; Docherty, JC; Gunter, HE; Kuzio, B; Shoemaker, L; Yang, L | 1 |
| Das, DK; Tosaki, A | 1 |
| Chuliá, S; D'Ocon, P; Ivorra, MD; Noguera, MA | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Endo, M; Izawa, T; Izumi, H; Jinno, Y; Kawahara, J; Takeuchi, A | 1 |
| Van de Voorde, J; Vanheel, B | 1 |
| Hosoki, K; Karasawa, T; Nagata, S; Takeyama, K | 1 |
| Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS | 1 |
| Forrest, CR; He, W; Hopper, R; Neligan, P; Pang, CY; Xu, H; Zhong, A | 1 |
| Champion, HC; Kadowitz, PJ | 1 |
| Li, L; Paakkari, I; Vaali, K; Vapaatalo, H | 1 |
| Barman, SA | 1 |
| Gomoll, AW; Weselcouch, EO | 1 |
| Farley, JM; Nuttle, LC | 1 |
| Cameron, AD; Cameron, IT; Greer, IA; Martin, W; McGrath, JC; Norman, JE; Ward, LM | 1 |
| Canzoniero, LM; Choi, DW; Dugan, LL; Farhangrazi, ZS; Gwag, BJ; Sensi, SL; Tian, M; Yeh, CH; Ying, HS; Yu, SP | 1 |
| Chapple, CR; Chess-Williams, R; Korstanje, C; Martin, SW; Radley, SC | 1 |
| Horibe, M; Murray, PA; Seki, S | 1 |
| Fujii, K; Fujishima, M; Ibayashi, S; Kitazono, T; Nagao, T; Toyoda, K | 1 |
| Chen, PS; Fishbein, MC; Garfinkel, A; Ikeda, T; Kamjoo, K; Karagueuzian, HS; Uchida, T; Weiss, JN | 1 |
| Lee, BH; Seo, HW; Shin, HS; Yoo, SE | 1 |
| Lee, BH; Oh, JH; Seo, HW; Shin, HS | 1 |
24 review(s) available for pyrroles and cromakalim
| Article | Year |
|---|---|
Potassium channel activators and bronchial asthma.
Topics: Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Humans; In Vitro Techniques; Muscle, Smooth; Potassium Channels; Pyrroles; Synaptic Transmission | 1992 |
[Advance in pharmacology of potassium channels in cardiovascular system and their clinical use].
Topics: Benzopyrans; Cromakalim; Guanidines; Humans; Muscle, Smooth, Vascular; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Potassium channel opening drugs and the airways.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; In Vitro Techniques; Ion Channel Gating; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles | 1992 |
Potassium channel openers: pharmacological and clinical aspects.
Topics: Animals; Benzopyrans; Cardiovascular Diseases; Cromakalim; Heart; Humans; Muscle, Smooth; Nervous System; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
[Differential action of nitrate derivatives and arterial vasodilators on coronary circulation. An experimental approach and therapeutic consequences].
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Diltiazem; Dogs; Drug Therapy, Combination; Female; Isosorbide Dinitrate; Male; Nitroglycerin; Pyrroles; Vasodilator Agents | 1992 |
Clinical pharmacology of potassium channel openers.
Topics: Antihypertensive Agents; Benzopyrans; Cardiovascular System; Cromakalim; Guanidines; Humans; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Respiratory System | 1992 |
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinical Trials as Topic; Cromakalim; Disease Models, Animal; Guanidines; Humans; Muscle, Smooth, Vascular; Muscles; Neurons; Niacinamide; Nicorandil; Pancreas; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
The potassium channel openers: a new class of vasorelaxants.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Membrane Potentials; Peptides; Potassium Channels; Potassium Chloride; Pyrroles; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
Potassium channels in nervous tissue.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Carbamazepine; Cromakalim; Electric Conductivity; Nervous System; Parasympatholytics; Potassium Channels; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
Potassium channel activators in vascular smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Heart; Hemodynamics; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles | 1991 |
K(+)-channel openers: new antihypertensive drugs?
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Hemodynamics; Humans; Hypertension; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1990 |
Smooth muscle K+ channel openers; their pharmacology and clinical potential.
Topics: Animals; Benzopyrans; Cromakalim; Guanidines; Humans; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular Diseases; Cromakalim; Diazoxide; Guanidines; Guinea Pigs; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Radioligand Assay; Rats; Structure-Activity Relationship; Vasodilator Agents | 1994 |
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disease Models, Animal; Dogs; Guanidines; Guinea Pigs; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rats; Vasodilator Agents | 1994 |
Cerebral vascular smooth muscle potassium channels and their possible role in the management of vasospasm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electrophysiology; Guanidines; Ischemic Attack, Transient; Muscle, Smooth, Vascular; Neuropeptides; Niacinamide; Nicorandil; Nitric Oxide; Pinacidil; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1994 |
Do potassium channel openers compete with ATP to activate ATP sensitive potassium channels?
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Guinea Pigs; Ion Channel Gating; Myocardium; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
[Potassium agonists].
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Humans; Membrane Potentials; Muscle, Smooth, Vascular; Myocardial Ischemia; Neuromuscular Junction; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents | 1994 |
Prospects for potassium channel activators in the treatment of airways obstruction.
Topics: Airway Obstruction; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Humans; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1993 |
Do the K+ channel openers relax smooth muscle by opening K+ channels?
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Humans; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guanidines; Heart Failure; Hemodynamics; Humans; In Vitro Techniques; Ion Channel Gating; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Potassium channel activation: a potential therapeutic approach?
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Bronchodilator Agents; Calcium; Cardiovascular Diseases; Cromakalim; Hair; Humans; Intraocular Pressure; Muscle, Skeletal; Nervous System Diseases; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Reproduction; Respiratory Tract Diseases; Synaptic Transmission; Urologic Diseases; Vasodilator Agents | 1996 |
Is there a therapeutic future for "potassium channel openers'?
Topics: Adenosine Triphosphate; Benzopyrans; Brain Diseases; Cardiovascular Diseases; Cromakalim; Humans; Ion Channel Gating; Lung Diseases; Potassium Channels; Pyrroles; Urinary Bladder Diseases | 1996 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Mitochondria, Heart; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Rats | 1997 |
12 trial(s) available for pyrroles and cromakalim
| Article | Year |
|---|---|
Effects of the potassium channel activator, cromakalim, on arterial and cardiac responses to norepinephrine, angiotensin II, and isoproterenol in normotensive men.
Topics: Adult; Angiotensin II; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Hemodynamics; Humans; Isoproterenol; Male; Norepinephrine; Potassium Channels; Pyrroles; Stereoisomerism | 1991 |
Effect of short-term administration of cromakalim on renal hemodynamics and eicosanoid excretion in essential hypertension.
Topics: Adult; Antihypertensive Agents; Atrial Natriuretic Factor; Benzopyrans; Blood Pressure; Chlorides; Cromakalim; Dinoprost; Dinoprostone; Eicosanoids; Female; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Humans; Hypertension; Kidney; Male; Middle Aged; Potassium; Prostaglandins; Pyrroles; Regional Blood Flow; Renin-Angiotensin System; Sodium; Thromboxane B2; Time Factors; Vascular Resistance | 1991 |
Cardiovascular effects of cromakalim (BRL 34915) in healthy volunteers.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Exercise; Heart Rate; Humans; Male; Posture; Pyrroles; Vascular Resistance | 1991 |
Attenuation of nocturnal asthma by cromakalim.
Topics: Adult; Analysis of Variance; Asthma; Benzopyrans; Bronchodilator Agents; Circadian Rhythm; Cromakalim; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Half-Life; Humans; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic | 1990 |
Acute haemodynamic effects of cromakalim in patients with angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Benzopyrans; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Disease; Cromakalim; Hemodynamics; Humans; Injections, Intravenous; Male; Middle Aged; Pyrroles; Stroke Volume; Vascular Resistance; Vasodilator Agents | 1990 |
Stimulation of renin secretion by potassium-channel activation with cromakalim.
Topics: Adult; Angiotensin II; Benzopyrans; Blood Pressure; Cells, Cultured; Cromakalim; Heart Rate; Humans; Juxtaglomerular Apparatus; Male; Potassium Channels; Pyrroles; Renin; Stimulation, Chemical | 1989 |
Humoral and cellular effects of the K(+)-channel activator cromakalim in man.
Topics: Adult; Antihypertensive Agents; Benzopyrans; Biological Transport, Active; Cromakalim; Double-Blind Method; Erythrocytes; Humans; Male; Parasympatholytics; Potassium Channels; Pyrroles; Randomized Controlled Trials as Topic; Regression Analysis; Renin-Angiotensin System; Single-Blind Method; Vasodilator Agents | 1989 |
Potassium channel stimulation in normal subjects and in patients with essential hypertension: an acute study with cromakalim (BRL 34915).
Topics: Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Double-Blind Method; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Potassium Channels; Pyrroles; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Stimulation, Chemical; Time Factors | 1989 |
The potassium channel opening drug cromakalim produces arterioselective vasodilation in the upper limbs of healthy volunteers.
Topics: Adult; Arteries; Benzopyrans; Cromakalim; Forearm; Hand; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Regional Blood Flow; Vascular Resistance; Vasodilation | 1989 |
Changes in potassium content and membrane potassium channels in circulating cells from normal volunteers treated with cromakalim.
Topics: Adult; Benzopyrans; Blood Pressure; Cromakalim; Double-Blind Method; Erythrocytes; Heart Rate; Humans; Leukocytes; Magnesium; Male; Potassium; Potassium Channels; Pyrroles; Random Allocation; Sodium | 1989 |
Antihypertensive effect of levcromakalim in patients with essential hypertension. Study by 24-h ambulatory blood pressure monitoring.
Topics: Adult; Aged; Antihypertensive Agents; Benzopyrans; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Cromakalim; Female; Humans; Hypertension; Male; Middle Aged; Pulse; Pyrroles | 1995 |
Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol.
Topics: Adult; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Pyrroles; Time Factors; Vital Capacity | 1993 |
794 other study(ies) available for pyrroles and cromakalim
| Article | Year |
|---|---|
Molecular mechanism of action of nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Niacinamide; Nicorandil; Nitroglycerin; Nitroprusside; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Differential effects of nitrovasodilators, K(+)-channel openers, and nicorandil on large and small coronary arteries in conscious dogs.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Injections, Intravenous; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Pharmacological characterization of nicorandil by 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1992 |
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Male; Muscle Contraction; Neuropeptide Y; Potassium Channels; Pyrroles; Scorpion Venoms; Synaptic Transmission; Trachea | 1992 |
Collateral perfusion: the role of endothelium-derived relaxing factor and effects of vasodilators.
Topics: Animals; Arginine; Benzopyrans; Collateral Circulation; Cromakalim; Ear; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pyrroles; Rabbits; Vasodilator Agents; Verapamil | 1992 |
Differences in the K(+)-channels opened by cromakalim, acetylcholine and substance P in rat aorta and porcine coronary artery.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Benzopyrans; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Male; omega-N-Methylarginine; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Swine | 1991 |
Effects of lemakalim and thalium on early afterdepolarization in mouse atrial fibers.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Heart Atria; In Vitro Techniques; Male; Mice; Potassium; Potassium Channels; Pyrroles; Thallium | 1992 |
Influence of KATP channel modulation on net potassium efflux from ischaemic mammalian cardiac tissue.
Topics: Action Potentials; Animals; Barium; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; Muscles; Myocardial Ischemia; Oxygen; Papillary Muscles; Potassium; Potassium Channels; Pyrroles; Tolbutamide; Vasodilator Agents | 1992 |
Effects of intracoronary cromakalim on postischaemic contractile function and action potential duration.
Topics: Action Potentials; Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Glyburide; Myocardial Contraction; Myocardial Ischemia; Pyrroles; Vasodilator Agents | 1992 |
Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia.
Topics: Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Glyburide; Heart Arrest, Induced; Myocardial Contraction; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1992 |
KATP channel opening and cardioprotection.
Topics: Benzopyrans; Cromakalim; Humans; Myocardial Ischemia; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
Inhibitory action of the potassium channel opener BRL 38227 on agonist-stimulated phosphoinositide metabolism in bovine tracheal smooth muscle.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Inositol Phosphates; Muscle, Smooth; Phosphatidylinositols; Phosphodiesterase Inhibitors; Potassium Channels; Pyrroles; Trachea | 1992 |
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Vasodilator Agents | 1992 |
Similarities between effects of superoxide-mediated endothelium-derived relaxing factor and cromakalim.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic GMP; Female; Hypoxanthine; Hypoxanthines; Male; Mesenteric Arteries; Nitric Oxide; Pyrroles; Rabbits; Rubidium; Superoxides; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 1992 |
One way cross tolerance between cromakalim and salbutamol in the uterus of the rat in vivo.
Topics: Albuterol; Animals; Benzopyrans; Cromakalim; Cyclic AMP; Drug Interactions; Drug Tolerance; Female; Glyburide; Muscle Relaxation; Propranolol; Pyrroles; Radioimmunoassay; Rats; Uterus | 1992 |
Comparative effects of BRL 38227, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle.
Topics: Animals; Benzopyrans; Carbachol; Cattle; Cromakalim; Histamine; In Vitro Techniques; Isoproterenol; Muscle, Smooth; Nitrendipine; Parasympatholytics; Phosphatidylinositols; Pyrroles; Trachea | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Cromakalim does not act as a calcium antagonist in isolated human mesenteric artery cells.
Topics: Benzopyrans; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cromakalim; Humans; Ion Channel Gating; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Pyrroles; Stereoisomerism; Vasodilator Agents | 1992 |
Inactivation of glibenclamide-sensitive K+ channels in Xenopus oocytes by various calmodulin antagonists.
Topics: Animals; Benzopyrans; Calmodulin; Cromakalim; Cyclic AMP; Female; Glyburide; In Vitro Techniques; Isoproterenol; Oocytes; Potassium Channels; Pyrroles; Up-Regulation; Xenopus | 1992 |
Potassium channel openers, NIP-121 and cromakalim, enhance the relaxation induced by sodium nitroprusside in the guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Drug Interactions; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; SRS-A; Trachea; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Behavioral effects of modulators of ATP-sensitive K+ channels in the rat dorsal pallidum.
Topics: Adenosine Triphosphate; Amphetamine; Animals; Behavior, Animal; Benzopyrans; Cromakalim; Dopamine Agents; Drug Administration Routes; Glipizide; Globus Pallidus; Male; Motor Activity; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity | 1992 |
Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Animals; Arginine; Benzopyrans; Bradykinin; Calcimycin; Calmodulin; Coronary Vessels; Cromakalim; Dogs; Endothelium, Vascular; Ethanolamines; Imidazoles; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nebivolol; Nitric Oxide; Nitroarginine; Pyrroles; Vasodilator Agents | 1992 |
Vasorelaxation of rat thoracic aorta caused by two Ca(2+)-channel blockers, HA-22 and HA-23.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Caffeine; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; In Vitro Techniques; Male; Nifedipine; Pyrans; Pyrazoles; Pyrroles; Rats; Rats, Inbred Strains; Vasodilation; Verapamil | 1992 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
Comparison of the effects of cromakalim in trachea isolated from normal and albumin-sensitive guinea-pigs.
Topics: Acetylcholine; Albumins; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Disease Models, Animal; Electric Stimulation; Flurbiprofen; Guinea Pigs; Immunization; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Trachea | 1992 |
Effect of cromakalim on the smooth muscle of the cat gastric antrum.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cats; Cromakalim; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyloric Antrum; Pyrroles | 1992 |
Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1991 |
Effects of cromakalim on the contraction and the membrane potential of the circular smooth muscle of guinea-pig stomach.
Topics: Acetylcholine; Animals; Benzopyrans; Charybdotoxin; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Pyrroles; Scorpion Venoms; Stomach | 1992 |
Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not modified by glibenclamide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiocardiography; Animals; Benzopyrans; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Male; Niacinamide; Nicorandil; Nitroglycerin; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Role of potassium channels in bronchodilator responses in human airways.
Topics: Adolescent; Adult; Apamin; Benzopyrans; Bronchi; Bronchodilator Agents; Charybdotoxin; Child; Cromakalim; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Pyrrolidines; Scorpion Venoms; Theophylline | 1992 |
The role of cyclic AMP in non-adrenergic non-cholinergic contraction in guinea-pig bronchi.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchi; Bronchodilator Agents; Bucladesine; Colforsin; Cromakalim; Cyclic AMP; Electric Stimulation; Ethanolamines; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons, Afferent; Nitroprusside; Procaterol; Pyrroles; Substance P; Theophylline | 1992 |
Effect of K+ channel-modulating drugs on the vasoconstrictor responses of leukotrienes C4, D4 and angiotensin II in the guinea-pig isolated perfused heart.
Topics: Angiotensin II; Animals; Benzopyrans; Charybdotoxin; Cromakalim; Galanin; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium; Nitroglycerin; Peptides; Potassium Channels; Pyrroles; Radioimmunoassay; Scorpion Venoms; SRS-A; Thromboxane A2; Vasoactive Intestinal Peptide; Vasoconstriction; Vasodilator Agents | 1992 |
Mechanisms of action of the dilatory response to calcitonin gene-related peptide in guinea pig basilary artery.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Basilar Artery; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Cromakalim; Cyclic AMP; Endothelium, Vascular; Glyburide; Guinea Pigs; In Vitro Techniques; Muscle, Smooth, Vascular; Neurokinin A; Nitric Oxide; Potassium Channels; Pyrroles; Second Messenger Systems; Substance P; Vasodilation; Vasodilator Agents | 1992 |
Excitation-contraction coupling in canine tracheal smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Dogs; Egtazic Acid; In Vitro Techniques; Models, Biological; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympatholytics; Pyrroles; Sarcoplasmic Reticulum; Tetraethylammonium; Tetraethylammonium Compounds; Trachea | 1992 |
K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Guinea Pigs; Male; Methacholine Compounds; Potassium Channels; Pyrroles; Smoking; Substance P; Trachea; Vagus Nerve | 1992 |
Comparison of the relaxing effects of cicletanine and cromakalim on vascular smooth muscle.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Diuretics; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Iliac Artery; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium; Pyridines; Pyrroles; Rabbits; Rats; Vasodilation; Vasodilator Agents | 1992 |
The indirect negative inotropic effects of the P1-receptor agonist, L-phenylisopropyladenosine, in guinea-pig isolated cardiac preparations: comparison with cromakalim.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Function; Atrial Function, Left; Benzopyrans; Cardiotonic Agents; Colforsin; Cromakalim; Depression, Chemical; Guinea Pigs; Heart Atria; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phenylisopropyladenosine; Pyrroles; Stimulation, Chemical; Time Factors | 1992 |
Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Benzopyrans; Cromakalim; Ear, External; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Verapamil | 1992 |
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.
Topics: Adrenergic Antagonists; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Rubidium Radioisotopes; Stereoisomerism; Theophylline; Trachea | 1992 |
Effects of K+ channel blockers on the relaxant action of dihydralazine, cromakalim and nitroprusside in isolated rabbit femoral arteries.
Topics: Animals; Benzopyrans; Cromakalim; Dihydralazine; Endothelium, Vascular; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Effects of imidazoline-related compounds on the mechanical response to nicorandil in the rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1992 |
Preferential small arteriolar vasodilatation by the potassium channel opener, BRL 38227, in conscious spontaneously hypertensive rats.
Topics: Animals; Arterioles; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Hypertension; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Vasodilation; Vasodilator Agents | 1992 |
Activation of phospholipase C by the agonist U46619 is inhibited by cromakalim-induced hyperpolarization in porcine coronary artery.
Topics: Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Enzyme Activation; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Muscle Contraction; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Thromboxane A2; Type C Phospholipases | 1992 |
Membrane permeability to K+ and the control of aldosterone synthesis: effects of valinomycin and cromakalim in bovine adrenocortical cells.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Benzopyrans; Cattle; Cell Membrane Permeability; Cromakalim; In Vitro Techniques; Ion Transport; Potassium; Pyrroles; Steroid 21-Hydroxylase; Valinomycin | 1992 |
Effects of cromakalim on the membrane potassium permeability of frog skeletal muscle in vitro.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cell Membrane Permeability; Cromakalim; In Vitro Techniques; Muscles; Parasympatholytics; Potassium; Potassium Channels; Pyrroles; Rana temporaria; Rubidium | 1992 |
Differential effects of endothelin-1 on the vasorelaxant properties of benzopyran and non-benzopyran potassium channel openers.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Cyclopentanes; Dihydropyridines; Dose-Response Relationship, Drug; Endothelins; Guanidines; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1992 |
Inhibition by adrenergic neurone blocking agents of the relaxation induced by BRL 38227 in vascular, intestinal and uterine smooth muscle.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Bretylium Compounds; Cromakalim; Female; Guanethidine; Guinea Pigs; Intestines; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Sympatholytics; Theophylline; Uterine Contraction | 1992 |
Calmodulin antagonists inhibit endothelium-dependent hyperpolarization in the canine coronary artery.
Topics: Animals; Benzopyrans; Bradykinin; Calcimycin; Calmodulin; Coronary Vessels; Cromakalim; Dogs; Endothelium, Vascular; Female; Fendiline; Imidazoles; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles | 1992 |
Activation of ATP-sensitive K+ channels by cromakalim. Effects on cellular K+ loss and cardiac function in ischemic and reperfused mammalian ventricle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Heart; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Parasympatholytics; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Cross tolerance between cromakalim and RP49356 in the uterus of the rat in vivo and in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Drug Tolerance; Female; In Vitro Techniques; Infusions, Intravenous; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Uterine Contraction; Uterus | 1992 |
Differential effects of cromakalim on pancreatic vascular resistance and insulin secretion in vitro.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Kinetics; Male; Pancreas; Pyrroles; Rats; Rats, Wistar; Vascular Resistance; Vasodilator Agents | 1992 |
Influence of ovarian steroids on myometrial sensitivity and tolerance to relaxin in the rat in vivo: lack of cross-tolerance between relaxin, salbutamol and cromakalim.
Topics: Albuterol; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Estradiol; Female; Gonadal Steroid Hormones; Myometrium; Ovariectomy; Parasympatholytics; Progesterone; Pyrroles; Rats; Relaxin; Uterine Contraction | 1992 |
Interaction between myometrial relaxants and oxytocin: a comparison between relaxin, cromakalim and salbutamol.
Topics: Albuterol; Animals; Benzopyrans; Cromakalim; Drug Interactions; Drug Resistance; Estradiol; Female; Myometrium; Ovariectomy; Oxytocin; Parasympatholytics; Pyrroles; Rats; Relaxin; Uterine Contraction | 1992 |
Ca2+ influx induced by the agonist U46619 is inhibited by hyperpolarization induced by the K+ channel opener cromakalim in canine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Fluorescence; In Vitro Techniques; Male; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1992 |
[Effect of potassium channel openers on hypoxic pulmonary vasoconstriction].
Topics: Angiotensin II; Animals; Benzopyrans; Cromakalim; Guanidines; Hypoxia; In Vitro Techniques; Pinacidil; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents | 1992 |
The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle.
Topics: Acetylcholine; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Interactions; Histamine; Humans; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pyrroles; SRS-A; Theophylline | 1992 |
Lack of evidence for coupling of the dopamine D2 receptor to an adenosine triphosphate-sensitive potassium (ATP-K+) channel in dopaminergic neurones of the rat substantia nigra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dopamine; Electrophysiology; Glyburide; Male; Neurons; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D2; Substantia Nigra; Tolbutamide | 1992 |
Hypoglycemia-activated K+ channels in hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glucose; Glyburide; Hippocampus; Hypoglycemia; Ion Channel Gating; Neurons; Potassium Channels; Pyrroles; Rats | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
Role of ATP-sensitive potassium channels in ovine fetal pulmonary vascular tone.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Cromakalim; Fetus; Glyburide; Nitroarginine; Potassium Channels; Pulmonary Circulation; Pyrroles; Sheep; Vasomotor System | 1992 |
K+ATP-channel activation causes marked vasodilation in the hypertensive neonatal pig lung.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cromakalim; Female; Glyburide; Hypertension, Pulmonary; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Swine; Vasodilation; Vasodilator Agents; Vasomotor System | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
On the pharmacological and physiological role of glibenclamide-sensitive potassium channels in colonic smooth muscle.
Topics: Animals; Benzopyrans; Carbachol; Colforsin; Colon; Cromakalim; Dogs; Drug Interactions; Electric Stimulation; Female; Gallopamil; Glyburide; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Stereoisomerism | 1992 |
Disposition of the enantiomers of cromakalim in rat and cynomolgus monkey.
Topics: Absorption; Administration, Oral; Animals; Benzopyrans; Carbon Radioisotopes; Cromakalim; Female; Injections, Intravenous; Macaca fascicularis; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1992 |
Cardioprotective effect of cromakalim (potassium channel opener) in isoproterenol induced myocardial infarction in rats.
Topics: Animals; Aspartate Aminotransferases; Benzopyrans; Blood Coagulation; Cromakalim; Female; Glycogen; Isoproterenol; L-Lactate Dehydrogenase; Leukocyte Count; Male; Myocardial Infarction; Myocardium; Pyrroles; Rats; Vasodilator Agents; Verapamil | 1992 |
Interpretation of epicardial mapping by means of computer simulations: applications to calcium, lidocaine and to BRL 34915.
Topics: Animals; Anisotropy; Antihypertensive Agents; Benzopyrans; Calcium; Computer Simulation; Cromakalim; Dogs; Electrophysiology; Heart Conduction System; Lidocaine; Models, Cardiovascular; Pyrroles; Tachycardia, Atrioventricular Nodal Reentry | 1992 |
Lack of effect of potassium channel openers on ATP-modulated potassium channels recorded from rat ventromedial hypothalamic neurones.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Diazoxide; Guanidines; Hypothalamus, Middle; In Vitro Techniques; Male; Membrane Potentials; Minoxidil; Neurons; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1992 |
Involvement of nitric oxide in the regional haemodynamic effects of perindoprilat and captopril in hypovolaemic Brattleboro rats.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Benzopyrans; Blood Volume; Bradykinin; Captopril; Cromakalim; Hemodynamics; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrroles; Random Allocation; Rats; Rats, Brattleboro; Vasodilation; Vasodilator Agents | 1992 |
Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.
Topics: Animals; Aorta; Benzopyrans; Calcium; Colforsin; Cromakalim; Guanidines; Male; Microelectrodes; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Pinacidil; Potassium; Potassium Channels; Pyridines; Pyrroles; Rabbits; Vasoconstriction | 1992 |
Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227).
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carboxylic Acids; Cromakalim; Electric Conductivity; Glucose; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1992 |
Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.
Topics: Albuterol; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea; Verapamil | 1992 |
Potassium channel openers dilate large epicardial coronary arteries in conscious dogs by an indirect, endothelium-dependent mechanism.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Endothelium, Vascular; Guanidines; In Vitro Techniques; Nitroglycerin; Pinacidil; Potassium Channels; Pyrroles; Vasodilation | 1992 |
Limitation of myocardial injury with the potassium channel opener cromakalim and the nonvasoactive analog U-89,232: vascular vs. cardiac actions in vitro and in vivo.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guanidines; Guinea Pigs; Heart; Hemodynamics; In Vitro Techniques; Male; Membrane Potentials; Myocardial Infarction; Potassium Channels; Pyrroles; Rabbits | 1992 |
Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices.
Topics: Animals; Benzopyrans; Cerebral Cortex; Cocaine; Cromakalim; Diazoxide; Electric Stimulation; Glyburide; Guanidines; Hydrocortisone; In Vitro Techniques; Male; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes | 1992 |
Inhibitory effect of a novel antianginal agent, E4080, on ST segment elevation induced by vasopressin in anesthetized guinea pigs.
Topics: Anesthesia; Animals; Benzopyrans; Cardiovascular Agents; Catechols; Clonidine; Coronary Vessels; Cromakalim; Electrocardiography; Guinea Pigs; Heart Rate; Imidazoles; In Vitro Techniques; Isosorbide Dinitrate; Male; Nifedipine; Pyrroles; Vasodilator Agents; Vasopressins | 1992 |
Calcium-activated potassium channels in native endothelial cells from rabbit aorta: conductance, Ca2+ sensitivity and block.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Bradykinin; Calcium; Cromakalim; Egtazic Acid; Endothelium, Vascular; Glyburide; Membrane Potentials; Potassium; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Rabbits; Vasodilator Agents | 1992 |
K+ channel openers, cromakalim and Ki4032, inhibit agonist-induced Ca2+ release in canine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Benzopyrans; Caffeine; Calcium; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyridines; Pyrroles; Vasoconstriction; Vasoconstrictor Agents | 1992 |
External ATP antagonizes the effect of potassium channel openers in guinea-pig ventricular papillary muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; Male; Myocardial Contraction; Papillary Muscles; Potassium Channels; Pyridines; Pyrroles; Suramin | 1992 |
Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Female; Glyburide; Guanidines; Humans; In Vitro Techniques; Isometric Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pregnancy; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine; Vasodilator Agents | 1992 |
Evidence that epithelium-dependent relaxation of vascular smooth muscle detected by co-axial bioassays is not attributable to hypoxia.
Topics: Animals; Aorta; Benzopyrans; Biological Assay; Biological Factors; Cromakalim; Epithelium; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Respiratory Physiological Phenomena | 1992 |
Effects of BRL 38227 on neurally-mediated responses in the guinea-pig isolated bronchus.
Topics: Albuterol; Animals; Benzopyrans; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Ketotifen; Male; Neuromuscular Junction; Phentolamine; Potassium Channels; Pyrroles; Salmeterol Xinafoate | 1992 |
The involvement of potassium channels in the action of ciclazindol in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasoconstriction; Vasodilator Agents | 1992 |
Comparison of the actions of acetylcholine and BRL 38227 in the guinea-pig coronary artery.
Topics: Acetylcholine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Rabbits; Scorpion Venoms; Vasodilator Agents | 1992 |
Characterization of potassium currents modulated by BRL 38227 in rat portal vein.
Topics: Algorithms; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
Hypoxia-evoked dilatation of rabbit isolated basilar arteries is not mediated by the opening of glibenclamide-sensitive potassium channels.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1992 |
Modulation of guinea-pig tracheal smooth muscle responsiveness by the potassium channel openers NIP-121 and cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Guinea Pigs; In Vitro Techniques; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea; Vasodilator Agents | 1992 |
Characterization of the vasodilatation by the K+ channel openers: cromakalim and pinacidil.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Guanidines; In Vitro Techniques; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Effect of BRL 38227 on K-currents in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1992 |
Effects of anti-asthma drugs and potassium channel openers on neurally-mediated contraction of isolated guinea pig trachea.
Topics: Acetylcholine; Aminophylline; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; Hydrocortisone; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Trachea | 1992 |
Effects of potassium channel blockers on the negative inotropic responses induced by cromakalim and pinacidil in guinea pig atrium.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Female; Glyburide; Guanidines; Guinea Pigs; Heart Atria; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Tacrine | 1992 |
Role of endothelium and hyperpolarization in CGRP-induced vasodilation of rabbit ophthalmic artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Electrophysiology; Endothelium, Vascular; Glyburide; Norepinephrine; Ophthalmic Artery; Potassium Channels; Pyrroles; Rabbits; Vasodilation | 1992 |
Potassium channel activators cromakalim and celikalim (WAY-120,491) fail to decrease myocardial infarct size in the anesthetized canine.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Disease Models, Animal; Dogs; Hemodynamics; Indoles; Myocardial Infarction; Perfusion; Potassium Channels; Pyrroles; Regional Blood Flow | 1992 |
Effects of cromakalim (BRL 34915) on resting and evoked activity in frog semicircular canals.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Evoked Potentials, Auditory; Glyburide; Hair Cells, Auditory; In Vitro Techniques; Lymph; Parasympatholytics; Physical Stimulation; Potassium; Potassium Channels; Pyrroles; Rana esculenta; Semicircular Canals | 1992 |
The resistance of some rat cerebral arteries to the vasorelaxant effect of cromakalim and other K+ channel openers.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cerebellum; Cerebral Arteries; Cromakalim; Guanidines; Guinea Pigs; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilator Agents | 1992 |
Potassium channel conductance: a mechanism affecting hair growth both in vitro and in vivo.
Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Hair; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Minoxidil; Potassium Channels; Pyrroles | 1992 |
ATP-sensitive potassium channel agonists do not alter MAC for isoflurane in rats.
Topics: Animals; Benzopyrans; Cell Membrane; Cromakalim; Drug Interactions; Guanidines; Injections, Intraventricular; Isoflurane; Male; Pinacidil; Potassium Channels; Pulmonary Alveoli; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1992 |
Effects of potassium channel openers and calcium channel blockers on the force responses of the electrically driven rat right ventricle strip.
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Ventricular Function, Right | 1992 |
A potassium current activated by lemakalim and metabolic inhibition in rabbit mesenteric artery.
Topics: Animals; Benzopyrans; Cromakalim; Dinitrophenols; Electrophysiology; Glyburide; Iodoacetates; Iodoacetic Acid; Male; Mesenteric Arteries; Potassium; Pyrroles; Rabbits | 1992 |
Effect of removing the endothelium on the vascular responses induced by leukotrienes C4 and D4 in guinea-pig isolated heart.
Topics: Animals; Benzopyrans; Cholic Acids; Coronary Vessels; Cromakalim; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Male; Pyrroles; SRS-A; Vasoconstriction; Vasodilator Agents | 1992 |
ATP-sensitive K+ channels regulate resting potential of pulmonary arterial smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pulmonary Artery; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit.
Topics: Animals; Benzopyrans; Calcium; Cell Line; Cells, Cultured; Cromakalim; Glyburide; Muscle, Smooth; Pyrroles; Rabbits; Sarcoplasmic Reticulum; Trachea | 1992 |
Effects of the K+ channel blocker tedisamil on 86Rb efflux induced by cromakalim, high potassium and noradrenaline, and on mechanical tension in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Cromakalim; Cyclopropanes; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium | 1992 |
Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cromakalim; Cyclopropanes; Glyburide; Male; Minoxidil; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium | 1992 |
Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glucose; Guanidines; Hypoxia; Permeability; Pinacidil; Portal Vein; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1992 |
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.
Topics: Animals; Benzopyrans; Bronchi; Bronchial Spasm; Bronchodilator Agents; Carbachol; Cromakalim; Drug Interactions; Female; Guanidines; Guinea Pigs; Humans; Male; Muscle Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Trachea; Vasodilator Agents; Verapamil | 1992 |
Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Female; Heart Rate; Hypertension, Renal; Male; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Prodrugs; Pyrroles; Rats; Rats, Inbred SHR; Tachycardia | 1992 |
Relaxant effects of BRL 38227 and pinacidil on the rat gastric fundus.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Gastric Fundus; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Relaxation; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1992 |
Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies.
Topics: Animals; Benzopyrans; Bronchoconstrictor Agents; Bronchodilator Agents; Carbachol; Chromans; Cromakalim; Dinoprostone; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Pyrrolidines; Trachea | 1992 |
Electromechanical effects of the putative potassium channel activator celikalim (WAY-120,491) on feline atrial and ventricular muscle.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cats; Cromakalim; Electric Stimulation; Guanidines; Heart; Indoles; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium; Pyrroles | 1992 |
The potassium channel opener BRL 38227 inhibits binding of [125I]-labelled endothelin-1 to rat cardiac membranes.
Topics: Animals; Benzopyrans; Binding, Competitive; Cromakalim; Endothelins; In Vitro Techniques; Ion Channel Gating; Myocardium; Nifedipine; Potassium Channels; Pyrroles; Rats; Sarcolemma | 1992 |
Smooth muscle relaxation and inhibition of responses to pinacidil and cromakalim induced by phentolamine in guinea-pig isolated trachea.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dinoprost; Female; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Pinacidil; Pyrroles; SRS-A; Trachea | 1992 |
Effects of BRL 38227 on potassium currents in smooth muscle cells isolated from rabbit portal vein and human mesenteric artery.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Humans; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Phentolamine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1992 |
Cromakalim and lemakalim activate Ca(2+)-dependent K+ channels in canine colon.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Colon; Cromakalim; Dogs; Glyburide; Ion Channel Gating; Membrane Potentials; Potassium Channels; Pyrroles | 1992 |
Action potential duration and endocardial modulation of myocardial contraction in the ferret.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Endocardium; Epithelium; Ferrets; Myocardial Contraction; Potassium Channels; Pyrroles | 1992 |
Hormone-regulated K+ channels in follicle-enclosed oocytes are activated by vasorelaxing K+ channel openers and blocked by antidiabetic sulfonylureas.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic AMP; Diabetes Mellitus, Experimental; Female; Hormones; Oocytes; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Vasodilator Agents; Xenopus laevis | 1991 |
Biochemical and electrical aspects of the tracheal relaxant action of AH 21-132.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Action Potentials; Airway Resistance; Animals; Benzopyrans; Biomechanical Phenomena; Cell Membrane; Colforsin; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Naphthyridines; Nucleotides, Cyclic; Papaverine; Pyrroles; Sodium Nitrite; Stereoisomerism; Trachea | 1991 |
The binding site for [3H]glibenclamide in the rat cerebral cortex does not recognize K-channel agonists or antagonists other than sulphonylureas.
Topics: Animals; Benzopyrans; Binding Sites; Calcium Channels; Cerebral Cortex; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Kinetics; Male; Membranes; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
Contribution of K+ channels to arachidonic acid-induced endothelium-dependent vasodilation in rat isolated perfused mesenteric arteries.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Cromakalim; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Lipoxygenase; Male; Mesenteric Arteries; Norepinephrine; Ouabain; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Vasodilation | 1991 |
Characterization of sulfonylurea receptors and the action of potassium channel openers on cholinergic neurotransmission in guinea pig isolated small intestine.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzopyrans; Choline; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; Intestine, Small; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Picolines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrans; Pyrroles; Receptors, Drug; Sulfonylurea Receptors; Synaptic Transmission; Tritium | 1991 |
Synthesis and antihypertensive activity of pyran oxygen and amide nitrogen replacement analogues of the potassium channel activator cromakalim.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Pyrroles; Quinolones; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
Effects of cromakalim on neurally-mediated responses of guinea-pig tracheal smooth muscle.
Topics: Animals; Autonomic Nervous System; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neuromuscular Junction; Neurons; Parasympathetic Nervous System; Pyrroles; Synaptic Transmission; Trachea; Vagus Nerve | 1991 |
Antagonism of relaxin by glibenclamide in the uterus of the rat in vivo.
Topics: Albuterol; Animals; Apamin; Benzopyrans; Cromakalim; Cyclic AMP; Female; Glyburide; Insulin; Ovariectomy; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Relaxin; Uterine Contraction | 1991 |
Mechanical, biochemical and electrophysiological studies of RP 49356 and cromakalim in guinea-pig and bovine trachealis muscle.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Benzopyrans; Bronchodilator Agents; Calcium; Cattle; Cromakalim; Cyclic AMP; Electrophysiology; Guinea Pigs; In Vitro Techniques; Intracellular Fluid; Kinetics; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Trachea | 1991 |
Cromakalim (BRL 34915) counteracts the epileptiform activity elicited by diltiazem and verapamil in rats.
Topics: Animals; Anticonvulsants; Benzopyrans; Cromakalim; Diltiazem; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Pentobarbital; Pyrroles; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Verapamil | 1991 |
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carbamates; Cromakalim; In Vitro Techniques; Isoquinolines; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phenylcarbamates; Phenylephrine; Phosphatidylinositols; Piperazines; Protease Inhibitors; Pyrroles; Rats | 1991 |
Characteristics of KRN2391, a novel vasodilator, compared with those of cromakalim, pinacidil and nifedipine in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guanylate Cyclase; Male; Muscle Relaxation; Nifedipine; Nitrogen Dioxide; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Rat peritoneal neutrophils selectively relax vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Atrial Function; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Female; Femoral Artery; Guanylate Cyclase; Guinea Pigs; Heart Atria; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Neutrophils; Nitric Oxide; Nitroprusside; Peritoneal Cavity; Pyrroles; Rabbits; Rats; Rats, Inbred Lew; Saphenous Vein; Trachea | 1991 |
Vasorelaxant and hypotensive effects of tilisolol hydrochloride (N-696) in isolated rat thoracic aorta and pithed rats.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypotension; In Vitro Techniques; Isoquinolines; Male; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Preclinical pharmacology of Ro 31-6930, a new potassium channel opener.
Topics: Anesthesia; Animals; Benzopyrans; Blood Pressure; Cardiac Output; Cats; Cromakalim; Female; Heart Rate; Hemodynamics; Male; Nitrendipine; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Regional Blood Flow; Vascular Resistance | 1990 |
Actions of cromakalim on ionic currents recorded from single smooth muscle cells of the rat portal vein.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Barium; Benzopyrans; Calcium; Calcium Channels; Cromakalim; In Vitro Techniques; Ion Channels; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sodium Channels | 1990 |
The effects of novel vasodilator long chain acyl carnitine esters in the isolated perfused heart of the rat.
Topics: Animals; Benzopyrans; Carnitine; Coronary Circulation; Cromakalim; Dose-Response Relationship, Drug; Epoprostenol; Heart; Iloprost; In Vitro Techniques; Male; Myocardial Contraction; Nitrates; Palmitoylcarnitine; Pentanols; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1990 |
Nicorandil improves postischemic contractile function independently of direct myocardial effects.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Dogs; Heart Function Tests; Heart Rate; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Perfusion; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
BRL 34915 ameliorates oxygen supply in ischemic myocardium by a simultaneous enhancement of coronary blood flow and a reduction of myocardial function.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Dogs; Female; Heart Function Tests; In Vitro Techniques; Male; Oxygen Consumption; Papillary Muscles; Pyrroles | 1990 |
Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cardiac Complexes, Premature; Cesium; Chlorides; Cromakalim; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Electrophysiology; Guanidines; Osmolar Concentration; Pinacidil; Potassium Channels; Pyrroles; Quinidine; Rabbits; Tachycardia, Supraventricular; Vasodilator Agents | 1990 |
Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents.
Topics: Animals; Benzopyrans; Calcium; Cells, Cultured; Cromakalim; Diuretics; Endothelium, Vascular; Guanidines; Ion Channels; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Swine | 1990 |
Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
Topics: Aminophylline; Animals; Benzopyrans; Calcium; Carbachol; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Scorpion Venoms; Serotonin; Trachea | 1990 |
Clinical studies with the potassium channel activator cromakalim in normotensive and hypertensive subjects.
Topics: Adult; Antihypertensive Agents; Atenolol; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Humans; Hypertension; Kidney; Liver Circulation; Lung; Male; Potassium Channels; Pyrroles; Renin | 1990 |
Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Benzopyrans; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Coronary Disease; Cromakalim; Decanoic Acids; Diltiazem; Dogs; Female; Glyburide; Heart; Heart Rate; Hydroxy Acids; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Oxygen Consumption; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
Effects of cromakalim, RP49356, diazoxide, glibenclamide and galanin in rat portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Galanin; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Picolines; Portal Vein; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
Effects of cromakalim on renal hemodynamics and function in dogs: comparison with nicardipine.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Diuresis; Dogs; Drug Interactions; Female; Infusions, Intra-Arterial; Kidney; Male; Nicardipine; Pyrroles; Renal Artery; Renal Circulation; Renin | 1991 |
Effects of SR 44866, a potassium channel opener, on action potentials of rabbit, guinea pig, and human heart fibers.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Electrophysiology; Guinea Pigs; Heart; Heart Atria; Humans; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Papillary Muscles; Potassium Channels; Purkinje Fibers; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Glyburide-sensitive K+ channels in cultured rat hippocampal neurons: activation by cromakalim and energy-depleting conditions.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Charybdotoxin; Cromakalim; Deoxyglucose; Glyburide; Hippocampus; Neurons; Oligomycins; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Scorpion Venoms | 1991 |
ATP-sensitive K+ channels from aortic smooth muscle incorporated into planar lipid bilayers.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Binding Sites; Charybdotoxin; Cromakalim; Dogs; Glyburide; Lipid Bilayers; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1991 |
The antihypertensive property of NIP-121, a novel potassium channel opener in rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Species Specificity | 1991 |
Alkali cation permeability and caesium blockade of cromakalim-activated current in guinea-pig ventricular myocytes.
Topics: Animals; Benzopyrans; Cations; Cesium; Cromakalim; Electrophysiology; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Ion Channels; Membrane Potentials; Myocardium; Potassium Channels; Pyrroles; Rubidium | 1991 |
Guinea-pig isolated trachealis: the effects of charybdotoxin on mechanical activity, membrane potential changes and the activity of plasmalemmal K(+)-channels.
Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium; Cell Membrane; Charybdotoxin; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Scorpion Venoms; Theophylline; Trachea; Vasodilator Agents | 1991 |
Effects of K+ channel blockers and cromakalim (BRL 34915) on the mechanical activity of guinea pig detrusor smooth muscle.
Topics: Animals; Benzopyrans; Charybdotoxin; Cromakalim; Drug Interactions; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Peptides; Potassium Channels; Pyrroles; Scorpion Venoms; Vasodilator Agents | 1991 |
ATP-sensitive potassium channels do not mediate vasorelaxation by acetylcholine or iloprost.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Electric Stimulation; Endothelium, Vascular; Glyburide; Iloprost; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilation | 1991 |
Different mechanisms of relaxation of pig coronary artery to bradykinin and cromakalim are distinguished by potassium channel blockers.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Benzopyrans; Bradykinin; Calcium; Coronary Vessels; Cromakalim; In Vitro Techniques; Methylene Blue; Muscle Relaxation; Potassium Channels; Procaine; Pyrroles; Quinine; Swine; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
Cromakalim effects of acetylcholine-induced changes in cytosolic calcium and tension in swine trachealis.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchodilator Agents; Calcium; Cromakalim; Cytosol; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Pyrroles; Swine; Trachea | 1992 |
Actions of cromakalim in isolated human saphenous vein.
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Norepinephrine; Potassium Chloride; Pyrroles; Saphenous Vein; Serotonin; Vasoconstriction | 1992 |
Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Cromakalim; Endothelins; Glyburide; Indomethacin; Male; Mesenteric Veins; Nicardipine; Phorbols; Portal Vein; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Vasodilator Agents | 1992 |
Tedisamil (KC 8857) differentially inhibits the 86Rb+ efflux-stimulating and vasorelaxant properties of cromakalim.
Topics: Animals; Aorta; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cardiotonic Agents; Cromakalim; Cyclopropanes; Glyburide; Isometric Contraction; Male; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
Modulation of intracellular calcium by potassium channel openers in vascular muscle.
Topics: Animals; Benzopyrans; Calcium; Cells, Cultured; Cromakalim; Guanidines; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1991 |
Cromakalim inhibits contractions of the rat isolated mesenteric bed induced by noradrenaline but not caffeine in Ca(2+)-free medium: evidence for interference with receptor-mediated Ca2+ mobilization.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Cromakalim; Culture Media; Endothelium, Vascular; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Perfusion; Pyrroles; Rats; Ryanodine; Vasodilator Agents | 1991 |
Effects of lemakalim on changes in Ca2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Escin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isometric Contraction; Male; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myelin Sheath; Neuromuscular Depolarizing Agents; Norepinephrine; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Influence of lemakalim on the pulmonary vascular bed of the cat.
Topics: Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Calcitonin; Calcitonin Gene-Related Peptide; Cats; Cromakalim; Female; Glyburide; Hydrogen-Ion Concentration; Male; Perfusion; Pulmonary Circulation; Pyrroles; Vasoactive Intestinal Peptide; Vasodilator Agents | 1991 |
Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Cats; Cromakalim; Female; Glyburide; Guanidines; Hydrogen-Ion Concentration; Isoproterenol; Male; Nitroprusside; Picolines; Pinacidil; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrans; Pyrroles; Vasodilation; Vasodilator Agents | 1991 |
Inhibition by glibenclamide of the effects of cromakalim on responses of rat vas deferens to naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
The effects of BRL 38227 on antigen-induced extravasation and cellular infiltration into the peritoneal cavity of actively sensitised rats.
Topics: Administration, Oral; Animals; Antigens; Benzopyrans; Cell Movement; Cromakalim; Immunization; Injections, Intraperitoneal; Leukocyte Count; Male; Neutrophils; Peritoneal Cavity; Pyrroles; Rats | 1991 |
Actions of SDZ PCO 400 and cromakalim on airway smooth muscle in vivo.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Cyclopentanes; Eosinophilia; Guinea Pigs; Male; Muscle, Smooth; Pyrroles; Respiratory Hypersensitivity; Respiratory System; Respiratory Tract Diseases | 1991 |
The effect of potassium channel opening drugs on pulmonary nerves.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Lung; Muscle Contraction; Parasympathetic Nervous System; Parasympatholytics; Pyrroles; Trachea | 1991 |
The relationship of KCl- and prostaglandin F2 alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular Ca2+ measured with fura-2.
Topics: Animals; Arteries; Benzopyrans; Biomechanical Phenomena; Calcium; Coronary Vessels; Cromakalim; Dinoprost; Fura-2; Membrane Potentials; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nitroprusside; Potassium Chloride; Pyrroles; Swine; Vasodilator Agents | 1991 |
Effects of NG-nitro-L-arginine methyl ester on vasodilator responses to adrenaline or BRL 38227 in conscious rats.
Topics: Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Epinephrine; Heart Rate; Male; NG-Nitroarginine Methyl Ester; Pyrroles; Rats; Regional Blood Flow; Vasodilator Agents | 1991 |
Antidiabetic sulfonylureas relax isolated rabbit coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dinoprost; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Pyrroles; Rabbits; Sulfonylurea Compounds; Vasodilator Agents | 1991 |
Action potential shortening and negative inotropic effects of a novel potassium channel opener, NIP-121, as compared with cromakalim in guinea pig ventricular myocardium.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Depression, Chemical; Guinea Pigs; Heart Rate; Heart Ventricles; Male; Myocardial Contraction; Oxadiazoles; Piperidines; Potassium Channels; Pyrroles | 1991 |
Evaluation of the potassium channel activator BRL 38227 as an inhaled bronchodilator in the guinea-pig: contrast with nifedipine and salbutamol.
Topics: Administration, Inhalation; Airway Resistance; Albuterol; Aminophylline; Animals; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Drug Evaluation, Preclinical; Guinea Pigs; Histamine; Lung; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles | 1991 |
Cromakalim and K+ channels in canine trachealis.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cholinergic Fibers; Cromakalim; Dogs; Electric Stimulation; Female; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Parasympatholytics; Potassium Channels; Pyrroles; Trachea | 1991 |
Comparison of rabbit coronary arterial relaxation induced by acetylcholine and lemakalim: activation of ATP sensitive potassium channels.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dinoprost; Glyburide; In Vitro Techniques; Potassium Channels; Pyrroles; Rabbits; Vasodilation | 1991 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
[Potassium channel activators. Perspectives in the treatment of arterial hypertension].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Guanidines; Humans; Hypertension; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1991 |
Effect of three novel K+ channel openers, cromakalim, pinacidil and nicorandil on allergic reaction and experimental asthma.
Topics: Airway Resistance; Animals; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Guinea Pigs; In Vitro Techniques; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Passive Cutaneous Anaphylaxis; Pinacidil; Potassium Channels; Pyrroles; Rats; Trachea; Vasculitis | 1991 |
Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel. A comparison with pinacidil and lemakalim.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Guanidines; Myocardium; Niacinamide; Nicorandil; Phosphorylation; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1991 |
K+ channel opening mediates the vasorelaxant effects of nicorandil in the intact vascular system.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Effects of pinacidil, cromakalim, and nicorandil on potassium currents of rat basilar artery smooth muscle.
Topics: Animals; Antihypertensive Agents; Basilar Artery; Benzopyrans; Calcium; Cerebrovascular Circulation; Cromakalim; Electrophysiology; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
The contribution of Rb-permeable potassium channels to the relaxant and membrane hyperpolarizing actions of cromakalim, RP49356 and diazoxide in bovine tracheal smooth muscle.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Diazoxide; Electrophysiology; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Picolines; Potassium Channels; Potassium Radioisotopes; Pyrans; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea | 1991 |
The effect of cromakalim on the normal and hyper-reflexic human detrusor muscle.
Topics: Acetylcholine; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Urinary Bladder | 1991 |
Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogues in guinea pig trachealis.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guinea Pigs; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Structure-Activity Relationship; Thioamides; Trachea | 1991 |
The diverse effects of cromakalim on tension and 86Rb efflux in canine arterial smooth muscle.
Topics: Animals; Arteries; Benzopyrans; Cromakalim; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1991 |
Comparison of the effects of the K(+)-channel openers cromakalim and minoxidil sulphate on vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Electrophysiological effects of cesium and tetraethylammonium in canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Benzopyrans; Cesium; Cromakalim; Dogs; Electrophysiology; Female; In Vitro Techniques; Kinetics; Lidocaine; Male; Purkinje Fibers; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1991 |
Activation by cromakalim of pre- and post-synaptic ATP-sensitive K+ channels in substantia nigra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Bicuculline; Cromakalim; Glyburide; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Substantia Nigra; Synapses | 1991 |
RP 49356 and cromakalim relax airway smooth muscle in vitro by opening a sulphonylurea-sensitive K+ channel: a comparison with nifedipine.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Picolines; Potassium Channels; Pyrans; Pyrroles; Trachea | 1991 |
Stimulation of arterial 42K efflux by ATP depletion and cromakalim is antagonized by glyburide.
Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Cromakalim; Glyburide; Male; Potassium; Potassium Radioisotopes; Pyrroles; Rabbits; Vasodilator Agents | 1991 |
Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions.
Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Calcium; Cromakalim; Electrophysiology; Glyburide; Ions; Kinetics; Potassium; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Potassium channel activation by cromakalim affects the slow wave type action potential of colonic smooth muscle.
Topics: Action Potentials; Animals; Benzopyrans; Colon; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle, Smooth; Potassium Channels; Pyrroles; Tetraethylammonium Compounds | 1991 |
Effects of glibenclamide on cytosolic calcium concentrations and on contraction of the rabbit aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Cytosol; Fura-2; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rabbits | 1991 |
Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Drug Interactions; Glucose; Glyburide; Infusions, Intravenous; Insulin; Male; Membrane Potentials; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Renin | 1991 |
Comparison of cromakalim-induced relaxation of potassium precontracted rabbit, cat, and rat isolated cerebral arteries.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Glyburide; Male; Muscle, Smooth, Vascular; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Vasodilation; Vasodilator Agents | 1991 |
LTD4 and bradykinin evoke endothelium-dependent relaxation of the renal vein: dissimilar mechanisms.
Topics: Animals; Arginine; Benzopyrans; Bradykinin; Chromones; Cromakalim; Dogs; Endothelium, Vascular; Glyburide; Hemoglobins; Male; Methylene Blue; omega-N-Methylarginine; Pyrroles; Renal Veins; SRS-A; Vasodilation; Vasodilator Agents; Vasomotor System | 1991 |
Antihypertensive and haemodynamic properties of the potassium channel activating (-) enantiomer of cromakalim in animal models.
Topics: Anesthesia; Animals; Antihypertensive Agents; Benzopyrans; Cats; Cromakalim; Dogs; Female; Glyburide; Heart; Heart Rate; Hemodynamics; Hypertension, Renal; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renal Circulation; Stereoisomerism | 1991 |
ATP-dependent K+ channels modulate vasoconstrictor responses to severe hypoxia in isolated ferret lungs.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Ferrets; Glucose; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Oxygen; Potassium Channels; Pyrroles; Vasoconstriction; Vasodilator Agents | 1991 |
Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries.
Topics: Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Glyburide; Guanidines; Male; Mesenteric Arteries; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1991 |
Evidence that acetylcholine-mediated hyperpolarization of the rat small mesenteric artery does not involve the K+ channel opened by cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Swine; Vasodilator Agents | 1991 |
Two different types of channels are targets for potassium channel openers in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electric Conductivity; Female; Glyburide; Guanidines; Oocytes; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents; Xenopus laevis | 1991 |
Spasmolytic effect of cromakalim in dog coronary artery in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; In Vitro Techniques; Muscle Relaxation; Nitroglycerin; Nitroprusside; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Serotonin; Vasodilator Agents | 1991 |
Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Lidocaine; Male; Piperidines; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains | 1991 |
MCD peptide and dendrotoxin I activate c-fos and c-jun expression by acting on two different types of K+ channels. A discrimination using the K+ channel opener lemakalim.
Topics: Animals; Antihypertensive Agents; Bee Venoms; Benzopyrans; Cerebral Ventricles; Cromakalim; Elapid Venoms; Gene Expression; Genes, fos; Genes, jun; Injections, Intraventricular; Male; Neurotoxins; Nucleic Acid Hybridization; Peptides; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; RNA, Messenger | 1991 |
Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.
Topics: Animals; Benzopyrans; Coronary Disease; Cromakalim; Decanoic Acids; Electrophysiology; Glyburide; Heart; Humans; Hydroxy Acids; In Vitro Techniques; Infant, Newborn; Male; Muscle, Smooth, Vascular; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Hyperpolarization of denervated skeletal muscle by lemakalim and its antagonism by glybenclamide and tolbutamide.
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cesium; Cromakalim; Female; Glyburide; Male; Membrane Potentials; Mice; Muscle Denervation; Muscles; Pyrroles; Tolbutamide | 1991 |
Effect of depolarizing and hyperpolarizing agents on the membrane potential difference of primary cultures of rabbit aorta vascular smooth muscle cells.
Topics: Animals; Aorta; Benzopyrans; Cattle; Cells, Cultured; Colforsin; Cromakalim; Glyburide; Membrane Potentials; Muscle, Smooth, Vascular; Nucleotides; Pyrroles; Rabbits | 1991 |
Effects of K+ channel agonists cromakalim and pinacidil on rat basilar artery smooth muscle cells are mediated by Ca(++)-activated K+ channels.
Topics: Animals; Basilar Artery; Benzopyrans; Calcium; Cells, Cultured; Cromakalim; Guanidines; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Some degree of overlap exists between the K(+)-channels opened by cromakalim and those opened by minoxidil sulphate in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Minoxidil; Muscle Contraction; Muscle, Smooth, Vascular; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1991 |
The design of a novel class of potassium channel activating drugs, 2-(2,2-dimethylbenzopyran-4-yl)-pyridine-1-oxides.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Cyclic N-Oxides; Drug Design; In Vitro Techniques; Male; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Effect of cromakalim and lemakalim on slow waves and membrane currents in colonic smooth muscle.
Topics: Animals; Benzopyrans; Colon; Cromakalim; Dogs; Evoked Potentials; Female; In Vitro Techniques; Isomerism; Male; Membrane Potentials; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyrroles; Structure-Activity Relationship | 1991 |
Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.
Topics: Amides; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guinea Pigs; Indans; Male; Molecular Structure; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Trachea | 1991 |
Cromakalim dilates rat cerebral arteries in vitro.
Topics: Animals; Benzopyrans; Cerebellum; Cerebral Arteries; Cromakalim; Dose-Response Relationship, Drug; Male; Muscle Tonus; Osmolar Concentration; Potassium; Pyrroles; Rats; Rats, Inbred WKY; Serotonin; Vasoconstrictor Agents; Vasodilator Agents | 1991 |
Differences between the effects of cromakalim and nifedipine on agonist-induced responses in rabbit aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Nifedipine; Norepinephrine; Potassium; Pyrroles; Rabbits; Vasodilation | 1991 |
Cardioprotective effects of the potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides.
Topics: Adenine Nucleotides; Animals; Benzopyrans; Cromakalim; Energy Metabolism; Heart; In Vitro Techniques; Male; Myocardium; Perfusion; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Stereoisomerism | 1991 |
Effects of cromakalim (BRL 34915) on mechanical responses of rat vas deferens to noradrenaline and naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens; Verapamil | 1991 |
Experimental hyperreflexia: effect of intravesical administration of various agents.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Diltiazem; Electric Stimulation; Electromyography; Hexamethonium Compounds; Male; Muscle Contraction; Nifedipine; Pyrroles; Rabbits; Reflex; Urinary Bladder Diseases; Vasodilator Agents; Verapamil | 1991 |
Pulmonary and systemic haemodynamic effects of cromakalim in conditions of normoxia and hypoxia in dogs.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Hemodynamics; Hypoxia; Infusions, Intravenous; Lung; Pulmonary Circulation; Pyrroles; Time Factors; Vasodilator Agents | 1990 |
Regulation of the ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Humans; Islets of Langerhans; Nucleotides; Phosphorylation; Potassium Channels; Protein Kinase C; Pyrroles; Sulfonylurea Compounds | 1990 |
Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Bradykinin; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Ischemia; Potassium Channels; Pyrroles; Vasodilation | 1990 |
A potassium channel activator modulates both excitatory noncholinergic and cholinergic neurotransmission in guinea pig airways.
Topics: Animals; Benzopyrans; Bronchi; Capsaicin; Cromakalim; Drug Interactions; Glyburide; Guinea Pigs; Hemodynamics; Male; Neural Conduction; Parasympatholytics; Phentolamine; Potassium Channels; Pyrroles; Vagus Nerve | 1990 |
Effects of BRL 34915 (cromakalim) on renal hemodynamics and function in anesthetized dogs.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glomerular Filtration Rate; Glyburide; Hemodynamics; Injections, Intravenous; Kidney; Male; Parasympatholytics; Pentobarbital; Pyrroles; Renal Circulation | 1990 |
Alterations by glyburide of effects of BRL 34915 and P 1060 on contraction, 86Rb efflux and the maxi-K+ channel in rat portal vein.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1990 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Evidence that pinacidil may promote the opening of ATP-sensitive K+ channels yet inhibit the opening of Ca2(+)-activated K+ channels in K(+)-contracted canine mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1990 |
Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Clonidine; Coronary Vessels; Cromakalim; Dogs; Electric Stimulation; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Phentolamine; Pinacidil; Potassium Channels; Pyrroles; Rats | 1990 |
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.
Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Potassium; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred Strains; Rest; Vasoconstriction; Vasodilator Agents; Verapamil | 1990 |
Action of cromakalim on potassium membrane conductance in isolated heart myocytes of frog.
Topics: Adenosine Triphosphate; Animals; Barium; Benzopyrans; Cesium; Cromakalim; Glyburide; In Vitro Techniques; Membranes; Myocardium; Potassium Channels; Pyrroles; Rana esculenta; Sulfonylurea Compounds; Tolbutamide | 1990 |
Functional changes in potassium channels in carotid arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Cerebrovascular Disorders; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Possible involvement of ATP-sensitive K+ channels in the relaxant response of dog middle cerebral artery to cromakalim.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Permeability; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1990 |
The action of a potassium channel activator, BRL 38227 (lemakalim), on human airway smooth muscle.
Topics: Benzopyrans; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Glyburide; Humans; In Vitro Techniques; Muscle, Smooth; Potassium Channels; Pyrroles | 1990 |
A comparison of the actions of cromakalim and nifedipine on rabbit isolated mesenteric artery.
Topics: Animals; Benzopyrans; Blood Pressure; Cell Membrane; Cromakalim; Electric Stimulation; Glyburide; Humans; In Vitro Techniques; Infant, Newborn; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Perfusion; Potassium Channels; Pyrroles; Rabbits | 1990 |
Paradoxical inhibitory effect of cromakalim on 86Rb outflow from pancreatic islet cells.
Topics: Animals; Benzopyrans; Calcium; Calcium Radioisotopes; Cromakalim; Extracellular Space; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Parasympatholytics; Perfusion; Potassium Chloride; Pyrroles; Rats; Rubidium; Rubidium Radioisotopes | 1990 |
Two different types of potassium channels in human skeletal muscle activated by potassium channel openers.
Topics: Adenosine Triphosphate; Benzopyrans; Cromakalim; Dihydropyridines; Electrophysiology; Glyburide; Humans; Muscles; Picolines; Potassium Channels; Pyrans; Pyrroles | 1990 |
Effects of several potassium channel openers and glibenclamide on the uterus of the rat.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Female; Glyburide; Guanidines; Heart Rate; Hemodynamics; In Vitro Techniques; Oxytocin; Parasympatholytics; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pregnancy; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterus; Vasodilator Agents | 1990 |
Na+1-activated and ATP-sensitive K+ channels in the heart.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Ferrets; Guinea Pigs; Heart; In Vitro Techniques; Ion Channel Gating; Kinetics; Membrane Potentials; Myocardial Contraction; Myocardium; Papillary Muscles; Potassium Channels; Pyrroles; Sodium; Sulfonylurea Compounds; Temperature | 1990 |
Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs.
Topics: Animals; Atrioventricular Node; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Guanidines; Heart Conduction System; Heart Rate; Male; Neural Conduction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Refractory Period, Electrophysiological | 1990 |
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally-anaesthetized dogs.
Topics: Anesthesia, Spinal; Animals; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium Channels; Pyrroles | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Comparison of effects of cromakalim and pinacidil on mechanical activity and 86Rb efflux in dog coronary arteries.
Topics: Animals; Benzopyrans; Calcium Channels; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1990 |
Adrenergic-cholinergic interactions in left atria: a study using K+ channel agonists, antagonist and pertussis toxin.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Dogs; Female; Guanidines; Heart; Isoproterenol; Male; Myocardial Contraction; Parasympathetic Nervous System; Pertussis Toxin; Phenylephrine; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sympathetic Nervous System; Virulence Factors, Bordetella | 1990 |
Endothelium-dependent and BRL 34915-induced vasodilatation in rat isolated perfused mesenteric arteries: role of G-proteins, K+ and calcium channels.
Topics: Acetylcholine; Animals; Benzopyrans; Calcimycin; Calcium Channel Blockers; Calcium Channels; Cromakalim; Endothelium, Vascular; GTP-Binding Proteins; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Pertussis Toxin; Potassium Channels; Pyrroles; Rats; Vasodilator Agents; Virulence Factors, Bordetella | 1990 |
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Diazoxide; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Minoxidil; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1990 |
Effects of cromakalim and pinacidil on large epicardial and small coronary arteries in conscious dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Female; Guanidines; Heart Rate; Male; Nitroglycerin; Pinacidil; Pyrroles; Receptors, Adrenergic, beta; Vascular Resistance; Vasodilator Agents | 1990 |
Mechanisms of inhibitory effects of CD-349 and K(+)-channel activators on noradrenaline-induced contraction and changes in levels of cyclic GMP in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dihydropyridines; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1990 |
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cell Line; Cromakalim; Diazoxide; Glucose; Islets of Langerhans; Kinetics; Membrane Potentials; Potassium Channels; Pyrroles; Tolbutamide | 1990 |
The effects of cromakalim on ATP-sensitive potassium channels in insulin-secreting cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Benzopyrans; Cell Line; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rubidium Radioisotopes; Sodium | 1990 |
A comparison of the haemodynamic profiles of Ro 31-6930, cromakalim and nifedipine in anaesthetised normotensive rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Hemodynamics; Iliac Artery; Male; Nifedipine; Pyridines; Pyrroles; Rats; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Vascular Resistance | 1990 |
Variation in the aromatic ring of cromakalim: antihypertensive activity of pyranopyridines and 6-alkyl-2H-1-benzopyrans.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Chemical Phenomena; Chemistry; Cromakalim; Hypertension; Pyrans; Pyridines; Pyrroles; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1990 |
Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis.
Topics: Amides; Animals; Benzopyrans; Bronchodilator Agents; Chemical Phenomena; Chemistry; Cromakalim; Guinea Pigs; Molecular Structure; Muscle Relaxation; Potassium Channels; Pyrroles; Structure-Activity Relationship; Trachea | 1990 |
Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Benzopyrans; Cell Survival; Cells, Cultured; Cromakalim; Diazoxide; Hippocampus; Potassium Channels; Pyrroles; Rats | 1990 |
Modulation of ATP-sensitive K+ channel activity and contractile behavior in mammalian ventricle by the potassium channel openers cromakalim and RP49356.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glucose; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats | 1990 |
An approach to differentiate between noradrenaline-elicited contractile processes in the rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Ryanodine | 1990 |
Effects of potassium channel openers on pentylenetetrazole-induced seizures in mice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Drug Antagonism; Female; Guanidines; Mice; Pentylenetetrazole; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1990 |
Non-junctional modulation of neurogenic twitches of the guinea-pig ileum by some peptides and other compounds in the triple bath.
Topics: Action Potentials; Animals; Benzopyrans; Bradykinin; Capsaicin; Cromakalim; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neural Conduction; Neurotensin; Peptides; Pyrroles; Vasoactive Intestinal Peptide | 1990 |
Effects of potassium channel openers on single potassium channels in mouse skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Female; Guanidines; In Vitro Techniques; Membrane Potentials; Mice; Muscles; Organ Specificity; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles | 1990 |
Effects of cromakalim, a potassium channel opener, on regional blood flow in conscious spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Heart Rate; Hemodynamics; Humans; Hypertension; Infant, Newborn; Microspheres; Nifedipine; Pyrroles; Rats; Rats, Inbred SHR; Regional Blood Flow; Vascular Resistance | 1990 |
K+ channel openers suppress myotonic activity of human skeletal muscle in vitro.
Topics: Benzopyrans; Cell Membrane Permeability; Cromakalim; Dihydropyridines; Humans; In Vitro Techniques; Microelectrodes; Muscle Contraction; Muscles; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Direct determination of the antihypertensive agent Cromakalim and its major metabolites in human urine by high-performance liquid chromatography.
Topics: Antihypertensive Agents; Benzopyrans; Chromatography, High Pressure Liquid; Cromakalim; Humans; Pyrroles | 1990 |
The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Pentobarbital; Pinacidil; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1990 |
Effects of putative K+ channel activator BRL-34915 on arterial contraction and 86Rb efflux.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Vasoconstriction | 1990 |
K(+)-channel activators in vascular smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Vasodilator Agents | 1990 |
Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guanidines; Hypertrophy; In Vitro Techniques; Muscle Contraction; Pinacidil; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Urinary Bladder; Vasodilator Agents | 1990 |
K+ channel openers activate brain sulfonylurea-sensitive K+ channels and block neurosecretion.
Topics: Animals; Benzopyrans; Brain; Cromakalim; gamma-Aminobutyric Acid; Hypoglycemic Agents; In Vitro Techniques; Kinetics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Structure-Activity Relationship; Sulfonylurea Compounds | 1990 |
Cromakalim, a vasodilator, differentially inhibits Ca2+ currents in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Biological Transport; Calcium; Cromakalim; Glioma; Hybrid Cells; Membrane Potentials; Mice; Neuroblastoma; Parasympatholytics; Pyrroles; Tumor Cells, Cultured; Vasodilator Agents | 1990 |
Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis.
Topics: Benzopyrans; Cromakalim; Humans; Hypokalemia; In Vitro Techniques; Muscle Contraction; Muscles; Paralyses, Familial Periodic; Potassium Channels; Pyrroles | 1990 |
Effects of the potassium channel activator, BRL 34915, on the action potential characteristics of canine cardiac Purkinje fibers.
Topics: Action Potentials; Animals; Antihypertensive Agents; Barium; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Female; Heart Conduction System; Male; Membrane Potentials; Potassium Channels; Purkinje Fibers; Pyrroles | 1990 |
K(+)-channel openers for relaxation of isolated penile erectile tissue from rabbit.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Penile Erection; Penis; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1990 |
Potassium channel blockers and the effects of cromakalim on the smooth muscle of the guinea-pig bladder.
Topics: 4-Aminopyridine; Animals; Apamin; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Membrane Potentials; Muscle, Smooth; Potassium Channels; Potassium Radioisotopes; Procaine; Pyrroles; Quinidine; Tetraethylammonium Compounds; Urinary Bladder | 1990 |
Possibilities of pharmacological prevention of thrombin-induced coronary vasospasm.
Topics: Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Dogs; Potassium Channels; Pyrroles; Thrombin | 1990 |
Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig.
Topics: Albuterol; Anesthesia; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Decerebrate State; Drug Interactions; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Seizures; Theophylline; Vagotomy | 1990 |
Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Bradykinin; Calcium; Cattle; Cell Membrane Permeability; Cells, Cultured; Cromakalim; Endothelium, Vascular; Homeostasis; Membrane Potentials; Nitric Oxide; Parasympatholytics; Potassium Channels; Pyrroles; Thimerosal | 1990 |
Systemic and regional haemodynamic interactions between K+ channel openers and the sympathetic nervous system in the pithed SHR.
Topics: Animals; Benzopyrans; Brimonidine Tartrate; Cromakalim; Decerebrate State; Dihydropyridines; Heart Rate; Hemodynamics; Imidazoles; Male; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Inbred SHR; Regional Blood Flow; Sympathetic Nervous System; Vascular Resistance | 1990 |
Hemodynamic and pharmacological evaluation of the vasodilator and vasoconstrictor effects of endothelin-1 in rats.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Drug Tolerance; Endothelins; Endothelium, Vascular; Hemodynamics; Imidazoles; In Vitro Techniques; Male; Nitrendipine; Peptides; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Tachyphylaxis; Vasoconstriction; Vasodilation; Vasopressins | 1990 |
Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Apamin; Bee Venoms; Benzopyrans; Cecum; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Muscle Relaxants, Central; Muscle Tonus; Muscle, Smooth; Niacinamide; Nicorandil; Norepinephrine; Pyrroles | 1986 |
The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Portal Vein; Pyrroles; Radioisotopes; Rats; Rats, Inbred Strains; Rubidium; Time Factors | 1986 |
Electrical and mechanical effects of BRL34915 in guinea-pig isolated trachealis.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; Histamine; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Potassium Chloride; Pyrroles; Trachea | 1986 |
Evidence for inhibition by ICS 205-930 and stimulation by BRL 34915 of K+ conductance in cardiac muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Indoles; Ion Channels; Male; Papillary Muscles; Potassium; Pyrroles; Sotalol; Tropisetron | 1987 |
The relaxant action of BRL 34915 in rat uterus.
Topics: Animals; Benzopyrans; Cromakalim; Female; In Vitro Techniques; Ion Channels; Membrane Potentials; Microelectrodes; Myometrium; Parasympatholytics; Potassium; Pregnancy; Propranolol; Pyrroles; Rats; Rubidium Radioisotopes; Uterine Contraction | 1987 |
Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Antihypertensive Agents; Apamin; Benzopyrans; Binding Sites; Cromakalim; Cyclic AMP; Cyclic GMP; Inositol Phosphates; Ion Channels; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrendipine; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Rubidium; Tetraethylammonium Compounds | 1987 |
Leiurus quinquestriatus venom inhibits BRL 34915-induced 86Rb+ efflux from the rat portal vein.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Isradipine; Oxadiazoles; Portal Vein; Potassium; Pyrroles; Rats; Rubidium Radioisotopes; Scorpion Venoms; Vasodilator Agents | 1988 |
Similarities in the mechanism of action of two new vasodilator drugs: pinacidil and BRL 34915.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Female; Guanidines; Guinea Pigs; In Vitro Techniques; Ion Channels; Male; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium; Pyrroles; Rabbits; Rats; Vasodilation; Vasodilator Agents | 1988 |
Mechanism of action and systemic and regional hemodynamics of the potassium channel activator BRL34915 and its enantiomers.
Topics: Animals; Aorta; Benzopyrans; Biomechanical Phenomena; Cromakalim; Female; Hemodynamics; Ion Channels; Isomerism; Male; Portal Vein; Potassium; Pyrroles; Rabbits; Rats; Regional Blood Flow; Vasoconstriction | 1988 |
Pertussis toxin treatment does not inhibit the effects of the potassium channel opener BRL 34915 on rat isolated vascular and cardiac tissues.
Topics: Action Potentials; Animals; Benzopyrans; Carbachol; Cromakalim; Heart; Heart Rate; In Vitro Techniques; Ion Channels; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Pertussis Toxin; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1988 |
The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Ion Channels; Myocardium; Potassium; Pyrroles | 1988 |
Is the cardiovascular profile of BRL 34915 characteristic of potassium channel activators?
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Heart; Heart Conduction System; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Potassium Channels; Pyrroles | 1988 |
BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electrophysiology; Ferrets; Glyburide; Guinea Pigs; Heart; Hypoxia; Ion Channels; Myocardium; Potassium; Pyrroles | 1988 |
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Antihypertensive Agents; Benzopyrans; Charybdotoxin; Cromakalim; Diazoxide; Glyburide; Male; Minoxidil; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilation | 1989 |
Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cats; Coronary Circulation; Cromakalim; Female; Guanidines; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Organ Specificity; Papillary Muscles; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rabbits | 1988 |
The haemodynamic profile of cromakalim in the cat.
Topics: Anesthesia; Animals; Benzopyrans; Blood Pressure; Cats; Cromakalim; Electrodes, Implanted; Female; Hemodynamics; Infusions, Intravenous; Male; Pyrroles; Time Factors | 1988 |
Differences in Ca2+ handling along the arterial tree: an update including studies in human mesenteric resistance vessels.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Humans; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle Contraction; Norepinephrine; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Rats, Inbred WKY; Vascular Resistance | 1988 |
Competitive antagonism by glibenclamide of cromakalim inhibition of twitch contractions in rabbit vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electric Stimulation; Glyburide; In Vitro Techniques; Male; Muscle, Smooth; Potassium Channels; Pyrroles; Rabbits; Vas Deferens | 1989 |
Endothelin-1-induced contractions of vascular and tracheal smooth muscle: effects of nicardipine and BRL 34915.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Endothelins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nicardipine; Parasympatholytics; Peptides; Pyrroles; Rats; Trachea | 1989 |
A simple method for quasi-isobaric (melotonic) measurements of contractile responses of the blood vessel wall.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Culture Techniques; Dinoprost; Muscle, Smooth, Vascular; Potassium; Pyrroles; Swine; Vasoconstriction | 1989 |
Potentiation of the effects of dopamine in the rabbit isolated splenic artery by 3-isobutyl-1-methylxanthine or forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Parasympatholytics; Purinergic Antagonists; Purinones; Pyrroles; Rabbits; Splenic Artery; Theophylline | 1989 |
Cardiohemodynamic effects of cromakalim and pinacidil, potassium-channel openers, in the dog, special reference to venous return.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Output; Cardiopulmonary Bypass; Carotid Sinus; Cromakalim; Dogs; Female; Guanidines; Heart; Hemodynamics; Male; Pinacidil; Potassium Channels; Pressoreceptors; Pyrroles; Vasodilator Agents; Vena Cava, Inferior; Vena Cava, Superior; Venous Pressure | 1989 |
Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Hemodynamics; In Vitro Techniques; Male; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Vasodilation | 1989 |
Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Glyburide; Heart Rate; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1989 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide.
Topics: Angiotensin II; Animals; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Glyburide; Heart Rate; In Vitro Techniques; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rubidium; Vasoconstriction | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
K+ channel openers decrease seizures in genetically epileptic rats.
Topics: Animals; Anticonvulsants; Benzopyrans; Cromakalim; Electrophysiology; Epilepsy, Absence; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; In Vitro Techniques; Male; Perfusion; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Tolbutamide; Vascular Resistance | 1989 |
A comparison of the effects and interactions of cromakalim and glibenclamide in cardiac and vascular tissues.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Muscle, Smooth, Vascular; Papillary Muscles; Portal Vein; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1989 |
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Disease; Cromakalim; Glyburide; Guanidines; In Vitro Techniques; Male; Membrane Potentials; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Ion Channel Gating; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Subtraction Technique | 1989 |
[Potassium agonists: regional vasodilator profile in rats].
Topics: Animals; Benzopyrans; Cromakalim; Dihydropyridines; Hemodynamics; Male; Nicardipine; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents | 1989 |
Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Egtazic Acid; Endothelins; Endothelium, Vascular; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Nicardipine; Peptides; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Valinomycin; Vasoconstriction; Vasodilator Agents; Verapamil | 1989 |
Cromakalim-induced relaxation of guinea-pig isolated trachealis: antagonism by glibenclamide and by phentolamine.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth; Parasympatholytics; Phentolamine; Potassium Channels; Pyrroles; Trachea | 1989 |
Effects of cromakalim and glibenclamide on isolated strips of bovine tracheal smooth muscle. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles; Rubidium Radioisotopes; Trachea | 1989 |
Effects of glibenclamide on cromakalim-induced responses in rabbit isolated aorta.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Parasympatholytics; Pyrroles; Rabbits | 1989 |
Cromakalim, RP49356, pinacidil and minoxidil sulphate in the rat uterus and their antagonism by glibenclamide. Smooth Muscle Research Group.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; In Vitro Techniques; Minoxidil; Parasympatholytics; Picolines; Pinacidil; Pyrans; Pyrroles; Rats; Rats, Inbred Strains; Uterine Contraction | 1989 |
Effect of cromakalim on smooth muscle cells of guinea-pig taenia caeci.
Topics: Animals; Benzopyrans; Cecum; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Pyrroles | 1989 |
Short-term monotherapy with the potassium channel activator BRL 34915 on endocrine sodium regulation in essential hypertension.
Topics: Administration, Oral; Adult; Aldosterone; Atrial Natriuretic Factor; Benzopyrans; Blood Pressure; Cromakalim; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pyrroles; Renin; Renin-Angiotensin System; Sodium | 1989 |
Effects of valinomycin on calcium mobilization in vascular smooth muscle cells induced by angiotensin II.
Topics: Angiotensin II; Animals; Benzopyrans; Calcium; Cromakalim; Endothelium, Vascular; Ethers; Female; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Ionophores; Monensin; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyrroles; Rats; Valinomycin | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Comparison of the effects of putative activators of K+ channels on pancreatic B-cell function.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; In Vitro Techniques; Islets of Langerhans; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Niacinamide; Nicorandil; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Effects of potassium channel toxins from Leiurus quinquestriatus hebraeus venom on responses to cromakalim in rabbit blood vessels.
Topics: Amino Acid Sequence; Animals; Aorta, Thoracic; Benzopyrans; Blood Vessels; Chromatography, Ion Exchange; Cromakalim; Erythrocytes; Glycosaminoglycans; In Vitro Techniques; Liver; Male; Molecular Sequence Data; Muscle, Smooth, Vascular; Parasympatholytics; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Scorpion Venoms | 1989 |
Effects of putative activators of K+ channels in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Electrophysiology; Female; Glucose; Guanidines; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1989 |
Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cromakalim; Guanidines; Guanylate Cyclase; Histamine; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Norepinephrine; Pinacidil; Pyrroles; Rabbits; Renal Artery; Vasodilator Agents | 1989 |
BRL 34915 (cromakalim) enhances voltage-dependent K+ current in cultured rat hippocampal neurons.
Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Hippocampus; Neurons; Potassium Channels; Pregnancy; Pyrroles; Rats; Rats, Inbred Strains; Tetraethylammonium Compounds | 1989 |
Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Guinea Pigs; Hippocampus; In Vitro Techniques; Membranes; Neurons; Potassium Channels; Pyramidal Tracts; Pyrroles; Tetrodotoxin | 1989 |
Properties of the cromakalim-induced potassium conductance in smooth muscle cells isolated from the rabbit portal vein.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; In Vitro Techniques; Indicators and Reagents; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Parasympatholytics; Portal Vein; Potassium Channels; Pyrroles; Rabbits | 1989 |
A Ca2+-activated K+ channel from rabbit aorta: modulation by cromakalim.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Drug Interactions; In Vitro Techniques; Kinetics; Lipid Bilayers; Microsomes; Muscle, Smooth, Vascular; Parasympatholytics; Potassium Channels; Pyrroles; Rabbits | 1989 |
Evaluation of inhaled cromakalim and its active enantiomer BRL 38277 as bronchodilators in the guinea-pig.
Topics: Administration, Inhalation; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; Male; Pyrroles; Stereoisomerism | 1989 |
The effect of cromakalim on kidney function in the anaesthetised rat.
Topics: Anesthesia; Animals; Benzopyrans; Blood Pressure; Cromakalim; Kidney; Kidney Function Tests; Kidney Tubules; Male; Pyrroles; Rats; Rats, Inbred Strains; Renal Circulation; Vasodilator Agents | 1989 |
Hyperpolarizing action of cromakalim on the rat aorta.
Topics: 5-Hydroxytryptophan; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cell Line; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Biotransformation; Cell Line; Cells, Cultured; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Magnesium; Membrane Potentials; Potassium Channels; Pyrroles; Rats; Solutions | 1989 |
Haemodynamic differences between cromakalim and pinacidil: comparison with nifedipine.
Topics: Animals; Benzopyrans; Blood Pressure; Cats; Cromakalim; Guanidines; Heart Rate; Hemodynamics; Male; Nifedipine; Pinacidil; Pyrroles; Renal Circulation; Renin | 1989 |
The effects of cromakalim on the detrusor muscle of human and pig urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Female; Humans; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urinary Bladder | 1989 |
Tolerance to cromakalim in the rat uterus in vivo.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Drug Tolerance; Female; Heart Rate; Hemodynamics; Pyrroles; Rats; Rats, Inbred Strains; Uterus | 1989 |
The effect of cromakalim on the smooth muscle of the guinea-pig urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Potassium Radioisotopes; Pyrroles; Rubidium Radioisotopes; Urinary Bladder | 1989 |
Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres.
Topics: Barium; Benzopyrans; Cromakalim; Humans; Hyperkalemia; In Vitro Techniques; Membrane Potentials; Muscles; Paralysis; Pyrroles; Tolbutamide | 1989 |
Pharmacokinetics of cromakalim--a new antihypertensive agent, in patients with mild essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Hypertension; Male; Middle Aged; Pyrroles | 1989 |
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Phorbol 12,13-Dibutyrate; Pyrroles; Rats; Rats, Inbred Strains; Xanthines | 1989 |
Phentolamine and structurally related compounds selectively antagonize the vascular actions of the K+ channel opener, cromromakalim.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Phentolamine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Inbred WKY | 1989 |
BRL 34915 (Cromakalim) stimulation of 42K efflux from rabbit arteries is modulated by calcium.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Male; Nifedipine; Nisoldipine; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Tetraethylammonium Compounds; Vasoconstriction | 1989 |
Effects of cromakalim on acetylcholine release and smooth muscle contraction in guinea-pig small intestine.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Intestine, Small; Isometric Contraction; Male; Muscle, Smooth; Pyrroles | 1989 |
Cromakalim (BRL 34915) acts on an inwardly rectifying neuronal K+ conductance, which is similar to that activated by adenosine.
Topics: Adenosine; Animals; Benzopyrans; Cromakalim; Electrophysiology; Guinea Pigs; Hippocampus; In Vitro Techniques; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Cromakalim, pinacidil and RP 49356 activate a tolbutamide-sensitive K+ conductance in human skeletal muscle fibres.
Topics: Benzopyrans; Cromakalim; Guanidines; Humans; In Vitro Techniques; Membrane Potentials; Muscles; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Tolbutamide; Vasodilator Agents | 1989 |
Comparison of the effects of RP 49356, cromakalim and nifedipine on guinea-pig trachea in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Nifedipine; Picolines; Potassium Channels; Pyrans; Pyrroles; Trachea | 1989 |
Pulmonary vascular and renal effects of cromakalim in anaesthetized dogs.
Topics: Animals; Benzopyrans; Cardiac Output; Cromakalim; Dogs; Kidney; Potassium Channels; Pulmonary Circulation; Pyrroles; Vasodilator Agents | 1989 |
Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guanidines; Hypertrophy; Pinacidil; Pyrroles; Rats; Rats, Inbred Strains; Reference Values; Urethral Obstruction; Urinary Bladder; Urinary Bladder Diseases | 1989 |
Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Female; In Vitro Techniques; Ketanserin; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Potassium Channels; Prazosin; Pyrroles; Rabbits; Serotonin Antagonists; Swine | 1989 |
Effect of cromakalim on bronchoconstriction evoked by cholinergic nerve stimulation in guinea-pig isolated trachea.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Parasympathetic Nervous System; Parasympatholytics; Pyrroles; Trachea; Vagus Nerve | 1989 |
Endothelium-dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Cyclic GMP; Endothelium, Vascular; Ferricyanides; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Microscopy, Electron; Nitroprusside; Norepinephrine; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1988 |
The lack of involvement of cyclic nucleotides in the smooth muscle relaxant action of BRL 34915.
Topics: Animals; Antihypertensive Agents; Apamin; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Drug Interactions; Female; Guinea Pigs; Hemoglobins; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pyrroles; Rabbits | 1988 |
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Procaine; Pyrroles; Rabbits; Rubidium Radioisotopes; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
The negative inotropic effect of nicorandil is independent of cyclic GMP changes: a comparison with pinacidil and cromakalim in canine atrial muscle.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Guanidines; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Myocardial Contraction; Myocardium; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1988 |
Differential effects of potassium channel blockers on neurohypophysial release of oxytocin and vasopressin. Evidence for frequency-dependent interaction with the endogenous opioid inhibition of oxytocin release.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Benzopyrans; Cromakalim; Electric Stimulation; Endorphins; Female; Naloxone; Oxytocin; Pituitary Gland, Posterior; Potassium Channels; Pyrroles; Radioimmunoassay; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Vasopressins | 1988 |
Increased vasodilator responsiveness to BRL 34915 in spontaneously hypertensive versus normotensive rats: contrast with nifedipine.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Pyrroles; Rats; Rats, Inbred SHR; Vascular Resistance; Vasodilation | 1989 |
K+ channels openers prevent epilepsy induced by the bee venom peptide MCD.
Topics: Animals; Antihypertensive Agents; Bee Venoms; Benzopyrans; Cromakalim; Epilepsy; Injections, Intraventricular; Male; Peptides; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains | 1989 |
Anti-spasmogenic and spasmolytic effects of BRL 34915: a comparison with nifedipine and nicorandil.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Norepinephrine; Parasympatholytics; Potassium Chloride; Pyrroles; Rabbits | 1987 |
Anti-vasoconstrictor effects of the K+ channel opener cromakalim on the rabbit aorta--comparison with the calcium antagonist isradipine.
Topics: Angiotensin II; Animals; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Female; In Vitro Techniques; Isradipine; Male; Norepinephrine; Potassium Channels; Pyridines; Pyrroles; Rabbits; Rubidium; Vasodilator Agents | 1988 |
Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Mesenteric Veins; Microelectrodes; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Vasodilator Agents | 1988 |
Effect of the K+ efflux stimulating vasodilator BRL 34915 on 86Rb+ efflux and spontaneous activity in guinea-pig portal vein.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antihypertensive Agents; Benzopyrans; Bucladesine; Cromakalim; Drug Interactions; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium; Pyrroles; Radioisotopes; Rubidium; Vasodilator Agents | 1987 |
The potassium channel activator, BRL 34915, antagonises a behavioural response to the muscarinic receptor agonist, pilocarpine.
Topics: Animals; Behavior, Animal; Benzopyrans; Brain; Cromakalim; Male; Mice; Pilocarpine; Potassium Channels; Pyrroles; Receptors, Muscarinic | 1988 |
Potassium efflux enhancement by cromakalim (BRL 34915) in rabbit mesenteric artery: an indirect effect independent of calcium?
Topics: Animals; Benzopyrans; Buffers; Calcium; Cromakalim; In Vitro Techniques; Lanthanum; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyrroles; Rabbits; Rubidium | 1988 |
Comparison of the effluxes of 42K+ and 86Rb+ elicited by cromakalim (BRL 34915) in tonic and phasic vascular tissue.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Guinea Pigs; Male; Muscle, Smooth, Vascular; Portal Vein; Potassium; Potassium Radioisotopes; Pyrroles; Rats; Rubidium; Rubidium Radioisotopes | 1988 |
Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in the guinea-pig: comparison with nifedipine.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; Histamine; In Vitro Techniques; Male; Nifedipine; Ovalbumin; Potassium Channels; Pyrroles; Serotonin Antagonists; Trachea | 1988 |
Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Electric Stimulation; Esophagus; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rubidium Radioisotopes; Tetrodotoxin | 1988 |
Inhibition of small intestine motility by cromakalim (BRL 34915).
Topics: Animals; Benzopyrans; Clonidine; Cromakalim; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestine, Small; Loperamide; Male; Mice; Peristalsis; Potassium Channels; Pyrroles | 1988 |
Effects of BRL 34915, a putative K channel opener, on transmembrane 45Ca movements in rabbit aortic smooth muscle.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Biological Transport, Active; Calcium; Cromakalim; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Tetraethylammonium Compounds; Vasoconstriction | 1988 |
Cardiovascular effects of apamin and BRL 34915 in rats and rabbits.
Topics: Animals; Antihypertensive Agents; Apamin; Bee Venoms; Benzopyrans; Blood Pressure; Cardiac Output; Cromakalim; Hemodynamics; Male; Pyrroles; Rabbits; Rats; Rats, Inbred Strains; Regional Blood Flow; Species Specificity | 1988 |
Modification of K+ conductance of heart cell membrane by BRL 34915.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cell Membrane; Cromakalim; Female; Guinea Pigs; Heart; Male; Membrane Potentials; Myocardium; Potassium; Pyrroles | 1988 |
Studies on the anti-vasoconstrictor activity of BRL 34915 in spontaneously hypertensive rats; a comparison with nifedipine.
Topics: Angiotensin II; Animals; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Female; Hypertension; Infusions, Intravenous; Nifedipine; Norepinephrine; Phenylephrine; Pyrroles; Rats; Rats, Inbred SHR; Vasoconstriction; Vasopressins | 1988 |
Enhancement of muscle blood cell flux and pO2 by cromakalim (BRL 34915) and other compounds enhancing membrane K+ conductance, but not by Ca2+ antagonists or hydralazine, in an animal model of occlusive arterial disease.
Topics: Animals; Antihypertensive Agents; Arterial Occlusive Diseases; Benzopyrans; Calcium Channel Blockers; Cell Membrane; Cromakalim; Hydralazine; In Vitro Techniques; Male; Muscles; Oxygen Consumption; Potassium; Pyrroles; Rats; Rats, Inbred Strains; Regional Blood Flow | 1988 |
Actions of BRL 34915 (Cromakalim) upon convulsive discharges in guinea pig hippocampal slices.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium; Cromakalim; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium; Neurons; Potassium; Pyrroles; Seizures | 1988 |
Dissociation of actions of BRL 34915 in the rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium; Potassium Radioisotopes; Pyrroles; Rats; Rats, Inbred Strains | 1987 |
Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Verapamil | 1986 |
KR-30450, a newly synthesized benzopyran derivative, activates the cardiac ATP-sensitive K+ channel.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Heart; Phenylbutyrates; Potassium Channels; Pyrroles; Pyrrolidinones; Rats | 1995 |
Effects of KRN4884, a novel K channel opener, on the cardiovascular system in anesthetized dogs: a comparison with levcromakalim, nilvadipine, and nifedipine.
Topics: Anesthesia; Animals; Antihypertensive Agents; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Nifedipine; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1995 |
Cardiovascular effects of the novel potassium channel opener UR-8225.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Heart Rate; Hemodynamics; Male; Naphthalenes; Potassium Channels; Pyridones; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Effects of cromakalim or glibenclamide on arrhythmias and dispersion of refractoriness in chronically infarcted in anesthetized dogs.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Electric Stimulation; Electrophysiology; Female; Glyburide; Heart Rate; In Vitro Techniques; Male; Myocardial Infarction; Potassium Channels; Pyrroles; Refractory Period, Electrophysiological; Ventricular Fibrillation; Ventricular Function | 1995 |
The KATP blocker sodium 5-hydroxydecanoate does not abolish preconditioning in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Blood Pressure; Coronary Circulation; Cromakalim; Decanoic Acids; Drug Interactions; Heart Ventricles; Hydroxy Acids; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardium; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1995 |
K+ channel openers produce epithelium-dependent relaxation of the guinea-pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Benzopyrans; Cromakalim; Epithelium; Guinea Pigs; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea; Vasoactive Intestinal Peptide | 1995 |
Cromakalim- and RP 49356-induced 42K+ and 86Rb+ efflux in rat myometrium.
Topics: Animals; Benzopyrans; Cromakalim; Female; Ion Transport; Myometrium; Oxytocin; Picolines; Potassium; Potassium Channels; Potassium Chloride; Pregnancy; Pyrans; Pyrroles; Rats; Rubidium; Time Factors; Vasodilator Agents | 1995 |
[Potassium channel activators: comparative structural study of pinacidil, diazoxide and cromakalim].
Topics: Antihypertensive Agents; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Molecular Conformation; Molecular Structure; Pinacidil; Potassium Channels; Pyrroles | 1995 |
Combined administration of an IK(ATP) activator and Ito blocker increases coronary flow independently of effects on heart rate, QT interval, and ischaemia-induced ventricular fibrillation in rats.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Cromakalim; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; Electrocardiography; Heart Rate; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Male; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Fibrillation | 1993 |
Electrophysiologic and arrhythmogenic effects of the potassium channel agonist BRL 38227 in anesthetized dogs.
Topics: Anesthesia; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Female; Heart; Hemodynamics; Injections, Intravenous; Male; Pentobarbital; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Potassium channel inhibitors attenuate neuromodulatory effects of atrial natriuretic factor in the rabbit isolated vas deferens.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Charybdotoxin; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Prazosin; Pyrroles; Rabbits; Receptors, Adrenergic; Scorpion Venoms; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds; Vas Deferens | 1994 |
Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Capsaicin; Cerebrovascular Circulation; Cromakalim; Glyburide; Homeostasis; Neuropeptides; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide; Substance P; Vasodilator Agents | 1994 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Modulators of calcium and potassium channels: their effects on endothelin-1 binding to cardiac membranes.
Topics: Animals; Benzopyrans; Calcium Channels; Cromakalim; Dihydropyridines; Endothelins; Heart; In Vitro Techniques; Male; Membranes; Myocardium; Nifedipine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Pharmacologic profiles of YM934, a novel potassium channel opener.
Topics: Anesthesia; Animals; Aorta; Benzopyrans; Benzoxazines; Cromakalim; Cyclic N-Oxides; Dogs; Female; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Oxazines; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Wistar; Vascular Resistance; Vasodilation | 1994 |
Action of KC-399, a newly synthesized potassium channel opener, on mechanical activity and 86Rb efflux in rat aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Charybdotoxin; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Scorpion Venoms; Vasodilation | 1994 |
Effects of the potassium channel openers cromakalim and pinacidil on catecholamine secretion and calcium mobilization in cultured bovine adrenal chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Barium; Benzopyrans; Bradykinin; Calcimycin; Calcium; Carbachol; Catecholamines; Cattle; Cells, Cultured; Cromakalim; Guanidines; Histamine; Pinacidil; Potassium; Potassium Channels; Pyrroles; Rubidium Radioisotopes | 1994 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Topics: 3T3 Cells; Animals; Base Sequence; Benzopyrans; Capsaicin; Cell Line; Cells, Cultured; Charybdotoxin; Cloning, Molecular; Cromakalim; Diltiazem; Diterpenes; Elapid Venoms; Flecainide; Ion Channel Gating; Mice; Molecular Sequence Data; Nifedipine; Oligodeoxyribonucleotides; Peptides; Potassium Channels; Pyrroles; Scorpion Venoms; Sotalol | 1994 |
Properties of single calcium-activated potassium channels of large conductance in rat hippocampal neurons in culture.
Topics: Animals; Animals, Newborn; Benzopyrans; Calcium; Cells, Cultured; Concanavalin A; Cromakalim; Cyclic AMP; Electric Conductivity; Hippocampus; Hydrogen-Ion Concentration; Ion Channel Gating; Membrane Potentials; Neuraminidase; Neurons; Potassium Channels; Probability; Pyrroles; Rats; Ruthenium Red; Tetraethylammonium; Tetraethylammonium Compounds; Thionucleotides; Time Factors | 1994 |
Antigen-induced airway responses are inhibited by a potassium channel opener.
Topics: Administration, Inhalation; Airway Resistance; Animals; Antigens; Benzopyrans; Blood Pressure; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capillary Permeability; Cromakalim; Dimethyl Sulfoxide; Evans Blue; Guinea Pigs; Histamine; Histamine Release; Leukotriene D4; Lung; Male; Ovalbumin; Potassium Channels; Pyrroles | 1994 |
Potassium channel opening properties of thiazide diuretics in isolated guinea pig resistance arteries.
Topics: Animals; Benzopyrans; Cromakalim; Diuretics; Guinea Pigs; Hydrochlorothiazide; Indapamide; Mesenteric Arteries; Muscle Relaxation; Potassium Channel Blockers; Potassium Channels; Pyrroles; Sodium Chloride Symporter Inhibitors; Vascular Resistance | 1994 |
Assessment of ability of levcromakalim and sodium nitroprusside to reverse the cardiovascular effects of nitric oxide synthase inhibition in the anaesthetised pig.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Benzopyrans; Blood Pressure; Cardiac Output; Cromakalim; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Pulmonary Artery; Pyrroles; Swine; Vascular Resistance; Vasoconstriction; Vasodilator Agents | 1994 |
Evidence that prostaglandins I2, E2, and D2 may activate ATP sensitive potassium channels in the isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprostone; Dose-Response Relationship, Drug; Glyburide; Iloprost; In Vitro Techniques; Ion Channel Gating; Male; Myocardium; Perfusion; Potassium Channels; Pressure; Prostaglandin D2; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Vasodilating actions of cromakalim in resting and contracting states of carotid arteries from spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Carotid Arteries; Charybdotoxin; Cromakalim; Drug Interactions; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Scorpion Venoms; Species Specificity; Vasodilator Agents | 1994 |
Actions of cromakalim on outward currents of CA1 neurones in hippocampal slices.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Evoked Potentials; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Ion Channels; Membrane Potentials; Neurons; Parasympatholytics; Patch-Clamp Techniques; Pyramidal Cells; Pyrroles; Rats; Rats, Sprague-Dawley | 1994 |
Functional evidence for a glibenclamide-sensitive K+ channel in rat ileal smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Carbachol; Cromakalim; Glyburide; Ileum; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1994 |
Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Tetrodotoxin; Ureter | 1995 |
Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation.
Topics: Amino Acid Oxidoreductases; Animals; Antihypertensive Agents; Benzopyrans; Calcium; Calmodulin-Binding Proteins; Cromakalim; Decamethonium Compounds; Electric Stimulation; Guinea Pigs; Hexamethonium; Histocytochemistry; Male; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Muscle, Smooth; Nifedipine; Nitric Oxide Synthase; Nitroprusside; Prazosin; Pyrroles; Urethra | 1995 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
ATP-sensitive K+ channels mediate regulation of substance P release via the prejunctional histamine H3 receptor.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Glyburide; Hindlimb; Histamine Agonists; Injections, Intravenous; Male; Methylhistamines; Neuromuscular Junction; Potassium Channel Blockers; Potassium Channels; Pyrroles; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Histamine H3; Skin; Stereoisomerism; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1995 |
Calcitonin gene-related peptide mediated neurogenic vasorelaxation in the isolated canine lingual artery.
Topics: Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Capsaicin; Cromakalim; Dogs; Electric Stimulation; Female; Glyburide; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Propranolol; Pyrroles; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Vasoconstriction; Vasodilator Agents | 1995 |
Does ischemic preconditioning in the human involve protein kinase C and the ATP-dependent K+ channel? Studies of contractile function after simulated ischemia in an atrial in vitro model.
Topics: Adenosine Triphosphate; Adult; Aged; Alkaloids; Benzophenanthridines; Benzopyrans; Cromakalim; Diglycerides; Female; Heart Atria; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Phenanthridines; Potassium Channels; Protein Kinase C; Pyrroles; Random Allocation; Time Factors | 1995 |
Pharmacological evidence for the persistent activation of ATP-sensitive K+ channels in early phase of reperfusion and its protective role against myocardial stunning.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Perfusion; Potassium Channels; Pyrroles | 1995 |
An ATP-sensitive potassium conductance in rabbit arterial endothelial cells.
Topics: Adenosine Triphosphatases; Animals; Aorta; Benzopyrans; Calcium; Cell Membrane Permeability; Cromakalim; Endothelium, Vascular; In Vitro Techniques; Intracellular Fluid; Ion Transport; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Pulmonary Artery; Pyrroles; Rabbits; Sulfonylurea Compounds; Tetraethylammonium; Tetraethylammonium Compounds; Vasodilator Agents | 1995 |
Comparative study of vasodilator effects of the potassium channel openers NIP-121 and levcromakalim in dogs and rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Female; Hemodynamics; Male; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Cardioprotection with the KATP opener cromakalim is not correlated with ischemic myocardial action potential duration.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Infusions, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenethylamines; Potassium Channels; Pyrroles; Regional Blood Flow; Sulfonamides | 1995 |
K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle.
Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Kinetics; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Rubidium; Urinary Bladder; Vasodilator Agents | 1995 |
Mechanisms of hypoxic vasodilation in ferret pulmonary arteries.
Topics: Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Ferrets; Hypoxia; Male; Nitric Oxide Synthase; Potassium Channel Blockers; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasomotor System | 1995 |
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hypercapnia; Hypoxia; Nitric Oxide Synthase; omega-N-Methylarginine; Pyrroles; Rats; Theophylline; Vasodilator Agents | 1995 |
The effects of glibenclamide on tetanic force and intracellular calcium in normal and fatigued mouse skeletal muscle.
Topics: Acidosis; Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Electric Stimulation; Glyburide; Intracellular Membranes; Male; Mice; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Potassium Channel Blockers; Potassium Channels; Pyrroles; Reference Values | 1995 |
Substance P-induced relaxation and hyperpolarization in human cerebral arteries.
Topics: Adult; Aged; Benzopyrans; Cerebral Arteries; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Male; Membrane Potentials; Middle Aged; Pyrroles; Substance P; Vasodilation; Vasodilator Agents | 1995 |
Regulation of glibenclamide-sensitive K+ current by nucleotide phosphates in isolated rabbit pulmonary myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Biological Transport, Active; Cells, Cultured; Cromakalim; Glyburide; Guanosine Diphosphate; Male; Patch-Clamp Techniques; Potassium Channels; Pulmonary Artery; Pyrroles; Rabbits; Vasodilator Agents | 1995 |
ATP-sensitive K+ channels are not involved in ischemia-reperfusion lung endothelial injury.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Capillary Permeability; Cromakalim; Endothelium; Glyburide; Hemodynamics; Hypoglycemic Agents; In Vitro Techniques; Ischemia; Lung; Male; Potassium Channels; Pulmonary Circulation; Pulmonary Wedge Pressure; Pyrroles; Rats; Reperfusion Injury; Vascular Resistance; Vasodilator Agents | 1995 |
Femoral vasodilation to cromakalim is blocked by U37883A, a non-sulphonylurea that selectively inhibits KATP channels.
Topics: Adamantane; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Dogs; Drug Interactions; Femur; Injections, Intravenous; Isoproterenol; Morpholines; Nitroglycerin; Potassium Channels; Pyrroles; Regional Blood Flow; Serotonin; Serotonin Receptor Agonists; Vasodilation; Vasodilator Agents | 1995 |
Barium inhibits the endothelium-dependent component of flow but not acetylcholine-induced relaxation in isolated rabbit cerebral arteries.
Topics: Acetylcholine; Animals; Barium Compounds; Benzopyrans; Cerebral Arteries; Chlorides; Cromakalim; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Nitroprusside; Potassium Channel Blockers; Pyrroles; Rabbits | 1995 |
K+ channels and guinea-pig trachea: a possible functional modulation by GABAB receptors.
Topics: Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Electric Stimulation; Guinea Pigs; Male; Muscle Relaxation; Neuromuscular Junction; Potassium Channels; Pyrroles; Receptors, GABA-B; Trachea | 1994 |
Subgroups among mu-opioid receptor agonists distinguished by ATP-sensitive K+ channel-acting drugs.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Baclofen; Benzopyrans; Cromakalim; Female; Mice; Neurons; Pain; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Sulfonylurea Compounds; Tetraethylammonium; Tetraethylammonium Compounds | 1995 |
Effects of levcromakalim and glibenclamide on paced guinea-pig atrial strips exposed to hypoxia.
Topics: Animals; Benzopyrans; Cardiac Pacing, Artificial; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Female; Glyburide; Glycolysis; Guinea Pigs; Heart Atria; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Potassium Channels; Pyrroles | 1995 |
ZENECA ZD6169: a novel KATP channel opener with in vivo selectivity for urinary bladder.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Urinary Bladder | 1995 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidines; Male; Mice; Mice, Inbred Strains; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Seizures | 1995 |
Involvement of K+ channels in the relaxant responses to various agonists in estrogen primed rat uterus.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dose-Response Relationship, Drug; Epinephrine; Estrogens; Female; Guanidines; Histamine; Isoproterenol; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Uterine Contraction; Uterus; Vasodilator Agents | 1995 |
Activation of ATP-dependent K+ channels by metabolic poisoning in adult mouse skeletal muscle: role of intracellular Mg(2+) and pH.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Antimetabolites; Benzopyrans; Cell Adhesion; Cromakalim; Cyanides; Dinitrofluorobenzene; Dinitrophenols; Electrophysiology; Glyburide; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Uncoupling Agents | 1995 |
The effect of intracavernous injection of potassium channel openers in monkeys and dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Guanidines; Injections; Macaca nemestrina; Male; Penile Erection; Penis; Pinacidil; Potassium Channels; Pyrroles; Regional Blood Flow; Vasodilator Agents | 1995 |
Cromakalim suppresses hypertonic saline-induced renal vasoconstriction in anaesthetized dogs.
Topics: Animals; Benzopyrans; Cromakalim; Disease Models, Animal; Diuresis; Dogs; Female; Glomerular Filtration Rate; Hematocrit; Male; Potassium Channels; Pyrroles; Renal Circulation; Saline Solution, Hypertonic; Sodium; Vasoconstriction; Vasodilator Agents | 1995 |
Pharmacological natures of caffeine-induced endothelium-dependent and -independent contraction in canine mesenteric artery.
Topics: Adenylyl Cyclases; Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Colforsin; Cromakalim; Dogs; Edetic Acid; Egtazic Acid; Endothelium, Vascular; Female; In Vitro Techniques; Magnesium; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Potassium channel blockade of atrial negative inotropic responses to P1-purinoceptor and muscarinic receptor agonists and to cromakalim.
Topics: 4-Aminopyridine; Adenosine; Animals; Benzopyrans; Carbachol; Cromakalim; Depression, Chemical; Glyburide; Guinea Pigs; Heart Atria; Hydrochloric Acid; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Phenylisopropyladenosine; Potassium Channels; Pyrroles; Receptors, Muscarinic; Receptors, Purinergic; Rubidium Radioisotopes | 1993 |
Effects of intracoronary cromakalim, pinacidil, or diltiazem on cesium chloride-induced arrhythmias in anesthetized dogs under conditions of controlled coronary blood flow.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cesium; Chlorides; Coronary Circulation; Cromakalim; Diltiazem; Dogs; Female; Guanidines; Male; Pinacidil; Pyrroles; Vasodilator Agents | 1993 |
Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Coronary Vessels; Cromakalim; Cyclic AMP; Endothelins; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine; Vasodilation | 1993 |
Functional study on the effects of nifedipine, cromakalim, and the absence of extracellular Ca2+ on alpha 1-adrenoceptor-mediated excitation-contraction coupling in isolated rat portal vein: comparison with depolarization-mediated excitation-contraction c
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Parasympatholytics; Phenylephrine; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcium; Cromakalim; Glyburide; In Vitro Techniques; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Pyrroles; Rabbits; Stereoisomerism; Vasodilator Agents | 1993 |
Distinct pathways to refill ACh-sensitive internal Ca2+ stores in canine airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Female; Indoles; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Trachea | 1993 |
In vivo cardiac electrophysiologic effects of RWJ 29009, a new potassium-channel activator, in comparison to cromakalim and nicardipine.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Dogs; Electrocardiography; Female; Heart Conduction System; Male; Nicardipine; Piperidones; Potassium Channels; Pyrans; Pyrroles; Thiophenes; Vasodilator Agents | 1993 |
Effect of KRN2391 on venous return: comparison with other vasodilators.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Vasodilator Agents; Veins | 1993 |
Effects of cromakalim on bradykinin-, histamine- and substance P-induced airway microvascular leakage in the guinea-pig.
Topics: Animals; Benzopyrans; Bradykinin; Bronchi; Capillary Permeability; Cromakalim; Electric Stimulation; Evans Blue; Female; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Lung; Male; Muscle Contraction; Muscle, Smooth; Pyrroles; Respiratory System; Substance P; Trachea | 1993 |
A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Topics: 4-Aminopyridine; Anesthesia; Animals; Benzopyrans; Cromakalim; Glyburide; Ion Channels; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Vasodilator Agents | 1993 |
Cardiovascular effects of YM099, a novel K+ channel opener, in anesthetized and conscious dogs.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Blood Flow Velocity; Blood Pressure; Cardiac Output; Cardiovascular System; Carotid Arteries; Coronary Circulation; Cromakalim; Cyclic N-Oxides; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Female; Femoral Artery; Glyburide; Heart Rate; Injections, Intravenous; Male; Mesenteric Arteries; Nitroglycerin; Oxadiazoles; Potassium Channels; Pyrroles; Renal Artery; Vascular Resistance; Vasodilator Agents | 1994 |
The endothelium mediates a nitric oxide-independent hyperpolarization and relaxation in the rat hepatic artery.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cell Polarity; Cromakalim; Endothelium, Vascular; Female; Hepatic Artery; Indomethacin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nimodipine; Nitric Oxide; Nitroarginine; Phenylephrine; Prazosin; Pyrroles; Rats; Rats, Sprague-Dawley | 1994 |
Drug-induced endothelium-dependent and -independent relaxations in isolated resistance vessels taken from simultaneously hypertensive and streptozotocin-diabetic rats.
Topics: Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glyburide; Histamine; Hypertension; Male; Mesenteric Arteries; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroprusside; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin; Vascular Resistance; Vasodilation; Vasodilator Agents | 1994 |
Inhibitory effects of Rb+ on the responses to levcromakalim and P1060 in the isolated human myometrium.
Topics: Benzopyrans; Cromakalim; Female; Guanidines; Humans; In Vitro Techniques; Potassium Channels; Pyrroles; Rubidium; Uterine Contraction; Verapamil | 1995 |
Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.
Topics: Adult; Benzopyrans; Cromakalim; Electrophysiology; Female; Humans; Male; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Channels; Pyrroles; Stress, Mechanical; Urinary Bladder | 1994 |
New drugs for renal colic therapy--in-vitro and animal experiments.
Topics: Acute Disease; Animals; Benzopyrans; Colic; Cromakalim; Dogs; Drug Evaluation, Preclinical; Female; Isometric Contraction; Kidney Calculi; Kidney Pelvis; Manometry; Muscle, Smooth; Potassium Channels; Pyrroles; Ureter; Ureteral Obstruction; Urodynamics | 1994 |
Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Aorta; Benzopyrans; Cromakalim; Decanoic Acids; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Heart; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
Differential responsiveness of atrial and ventricular myocytes to potassium channel openers.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cells, Cultured; Cromakalim; Guanidines; Guinea Pigs; Heart Atria; Heart Ventricles; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1995 |
Ventricular overdrive pacing-induced preconditioning and no-flow ischemia-induced preconditioning in isolated working rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Coronary Circulation; Cromakalim; Disease Models, Animal; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Urinary Bladder; Vasodilator Agents | 1995 |
The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions.
Topics: Adult; Analysis of Variance; Benzopyrans; Blood Pressure; Cromakalim; Humans; Infusions, Intravenous; Male; Potassium Channels; Pyrroles; Spinal Cord Injuries; Urinary Bladder, Neurogenic; Urodynamics | 1995 |
Structure-activity relationship of glibenclamide analogs: a comparison of potency as levcromakalim antagonists in rat aorta vs. affinity for [3H]-glibenclamide binding to membranes from rat cerebral cortex.
Topics: Animals; Aorta; Benzopyrans; Binding Sites; Cell Membrane; Cerebral Cortex; Cromakalim; Glyburide; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Structure-Activity Relationship; Vasodilator Agents | 1995 |
Potassium channel activators counteract anoxic hyperexcitability but not 4-aminopyridine-induced epileptiform activity in the rat hippocampal slice.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Cromakalim; Diazoxide; Epilepsy; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1994 |
Effects of potassium channel openers on Na+ and K+ currents in rabbit sinus node and atrial myocytes.
Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Heart Atria; Potassium; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Sodium; Tetrodotoxin | 1995 |
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.
Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Verapamil | 1995 |
Calcitonin gene-related peptide selectively increases cAMP levels in the guinea-pig ureter.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Drug Interactions; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Potassium Channels; Pyrroles; Ureter | 1995 |
Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Dihydropyridines; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Uridine Triphosphate; Vasodilator Agents | 1995 |
Demonstration of the potassium channel opening activity of GYKI-12743 by 86Rb+ efflux studies.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Cromakalim; Dioxanes; Dose-Response Relationship, Drug; Ear; Guanidines; Ion Channel Gating; Pinacidil; Potassium Channels; Pyridazines; Pyrroles; Rabbits; Rubidium Radioisotopes | 1994 |
Effects of glibenclamide on negative cardiac responses to cholinergic and purinergic stimuli and cromakalim in the isolated dog heart.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cholinergic Agonists; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; In Vitro Techniques; Myocardial Contraction; Parasympathetic Nervous System; Potassium Channels; Purinergic Agonists; Pyrroles; Receptors, Cholinergic; Receptors, Purinergic; Vasodilator Agents | 1994 |
Effects of inhibitor of endothelium-derived relaxing factor on hypoxic contraction of isolated pig coronary artery.
Topics: Animals; Arginine; Benzopyrans; Cell Hypoxia; Coronary Vessels; Cromakalim; In Vitro Techniques; Nitric Oxide; Nitroarginine; Pyrroles; Swine; Vasoconstriction; Vasodilator Agents | 1994 |
Potentiation by insulin and insulin-like growth factor-1 of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
Topics: Animals; Antihypertensive Agents; Arsenicals; Benzopyrans; Cromakalim; Drug Synergism; Female; Glyburide; Insulin; Insulin-Like Growth Factor I; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channels; Pyrroles; Virulence Factors, Bordetella; Xenopus laevis | 1994 |
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
Levcromakalim- and isoprenaline-induced relaxation of human isolated airways--role of the epithelium and of K+ channel activation.
Topics: Adult; Aged; Airway Resistance; Benzopyrans; Bronchodilator Agents; Cromakalim; Epithelium; Humans; In Vitro Techniques; Isoproterenol; Middle Aged; Potassium Channel Blockers; Potassium Channels; Pyrroles | 1994 |
Mechanism-specific antiarrhythmic effects of the potassium channel activator levcromakalim against repolarization-dependent tachycardias.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Dogs; Electrocardiography; Female; Heart; Heart Block; Hemodynamics; Male; Ouabain; Pyrroles; Tachycardia, Ventricular; Torsades de Pointes | 1994 |
Differential effects of pinacidil and cromakalim on vascular relaxation and sympathetic neurotransmission.
Topics: Animals; Benzopyrans; Cattle; Cromakalim; Dogs; Electric Stimulation; Female; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pinacidil; Potassium Chloride; Pyrroles; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diuretics; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Guinea Pigs; Hypertension; In Vitro Techniques; Injections, Intravenous; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Stereoisomerism; Tolbutamide | 1994 |
Ionic dependence of adenosine uptake into cultured astrocytes.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Biological Transport; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Cortex; Cromakalim; Furosemide; Glyburide; Ionophores; Kinetics; Mice; Niacinamide; Nicorandil; Nigericin; Omeprazole; Potassium; Pyrroles; Sodium; Valinomycin; Vasodilator Agents | 1994 |
Pharmacological analysis of the inhibitory effects of KRN2391 on endothelin-1-induced contraction in isolated large coronary artery of the pig.
Topics: Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Endothelins; Glyburide; In Vitro Techniques; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Swine; Vasoconstriction; Vasodilator Agents | 1994 |
Cardiovascular effects of KRN2391, nitroglycerin and cromakalim in dihydroergotamine-treated pithed rats.
Topics: Animals; Benzopyrans; Cromakalim; Decerebrate State; Dihydroergotamine; Hemodynamics; Male; Nitroglycerin; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Light-dependent effects of zinc protoporphyrin IX on endothelium-dependent relaxation resistant to N omega-nitro-L-arginine.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Biliverdine; Carbon Monoxide; Cromakalim; Darkness; Endothelium, Vascular; Female; Heme Oxygenase (Decyclizing); Hepatic Artery; In Vitro Techniques; Indomethacin; Light; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Oxyhemoglobins; Phenylephrine; Potassium; Potassium Channels; Protoporphyrins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Is the ventricular effective refractory period different when determined by incremental versus decremental scanning?: the effect of pacing cycle length, d-sotalol, and levcromakalim.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cardiac Pacing, Artificial; Cromakalim; Dogs; Electrocardiography; Female; Male; Pyrroles; Refractory Period, Electrophysiological; Sotalol; Ventricular Function | 1994 |
[Ion channels of vascular smooth muscle and pharmacological effects of calcium antagonists and potassium channel openers].
Topics: Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels; Cromakalim; Ion Channel Gating; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles | 1994 |
Influence of K+ channel openers on interferon-gamma dependent immune response in experimental allergic neuritis (EAN).
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Guanidines; Interferon-gamma; Ion Channel Gating; Lymph Nodes; Lymphocyte Activation; Neuritis, Autoimmune, Experimental; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Lew | 1994 |
Regional and species differences in glyburide-sensitive K+ channels in airway smooth muscles as estimated from actions of KC 128 and levcromakalim.
Topics: Animals; Benzopyrans; Bronchi; Carbachol; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Species Specificity; Trachea | 1994 |
Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Cromakalim; Glyburide; Injections, Intraventricular; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Morphine; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord; Stimulation, Chemical | 1993 |
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Topics: Adenosine Triphosphate; Analgesics; Animals; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Male; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Potassium Channels; Pyrroles; Receptors, Opioid, mu; Tetraethylammonium Compounds | 1994 |
Effect of an ATP sensitive potassium channel opener, levcromakalim, on coronary arterial microvessels in the beating canine heart.
Topics: Animals; Benzopyrans; Capillaries; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Glyburide; Hemodynamics; Microscopy, Fluorescence; Nitroprusside; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilator Agents | 1994 |
Dilating effect of perivascularly applied potassium channel openers cromakalim and pinacidil in rat and cat pial arteries in situ.
Topics: Animals; Benzopyrans; Cats; Cerebral Arteries; Cromakalim; Female; Glyburide; Guanidines; Ion Channel Gating; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Multiple mechanisms in the smooth muscle relaxant action of calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.
Topics: Action Potentials; Animals; Arginine; Benzopyrans; Calcitonin Gene-Related Peptide; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Nitroarginine; Parasympatholytics; Pyrroles; Ureter | 1994 |
Vasospasmolytic effect of KRN2391 on 3,4-diaminopyridine-induced rhythmic contraction of porcine coronary artery.
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; In Vitro Techniques; Ion Channel Gating; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Swine; Vasoconstriction; Vasodilator Agents | 1994 |
Inhibition of delayed rectifier K(+)-current by levcromakalim in single intestinal smooth muscle cells: effects of cations and dependence on K(+)-flux.
Topics: Animals; Barium; Benzopyrans; Cations; Cricetinae; Cromakalim; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Rubidium; Zinc | 1995 |
The effects of a novel vasodilator, LP-805, on cytosolic Ca2+ concentrations and on tension in rabbit isolated femoral arteries.
Topics: Animals; Arginine; Benzopyrans; Calcium; Cromakalim; Cytosol; Endothelium, Vascular; Femoral Artery; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Norepinephrine; Potassium; Pyrazoles; Pyrimidines; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Oxadiazoles; Piperidines; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1994 |
Antihypertensive and cardiovascular effects of a new potassium channel opener, TCV-295, in rats and dogs.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Benzoxazines; Cromakalim; Cyclic N-Oxides; Dogs; Hemodynamics; Male; Nisoldipine; Oxazines; Oxygen Consumption; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar | 1994 |
Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Histamine H1 Antagonists; Membrane Potentials; Oocytes; Ovarian Follicle; Potassium; Potassium Channels; Pyrroles; Xenopus laevis | 1994 |
Negative inotropic effect of pinacidil on the rat left atria.
Topics: Animals; Benzopyrans; Cromakalim; Depression, Chemical; Electric Stimulation; Guanidines; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Guanosine diphosphate is required for activation of a glyburide, ATP and cromakalim-sensitive outward current in rat hippocampal neurones.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Bicuculline; Cells, Cultured; Cromakalim; Glyburide; Guanosine Diphosphate; Hippocampus; Ion Channel Gating; Kynurenic Acid; Neurons; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1994 |
KATP--fact or artefact? New thoughts on the mode of action of the potassium channel openers.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Guanidines; Insulinoma; Ion Channel Gating; Muscle, Smooth, Vascular; Pancreatic Neoplasms; Phosphorylation; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Tumor Cells, Cultured; Vasodilator Agents | 1994 |
The KATP and Kv channels are distinct entities: a reply to Edwards and Weston.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Diazoxide; Ion Channel Gating; Islets of Langerhans; Mice; Muscle, Smooth, Vascular; Phosphorylation; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effect of glibenclamide, forskolin, and isoprenaline on the parallel activation of KATP and reduction of IK by cromakalim in cardiac myocytes.
Topics: Animals; Benzopyrans; Cells, Cultured; Colforsin; Cromakalim; Glyburide; Guinea Pigs; Isoproterenol; Myocardium; Potassium Channels; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
A glibenclamide sensitive potassium conductance in terminal arterioles isolated from guinea pig heart.
Topics: Action Potentials; Animals; Arterioles; Benzopyrans; Coronary Vessels; Cromakalim; Culture Techniques; Glyburide; Guinea Pigs; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effect of lemakalim on action potentials, intracellular calcium, and contraction in guinea pig and human cardiac myocytes.
Topics: Action Potentials; Animals; Benzopyrans; Calcium; Cell Size; Cells, Cultured; Cromakalim; Dose-Response Relationship, Drug; Fura-2; Glyburide; Guinea Pigs; Heart; Humans; Intracellular Fluid; Male; Membrane Potentials; Myocardium; Pyrroles; Vasodilator Agents | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Pinacidil; Potassium; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
The sensitivity of coronary vascular tone to glibenclamide: a study on the isolated perfused guinea pig heart.
Topics: Animals; Benzopyrans; Biological Assay; Coronary Vessels; Cromakalim; Glyburide; Guinea Pigs; Hypoxia; In Vitro Techniques; Muscle, Smooth, Vascular; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Pharmacological analysis of the effect of KRN2391 on coronary vasculature in perfused rat heart.
Topics: Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Nifedipine; Perfusion; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1994 |
Properties of the ATP-sensitive K+ current activated by levcromakalim in isolated pulmonary arterial myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cell Separation; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Phencyclidine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats | 1994 |
Role of ATP-sensitive K+ channels in antinociception induced by R-PIA, an adenosine A1 receptor agonist.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Analgesia; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Mice; Parasympatholytics; Phenylisopropyladenosine; Potassium Channel Blockers; Potassium Channels; Purinergic P1 Receptor Agonists; Pyrroles; Sulfonylurea Compounds; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Maturation enhances the sensitivity of ovine cerebral arteries to the ATP-sensitive potassium channel activator lemakalim.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cerebral Arteries; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Potassium Channels; Pyrroles; Sheep; Vasodilation | 1994 |
[Cardioprotective effect of levcromakalim in isolated guinea pig heart preparations].
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiotonic Agents; Cromakalim; Energy Metabolism; Glycogen; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Lactates; Myocardium; Phosphocreatine; Pyrroles | 1994 |
Antagonism by lipophilic quaternary ions of the K+ channel opener, levcromakalim, in vascular smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Onium Compounds; Organophosphorus Compounds; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Tetraphenylborate; Vasoconstriction; Vasodilation | 1994 |
Mechanical and electrophysiological effects of cromakalim on the human urinary bladder.
Topics: Animals; Benzopyrans; Cromakalim; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Urinary Bladder | 1994 |
Effect of levcromakalim on hypoxia-, KCl- and prostaglandin F2 alpha-induced contractions in isolated rat pulmonary artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dinoprost; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Potassium Chloride; Pulmonary Artery; Pyrroles; Quaternary Ammonium Compounds; Rats; Vasoconstriction; Vasodilator Agents | 1994 |
Activation of ATP-sensitive potassium currents in guinea-pig gall-bladder smooth muscle by the neuropeptide CGRP.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Female; Gallbladder; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Tetraethylammonium Compounds | 1994 |
Mechanism of action of a K+ channel activator BRL 38227 on ATP-sensitive K+ channels in mouse skeletal muscle fibres.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Patch-Clamp Techniques; Potassium Channels; Pyrroles | 1994 |
Effects of albumin sensitization and challenge of guinea pigs on uptake2 of isoprenaline in trachealis muscle.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Animals; Benzopyrans; Cromakalim; Female; Guinea Pigs; Isoproterenol; Membrane Potentials; Muscle, Smooth; Ovalbumin; Potassium Channels; Pyrroles; Trachea | 1994 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
In vitro antitumor activity of cromakalim in human brain tumor cells.
Topics: Antineoplastic Agents; Astrocytoma; Benzopyrans; Brain; Brain Neoplasms; Calcium; Cell Survival; Cromakalim; Dose-Response Relationship, Drug; Humans; Neuroblastoma; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Tumor Cells, Cultured | 1994 |
Effect of cromakalim on skeletal muscle function and blood flow in the ferret ischemic hindlimb.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Electric Stimulation; Ferrets; Hindlimb; Infusions, Intra-Arterial; Ischemia; Isometric Contraction; Male; Muscle, Skeletal; Parasympatholytics; Potassium Channels; Pyrroles; Regional Blood Flow | 1994 |
Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1994 |
Effect of cromakalim and pinacidil on 86Rb efflux from guinea pig urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Male; Membrane Potentials; Muscle, Smooth; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rubidium Radioisotopes; Stereoisomerism; Urinary Bladder; Vasodilator Agents | 1994 |
[Inhibitory effect of berberine on potassium channels in guinea pig ventricular myocytes].
Topics: Action Potentials; Animals; Benzopyrans; Berberine; Cromakalim; Guinea Pigs; Male; Myocardium; Parasympatholytics; Potassium Channels; Pyrroles | 1994 |
Comparison of the cromakalim antagonism and bradycardic actions of a series of novel alinidine analogues in the rat.
Topics: Animals; Benzopyrans; Cardiovascular Agents; Clonidine; Cromakalim; Heart Rate; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Rats; Structure-Activity Relationship | 1994 |
Differential effects of prostanoid synthesis inhibitors on cicletanine-induced relaxation of isolated human epigastric arteries.
Topics: Abdominal Muscles; Antihypertensive Agents; Arteries; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Meclofenamic Acid; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Pyridines; Pyrroles; Tranylcypromine | 1994 |
[Potassium channel openers. A new possible therapeutic principle in several diseases].
Topics: Antihypertensive Agents; Benzopyrans; Bronchodilator Agents; Cromakalim; Guanidines; Humans; Minoxidil; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Differential vasodilator properties of KRN2391, cromakalim, nitroglycerin and nifedipine in rabbit isolated femoral artery and vein.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Femoral Artery; Femoral Vein; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Pyridines; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Pulmonary hydraulic impedance response to cromakalim (BRL 34915) in newborn pigs.
Topics: Animals; Animals, Newborn; Benzopyrans; Blood Pressure; Cromakalim; Pulmonary Circulation; Pulsatile Flow; Pyrroles; Swine; Vascular Resistance; Vasodilator Agents | 1994 |
Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guinea Pigs; In Vitro Techniques; Kidney Pelvis; Male; Membrane Potentials; Muscle Contraction; Potassium Channels; Pyrroles; Ureter | 1994 |
Role of K+ channels in neuropeptide Y-induced vasoconstriction in rabbit cerebral basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Blood Pressure; Cromakalim; Diazoxide; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Potassium Channels; Pyrroles; Rabbits; Vasoconstrictor Agents | 1994 |
Differential effects of hypoxia on electrical and mechanical activities of isolated ventricular muscles from fetal and adult guinea-pigs.
Topics: Action Potentials; Adenosine Triphosphate; Aging; Animals; Benzopyrans; Cromakalim; Depression, Chemical; Electrophysiology; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Potassium Channels; Pregnancy; Pyrroles; Ventricular Function | 1994 |
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pinacidil; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Xanthines | 1994 |
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cromakalim; Diazoxide; Embryo, Mammalian; Glutamates; Hypoglycemia; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; Neurons; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 1994 |
Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments.
Topics: Administration, Topical; Animals; Arterioles; Benzopyrans; Cromakalim; Dimethyl Sulfoxide; Dogs; Glyburide; Methylene Blue; Microcirculation; Niacinamide; Nicorandil; Nitroglycerin; Pia Mater; Pyrroles; Vasodilation; Vasodilator Agents; Venules | 1994 |
Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Coronary Circulation; Cromakalim; Electric Stimulation; Glyburide; Heart; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rabbits; Refractory Period, Electrophysiological; Vasodilator Agents | 1994 |
Prejunctional effects of cromakalim, nicorandil and pinacidil on noradrenergic transmission in rat isolated mesenteric artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Desipramine; Electric Stimulation; Extracellular Space; Female; Guanidines; In Vitro Techniques; Male; Mesenteric Arteries; Neuromuscular Junction; Niacinamide; Nicorandil; Norepinephrine; Pargyline; Phentolamine; Pinacidil; Pyrroles; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Synaptic Transmission; Vasodilator Agents | 1994 |
The effects of racemic cromakalim, BRL 38226 and levcromakalim on the membrane potential of the rat aorta and of BRL 38226 on the contractile activity of the rat aorta and portal vein.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Vasoconstrictor Agents | 1994 |
A possibility that the ATP-sensitive potassium channel in coronary artery has a high-affinity internal binding site for tetraalkylammonium.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Binding Sites; Coronary Vessels; Cromakalim; Dogs; Female; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Levcromakalim-induced modulation of membrane potassium currents, intracellular calcium and mechanical activity in rat mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Calcium; Cell Membrane; Cromakalim; Electrophysiology; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Characteristics of early afterdepolarization in mouse atrial fibers.
Topics: Aconitine; Action Potentials; Animals; Atrial Function; Benzopyrans; Cromakalim; Electrophysiology; Female; Heart; Male; Mice; Nifedipine; Pyrroles; Quinidine; Ryanodine; Tetrodotoxin | 1994 |
Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium.
Topics: Acetylcholine; Action Potentials; Animals; Arteries; Autonomic Nervous System; Benzopyrans; Cromakalim; Endothelium, Vascular; Female; In Vitro Techniques; Isoproterenol; Male; Membrane Potentials; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Pilocarpine; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tail | 1994 |
Evaluation of the novel potassium channel activator BRL 55834 as an inhaled bronchodilator in guinea-pigs and rats: comparison with levcromakalim and salbutamol.
Topics: Administration, Inhalation; Aerosols; Albuterol; Animals; Atmosphere Exposure Chambers; Benzopyrans; Blood Pressure; Bronchi; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Drug Evaluation, Preclinical; Guinea Pigs; Histamine Antagonists; Male; Methacholine Chloride; Nebulizers and Vaporizers; Piperidones; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1994 |
K+ channel activators, acute glucose tolerance and glibenclamide-induced hypoglycaemia in the hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Guanidines; Hypertension; Hypoglycemia; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR | 1994 |
Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Coagulation; Cromakalim; Disease Models, Animal; Evaluation Studies as Topic; Guanidines; Humans; Indoles; Male; Molecular Structure; Pinacidil; Platelet Aggregation Inhibitors; Potassium Channels; Pyrroles; Rabbits; Stereoisomerism; Thrombosis | 1994 |
Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems--XVII.
Topics: Animals; Antihypertensive Agents; Aorta; Benzopyrans; Cromakalim; Drug Evaluation, Preclinical; Glyburide; Hypertension; In Vitro Techniques; Models, Molecular; Molecular Structure; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Thiophenes | 1993 |
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Potassium Chloride; Pyridines; Pyrroles; Renal Artery; Vasodilator Agents | 1993 |
Differential vasorelaxant effects of K(+)-channel openers and Ca(2+)-channel blockers on canine isolated arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Pinacidil; Piperazines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Verapamil | 1993 |
Effects of ATP-sensitive K(+)-channel activators on transmitter release parameters at the frog neuromuscular junction.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; In Vitro Techniques; Membrane Potentials; Motor Endplate; Muscles; Neuromuscular Junction; Neurotransmitter Agents; Parasympatholytics; Potassium Channels; Pyrroles; Rana pipiens | 1993 |
Effects of cromakalim (BRL 34915) in trachea isolated from actively sensitized guinea-pigs.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Female; Guinea Pigs; Histamine; Immunization; Kinetics; Male; Muscle Tonus; Muscle, Smooth; Potassium; Potassium Channels; Pyrroles; Serum Albumin, Bovine; Trachea | 1993 |
Comparison of the effects of KRN2391 and other coronary dilators on porcine isolated coronary arteries of different sizes.
Topics: Adenosine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Beta-adrenoceptor subtypes and the opening of plasmalemmal K(+)-channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Benzopyrans; Cell Membrane; Cromakalim; Electrophysiology; Female; Guinea Pigs; Heart; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Myocardium; Norepinephrine; Potassium Channels; Procaterol; Propanolamines; Pyrroles; Receptors, Adrenergic, beta; Rubidium Radioisotopes; Salmeterol Xinafoate; Trachea | 1993 |
Mechanism of action of KRN2391 in canine coronary vascular bed.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Vasodilator Agents | 1993 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Pyrans; Pyrroles; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1994 |
Pharmacological analysis of the vasodepressor effect of KRN2391 in pithed rats.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Decerebrate State; Dose-Response Relationship, Drug; Glyburide; In Vitro Techniques; Male; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
The effect of a novel benzopyran derivative, KC 399, on the isolated guinea-pig trachealis and human bronchi.
Topics: Albuterol; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Guinea Pigs; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1993 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Cromakalim and cicletanine against pacing-induced myocardial ischemia in conscious rabbits.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cardiac Pacing, Artificial; Consciousness; Cromakalim; Heart Rate; Male; Myocardial Ischemia; Potassium Channels; Pyridines; Pyrroles; Rabbits; Stroke Volume; Vasodilator Agents; Ventricular Function, Left | 1994 |
Cromakalim does not protect against skeletal muscle fatigue in an anaesthetized rat model of acute hindlimb ischaemia.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Heart Rate; Hindlimb; Ischemia; Male; Muscle Contraction; Muscles; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasodilator Agents | 1993 |
Effects of levcromakalim on ureteral peristaltic function and cystometrogram in rats.
Topics: Administration, Topical; Animals; Benzopyrans; Cromakalim; Glyburide; Injections, Intraperitoneal; Injections, Intravenous; Male; Nifedipine; Parasympatholytics; Pyrroles; Rats; Rats, Sprague-Dawley; Ureter; Urinary Bladder | 1993 |
Effects of nicorandil on human isolated corpus cavernosum and cavernous artery.
Topics: Adult; Aged; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Male; Middle Aged; Molsidomine; Niacinamide; Nicorandil; Penis; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Activation of potassium channels by diazoxide and cromakalim in insulin-secreting cells is dependent upon internal ADP and channel run-down.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cell Line; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Pancreatic Neoplasms; Potassium Channels; Pyrroles; Tumor Cells, Cultured | 1993 |
ATP-sensitive K+ channel openers inhibit morphine withdrawal.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Benzopyrans; Body Weight; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Mice, Inbred Strains; Morphine; Naloxone; Potassium Channels; Pyrroles; Substance Withdrawal Syndrome | 1994 |
Potassium channels are not involved in vasopressin-induced vasodilation in the rat lung.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arginine; Arginine Vasopressin; Barium; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Kinetics; Lung; Male; Muscle, Smooth, Vascular; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pyrroles; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1994 |
Effects of trypsin on cardiac ATP-sensitive K+ channels.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Glyburide; Glyoxal; Guinea Pigs; Heart; Magnesium; Male; Membrane Potentials; Phenylglyoxal; Potassium Channels; Pyrroles; Trypsin | 1994 |
Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Glyburide; Oocytes; Phospholipases A; Phospholipases A2; Potassium Channels; Proadifen; Pyrroles; Quinacrine; Xenopus laevis | 1994 |
Intracellular mechanism of penile erection in monkeys.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Ethylmaleimide; Macaca nemestrina; Male; Methylene Blue; Nitroprusside; Penile Erection; Penis; Phosphodiesterase Inhibitors; Purinones; Pyrroles; Ultrasonography | 1994 |
Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Basilar Artery; Benzopyrans; Blood Pressure; Cromakalim; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Nitroglycerin; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Role of potassium channels in hypoxic relaxation of porcine bronchi in vitro.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypoxia; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Potassium Channels; Pyrroles; Swine | 1994 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
In vivo bronchodilator action of a novel K+ channel opener, KC 399, in the guinea pig.
Topics: Administration, Inhalation; Albuterol; Anesthesia; Animals; Antigens; Asthma; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Consciousness; Cromakalim; Disease Models, Animal; Guinea Pigs; Histamine; Immunization; Injections, Intravenous; Male; Potassium Channels; Pyrroles | 1994 |
Enhancement of endothelium dependent relaxation in the rat aortic ring by selenium supplement.
Topics: Acetylcholine; Animals; Aorta; Arginine; Benzopyrans; Cromakalim; Culture Techniques; Endothelium, Vascular; Glutathione Peroxidase; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyrroles; Rats; Rats, Sprague-Dawley; Selenium; Vasoconstriction; Vasodilator Agents | 1994 |
The cardioprotective and electrophysiological effects of cromakalim are attenuated by meclofenamate through a cyclooxygenase-independent mechanism.
Topics: Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Evoked Potentials; Guinea Pigs; Heart; In Vitro Techniques; Male; Meclofenamic Acid; Myocardium; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
2-Deoxyglucose-induced vasodilation and hyperpolarization in rat coronary artery are reversed by glibenclamide.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Dose-Response Relationship, Drug; Electrophysiology; Female; Glyburide; Male; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation | 1994 |
Regulation of ATP-sensitive K+ channels by ATP and nucleotide diphosphate in rabbit portal vein.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Egtazic Acid; Guanidines; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Membrane Potentials; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Probability; Pyrroles; Rabbits; Ribonucleotides; Time Factors; Vasodilator Agents | 1994 |
Effects of antidiabetic sulphonylureas, cromakalim and their interaction in guinea-pig isolated tracheal smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Trachea | 1993 |
Effects of levcromakalim and RP52891 on NANCe nerve-mediated changes in pulmonary dynamics evoked by vagal stimulation in the guinea-pig.
Topics: Airway Resistance; Animals; Autonomic Nervous System; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Lung; Male; Picolines; Potassium Channels; Pyrans; Pyrroles; Respiration; Respiratory Function Tests; Vagus Nerve | 1993 |
Partial inhibition by epithelium of tracheal smooth muscle relaxation induced by the potassium channel activator, BRL 38227.
Topics: Aminophylline; Animals; Benzopyrans; Biotransformation; Bronchodilator Agents; Carbachol; Cromakalim; Epithelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Trachea | 1993 |
Effects of three K+ channel openers on airways and pulmonary circulation in the isolated guinea-pig lung.
Topics: Animals; Benzopyrans; Bronchoconstriction; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth, Vascular; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Circulation; Pyrans; Pyrroles | 1993 |
Inhibition of neurogenic plasma exudation and bronchoconstriction by a K+ channel activator, BRL 38227, in guinea pig airways in vivo.
Topics: Animals; Benzopyrans; Bronchi; Bronchoconstriction; Bronchodilator Agents; Capillary Permeability; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Male; Potassium Channels; Pyrroles; Smoke; Vagus Nerve; Vasodilator Agents | 1993 |
In vivo reactivity of resistance arterioles to activation of ATP-sensitive K+ channels.
Topics: Animals; Antihypertensive Agents; Arginine; Benzopyrans; Cheek; Cricetinae; Cromakalim; Male; Mesocricetus; Microcirculation; Muscle, Smooth, Vascular; Nitric Acid; omega-N-Methylarginine; Picolines; Potassium Channels; Pyrans; Pyrroles | 1993 |
Cardioprotective effects of a novel calcium antagonist related to the structure of cromakalim.
Topics: Action Potentials; Animals; Benzopyrans; Calcium Channel Blockers; Coronary Circulation; Cromakalim; Glyburide; Heart; Hemodynamics; Male; Potassium Channels; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium Channels | 1993 |
Synergistic effects of glyburide and U-37883A, two structurally different vascular ATP-sensitive potassium channel antagonists.
Topics: Adamantane; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Synergism; Gallopamil; Glyburide; In Vitro Techniques; Ion Channel Gating; Male; Mesenteric Arteries; Minoxidil; Morpholines; Potassium Channels; Pyrroles; Rabbits; Vasodilation | 1993 |
ATP-sensitive potassium channels and skeletal muscle function in vitro.
Topics: Animals; Benzopyrans; Cromakalim; Electric Stimulation; Energy Metabolism; Gallamine Triethiodide; Glyburide; Guanidines; In Vitro Techniques; Ischemia; Male; Muscle Contraction; Muscles; Pinacidil; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Potassium channel blockade and halothane vasodilation in conducting and resistance coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Halothane; In Vitro Techniques; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Tetraethylammonium Compounds; Vasodilation | 1993 |
BRL 38227--a potassium channel opener, antagonizes digoxin-induced convulsions.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Brain; Cromakalim; Digoxin; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Seizures | 1993 |
The effects of potassium channel openers on isolated pregnant human myometrium before and after the onset of labor: potential for tocolysis.
Topics: Benzopyrans; Cromakalim; Female; Guanidines; Humans; In Vitro Techniques; Labor Onset; Myometrium; Oxytocin; Phenylephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pregnancy; Pyrroles; Sulfonylurea Compounds; Tocolytic Agents; Uterine Contraction | 1993 |
Venoconstriction to endothelin-1 in humans: role of calcium and potassium channels.
Topics: Adult; Benzopyrans; Calcium Channels; Cromakalim; Diastole; Endothelins; Hand; Humans; Hydralazine; Infusions, Intravenous; Male; Muscle, Smooth, Vascular; Nicardipine; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Systole; Time Factors; Vasoconstriction; Vasodilator Agents; Veins | 1993 |
Arteriolar tone is determined by activity of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Bucladesine; Colforsin; Cricetinae; Cromakalim; Epoprostenol; Glyburide; Guanidines; Isoproterenol; Male; Mesocricetus; Methacholine Chloride; Muscle Tonus; Muscle, Smooth, Vascular; Muscles; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Quaternary Ammonium Compounds; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Pyrroles; Swine; Vasodilator Agents | 1993 |
Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guanosine Diphosphate; In Vitro Techniques; Magnesium; Muscle, Smooth, Vascular; Portal Vein; Potassium Channels; Pyrroles; Rabbits; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Differential effects of acetylcholine, nitric oxide and levcromakalim on smooth muscle membrane potential and tone in the rabbit basilar artery.
Topics: Acetylcholine; Animals; Basilar Artery; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Humans; In Vitro Techniques; Infant, Newborn; Male; Membrane Potentials; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Vasodilator action of cromakalim on human mesenteric artery.
Topics: Aged; Aged, 80 and over; Benzopyrans; Cromakalim; Humans; In Vitro Techniques; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents | 1993 |
RWJ 26629, a new potassium channel opener and vascular smooth muscle relaxant: a potential antihypertensive and antianginal agent.
Topics: Angina Pectoris; Animals; Antihypertensive Agents; Benzopyrans; Bronchoconstriction; Calcium Channel Blockers; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Ferrets; Gastrointestinal Motility; Guinea Pigs; Heart Atria; Macaca mulatta; Male; Mice; Mice, Inbred Strains; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Papillary Muscles; Pilocarpine; Potassium Channels; Pyrans; Pyrroles; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Thiophenes; Vasodilator Agents | 1993 |
Dynamic effects and pharmacokinetics of lemakalim in the isolated guinea-pig heart.
Topics: Animals; Benzopyrans; Coronary Circulation; Cromakalim; Depression, Chemical; Electrocardiography; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Isotonic Contraction; Male; Myocardial Contraction; Myocardium; Oxygen Consumption; Pyrroles | 1993 |
Therapeutic potential of potassium channel openers in peripheral vascular disease and asthma.
Topics: Animals; Asthma; Benzopyrans; Cromakalim; Cyclopentanes; Disease Models, Animal; Humans; Parasympatholytics; Peripheral Vascular Diseases; Potassium Channels; Pyrroles; Rats | 1993 |
Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Benzopyrans; Bradykinin; Calcimycin; Child; Coronary Vessels; Cromakalim; Dinoprost; Endothelium, Vascular; Glyburide; Humans; In Vitro Techniques; Indoles; Indomethacin; Infant; Male; Membrane Potentials; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Pyrroles; Vasodilator Agents | 1993 |
Cardioselective anti-ischemic ATP-sensitive potassium channel openers.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Biological Availability; Cocaine; Cromakalim; Guanidines; Ion Channel Gating; Molecular Structure; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Structure-Activity Relationship; Vasodilation | 1993 |
Lemakalim, a potassium channel agonist, reverses electrophysiological impairments induced by a large dose of bupivacaine in anaesthetized dogs.
Topics: Anesthesia, General; Animals; Atropine; Benzopyrans; Bupivacaine; Cromakalim; Dogs; Electrocardiography; Female; Heart; Heart Rate; Male; Potassium Channels; Pyrroles; Time Factors | 1993 |
Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Glyburide; Heart; Ion Channel Gating; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
ATP-sensitive K+ channel activators suppress the GABAergic inhibitory transmission by acting on both presynaptic and postsynaptic sites in rat cultured hippocampal neurons.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Animals, Newborn; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; gamma-Aminobutyric Acid; Hippocampus; Neurons; Potassium Channels; Pyrroles; Rats; Receptors, Presynaptic; Synapses; Synaptic Transmission | 1993 |
Potassium channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures.
Topics: Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; DNA; Guanidines; Hair; Keratinocytes; Kinetics; Mice; Minoxidil; Pinacidil; Potassium Channels; Pyrroles; Vibrissae | 1993 |
Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Diglycerides; Glyburide; Guanosine Diphosphate; Guinea Pigs; In Vitro Techniques; Indoles; Maleimides; Membrane Potentials; Muscarinic Antagonists; Muscle, Smooth; Potassium Channels; Protein Kinase C; Pyrroles; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Thionucleotides; Urinary Bladder | 1993 |
Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischemia/reperfusion-induced injury. Heart function studies in nonfibrillating isolated hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Pyrroles; Tachycardia, Ventricular; Ventricular Fibrillation | 1994 |
Levcromakalim may induce a voltage-independent K-current in rat portal veins by modifying the gating properties of the delayed rectifier.
Topics: Animals; Benzopyrans; Cromakalim; Diacetyl; Electrophysiology; Ion Channel Gating; Magnesium; Male; Muscle, Smooth, Vascular; Phosphoric Monoester Hydrolases; Phosphorylation; Portal Vein; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1993 |
Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium; Cromakalim; Female; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Norepinephrine; Portal Vein; Potassium Channels; Potassium Chloride; Pyridones; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1993 |
Attenuation by phentolamine of hypoxia and levcromakalim-induced abbreviation of the cardiac action potential.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glucose; Glyburide; Guinea Pigs; Heart; Hypoxia; In Vitro Techniques; Kinetics; Papillary Muscles; Phentolamine; Potassium Channels; Pyrroles | 1993 |
Mechanism of cyclic AMP-induced hyperpolarization in canine colon.
Topics: Animals; Benzopyrans; Calcium; Colforsin; Colon; Cromakalim; Cyclic AMP; Dogs; Female; In Vitro Techniques; Male; Membrane Potentials; Potassium Channels; Pyrroles | 1994 |
Effects of KC 399, a novel ATP-sensitive K+ channel opener, on electrical and mechanical responses in dog tracheal smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbachol; Cromakalim; Cyclic AMP; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1994 |
Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Insulinoma; Neurotoxins; Phosphorylation; Portal Vein; Potassium Channels; Pyrroles; Rats; Scorpion Venoms; Tumor Cells, Cultured | 1993 |
Antagonism of levcromakalim by imidazoline- and guanidine-derivatives in rat portal vein: involvement of the delayed rectifier.
Topics: Animals; Antazoline; Benzopyrans; Clonidine; Cromakalim; Glyburide; Guanabenz; Imidazoline Receptors; Male; Phentolamine; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1993 |
Characterisation of the effect of oxygen tension on response of fetal rabbit ductus arteriosus to vasodilators.
Topics: Adenosine; Animals; Atrial Natriuretic Factor; Benzopyrans; Colforsin; Cromakalim; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Flurbiprofen; Indomethacin; Nifedipine; Nitroprusside; Norepinephrine; Oxygen; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Mechanism of action of KRN2391, a novel vasodilator, in canine mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Mesenteric Arteries; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1993 |
ATP-sensitive K+ channels mediate vasodilation produced by lemakalim in rabbit pulmonary artery.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electric Conductivity; Male; Membrane Potentials; Potassium Channels; Pulmonary Artery; Pyrroles; Rabbits; Vasoconstriction; Vasodilation; Vasodilator Agents | 1993 |
Actions of potassium channel openers in rat detrusor urinae.
Topics: Animals; Benzopyrans; Cromakalim; Guanidines; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Picolines; Potassium Channels; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1993 |
4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers.
Topics: Adamantane; Adenosine Triphosphate; Animals; Benzopyrans; Blood Pressure; Cats; Cromakalim; Dogs; Female; In Vitro Techniques; Male; Mesenteric Arteries; Minoxidil; Morpholines; Potassium; Potassium Channels; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Vasodilation | 1993 |
Effects of potassium channel openers and their antagonists on rat locus coeruleus neurones.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Kynurenic Acid; Locus Coeruleus; Male; Membrane Potentials; Neurons; Parasympatholytics; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Substantia Nigra; Tetrodotoxin; Tolbutamide | 1993 |
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxidative Phosphorylation; Pinacidil; Piperazines; Pyrroles; Rabbits; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Vasodilator Agents; Verapamil | 1993 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Oxyhemoglobins; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery.
Topics: Acetylcholine; Aging; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Endothelium, Vascular; Indomethacin; Male; Mesenteric Arteries; Norepinephrine; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1993 |
Functional evidence for different endothelin receptors in the lung.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Anesthesia; Animals; Benzopyrans; Bradykinin; Cats; Cromakalim; Endothelins; Female; Glyburide; Hemodynamics; Lung; Male; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Pulmonary Gas Exchange; Pyrroles; Receptors, Endothelin; Tachyphylaxis; Vascular Resistance; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms | 1993 |
Lemakalim attenuates hypocapnia- and dry air-induced bronchoconstriction in canine peripheral airways.
Topics: Acetylcholine; Adenosine Triphosphate; Aerosols; Airway Resistance; Albuterol; Animals; Benzopyrans; Blood Pressure; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Dogs; Glyburide; Heart Rate; Humidity; Hypocapnia; Injections, Intravenous; Lung; Male; Nifedipine; Potassium Channels; Pyrroles | 1993 |
Cromakalim inhibits electrically-evoked [3H]acetylcholine release from a tube-preparation of the rat isolated trachea by an epithelium-dependent mechanism.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Epithelium; In Vitro Techniques; Potassium Channels; Pyrroles; Rats; Stereoisomerism; Trachea | 1993 |
The effects of (-)-cromakalim and glibenclamide on uptake2 in guinea-pig trachealis muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guinea Pigs; Isoproterenol; Male; Membrane Potentials; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Trachea | 1993 |
Effect of ouabain on relaxation induced by cromakalim in human and canine mesenteric arteries.
Topics: Adult; Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Humans; Male; Mesenteric Arteries; Middle Aged; Muscle, Smooth, Vascular; Ouabain; Pyrroles; Rubidium Radioisotopes; Sensitivity and Specificity; Sodium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Vasodilator Agents | 1993 |
Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Methylene Blue; Niacinamide; Nicorandil; Nitroprusside; Oocytes; Potassium Channels; Pyridines; Pyrroles; Xenopus laevis | 1993 |
Sensitization decreases relaxation in human isolated airways.
Topics: Asthma; Benzopyrans; Bronchi; Bucladesine; Carbachol; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Humans; Immunization, Passive; Immunoglobulin E; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Muscle Tonus; Parasympatholytics; Pyrroles; Verapamil | 1993 |
The antitussive effect of cromakalim in rats is not associated with adenosine triphosphate sensitive K+ channels.
Topics: Adenosine Triphosphate; Animals; Antitussive Agents; Benzopyrans; Calcium Channels; Capsaicin; Cough; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Injections, Intraperitoneal; Male; Methysergide; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Reflex; Tetraethylammonium Compounds | 1993 |
Possible involvement of K(ATP) channels in the control of 5-HT neurons.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Benzopyrans; Cromakalim; Electrophysiology; GABA-A Receptor Antagonists; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Neurons; Picolines; Potassium Channels; Pyrans; Pyrroles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Sulfonylurea Compounds | 1993 |
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Egtazic Acid; Epithelium; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitroprusside; Phenanthrenes; Plants, Medicinal; Propranolol; Pyrroles; Theophylline; Trachea; Vasodilator Agents | 1993 |
Effects of cromakalim on the electrical slow wave in the circular muscle of guinea-pig gastric antrum.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium; Pyloric Antrum; Pyrroles; Sodium | 1993 |
Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats.
Topics: Administration, Oral; Aerosols; Airway Resistance; Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Duodenum; Guinea Pigs; Histamine; Histamine Antagonists; Injections, Intravenous; Intubation, Gastrointestinal; Lung Compliance; Male; Methacholine Compounds; Piperidones; Pyrroles; Rats; Rats, Sprague-Dawley | 1993 |
Effects of rubidium on responses to potassium channel openers in rat isolated aorta.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Microelectrodes; Muscle Relaxation; Muscle, Smooth, Vascular; Picolines; Portal Vein; Potassium Channels; Potassium Chloride; Potassium Radioisotopes; Pyrans; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Tachyphylaxis; Vasodilator Agents | 1993 |
The inhibitory effects of Ro 31-6930 and BRL 38227 on cholinergically-mediated bronchoconstriction in the guinea-pig.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchoconstriction; Bronchodilator Agents; Cromakalim; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyridines; Pyrroles; Trachea; Vagus Nerve | 1993 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Ischemia; Cell Death; Cromakalim; Gene Expression Regulation; Guanidines; Heat-Shock Proteins; Hippocampus; In Situ Hybridization; Male; Molecular Sequence Data; Neurons; Niacinamide; Nicorandil; Oligonucleotide Probes; Pinacidil; Potassium Channels; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrroles; Rats; Rats, Wistar; RNA, Messenger | 1993 |
Effect of BRL 38227 on the adrenergic regulation of the kidney vasculature of the rat.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Kidney; Male; Methoxamine; Norepinephrine; Phenylephrine; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Renal Circulation; Sympathetic Nervous System; Vasoconstriction; Vasodilator Agents | 1993 |
Properties of diazoxide and cromakalim-induced activation of potassium channels in cultured rat and RINm5F insulin-secreting cells; effects of GTP.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; Guanosine Triphosphate; Insulin; Insulin Secretion; Islets of Langerhans; Pertussis Toxin; Potassium Channels; Pyrroles; Rats; Virulence Factors, Bordetella | 1993 |
Effects of K+ channel openers on ischemic dysfunction and metabolic disturbance in isolated perfused rat heart.
Topics: Animals; Benzopyrans; Cromakalim; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Diazoxide; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; Potassium Channels; Pyrroles; Rats | 1993 |
Inhibition of contractions of the isolated human myometrium by potassium channel openers.
Topics: Benzopyrans; Cromakalim; Female; Glyburide; Humans; Ion Channel Gating; Oxytocin; Parasympatholytics; Picolines; Potassium Channels; Potassium Chloride; Potassium Radioisotopes; Pregnancy; Pyrans; Pyrroles; Uterine Contraction | 1993 |
Activation by KRN2391 and nicorandil of glibenclamide-sensitive K+ channels in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Epinephrine; Female; Glyburide; Niacinamide; Nicorandil; Oocytes; Phentolamine; Potassium Channels; Pyridines; Pyrroles; Trifluoperazine; Vasodilator Agents; Xenopus laevis | 1993 |
Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro.
Topics: Adenosine Triphosphate; Adult; Benzopyrans; Bronchi; Bronchodilator Agents; Chromans; Cromakalim; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Pyrrolidines | 1993 |
Effect of cromakalim on KCl-, noradrenaline- and angiotensin II-induced contractions in the rat pulmonary artery.
Topics: Angiotensin II; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Glyburide; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Potassium Chloride; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Tetraethylammonium Compounds | 1993 |
Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Bronchi; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Pinacidil; Potassium; Potassium Channels; Potassium Radioisotopes; Pyrroles; Pyrrolidines; Respiratory System; Trachea; Vasodilator Agents | 1993 |
[Cardioprotective effect of cromakalim, a K+ channel opener, on isolated globally ischemic and reperfused rat hearts].
Topics: Animals; Benzopyrans; Cardioplegic Solutions; Coronary Circulation; Cromakalim; Heart Arrest, Induced; Heart Rate; In Vitro Techniques; Male; Myocardial Reperfusion; Myocardium; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1993 |
Effect of cromakalim on micturition function in rats.
Topics: Administration, Oral; Animals; Benzopyrans; Blood Pressure; Circadian Rhythm; Cromakalim; Diuresis; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Pyrroles; Rats; Rats, Wistar; Sodium Chloride; Time Factors; Urination | 1993 |
Selective and complete blockade of acetylcholine-induced relaxation in rabbit aortic rings by N omega-nitro-L-arginine but not by glybenclamide.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Arginine; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Nitroglycerin; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Inhibitory effect of cromakalim in human detrusor muscle is mediated by glibenclamide-sensitive potassium channels.
Topics: Benzopyrans; Cromakalim; Depression, Chemical; Dose-Response Relationship, Drug; Glyburide; Humans; In Vitro Techniques; Male; Muscle Contraction; Potassium Channels; Pyrroles; Urinary Bladder | 1993 |
The effect of cromakalim on the electrical properties of and [86Rb+] efflux from normal and hypertrophied rat bladder.
Topics: Action Potentials; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Female; Hypertrophy; In Vitro Techniques; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympatholytics; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Urinary Bladder | 1993 |
The individual enantiomers of cis-cromakalim possess K+ channel opening activity.
Topics: Anesthesia; Animals; Aorta, Thoracic; Benzopyrans; Binding, Competitive; Blood Pressure; Cromakalim; Endothelium, Vascular; Guanidines; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Rubidium Radioisotopes; Stereoisomerism; Vasodilation; Vasodilator Agents | 1993 |
Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Diltiazem; Ductus Arteriosus; Glyburide; In Vitro Techniques; Nickel; Norepinephrine; Oxygen; Potassium; Pyrroles; Rabbits; Vasoconstriction; Verapamil | 1993 |
Effects of a K+ATP channel opener, lemakalim, on systemic, coronary and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerin and acetylcholine.
Topics: Acetylcholine; Adenosine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Hemodynamics; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1993 |
A bradycardic agent, UL-FS 49, increases atrial force and decreases ventricular force in isolated, perfused heart preparations of dogs.
Topics: Acetylcholine; Adenosine; Animals; Atrial Function; Benzazepines; Benzopyrans; Cardiovascular Agents; Cromakalim; Dogs; Heart Atria; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Perfusion; Potassium Channels; Pyrroles; Sinoatrial Node; Ventricular Function | 1993 |
Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers.
Topics: Animals; Benzopyrans; Cromakalim; Female; Imidazoles; Membrane Potentials; Muscle, Smooth, Vascular; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Spiro Compounds; Structure-Activity Relationship | 1993 |
Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide.
Topics: Animals; Aorta; Benzopyrans; Calcium; Cations; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Lipid Bilayers; Membrane Potentials; Microsomes; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Analysis of Variance; Animals; Barium; Benzopyrans; Cromakalim; Deoxyglucose; Dinitrophenols; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Kinetics; Male; Membrane Potentials; Models, Biological; Muscle, Smooth; Potassium Channels; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Urinary Bladder; Vasodilator Agents | 1993 |
Vasorelaxant effect of the potassium channel activator, RWJ 29009, is tissue selective.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Endothelins; Female; Femoral Artery; In Vitro Techniques; Male; Nicardipine; Nitroprusside; Piperidones; Potassium Channels; Pyrans; Pyrroles; Saphenous Vein; Thiophenes; Vasodilation; Vasodilator Agents | 1993 |
8-(Diethylamino)-octyl-3,4,5-trimethoxybenzoate inhibits cromakalim-induced 86Rb efflux from the rat aorta.
Topics: Animals; Aorta; Benzopyrans; Biological Transport; Cromakalim; Gallic Acid; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium | 1993 |
BRL 38227 (levcromakalim)-induced hyperpolarization reduces the sensitivity to Ca2+ of contractile elements in canine coronary artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart; Male; Membrane Potentials; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1993 |
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Cations; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; Heart Function Tests; Hypoglycemic Agents; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin | 1995 |
[Effects of the potassium channel activator cromakalim on human isolated bronchial smooth muscle].
Topics: Adult; Albuterol; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Synergism; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles | 1995 |
The effect of K+ channel openers on submucosal gland function and epithelial transport of the ferret trachea, in vitro.
Topics: Albumins; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Epithelium; Female; Ferrets; In Vitro Techniques; Male; Methacholine Chloride; Muramidase; Muscle, Smooth; Phenylephrine; Potassium Channels; Pyridines; Pyrroles; Trachea | 1995 |
Glibenclamide does not reverse attenuated vasoreactivity to acute or chronic hypoxia.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Benzopyrans; Blood Gas Analysis; Blood Pressure; Chronic Disease; Cromakalim; Glyburide; Heart Rate; Hemodynamics; Hypoglycemic Agents; Hypoxia; Male; Phenylephrine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstrictor Agents | 1995 |
K+ channel-opening properties of a novel compound, NIP-121, in guinea pig myocardium as compared with those of cromakalim.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Oxadiazoles; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; In Vitro Techniques; Ischemic Attack, Transient; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium; Potassium Channels; Pyrroles; Rabbits; Subarachnoid Hemorrhage; Time Factors; Vasodilator Agents | 1996 |
Effects of potassium channel openers in isolated human cerebral arteries.
Topics: Benzopyrans; Calcium Channel Blockers; Carbachol; Cerebral Arteries; Cromakalim; Culture Techniques; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Humans; Iloprost; Nifedipine; Nimodipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Effects of cromakalim and nicorandil on intraocular pressure after topical administration in rabbit eyes.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Benzopyrans; Blood Flow Velocity; Chymotrypsin; Cromakalim; Eye; Female; Intraocular Pressure; Male; Niacinamide; Nicorandil; Ocular Hypertension; Ophthalmic Solutions; Potassium Channels; Pyrroles; Rabbits | 1995 |
Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Myocardial Infarction; Myocardial Ischemia; Perfusion; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Heart; Ion Channel Gating; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Differential vasorelaxant effects of levcromakalim and P1060 in the isolated KCl- and RbCl-precontracted human saphenous vein: possible involvement of intracellular Ca2+ stores.
Topics: Benzopyrans; Caffeine; Calcium; Chlorides; Cromakalim; Guanidines; Humans; In Vitro Techniques; Nifedipine; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rubidium; Saphenous Vein; Vasodilator Agents | 1995 |
Regional differences in endothelium-dependent relaxation in the rat: contribution of nitric oxide and nitric oxide-independent mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta; Arginine; Benzopyrans; Calcimycin; Calcitonin Gene-Related Peptide; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Femoral Artery; Histamine; Ionophores; Liver; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Renal Artery; Thromboxane A2; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1995 |
The mitochondrial KATP channel as a receptor for potassium channel openers.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cattle; Cell-Free System; Cromakalim; Diazoxide; Liposomes; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Potassium; Potassium Channels; Pyrroles; Rats | 1996 |
Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzopyrans; Cromakalim; Diazoxide; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Globus Pallidus; Ion Channel Gating; Locomotion; Male; Parkinson Disease; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors | 1996 |
Protective effect of K(ATP) openers in ischemic rat hearts treated with a potassium cardioplegic solution.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cardioplegic Solutions; Cromakalim; Guanidines; Heart; Male; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1995 |
Impaired action of levcromakalim on ATP-sensitive K+ channels in mesenteric artery cells from spontaneously hypertensive rats.
Topics: Animals; Benzopyrans; Blood Pressure; Body Weight; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hydralazine; Membrane Potentials; Mesenteric Arteries; Parasympatholytics; Patch-Clamp Techniques; Potassium Channels; Pulse; Pyrroles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity | 1996 |
Effects of potassium channel modulators cromakalim, tetraethylammonium and glibenclamide on the contractility of the isolated human ureter.
Topics: Benzopyrans; Cromakalim; Glyburide; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Potassium Channels; Potassium Chloride; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Ureter | 1996 |
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Azepines; Benzopyrans; Cromakalim; Endothelin Receptor Antagonists; Endothelins; Female; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Oligopeptides; Papillary Muscles; Potassium Channels; Protein Kinase C; Pyrroles; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
Cellular localization of the inhibitory action of relaxin against uterine spasm.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Benzopyrans; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Cell Membrane; Cromakalim; Female; Nifedipine; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Relaxin; Spasm; Uterine Diseases | 1995 |
The involvement of ATP-sensitive potassium channels and adenosine in the regulation of coronary flow in the isolated perfused rat heart.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Glyburide; Heart; In Vitro Techniques; Male; Perfusion; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Theophylline; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Lack of a pharmacologic interaction between ATP-sensitive potassium channels and adenosine A1 receptors in ischemic rat hearts.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Male; Myocardial Ischemia; Myocardium; Perfusion; Phenylisopropyladenosine; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Xanthines | 1996 |
Effects of KRN2391, a novel vasodilator acting as a nitrate and a K+ channel opener, on the rabbit lower urinary tract.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electrophysiology; Female; Hypoglycemic Agents; Molsidomine; Muscle Relaxation; Muscle, Smooth; Pyridines; Pyrroles; Rabbits; Urethra; Vasodilator Agents | 1995 |
Effect of selective inhibition of potassium channels on vasorelaxing response to cromakalim, nitroglycerin and nitric oxide of canine coronary arteries.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Peptides; Potassium Channel Blockers; Potassium Chloride; Pyrroles; Vasodilation; Vasodilator Agents | 1995 |
The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs.
Topics: Administration, Inhalation; Animals; Benzopyrans; Blood Pressure; Bronchoconstriction; Bronchodilator Agents; Capillary Permeability; Chromans; Cromakalim; Female; Guinea Pigs; Histamine; Muscle Relaxants, Central; Potassium Channels; Pyrroles; Pyrrolidines; Vagus Nerve; Vasodilator Agents | 1996 |
The lack of a role for potassium channel opening in the action of relaxin in the rat isolated uterus; a comparison with levcromakalim and salbutamol.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Benzopyrans; Cromakalim; Electrophysiology; Female; Glyburide; In Vitro Techniques; Oxytocin; Parasympatholytics; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Sprague-Dawley; Relaxin; Uterine Contraction; Uterus | 1996 |
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Glyburide; Guanidines; Male; Membrane Potentials; Muscle, Smooth, Vascular; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Sensitivity and Specificity; Uridine Diphosphate | 1996 |
Effects of cromakalim, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzopyrans; Cholinergic Fibers; Cromakalim; Female; Glyburide; Guanidines; Heart; Hypoglycemic Agents; Male; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1995 |
K+ channel openers delay intestinal transit and have antidiarrheal activity.
Topics: Animals; Benzopyrans; Cromakalim; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guanidines; Male; Mice; Mice, Inbred Strains; Morphine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1995 |
Allergic airway response and potassium channels: histamine release and airway inflammation.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Bronchoconstriction; Capillary Permeability; Cromakalim; Guinea Pigs; Histamine Release; Hypersensitivity; Male; Ovalbumin; Potassium Channels; Pyrroles | 1995 |
Ba2+ differentially inhibits the Rb+ efflux promoting and the vasorelaxant effects of levcromakalim and minoxidil sulfate in rat isolated aorta.
Topics: Animals; Aorta; Barium; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Minoxidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Vasoconstriction; Vasodilator Agents | 1995 |
Activation by levcromakalim and metabolic inhibition of glibenclamide-sensitive K channels in smooth muscle cells of pig proximal urethra.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urethra; Vasodilator Agents | 1996 |
Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle.
Topics: 4-Aminopyridine; Action Potentials; Animals; Benzopyrans; Cromakalim; Cytosol; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rabbits; Rats; Sodium; Strophanthidin; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Comparative cardioprotective effects of cromakalim and diltiazem in ischemic hypertrophied rat hearts.
Topics: Animals; Benzopyrans; Blood Pressure; Cardiomegaly; Cromakalim; Diltiazem; Heart; Heart Rate; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Ventricular Function, Left | 1996 |
Pharmacological coupling and functional role for CGRP receptors in the vasodilation of rat pial arterioles.
Topics: Animals; Arterioles; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Cyclic AMP; Immune Sera; Isoproterenol; Peptide Fragments; Pia Mater; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Vasodilation | 1996 |
Activators of sodium, calcium and potassium channels modulate the cardiac effects of quinidine in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Azetidines; Benzopyrans; Calcium Channel Agonists; Cardiotonic Agents; Cardiovascular Agents; Cromakalim; Drug Combinations; Guinea Pigs; Heart; Heart Atria; Hemodynamics; In Vitro Techniques; Male; Papillary Muscles; Potassium Channels; Pyrroles; Quinidine; Sodium Channels | 1995 |
Cromakalim differentially enhances antinociception induced by agonists of alpha(2)adrenoceptors, gamma-aminobutyric acid(B), mu and kappa opioid receptors.
Topics: Animals; Baclofen; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain; Pyrroles; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 1996 |
A comparison between the effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog.
Topics: Animals; Anti-Arrhythmia Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cardiotonic Agents; Cromakalim; Dogs; Electrophysiology; Guanidines; Heart; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Ischemia; Potassium Channels; Pyrroles; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Refractory Period, Electrophysiological; Species Specificity | 1995 |
Acute hypoxic vasoconstriction in isolated rat small and large pulmonary arteries.
Topics: Acute Disease; Amlodipine; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Endothelium, Vascular; Hypoxia; In Vitro Techniques; Male; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1995 |
The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diaphragm; Electrophysiology; Glyburide; Guanidines; Guinea Pigs; Indoles; Male; Membrane Potentials; Muscle Contraction; Muscle Tonus; Phentolamine; Pinacidil; Potassium Channels; Pyrroles | 1996 |
Effect of the K+ channel openers NIP-121 and cromakalim on melittin-induced relaxation of guinea-pig isolated trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Epithelium; Guinea Pigs; Histamine; Indomethacin; Leukotriene D4; Male; Melitten; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Phospholipases A; Phospholipases A2; Piperidines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Thromboxane A2; Trachea | 1996 |
Inhibition of food intake in rats by the K+ channel opener cromakalim.
Topics: Animals; Benzopyrans; Cromakalim; Depression, Chemical; Diet; Eating; Gastric Emptying; Male; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Taste; Vagotomy | 1996 |
Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Vasodilator Agents; Verapamil | 1996 |
In vitro hypoxia on rat pulmonary artery: effects on contractions to spasmogens and role of KATP channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Hypoxia; In Vitro Techniques; Male; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery.
Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Clotrimazole; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hepatic Artery; Indomethacin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Potassium Channels; Proadifen; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1996 |
Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hydrogen-Ion Concentration; Kinetics; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Sodium Cyanide; Vasodilator Agents | 1996 |
Effects of glibenclamide on the regional haemodynamic actions of alpha-trinositol and its influence on responses to vasodilators in conscious rats.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Blood Glucose; Bradykinin; Cromakalim; Glyburide; Hemodynamics; Hindlimb; Hypoglycemic Agents; Inositol Phosphates; Male; Nitroprusside; Platelet Aggregation Inhibitors; Potassium Channels; Pyrroles; Rats; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Vasodilator Agents | 1996 |
Contribution of calcium-activated potassium channels to the vasodilator effect of bradykinin in the isolated, perfused kidney of the rat.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Bradykinin; Calcium; Cromakalim; Endothelium, Vascular; In Vitro Techniques; Kidney; Male; Nitric Oxide; Nitroprusside; Potassium Channels; Prostaglandin Antagonists; Pyrroles; Rats; Rats, Wistar; Renal Circulation; Vasodilation; Vasodilator Agents | 1996 |
Comparative effects of intravesical versus extravesical administration of ZD6169 and cromakalim on the response of the in vitro rat whole bladder to field stimulation.
Topics: Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1996 |
Three components of potassium outward current in cells isolated from the circular layer of guinea-pig ileum.
Topics: Animals; Apamin; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Ileum; Male; Membrane Potentials; Muscle, Smooth; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Pyrroles | 1995 |
ATP-sensitive K+ channel openers block sulpiride-induced dopamine release in the rat striatum.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Microdialysis; Monoamine Oxidase Inhibitors; Neostriatum; Nerve Endings; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Substantia Nigra; Sulpiride; Vasodilator Agents | 1996 |
Modulation of vasorelaxant responses to potassium channel openers by basal nitric oxide in the rat isolated superior mesenteric arterial bed.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Papaverine; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Stereoisomerism; Theophylline; Vasodilation; Vasodilator Agents | 1996 |
Hemodynamic and cardiac effects of BMS-180448, a novel K+ATP opener, in anesthetized dogs and isolated rat hearts.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Benzopyrans; Blood Pressure; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Guanidines; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Myocardial Contraction; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vascular Resistance | 1996 |
Implication of ATP-sensitive K+ channels in various stress-induced analgesia (SIA) in mice.
Topics: Adenosine Triphosphate; Analgesia; Animals; Benzopyrans; Cromakalim; Glyburide; Male; Mice; Potassium Channels; Pyrroles; Stress, Physiological | 1996 |
Modulation of vascular KATP channels in hypothyroidism.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Hypothyroidism; Male; Pinacidil; Portal Vein; Potassium Channels; Pyrroles; Rats; Vasodilator Agents | 1996 |
Pharmacodynamic behaviour of isolated resistance vessels obtained from hypertensive-diabetic rats.
Topics: Animals; Benzopyrans; Blood Glucose; Calcium Channels; Calcium Chloride; Cromakalim; Glyburide; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Methacholine Chloride; Methoxamine; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitroprusside; Norepinephrine; Obesity; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Zucker; Serotonin; Tunica Media; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim.
Topics: Acetylcholine; Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Capsaicin; Charybdotoxin; Cromakalim; Electric Stimulation; Female; Glyburide; Guinea Pigs; Humans; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurokinin A; Nitroprusside; Osmolar Concentration; Parasympatholytics; Potassium Channel Blockers; Potassium Channels; Pyrazines; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds | 1996 |
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Bronchi; Bronchodilator Agents; Calcium; Cardiotonic Agents; Cromakalim; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Leukocyte Elastase; Leukotriene B4; Muscle Relaxation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoric Diester Hydrolases; Pyrazines; Pyrroles; Pyrrolidinones; Rolipram; Superoxides | 1996 |
Anti- and proconvulsive actions of levcromakalim, an opener of ATP-sensitive K+ channel, in the model of hippocampus-generating partial seizures in rats.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Convulsants; Cromakalim; Dentate Gyrus; Electric Stimulation; Electroencephalography; Epilepsies, Partial; Glyburide; Hippocampus; Hypoglycemic Agents; Injections, Intraventricular; Male; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Tetraethylammonium Compounds; Tumor Cells, Cultured | 1996 |
Possible mechanism of the potent vasoconstrictor responses to ryanodine in dog cerebral arteries.
Topics: Animals; Benzopyrans; Caffeine; Calcium; Calcium Channel Blockers; Cerebral Arteries; Cromakalim; Dogs; Female; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nifedipine; Phosphodiesterase Inhibitors; Potassium; Pyrroles; Ryanodine; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Calcimycin; Calcium; Calcium Channel Blockers; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1996 |
Effect of inhibition of the electrogenic Na+/K+ pump on the mechanical activity in the rat uterus.
Topics: Acetylcholine; Animals; Benzopyrans; Calcium; Cromakalim; Enzyme Inhibitors; Female; In Vitro Techniques; Ouabain; Oxytocin; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Uterine Contraction; Uterus | 1996 |
Allergic responses reduce the relaxant effect of beta-agonists but not potassium channel openers in guinea-pig isolated trachea.
Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Immunization; Isometric Contraction; Isoproterenol; Male; Muscle, Smooth; Ovalbumin; Potassium Channels; Pyrroles; Receptors, Adrenergic, beta; Respiratory Hypersensitivity; Theophylline; Trachea | 1996 |
Effects of cromakalim and glibenclamide in ischemic and reperfused hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Diabetes Mellitus, Experimental; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrroles; Rats; Rats, Sprague-Dawley | 1996 |
Activation of vascular thrombin receptors mediates cardiac response to alpha-thrombin in isolated, perfused guinea pig heart.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Guinea Pigs; Heart; Hirudins; In Vitro Techniques; Male; Peptide Fragments; Perfusion; Protease Inhibitors; Pyrroles; Receptors, Thrombin; Thrombin; Vasodilator Agents; Ventricular Function, Left | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
Mechanical and energetic effects of cromakalim on guinea pig left ventricular papillary muscle.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Energy Metabolism; Guinea Pigs; Myocardial Contraction; Papillary Muscles; Potassium Channels; Pyrroles; Ventricular Function, Left | 1996 |
Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig.
Topics: Adenosine Triphosphate; Amides; Animals; Benzophenones; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Enzyme Activation; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle, Smooth; Potassium Channels; Protein Kinase C; Pyrroles; Urinary Bladder | 1996 |
Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Diazoxide; Guanosine Diphosphate; Guanosine Triphosphate; Magnesium; Mitochondria, Liver; Palmitoyl Coenzyme A; Potassium; Potassium Channel Blockers; Pyrroles; Rats | 1996 |
Acute simulated ischaemia produces both inhibition and activation of K+ currents in isolated ventricular myocytes.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardium; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Sodium-Potassium-Exchanging ATPase | 1996 |
Prevention by cromakalim of spontaneously occurring cardiac necroses in polymyopathic hamsters.
Topics: Animals; Benzopyrans; Cardiomyopathies; Creatine Kinase; Cricetinae; Cromakalim; Female; Male; Myocardium; Necrosis; Parasympatholytics; Potassium Channels; Pyrroles | 1996 |
Potassium channel modulation: a new drug principle for regulation of smooth muscle contractility. Studies on isolated airways and arteries.
Topics: Animals; Arteries; Asthma; Benzopyrans; Bronchi; Cardiovascular Diseases; Cromakalim; Female; Guinea Pigs; Humans; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Sulfonylurea Compounds; Synaptic Transmission; Trachea; Vasodilator Agents | 1996 |
alpha 1-Adrenoceptor stimulation partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells: attenuation of the action potential shortening induced by hypoxia and K+ channel openers.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Female; Guinea Pigs; Heart; Heart Ventricles; Hypoxia; Male; Methoxamine; Niacinamide; Nicorandil; Papillary Muscles; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Ventricular Function | 1996 |
The relaxant effect of extract of Phyllanthus urinaria in the guinea-pig isolated trachea. Evidence for involvement of ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Apamin; Benzopyrans; Calcitonin Gene-Related Peptide; Calcium; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Plant Extracts; Plants, Medicinal; Potassium Channels; Potassium Chloride; Propranolol; Pyrroles; Tetraethylammonium; Tetraethylammonium Compounds; Trachea | 1996 |
KATP channels mediate adenosine-induced hyperemia in retina.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fluorescein Angiography; Glyburide; Hyperemia; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Pyrroles; Regional Blood Flow; Retinal Vessels; Second Messenger Systems; Signal Transduction; Swine; Vasodilation; Vasodilator Agents | 1996 |
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Involvement of K+ channel modulation in the proabsorptive effect of nitric oxide in the rat jejunum in vivo.
Topics: Animals; Benzopyrans; Biological Transport; Cromakalim; Female; Jejunum; Nitric Oxide; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1996 |
The effect of the potassium channel activator, cromakalim, on antidepressant drugs in the forced swimming test in mice.
Topics: Amitriptyline; Animals; Antidepressive Agents; Benzopyrans; Cromakalim; Desipramine; Drug Interactions; Imipramine; Locomotion; Male; Mianserin; Mice; Minoxidil; Paroxetine; Physical Exertion; Potassium Channels; Pyrroles; Swimming | 1996 |
Relaxant effect of levcromakalim in isolated human small subcutaneous arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Adolescent; Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Humans; In Vitro Techniques; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Skin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Swine; Urethra | 1997 |
Inhibition by hydroxyl radicals of calcitonin gene-related peptide-mediated neurogenic vasorelaxation in isolated canine lingual artery.
Topics: Animals; Benzopyrans; Calcitonin Gene-Related Peptide; Cromakalim; Cyclic GMP; Dogs; Female; Humans; Hydroxyl Radical; In Vitro Techniques; Male; Potassium Channels; Pyrroles; Vasodilation | 1997 |
Age-related changes in response of brain stem vessels to opening of ATP-sensitive potassium channels.
Topics: Aging; Analysis of Variance; Animals; Antihypertensive Agents; Basilar Artery; Benzopyrans; Brain Stem; Cromakalim; Ion Channel Gating; Male; Muscle Development; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1997 |
The effects of cromakalim on the mediator releases from guinea pig lung mast cell activated by specific antigen-antibody reactions.
Topics: Adenylyl Cyclases; Animals; Antigen-Antibody Reactions; Benzopyrans; Cromakalim; Diglycerides; Female; Guinea Pigs; Histamine Release; Leukotrienes; Lung; Mast Cells; Methylation; Phospholipase D; Phospholipids; Potassium Channels; Pyrroles | 1996 |
The effects of cetiedil and its congeners on levcromakalim-stimulated 86Rb efflux from smooth and skeletal muscle.
Topics: Animals; Antisickling Agents; Aorta, Thoracic; Azepines; Benzopyrans; Cromakalim; Erythrocyte Membrane; In Vitro Techniques; Male; Muscle, Skeletal; Muscle, Smooth; Potassium Channels; Pyrroles; Rana temporaria; Rats; Rats, Sprague-Dawley; Rubidium; Rubidium Radioisotopes; Vasodilator Agents | 1996 |
Inhibition of contractile responses of human myometrium and intramyometrial arteries by potassium channel openers.
Topics: Adult; Arteries; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Guanidines; Humans; In Vitro Techniques; Isometric Contraction; Muscle, Smooth, Vascular; Myometrium; Pinacidil; Potassium Channels; Pyrroles; Uterine Contraction; Vasodilator Agents | 1996 |
Regional hemodynamic dose-response of lemakalim and glybenclamide in anesthetized rats.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Benzopyrans; Blood Circulation; Blood Pressure; Coronary Circulation; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hindlimb; Male; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Renal Circulation; Splanchnic Circulation; Vascular Resistance | 1997 |
Comparison of proarrhythmogenic effects of two potassium channel openers, levcromakalim (BRL 38227) and nicorandil (RP 46417): a high-resolution mapping study on rabbit heart.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Bradycardia; Cromakalim; Dose-Response Relationship, Drug; Electrophysiology; Heart; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Rabbits; Tachycardia; Vasodilator Agents; Ventricular Fibrillation | 1997 |
ATP-sensitive potassium channels in isolated rat aorta during physiologic, hypoxic, and low-glucose conditions.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Glyburide; Hypoglycemia; Hypoxia; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1997 |
Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat.
Topics: Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cromakalim; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Free Radical Scavengers; Heart; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; Indomethacin; Kidney Cortex; Luminescent Measurements; Male; Microsomes; Nitric Oxide; Nitroarginine; Parasympatholytics; Perfusion; Pyrazines; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasodilator Agents | 1997 |
Cromakalim blocks the purinergic response evoked in rat vas deferens by single-pulse electrical stimulation.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; Male; Norepinephrine; Potassium Channels; Prazosin; Pyrroles; Rats; Rats, Wistar; Suramin; Vas Deferens | 1997 |
Similarity of ATP-dependent K+ channels in skeletal muscle fibres from normal and mutant mdx mice.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Neural Conduction; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Sarcolemma | 1997 |
AMPA receptors modulate extracellular 5-hydroxytryptamine concentration and metabolism in rat striatum in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; Benzopyrans; Corpus Striatum; Cromakalim; Diazoxide; Excitatory Amino Acid Antagonists; Hydroxyindoleacetic Acid; Male; Pyrroles; Rats; Rats, Wistar; Receptors, AMPA; Serotonin; Vasodilator Agents | 1997 |
Endothelium-mediated and N omega-nitro-L-arginine methyl ester-sensitive responses to cromakalim and diazoxide in the rat mesenteric bed.
Topics: Adrenergic alpha-Agonists; Animals; Benzopyrans; Cromakalim; Diazoxide; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Wistar; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1997 |
Involvement of K+ channels in the relaxant effect of vasoactive intestinal peptide and atrial natriuretic peptide in isolated guinea-pig trachea.
Topics: Adenosine Triphosphate; Animals; Atrial Natriuretic Factor; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guinea Pigs; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea; Vasoactive Intestinal Peptide | 1997 |
Hypoxic dilatation of porcine small coronary arteries: role of endothelium and KATP-channels.
Topics: Animals; Benzopyrans; Cell Hypoxia; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Pyrroles; Swine; Vasodilation | 1997 |
Anti-ulcer activity of cromakalim (BRL 34915), a potassium-channel opener, against experimentally induced gastric and duodenal ulcers in rats and guinea-pigs.
Topics: Animals; Aspirin; Benzopyrans; Cromakalim; Duodenal Ulcer; Female; Guinea Pigs; Histamine; Male; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Stomach Ulcer | 1997 |
Effects of tolbutamide on ATP-sensitive K+ channels from human right atrial cardiac myocytes.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Atrial Function, Right; Benzopyrans; Child; Cromakalim; Drug Interactions; Female; Heart Atria; Humans; Hypoglycemic Agents; Kinetics; Male; Membrane Potentials; Middle Aged; Myocardial Ischemia; Myocardium; Potassium Channels; Pyrroles; Sensitivity and Specificity; Tolbutamide | 1997 |
Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Bradykinin; Calcium; Cattle; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Membrane Potentials; Microelectrodes; Microscopy, Video; Oxygen; Perfusion; Pyrroles; Vascular Resistance; Vasodilation; Vasodilator Agents | 1997 |
Structure-activity relationship of quaternary ion antagonism of levcromakalim-induced relaxation in pig coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzopyrans; Chemical Phenomena; Chemistry, Physical; Coronary Vessels; Cromakalim; Guanethidine; In Vitro Techniques; Ions; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Quaternary Ammonium Compounds; Structure-Activity Relationship; Swine; Tetraphenylborate; Thromboxane A2; Uncoupling Agents; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Cardiovascular responses to glibenclamide during endotoxaemia in the pig.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cardiac Output; Cardiovascular Physiological Phenomena; Cardiovascular System; Cromakalim; Endotoxemia; Endotoxins; Female; Glyburide; Hemodynamics; Hydrogen-Ion Concentration; Hypoglycemic Agents; Infusion Pumps; Infusions, Intravenous; Injections; Male; Potassium Channels; Pyrroles; Swine; Swine Diseases; Time Factors; Vascular Resistance | 1997 |
Effect of cromakalim on ischemic and reperfused immature heart: experiments with isolated neonatal New Zealand white rabbit hearts.
Topics: Animals; Animals, Newborn; Benzopyrans; Cromakalim; In Vitro Techniques; Myocardial Contraction; Myocardial Reperfusion Injury; Potassium; Potassium Channels; Pyrroles; Rabbits; Sodium | 1996 |
Halothane and enflurane attenuate pulmonary vasodilation mediated by adenosine triphosphate-sensitive potassium channels compared to the conscious state.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Consciousness; Cromakalim; Dogs; Dose-Response Relationship, Drug; Enflurane; Glyburide; Halothane; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Vasodilation | 1997 |
Effects of levcromakalim and nucleoside diphosphates on glibenclamide-sensitive K+ channels in pig urethral myocytes.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Female; Glyburide; In Vitro Techniques; Magnesium; Muscle, Smooth; Potassium Channels; Pyrroles; Swine; Urethra; Uridine Diphosphate | 1997 |
Enhancement of the ATP-sensitive K+ current by extracellular ATP in rat ventricular myocytes. Involvement of adenylyl cyclase-induced subsarcolemmal ATP depletion.
Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Animals; Benzopyrans; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Colforsin; Cromakalim; Deoxyadenine Nucleotides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; GTP-Binding Proteins; Guanidines; Guanosine Triphosphate; Heart Ventricles; Male; Patch-Clamp Techniques; Peptide Fragments; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Uncoupling Agents | 1997 |
Beta 2-adrenergic dilation of resistance coronary vessels involves KATP channels and nitric oxide in conscious dogs.
Topics: Acetylcholine; Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Enzyme Inhibitors; Ethanolamines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Potassium Channel Blockers; Potassium Channels; Pyrroles; Vascular Resistance; Vasodilation; Vasodilator Agents | 1997 |
Modulation of K+ channels by intracellular ATP in human neocortical neurons.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Cortex; Cromakalim; Electrophysiology; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley | 1997 |
Effect of JTV-506, a novel vasodilator, on coronary blood flow in conscious dogs.
Topics: Administration, Oral; Animals; Benzopyrans; Blood Pressure; Chromans; Coronary Circulation; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Pyrroles; Vasodilator Agents | 1997 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Wistar; Tumor Cells, Cultured | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Cromakalim; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Glyburide; Guanidines; Heart Rate; Male; Myocardial Reperfusion Injury; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Survival Rate; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Role of activation of calcium-sensitive K+ channels in NO- and hypoxia-induced pial artery vasodilation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Arterioles; Benzimidazoles; Benzopyrans; Cerebral Arteries; Cromakalim; Cyclic GMP; Female; Hypoxia; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Penicillamine; Pia Mater; Potassium Channels; Pyrroles; S-Nitroso-N-Acetylpenicillamine; Swine; Vasodilation; Vasodilator Agents | 1997 |
The thromboxane A2 and K(ATP) channel antagonist actions of a series of sulphonylurea derivatives in the pig coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; Onium Compounds; Organophosphorus Compounds; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Structure-Activity Relationship; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Novel effects of guanidine on the neuromuscular junction.
Topics: 4-Aminopyridine; Animals; Benzopyrans; Calcium; Chickens; Cromakalim; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Guanidine; Guanidines; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Junction; Potassium Channels; Pyrroles | 1997 |
The role of a cAMP-dependent pathway in the uterine relaxant action of relaxin in rats.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP-Dependent Protein Kinases; Female; In Vitro Techniques; Isoquinolines; Myometrium; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Relaxin; Signal Transduction; Uterine Contraction; Uterus | 1997 |
Effects of putative K+ channel blockers on beta-adrenoceptor-mediated vasorelaxation of rat mesenteric artery.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Barium; Benzopyrans; Calcium; Charybdotoxin; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fenoterol; Glyburide; Isoproterenol; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Potassium Channel Blockers; Pyrroles; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Characterization of ATP-sensitive potassium channels in freshly dissociated rabbit aortic endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Electric Conductivity; Endothelium, Vascular; Glyburide; In Vitro Techniques; Ion Channel Gating; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Rabbits | 1997 |
The effect of cromakalim on intracellular [Ca2+] in isolated rat skeletal muscle during fatigue and metabolic blockade.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Cyanides; In Vitro Techniques; Intracellular Fluid; Iodoacetates; Iodoacetic Acid; Male; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Osmolar Concentration; Potassium Channels; Pyrroles; Rats; Rats, Wistar | 1997 |
Halothane inhibits endothelium-dependent relaxation elicited by acetylcholine in human isolated pulmonary arteries.
Topics: Acetylcholine; Adenylyl Cyclases; Anesthetics, Inhalation; Benzopyrans; Colforsin; Cromakalim; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Halothane; Humans; Immunoglobulin E; In Vitro Techniques; Nitroprusside; Pulmonary Artery; Pyrroles; Vasodilator Agents | 1997 |
In vitro studies on the interactions of beta2-adrenoceptor agonists, methylxanthines, Ca2+-channel blockers, K+-channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea.
Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Isradipine; Male; Muscle Relaxation; Muscle, Smooth; Nitroprusside; Potassium Channels; Pyrroles; Regression Analysis; Terbutaline; Theophylline; Trachea; Vasodilator Agents | 1997 |
Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells.
Topics: Animals; Benzopyrans; Buffers; Calcium; Carotid Body; Catecholamines; Cell Hypoxia; CHO Cells; Chromaffin Cells; Cricetinae; Cromakalim; Diazoxide; Glioma; Glyburide; Guanidines; Hybrid Cells; Hypoglycemic Agents; Male; Membrane Potentials; Minoxidil; Neuroblastoma; Parasympatholytics; Patch-Clamp Techniques; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure.
Topics: Animals; Benzopyrans; Blood Pressure; Bronchodilator Agents; Chromans; Cromakalim; Guinea Pigs; Histamine; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth; Potassium Channels; Pyrroles; Trachea | 1997 |
Effects of cromakalim and glibenclamide on myocardial high energy phosphates and intracellular pH during ischemia-reperfusion: 31P NMR studies.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzopyrans; Coronary Circulation; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Glyburide; Hydrogen-Ion Concentration; Hydroxy Acids; Hypoglycemic Agents; In Vitro Techniques; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Phosphorus Isotopes; Pyrroles; Rats; Rats, Sprague-Dawley | 1997 |
Extracellular Mg++ manipulation prevents the proarrhythmic activity of cromakalim in ischemic/reperfused diabetic hearts.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Calcium; Cromakalim; Diabetes Mellitus, Experimental; Heart; Magnesium; Male; Myocardial Ischemia; Myocardial Reperfusion; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium; Streptozocin | 1997 |
Capacitative Ca2+ entry associated with alpha1-adrenoceptors in rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Tonus; Nimodipine; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetraethylammonium Compounds | 1997 |
Kinetics of bupivacaine after levcromakalim treatment in mice.
Topics: Anesthetics, Local; Animals; Benzopyrans; Bupivacaine; Cromakalim; Drug Synergism; Male; Mice; Pyrroles; Vasodilator Agents | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
KRN4884, a novel K channel opener: antihypertensive effects in conscious renal hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Female; Hypertension, Renal; Male; Nifedipine; Potassium Channels; Pyridines; Pyrroles | 1997 |
Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries.
Topics: Acetylcholine; Animals; Benzopyrans; Biological Factors; Cromakalim; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Mesenteric Arteries; Miconazole; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Proadifen; Pyrroles; Rats; Rats, Wistar; Triazoles; Vasodilator Agents | 1997 |
Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
Topics: Adenosine Triphosphate; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antitussive Agents; Aorta, Thoracic; Benzopyrans; Blood Pressure; Cromakalim; Dipeptides; Glyburide; Guinea Pigs; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Role of ATP-sensitive K+ channels in ischemic preconditioning of skeletal muscle against infarction.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Energy Metabolism; Hypoxanthine; Infarction; Ischemic Preconditioning; Muscle, Skeletal; Phosphocreatine; Potassium Channels; Pyrroles; Reperfusion; Surgical Flaps; Swine; Vasodilator Agents; Xanthine; Xanthines | 1997 |
Vasodilator responses to acetylcholine, bradykinin, and substance P are mediated by a TEA-sensitive mechanism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Albuterol; Alprostadil; Analysis of Variance; Angiotensin II; Animals; Benzopyrans; Blood Pressure; Bradykinin; Cats; Cromakalim; Endothelium, Vascular; Female; Glyburide; Heart Rate; Hindlimb; Hydrazines; Isradipine; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitrogen Oxides; Nitroprusside; Norepinephrine; Penicillamine; Prostaglandin Endoperoxides, Synthetic; Pyrroles; S-Nitroso-N-Acetylpenicillamine; Substance P; Tetraethylammonium; Tetraethylammonium Compounds; Thromboxane A2; Vasoactive Intestinal Peptide; Vasodilation; Vasodilator Agents | 1997 |
Bradykinin, lemakalim and sodium nitroprusside relax the mouse trachea in vitro by different mechanisms.
Topics: Animals; Benzopyrans; Bradykinin; Cromakalim; Female; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Nitroprusside; Potassium Channels; Pyrroles; Trachea | 1997 |
Pulmonary vasoreactivity to serotonin during hypoxia is modulated by ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Arteries; Benzopyrans; Blood Pressure; Capillaries; Cromakalim; Dogs; Female; Hypoxia; Male; Potassium Channels; Pulmonary Circulation; Pyrroles; Serotonin; Serotonin Antagonists; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents; Veins | 1997 |
Selectivity of BMS-180448 on myocardial versus brain blood flow in dogs and ferrets.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cerebrovascular Circulation; Coronary Circulation; Cromakalim; Dogs; Electrophysiology; Ferrets; Guanidines; Hemodynamics; Male; Potassium Channels; Pyrroles; Vasodilator Agents | 1997 |
Muscarinic receptors inhibit ATP-sensitive K+ channels in swine tracheal smooth muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electric Conductivity; Male; Muscle, Smooth; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Pyrroles; Receptors, Muscarinic; Swine; Trachea | 1997 |
Effects of cGMP and the nitric oxide donors glyceryl trinitrate and sodium nitroprusside on contractions in vitro of isolated myometrial tissue from pregnant women.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Myometrium; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Pregnancy; Pyrroles; Uterine Contraction; Vasodilator Agents; Verapamil | 1997 |
Mediation of neuronal apoptosis by enhancement of outward potassium current.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzopyrans; Calcium; Cerebral Cortex; Cromakalim; Cycloheximide; Cysteine Proteinase Inhibitors; Gadolinium; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Nifedipine; Patch-Clamp Techniques; Potassium; Potassium Channels; Pyrroles; Staurosporine; Tetraethylammonium; Tetraethylammonium Compounds; Veratridine | 1997 |
Relaxant effects of potassium-channel openers on normal and hyper-reflexic detrusor muscle.
Topics: Benzopyrans; Benzoxazines; Carbachol; Cromakalim; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Muscle Relaxation; Oxazines; Parasympatholytics; Potassium Channels; Pyrroles; Reflex, Abnormal; Urinary Bladder | 1997 |
Halothane attenuates endothelium-dependent pulmonary vasorelaxant response to lemakalim, an adenosine triphosphate (ATP)-sensitive potassium channel agonist.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Cromakalim; Dogs; Endothelium, Vascular; Glyburide; Halothane; Humans; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasodilator Agents | 1997 |
Role of ATP-sensitive potassium channels in brain stem circulation during hypotension.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arterioles; ATP-Binding Cassette Transporters; Basilar Artery; Benzopyrans; Blood Pressure; Brain Stem; Carbon Dioxide; Coronary Circulation; Cromakalim; Glyburide; Homeostasis; Hypotension; KATP Channels; Male; Oxygen; Partial Pressure; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilation | 1997 |
Importance of location and timing of electrical stimuli in terminating sustained functional reentry in isolated swine ventricular tissues: evidence in support of a small reentrant circuit.
Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cromakalim; Electric Countershock; Electrocardiography; Electrophysiology; Heart Conduction System; In Vitro Techniques; Muscle Fibers, Skeletal; Pacemaker, Artificial; Pyrroles; Swine; Tachycardia, Atrioventricular Nodal Reentry | 1997 |
Cardiovascular pharmacology of SKP-450, a new potassium channel activator, and its major metabolites SKP-818 and SKP-310.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Pyrroles; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1998 |
Antihypertensive effects of the novel potassium channel activator SKP-450 and its major metabolites in rats.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Desoxycorticosterone; Heart Rate; Hypertension; Hypertension, Renal; Male; Potassium Channels; Pyrroles; Pyrrolidinones; Rats; Rats, Inbred SHR; Vasodilator Agents | 1998 |