pyrroles has been researched along with colchicine in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 14 (50.00) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Devis, G; Malaisse, WJ; Malaisse-Lagae, F; Ravazzola, M; Somers, G; Van Obberghen, E | 1 |
| Abe, K; Misawa, M | 1 |
| SERVIERE, P | 1 |
| Chen, Z; Kovar, P; Lin, NH; Merta, PJ; Sham, HL; Tahir, SK; Zhang, H | 1 |
| Boiadjiev, SE; Lightner, DA; McDonagh, AF; Norona, WS; Woydziak, ZR | 1 |
| Campiani, G; Cloonan, S; Fattorusso, C; Greene, LM; Lawler, M; Mc Gee, MM; Mulligan, JM; Onnis, V; Williams, DC; Zisterer, DM | 1 |
| Nidorf, M; Thompson, PL | 1 |
| Banner, EJ; Brown, ML; Dakshanamurthy, S; Gupton, JT; Hamel, E; Hempel, J; Kharlamova, A; Mooberry, SL; Weiderhold, KN | 1 |
| Chapman, J; Gaus, K; Guo, DL; Hill, M; Huby, T; Jary, E; Jessup, W; Kay, J; Kockx, M; Kritharides, L; Lesnik, P; Sabaretnam, T; Stow, JL | 1 |
| Fornabaio, M; Gewirtz, DA; Gupton, JT; Kellogg, GE; Mooberry, SL; Tripathi, A; Vega, NE; Yeudall, WA | 1 |
| Dalyot-Herman, N; Delgado-Lopez, F; Gewirtz, DA; Gupton, JT; Schwartz, EL | 1 |
| Bonbled, F; Hantson, P; Huberlant, V; Montiel, V; Vincent, MF | 1 |
| Gangjee, A; Hamel, E; Lin, L; Mooberry, SL; Raghavan, S; Risinger, AL; Roberts, EG; Zhao, Y | 1 |
| Gangjee, A; Hamel, E; Li, W; Mooberry, SL; Pavana, RK; Westbrook, C | 1 |
| Enache, I; Garrouste, C; Heng, AE; Kaysi, S; Philipponnet, C; Tiple, A | 1 |
| Abodunde, OA; Berrou, M; Desai, R; LevakaVeera, RR; Nweke, N | 1 |
| Deodhar, A | 1 |
| Davis, MW; Wason, S | 1 |
| Cen, C; Ding, X; Huang, C; Wang, C; Zhan, H | 1 |
| Alfonsi, R; Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Mazzoccoli, C; Mercurio, C; Miele, A; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Rensen, WM; Ruggieri, V; Silvestri, R; Sisinni, L; Varasi, M; Vultaggio, S | 1 |
| Basso, G; Bortolozzi, R; Carta, D; Ferlin, MG; Hamel, E; Moro, S; Viola, G | 1 |
| Da, C; Gupton, JT; Kellogg, GE; Mooberry, SL; Risinger, AL; Rohena, CC; Sikorski, JA; Telang, NS | 1 |
| Beauvineau, C; Busser, B; Coll, JL; Falson, P; Fernando Díaz, J; Frachet, V; Gilson, P; Hurbin, A; Josa-Prado, F; Lafanechère, L; Mahuteau-Betzer, F; Moreno, A; Naud-Martin, D; Vanwonterghem, L | 1 |
| Azad, N; Iyer, AKV; Kaushik, V; Way, LF; Yakisich, JS | 1 |
| Baulin, V; Busser, B; Coll, JL; Couvet, M; Gilson, P; Henry, M; Hurbin, A; Josserand, V; Lafanechère, L; Mahuteau-Betzer, F; Orlowska, A; Vanwonterghem, L; Vollaire, J; Werner, M | 1 |
| Bortolozzi, R; Brancale, A; Ferla, S; Hamel, E; Maccarinelli, F; Manfredini, S; Mariotto, E; Oliva, P; Padroni, C; Romagnoli, R; Ronca, R; Rruga, F; Salvador, MK; Viola, G | 1 |
| Aukhadieva, A; Bikinieva, F; Boichuk, S; Dunaev, P; Galembikova, A; Gankova, K; Igidov, N; Kopnin, P; Novikova, M; Syuzov, K; Zykova, S | 1 |
| Bikinieva, F; Boichuk, S; Galembikova, A; Gankova, K; Igidov, N; Igidov, S; Syuzov, K; Zykova, S | 1 |
2 trial(s) available for pyrroles and colchicine
| Article | Year |
|---|---|
Effect of colchicine (0.5 mg twice daily) on high-sensitivity C-reactive protein independent of aspirin and atorvastatin in patients with stable coronary artery disease.
Topics: Aspirin; Atorvastatin; Biomarkers; C-Reactive Protein; Colchicine; Coronary Angiography; Coronary Artery Disease; Drug Administration Schedule; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Pyrroles; Treatment Outcome | 2007 |
Effect of steady-state atorvastatin on the pharmacokinetics of a single dose of colchicine in healthy adults under fasted conditions.
Topics: Adult; Anticholesteremic Agents; Area Under Curve; Atorvastatin; Colchicine; Drug Interactions; Fasting; Female; Gout Suppressants; Healthy Volunteers; Heptanoic Acids; Humans; Male; Pyrroles; Young Adult | 2014 |
26 other study(ies) available for pyrroles and colchicine
| Article | Year |
|---|---|
Dynamics of insulin release and microtubular-microfilamentous system. IV. Effect of colchicine upon sulphonylurea-induced insulin secretion.
Topics: Animals; Colchicine; Cyclopentanes; Drug Synergism; Hypoglycemic Agents; Insulin; Insulin Secretion; Microtubules; Pancreas; Perfusion; Pyrroles; Rats; Stimulation, Chemical; Sulfonylurea Compounds; Time Factors | 1974 |
Astrocyte stellation induced by Rho kinase inhibitors in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Amides; Animals; Astrocytes; Carbazoles; Cell Size; Cells, Cultured; Cerebral Cortex; Colchicine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gout Suppressants; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Phalloidine; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; rho-Associated Kinases | 2003 |
[CONTRACTURE OF THE ANAL SPHINCTER AND ITS TREATMENT. (APROPOS OF 108 CASES)].
Topics: Anal Canal; Colchicine; Contracture; Diathermy; Electrocoagulation; Fissure in Ano; Hemorrhoids; Humans; Muscle Relaxants, Central; Pyrroles; Spasm | 1963 |
A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth.
Topics: Antineoplastic Agents; Binding Sites; Binding, Competitive; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Separation; Colchicine; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; Endothelium, Vascular; Flow Cytometry; HeLa Cells; Histones; Humans; Immunohistochemistry; Indoles; Microscopy, Fluorescence; Microtubules; Models, Chemical; Neoplasm Proteins; Pyrroles; Securin; Spindle Apparatus; Time Factors; Tubulin; Tyrosine | 2005 |
Synthesis and hepatic transport of strongly fluorescent cholephilic dipyrrinones.
Topics: Animals; Bile; Bilirubin; Colchicine; Drug Evaluation, Preclinical; Feasibility Studies; Fluorescent Dyes; Liver; Liver Diseases; Male; Mitochondrial Proteins; Pyrimidinones; Pyrroles; Rats; Rats, Gunn; Rats, Sprague-Dawley; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Spectrometry, Fluorescence; Sulfonic Acids; Urine | 2005 |
Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Binding Sites; Binding, Competitive; Blotting, Western; Carbamates; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Colchicine; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; G2 Phase; Humans; K562 Cells; Metaphase; Microtubules; Oxazepines; Pyrroles; Time Factors; Tubulin; Vinblastine | 2006 |
Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Colchicine; Drug Resistance, Neoplasm; Microtubules; Models, Molecular; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Tubulin | 2007 |
Secretion of apolipoprotein E from macrophages occurs via a protein kinase A and calcium-dependent pathway along the microtubule network.
Topics: Actins; Animals; Apolipoprotein A-I; Apolipoproteins E; Calcium Signaling; Carbazoles; Carrier Proteins; Cell Line; Cell Transplantation; Chelating Agents; Colchicine; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Female; Humans; Indoles; Isoquinolines; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubules; Peptide Fragments; Protein Kinase Inhibitors; Protein Transport; Pyrroles; Sulfonamides; Time Factors; Tubulin Modulators; Vinblastine | 2007 |
Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity.
Topics: Binding Sites; Cell Proliferation; Colchicine; Ligands; Models, Molecular; Molecular Structure; Protein Subunits; Pyrroles; Structure-Activity Relationship; Tubulin | 2008 |
Interference with endothelial cell function by JG-03-14, an agent that binds to the colchicine site on microtubules.
Topics: Binding Sites; Cells, Cultured; Colchicine; Endothelium, Vascular; Focal Adhesion Protein-Tyrosine Kinases; Humans; Microtubules; Phosphorylation; Pyrroles; Wound Healing | 2009 |
Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.
Topics: Adult; Atorvastatin; Colchicine; Critical Care; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Overdose; Female; Heptanoic Acids; Humans; Multiple Organ Failure; Propofol; Pyrroles; Rhabdomyolysis | 2010 |
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cattle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Protein Binding; Pyrimidines; Pyrroles; Solubility; Stereoisomerism; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Water | 2010 |
Novel water-soluble substituted pyrrolo[3,2-d]pyrimidines: design, synthesis, and biological evaluation as antitubulin antitumor agents.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Screening Assays, Antitumor; Humans; Pyrimidines; Pyrroles; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Water | 2012 |
Severe colchicine intoxication in a renal transplant recipient on cyclosporine.
Topics: Acute Kidney Injury; Atorvastatin; Colchicine; Cyclosporine; Drug Interactions; Gout; Gout Suppressants; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Pyrroles; Quadriplegia; Rhabdomyolysis; Treatment Outcome | 2012 |
Colchicine toxicity precipitated by interaction with sunitinib.
Topics: Aged, 80 and over; Angiogenesis Inhibitors; Anti-Inflammatory Agents; Colchicine; Drug Interactions; Humans; Indoles; Male; Pyrroles; Sunitinib | 2013 |
Update in rheumatology: evidence published in 2012.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Antiviral Agents; Arthritis; Arthritis, Gouty; Arthritis, Rheumatoid; Autoimmune Diseases; Bacterial Infections; Calcitonin; Colchicine; Cryoglobulinemia; Death, Sudden, Cardiac; Drug Resistance, Viral; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Hand Joints; Hepatitis C, Chronic; Humans; Hyperuricemia; Immunologic Factors; Janus Kinase 3; Male; Myocardial Infarction; Neoplasms; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Practice Guidelines as Topic; Protein Precursors; Pyrimidines; Pyrroles; Registries; Tumor Necrosis Factor-alpha | 2013 |
Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Atorvastatin; C-Reactive Protein; Colchicine; Diet, High-Fat; Heptanoic Acids; Hyperlipidemias; Male; Nitrogen Oxides; Pyrroles; Rats; Rats, Sprague-Dawley | 2014 |
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Guanidines; Hedgehog Proteins; Humans; M Phase Cell Cycle Checkpoints; Mice; Molecular Docking Simulation; Neoplasms; Polymerization; Protein Binding; Pyrroles; Signal Transduction; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2014 |
Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Interactions; HeLa Cells; Humans; Protein Kinase Inhibitors; Pyrroles; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2015 |
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design.
Topics: Animals; Binding Sites; Colchicine; Crystallography, X-Ray; Female; HeLa Cells; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Pyrroles; Structure-Activity Relationship; Tubulin | 2016 |
Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chick Embryo; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Neoplasms, Experimental; Pyrimidines; Pyrroles; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays | 2017 |
Chemoresistance of cancer floating cells is independent of their ability to form 3D structures: Implications for anticancer drug screening.
Topics: Antibodies; Antigens, CD; Antineoplastic Agents; Cadherins; Cell Adhesion; Cell Culture Techniques; Cell Survival; Colchicine; Culture Media, Serum-Free; Drug Resistance, Neoplasm; Female; Humans; Hydroxyurea; Indoles; Male; MCF-7 Cells; Neoplasms; PC-3 Cells; Phenotype; Pyrroles; Spheroids, Cellular | 2019 |
The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo.
Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chick Embryo; Colchicine; Female; Humans; Mice, Inbred Strains; Neovascularization, Pathologic; Pyrimidines; Pyrroles; Spheroids, Cellular; Xenograft Model Antitumor Assays | 2019 |
A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents.
Topics: Antimitotic Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Polymerization; Pyrroles; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2021 |
The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Design; Female; Mice; Mice, Nude; Molecular Conformation; Molecular Docking Simulation; Molecular Structure; Pyrroles; Structure-Activity Relationship; Tubulin Modulators; Xenograft Model Antitumor Assays | 2021 |
Computational-Based Discovery of the Anti-Cancer Activities of Pyrrole-Based Compounds Targeting the Colchicine-Binding Site of Tubulin.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Humans; Microtubules; Pyrroles; Tubulin; Tubulin Modulators | 2022 |