pyrroles has been researched along with carbostyril in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.96) | 18.7374 |
| 1990's | 15 (14.42) | 18.2507 |
| 2000's | 44 (42.31) | 29.6817 |
| 2010's | 42 (40.38) | 24.3611 |
| 2020's | 2 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Anzini, M; Cagnotto, A; Cappelli, A; Skorupska, M; Vomero, S | 1 |
| Deguchi, K; Komada, F; Morita, K; Nishikawa, M; Shirakawa, S | 1 |
| Ashwood, VA; Cassidy, F; Evans, JM; Gagliardi, S; Stemp, G | 1 |
| Aki, S; Miyamoto, H; Nakagawa, K; Otsuka, T; Tamaoka, H; Tominaga, M; Ueda, H | 1 |
| Anzini, M; Botta, M; Cagnotto, A; Cappelli, A; Vomero, S | 1 |
| Cros, S; Giorgi-Renault, S; Helissey, P; Renault, J | 1 |
| Baccichetti, F; Bordin, F; Carlassare, F; Chilin, A; Guiotto, A; Marzano, C; Rodighiero, P | 1 |
| Dzwonczyk, S; Grover, GJ; McCullough, JR; Sleph, PG | 1 |
| Défago, G; Haas, D; Keel, C; Schnider, U; Voisard, C | 1 |
| Jones, RN; Marshall, SA; Zerva, L | 1 |
| Barrows, LR; Concepción, GP; Ireland, CM; Matsumoto, SS; Venables, DA | 1 |
| Salmon, SA; Sanchez, MS; Watts, JL; Yancey, RJ | 1 |
| Baccichetti, F; Bordin, F; Carlassare, F; Guiotto, A; Marzano, C | 1 |
| Aldrich, DS; Bergren, MS; Chao, RS; Dunn, MJ; Jeganathan, A; Madden, LM; Schinzer, WC | 1 |
| Huang, LJ; Kuo, SC; Raung, SL; Wang, JP | 1 |
| Barrows, LR; Haughey, HM; Holden, JA; Ireland, CM; Matsumoto, SS; Schmehl, DM; Venables, DA | 1 |
| Gosselin, F; Lubell, WD | 1 |
| Boger, DL; Boyce, CW | 1 |
| Boger, DL; Brunette, SR; Hedrick, MP; Jin, Q; Santillán, A; Searcey, M; Wolkenberg, SE | 1 |
| Tohma, H | 1 |
| Bénéteau, V; Besson, T; Pfeiffer, B; Pierré, A; Renard, P | 1 |
| Fang, W; Pearson, WH | 1 |
| Hooper, DC; Ince, D | 1 |
| Inoue, T; Kirchhoff, JR | 1 |
| Imai, S; Ishibashi, M; Ito, A; Iwasaki, T; Sakamoto, S; Yamaguchi, K | 1 |
| Boger, DL; Ellis, DA; Wolkenberg, SE | 1 |
| Kang, MJ; Park, SY; Suh, ME | 1 |
| Bifulco, G; Bruno, I; Casapullo, A; Cutignano, A; Debitus, C; Gomez-Paloma, L; Riccio, R | 1 |
| Hackl, T; Hamel, E; Lee, KH; Mauger, A; Wu, JH; Xia, P; Xia, Y; Yang, ZY | 1 |
| Alvaro, G; Bertani, B; Donati, D; Fabio, RD; Giacobbe, S; Lynn, SM; Marchioro, C; Palma, C | 1 |
| Ferguson, JW; Hayes, PC; Newby, DE; Therapondos, G | 1 |
| Katz, E; Willner, I | 1 |
| Almerico, AM; Barraja, P; Cirrincione, G; Dall'Acqua, F; Dattolo, G; Diana, P; Lauria, A; Montalbano, A; Viola, G | 1 |
| Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL | 1 |
| DeKam, RN; Fleck, TJ; McWhorter, WW; Pearlman, BA | 1 |
| Bhattacharjee, S; Clancy, J; Craig, E; Fiordeliso, JJ; Haynes-Johnson, D; Jiang, W; John, TM; Kraft, P; Lanter, JC; Macielag, MJ; Qiu, Y; Sui, Z | 1 |
| Brocca-Cofano, E; Del Vecchio, C; Fravolini, A; Gatto, B; Palù, G; Palumbo, M; Parolin, C; Richter, S | 1 |
| Doi, T; Nagabukuro, H; Okanishi, S | 1 |
| Basile, AS; Lippa, AS; Skolnick, P | 1 |
| Doi, T; Imai, S; Ishichi, Y; Ishihara, Y; Miwatashi, S; Nagabukuro, H; Okanishi, S; Saikawa, R; Sasaki, M; Setoh, M; Tsukamoto, T | 1 |
| Bhattacharjee, S; Guan, J; Haynes-Johnson, D; Jiang, W; John, TM; Kraft, P; Lundeen, S; Macielag, MJ; Qiu, Y; Sui, Z; Zhang, S | 1 |
| Doi, T; Hashimoto, T; Iwata, M; Nagabukuro, H | 1 |
| Doi, T; Nagabukuro, H | 1 |
| Doi, T; Hashimoto, T; Nagabukuro, H | 1 |
| Brun, P; Castagliuolo, I; Chiarelotto, G; Ferlin, MG; Gasparotto, V; Montanaro, D; Palù, G; Pezzi, V; Viola, G | 1 |
| Borner, MM | 1 |
| Kawamoto, Y; Sakai, T; Tomioka, K | 1 |
| Bhattachar, SN; Fioritto, AF; Wesley, JA | 1 |
| Fan, L; Raisch, KP; Shinkre, BA; Velu, SE | 2 |
| Hoang, H; Ireland, CM; LaBarbera, DV; Mohammed, KA; Skibo, EB | 1 |
| Al-Mawsawi, LQ; Dayam, R; Neamati, N | 1 |
| Castagliuolo, I; Ferlin, MG; Gasparotto, V | 1 |
| Han, HJ; Jin, YR; Kim, DW; Kim, TJ; Ryu, CK; Seo, JM; Sheen, YY; Yun, YP | 1 |
| Bag, S; Degani, MS; Tawari, NR | 1 |
| Burnett, K; Chang, WY; Chen, Y; Griffiths, KN; Hogue, A; López, FJ; Mais, DE; Marschke, K; Meglasson, MD; Pedram, B; Shen, Y; Vajda, EG; van Oeveren, A; Zhi, L | 1 |
| Chang, WY; Chen, Y; Hill, R; Lee, KJ; Lee, YH; López, FJ; Meglasson, MD; O'Brien, Z; Rix, P; Vajda, EG | 1 |
| Ezell, SJ; Murugesan, S; Nadkarni, DH; Rayburn, ER; Velu, SE; Wang, F; Wang, W; Zhang, R; Zhang, Y | 1 |
| Murugesan, S; Nadkarni, DH; Rayburn, ER; Velu, SE; Wang, W; Zhang, R | 1 |
| Barreca, ML; Chimirri, A; De Luca, L; Iraci, N | 1 |
| Feng, E; Jiang, H; Li, J; Liu, G; Liu, H; Ye, D; Zhou, Y | 1 |
| Chen, D; Murugesan, S; Nadkarni, DH; Rayburn, ER; Velu, SE; Wang, W; Zhang, R | 1 |
| Furuya, K | 1 |
| Handa, RJ; Kudwa, AE; López, FJ; McGivern, RF | 1 |
| Ezell, SJ; Gurpinar, E; Li, H; Rayburn, ER; Sommers, CI; Velu, SE; Wang, W; Xu, H; Yang, X; Zhang, R; Zhang, X | 2 |
| Blunt, JW; Copp, BR; Davies-Coleman, MT; Grkovic, T; Munro, MH; Pearce, AN | 1 |
| Chester, JD; Cooper, PA; Knowles, MA; Lamont, FR; Shnyder, SD; Tomlinson, DC | 1 |
| Alvala, M; Arunasree, MK; Iqbal, J; Islam, A; Layek, M; Mukkanti, K; Pal, M; Rao, AV; Reddy M, A | 1 |
| Barraja, P; Basso, G; Carbone, A; Cirrincione, G; Dall'Acqua, F; Diana, P; Montalbano, A; Salvador, A; Vedaldi, D; Viola, G | 1 |
| Fujioka, H; Kita, Y | 1 |
| Chen, T; Ge, S; Guo, H; Hu, P; Li, X; Liu, Y; Nadkarni, DH; Velu, SE; Wang, H; Wang, W; Xu, Y; Yang, X; Zhang, R | 1 |
| Bernhard, JC; De Clermont, H; Gross-Goupil, M; Quivy, A; Ravaud, A; Roca, S | 1 |
| Di Santo, R | 1 |
| Chapdelaine, MJ; Daskalakis, ZJ; Elmore, CS; Graff, A; Houle, S; Moran, MD; Ng, A; Parkes, J; Sadovski, O; Vasdev, N; Wilson, AA | 1 |
| Murugesan, S; Nadkarni, DH; Velu, SE; Voruganti, S; Wang, MH; Wang, W; Xu, H; Zhang, R; Zhang, X | 1 |
| Cavitt, MA; France, S; Grzybowski, P; Patil, DV | 1 |
| D'Haens, G; Löwenberg, M | 1 |
| Beuselinck, B; Blesius, A; Chevreau, C; Escudier, B; Oudard, S; Ravaud, A; Rolland, F | 1 |
| Deepa, HR; Suresh Kumar, HM; Thipperudrappa, J | 1 |
| Asahi, S; Kakehi, M; Kondo, T; Tagawa, Y | 1 |
| Chen, D; Murugesan, S; Nadkarni, DH; Qin, JJ; Velu, SE; Wang, H; Wang, MH; Wang, W; Zhang, R | 1 |
| Atkins, J; Busaidy, N; Fu, S; Hong, D; Kurzrock, R; Naing, A; Sherman, S; Wheler, J | 1 |
| Hussar, DA | 1 |
| Choi, YJ; Jo, J; Kang, YK; Lee, JJ; Park, I; Park, JH; Ryoo, BY; Ryu, JS; Ryu, MH; Tan, E; Yoo, C | 1 |
| Asahi, S; Kondo, T; Mouri, K; Nishihara, M; Takahashi, J | 1 |
| Utkina, NK | 1 |
| Chilin, A; Dalla Via, L; Ferrarese, A; Gia, O; Marzaro, G | 1 |
| Conney, AH; Cui, XX; Ding, N; Du, Z; Gao, Z; Hu, C; Huang, H; Lin, Y; Rabson, AB; Shih, WJ; Wei, X; Zheng, X | 1 |
| Gevorgyan, V; Gulevich, AV; Kuznetsov, A; Wink, DJ | 1 |
| Fang, L; He, Y; Wang, Z; Weng, L; Xue, L | 1 |
| Boucle, S; Clastre, M; Guillard, J; Melin, C | 1 |
| Li, DD; Nag, S; Qin, JJ; Velu, SE; Voruganti, S; Wang, W; Xu, S; Yu, JX; Zhang, R | 1 |
| Basso, G; Bortolozzi, R; Carta, D; Ferlin, MG; Hamel, E; Moro, S; Viola, G | 1 |
| Chen, X; He, Z; Tang, T; Yang, C | 1 |
| Blankenfeldt, W; Drees, SL; Empting, M; Fetzner, S; Hartmann, RW; Maurer, CK; Weidel, E; Witzgall, F; Zender, M | 1 |
| Asahi, S; Goto, A; Kakehi, M; Kondo, T; Tagawa, Y | 1 |
| Alonso, E; Alvariño, R; Botana, LM; Dam, MA; Feussner, K; Jaspars, M; Leirós, M; Rateb, ME; Tabudravu, JN | 1 |
| Danese, S; Olivera, P; Peyrin-Biroulet, L | 1 |
| Albiges, L; Bensalah, K; Bex, A; Canfield, SE; Dabestani, S; Fernández-Pello, S; Giles, RH; Hofmann, F; Hora, M; Kuczyk, MA; Lam, TB; Ljungberg, B; Marconi, L; Merseburger, AS; Powles, T; Staehler, M; Tahbaz, R; Volpe, A | 1 |
| Ackermann, L; Cera, G; Haven, T | 1 |
| Eto, T; Ichida, T; Kusano, F; Sakai, Y; Ueyama, S | 1 |
| Khlebnikov, AF; Novikov, MS; Rostovskii, NV; Sakharov, PA | 1 |
10 review(s) available for pyrroles and carbostyril
| Article | Year |
|---|---|
[Development of novel oxidation reactions using hypervalent iodine reagents and their application to total synthesis of biologically active natural products].
Topics: Alkaloids; Antineoplastic Agents; Cyclization; Indicators and Reagents; Iodine; Oxidation-Reduction; Phenyl Ethers; Pyrroles; Quinolones | 2000 |
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Diuretics; Heart Failure; Homeostasis; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Animal; Morpholines; Piperidines; Pyrroles; Quinolones; Rats; Spiro Compounds; Vasopressins | 2003 |
Anxioselective anxiolytics: can less be more?
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepinones; Carbolines; Clinical Trials as Topic; Fluorobenzenes; GABA-A Receptor Agonists; Humans; Indoles; Pyrroles; Quinolones; Triazoles | 2004 |
[Molecular targets in colon cancer].
Topics: Angiogenesis Inhibitors; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Camptothecin; Cetuximab; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Drug Delivery Systems; ErbB Receptors; Gefitinib; Humans; Imatinib Mesylate; Indoles; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Phthalazines; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolones; Receptors, Platelet-Derived Growth Factor; Receptors, Somatomedin; Signal Transduction; Sirolimus; Sunitinib | 2006 |
[Bone and Men's Health. Bone selective androgen receptor modulators].
Topics: Acetamides; Amides; Aminophenols; Androgens; Anilides; Animals; Drug Design; Female; Humans; Male; Osteogenesis; Osteoporosis; Pyrroles; Pyrrolidines; Quinolones; Receptors, Androgen | 2010 |
Marine pyrroloiminoquinone alkaloids.
Topics: Alkaloids; Animals; Aquatic Organisms; Heterocyclic Compounds, 4 or More Rings; Models, Chemical; Molecular Structure; Porifera; Pyrroles; Pyrroloiminoquinones; Quinolines; Quinolones; Quinones; Thiazepines | 2012 |
Diketo acids derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Topics: HIV Integrase Inhibitors; HIV Reverse Transcriptase; Humans; Keto Acids; Pyrroles; Quinolones; Reverse Transcriptase Inhibitors; Ribonuclease H; Structure-Activity Relationship | 2011 |
Novel targets for inflammatory bowel disease therapeutics.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cell Adhesion Molecules; Certolizumab Pegol; Colitis, Ulcerative; Crohn Disease; Humans; Immunoglobulin Fab Fragments; Infliximab; Natalizumab; Piperidines; Polyethylene Glycols; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolones; Tumor Necrosis Factor-alpha; Ustekinumab | 2013 |
A Systematic Review and Meta-analysis Comparing the Effectiveness and Adverse Effects of Different Systemic Treatments for Non-clear Cell Renal Cell Carcinoma.
Topics: Anilides; Antineoplastic Agents; Axitinib; Benzimidazoles; Bevacizumab; Carcinoma, Renal Cell; Comparative Effectiveness Research; Disease-Free Survival; Erlotinib Hydrochloride; Everolimus; Humans; Imidazoles; Indazoles; Indoles; Interferons; Interleukin-2; Kidney Neoplasms; Niacinamide; Phenylurea Compounds; Pyridines; Pyrimidines; Pyrroles; Pyrrolidinones; Quinolines; Quinolones; Sirolimus; Sorafenib; Sulfonamides; Sunitinib | 2017 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
6 trial(s) available for pyrroles and carbostyril
| Article | Year |
|---|---|
Are tyrosine kinase inhibitors still active in patients with metastatic renal cell carcinoma previously treated with a tyrosine kinase inhibitor and everolimus? Experience of 36 patients treated in France in the RECORD-1 Trial.
Topics: Adult; Aged; Antineoplastic Agents; Benzimidazoles; Carcinoma, Renal Cell; Disease-Free Survival; Everolimus; Female; France; Humans; Indoles; Kidney Neoplasms; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrroles; Quinolones; Salvage Therapy; Sirolimus; Sorafenib; Sunitinib; TOR Serine-Threonine Kinases; Treatment Failure; Treatment Outcome | 2013 |
Tumor marker and measurement fluctuations may not reflect treatment efficacy in patients with medullary thyroid carcinoma on long-term RET inhibitor therapy.
Topics: Adult; Aged; Aged, 80 and over; Anilides; Antineoplastic Agents; Biomarkers, Tumor; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Neuroendocrine; Disease Progression; Female; Humans; Indoles; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-ret; Pyridines; Pyrroles; Quinolines; Quinolones; Retrospective Studies; Sorafenib; Sunitinib; Thyroid Neoplasms; Treatment Outcome; Valproic Acid | 2013 |
Phase II study of dovitinib in patients with metastatic and/or unresectable gastrointestinal stromal tumours after failure of imatinib and sunitinib.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Benzamides; Benzimidazoles; Disease Progression; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Male; Middle Aged; Piperazines; Prospective Studies; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolones; Sunitinib | 2013 |
Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11β-hydroxysteroid dehydrogenase 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Dogs; Dose-Response Relationship, Drug; Glycyrrhetinic Acid; Haplorhini; Humans; Male; Microsomes, Liver; Pyrroles; Quinolones; Rats; Species Specificity | 2014 |
Randomized Controlled Trial Comparing the Effects of Vonoprazan Plus Rebamipide and Esomeprazole Plus Rebamipide on Gastric Ulcer Healing Induced by Endoscopic Submucosal Dissection.
Topics: Aged; Aged, 80 and over; Alanine; Anti-Ulcer Agents; Drug Therapy, Combination; Endoscopic Mucosal Resection; Esomeprazole; Female; Humans; Male; Middle Aged; Proton Pump Inhibitors; Pyrroles; Quinolones; Severity of Illness Index; Stomach Neoplasms; Stomach Ulcer; Sulfonamides; Wound Healing | 2019 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide | 2023 |
89 other study(ies) available for pyrroles and carbostyril
| Article | Year |
|---|---|
Synthesis and benzodiazepine receptors affinity of 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-1-one and 3-carbethoxy-4-phenylquinoline derivatives.
Topics: Animals; Brain Chemistry; In Vitro Techniques; Mice; Mice, Inbred Strains; Pyrroles; Quinolones; Rats; Receptors, GABA-A | 1992 |
Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Blood Platelets; Calcium; Carbazoles; Cyclic AMP; Humans; Indoles; Phosphorylation; Platelet Aggregation Inhibitors; Protein Kinases; Pyrroles; Quinolones; Thromboxane A2 | 1992 |
Synthesis and antihypertensive activity of pyran oxygen and amide nitrogen replacement analogues of the potassium channel activator cromakalim.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Benzopyrans; Blood Pressure; Cromakalim; Pyrroles; Quinolones; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
Studies on antibacterial agents. III. Synthesis and antibacterial activities of substituted 1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acids.
Topics: Acinetobacter; Anti-Bacterial Agents; Cyclopropanes; Escherichia coli; Pseudomonas aeruginosa; Pyrroles; Quinolines; Quinolones; Staphylococcus aureus; Streptococcus pyogenes | 1990 |
5-HT and benzodiazepine receptor ligands. III. Synthesis and receptor affinities of 1,2,4-triazolo[4',3':1,6]pyridazino[4,5-b]quinoline and 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one derivatives.
Topics: Animals; Binding, Competitive; Brain; Cerebellum; Flumazenil; In Vitro Techniques; Isoquinolines; Ligands; Pyrroles; Quinolones; Rats; Receptors, GABA-A; Receptors, Serotonin | 1990 |
Heterocyclic quinones. XVI. Pharmacomodulation in the series of 11H-indolo[3,2-c]quinolinediones: synthesis, cytotoxicity and antitumor activity of 3-substituted 11H-pyrido[3',4':4,5]pyrrolo[3,2-c]quinoline-1,4-diones.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Indoles; Leukemia L1210; Leukemia P388; Mice; Pyridines; Pyrroles; Quinolones | 1989 |
2,6-Dimethyl-9-methoxy-4H-pyrrolo[3,2,1-ij]quinolin-4-one, a new compound with unusual photosensitizing properties.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; CHO Cells; Cricetinae; DNA, Neoplasm; Dose-Response Relationship, Radiation; Kinetics; Methoxsalen; Mice; Neoplasm Proteins; Photosensitizing Agents; Pyrroles; Quinolones; RNA, Neoplasm; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured; Ultraviolet Rays | 1994 |
Cardioprotective effects of a novel calcium antagonist related to the structure of cromakalim.
Topics: Action Potentials; Animals; Benzopyrans; Calcium Channel Blockers; Coronary Circulation; Cromakalim; Glyburide; Heart; Hemodynamics; Male; Potassium Channels; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium Channels | 1993 |
Tn5-directed cloning of pqq genes from Pseudomonas fluorescens CHA0: mutational inactivation of the genes results in overproduction of the antibiotic pyoluteorin.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Chromosome Mapping; Cloning, Molecular; DNA Transposable Elements; DNA, Bacterial; Ethanol; Genes, Bacterial; Glucose; Molecular Sequence Data; Mutation; Phenols; PQQ Cofactor; Pseudomonas fluorescens; Pyrroles; Quinolones; Sequence Homology, Amino Acid | 1995 |
Premafloxacin: a projected veterinary use fluoro-quinolone with significant activity against multi-resistant gram-positive human pathogens.
Topics: Anti-Infective Agents; Bacterial Infections; Drug Resistance, Multiple; Fluoroquinolones; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Pyrroles; Quinolones | 1996 |
Makaluvamine N: a new pyrroloiminoquinone from Zyzzya fuliginosa.
Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Porifera; Pyrroles; Quinolones; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1997 |
In vitro activity of premafloxacin, a new extended-spectrum fluoroquinolone, against pathogens of veterinary importance.
Topics: Animals; Anti-Infective Agents; Bacterial Infections; Fluoroquinolones; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Pyrroles; Quinolones | 1997 |
RNA-protein cross-links induced by sensitization with a pyrroloquinolinone derivative, a furocoumarin analogue.
Topics: Cross-Linking Reagents; HL-60 Cells; Humans; Nitrogen; Oxygen; Photosensitizing Agents; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyrroles; Quinolones; RNA; Ultraviolet Rays | 1997 |
Characterization and interconversion of polymorphs of premafloxacin, a new quinolone antibiotic.
Topics: Anti-Infective Agents; Calorimetry, Differential Scanning; Crystallization; Fluoroquinolones; Methanol; Pyrroles; Quinolones; Solubility; Water; X-Ray Diffraction | 1997 |
Involvement of cyclic AMP generation in the inhibition of respiratory burst by 2-phenyl-4-quinolone (YT-1) in rat neutrophils.
Topics: Adenylyl Cyclases; Alprostadil; Animals; Bucladesine; Calcium; Carbazoles; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cytosol; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Pyrroles; Quinolones; Rats; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Makaluvamines vary in ability to induce dose-dependent DNA cleavage via topoisomerase II interaction.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; DNA; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Humans; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Pyrroles; Quinolones; Topoisomerase II Inhibitors | 1999 |
Rigid dipeptide surrogates: syntheses of enantiopure quinolizidinone and pyrroloazepinone amino acids from a common diaminodicarboxylate precursor.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Azepines; Crystallography, X-Ray; Dipeptides; Molecular Conformation; Pyrroles; Quinolones; Stereoisomerism | 2000 |
Selective metal cation activation of a DNA alkylating agent: synthesis and evaluation of methyl 1,2,9, 9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI).
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Catalysis; Cations, Divalent; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indoles; Metals; Molecular Conformation; Molecular Structure; Pyrroles; Quinolones; Spectrophotometry, Ultraviolet; Stereoisomerism | 2000 |
Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Crystallography, X-Ray; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indolequinones; Indoles; Leucomycins; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Pyrroles; Quinolones | 2000 |
Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives.
Topics: Alkaloids; Animals; Antineoplastic Agents; Leukemia L1210; Molecular Structure; Pyrroles; Quinolones; Rats; Tumor Cells, Cultured | 2000 |
Synthesis of benzo-fused 1-azabicyclo[m.n.0]alkanes via the Schmidt reaction: a formal synthesis of gephyrotoxin.
Topics: Alkaloids; Alkanes; Amphibian Venoms; Aza Compounds; Bridged Bicyclo Compounds; Cyclization; Oxidation-Reduction; Pyrroles; Quinolones; Stereoisomerism | 2000 |
Mechanisms and frequency of resistance to premafloxacin in Staphylococcus aureus: novel mutations suggest novel drug-target interactions.
Topics: Alleles; Anti-Infective Agents; DNA Topoisomerase IV; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Fluoroquinolones; Gene Frequency; Mutation; Pyrroles; Quinolones; Selection, Genetic; Staphylococcus aureus; Transformation, Bacterial | 2000 |
Electrochemical detection of thiols with a coenzyme pyrroloquinoline quinone modified electrode.
Topics: Coenzymes; Electrochemistry; Electrodes; Indicators and Reagents; Oxidation-Reduction; PQQ Cofactor; Pyrroles; Quinolones; Quinones; Sensitivity and Specificity; Sulfhydryl Compounds | 2000 |
Laboratory culture of the myxomycetes: formation of fruiting bodies of Didymium bahiense and its plasmodial production of Makaluvamine A.
Topics: Animals; Chromatography, Thin Layer; Magnetic Resonance Spectroscopy; Myxomycetes; Porifera; Pyrroles; Quinolones; Spores, Fungal | 2001 |
Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Leukemia L1210; Pyrroles; Quinolones; Stereoisomerism | 2001 |
The 3-D QSAR study of anticancer 1-N-substituted imidazo- and pyrrolo-quinoline-4,9-dione derivatives by CoMFA and CoMSIA.
Topics: Antineoplastic Agents; Cell Division; Humans; Imidazoles; Models, Molecular; Molecular Conformation; Pyrroles; Quantitative Structure-Activity Relationship; Quinolones; Tumor Cells, Cultured | 2001 |
Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa.
Topics: Animals; Antineoplastic Agents; Australia; Enzyme Inhibitors; Humans; KB Cells; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Nasopharyngeal Neoplasms; Porifera; Pyrroles; Quinolones; Toxicity Tests; Tumor Cells, Cultured; Xanthine Oxidase | 2001 |
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Topics: Antineoplastic Agents; Biopolymers; Drug Screening Assays, Antitumor; Humans; Mitosis; Pyrroles; Quinolones; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured | 2001 |
Novel stereocontrolled addition of allylmetal reagents to alpha-imino esters: efficient synthesis of chiral tetrahydroquinoline derivatives.
Topics: Allyl Compounds; Catalysis; Imines; Indicators and Reagents; Indoles; Metals; Molecular Structure; Oxidation-Reduction; Pyrroles; Quinolones; Stereoisomerism; Structure-Activity Relationship | 2002 |
A biofuel cell with electrochemically switchable and tunable power output.
Topics: Bioelectric Energy Sources; Copper; Cytochrome c Group; Electrochemistry; Electrodes; Flavin-Adenine Dinucleotide; Glucose; Glucose Oxidase; Oxidation-Reduction; PQQ Cofactor; Pyrroles; Quinolines; Quinolones; Quinones | 2003 |
Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Fibrosarcoma; Humans; Photochemotherapy; Photosensitizing Agents; Pyrroles; Quinolones; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation | 2003 |
Synthesis of N-methyl-N-[(1S)-1-[(3R)-pyrrolidin-3-yl]ethyl]amine.
Topics: Alkylation; Amines; Anti-Bacterial Agents; Fluoroquinolones; Pyrroles; Pyrrolidines; Quinolones; Stereoisomerism; Structure-Activity Relationship | 2003 |
Structure-activity relationships of N-acyl pyrroloquinolone PDE-5 inhibitors.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Administration, Oral; Animals; Biological Availability; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 5; Dioxoles; Dogs; Injections, Intravenous; Male; Penile Erection; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrroles; Quinolones; Rats; Stereoisomerism; Structure-Activity Relationship | 2004 |
Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.
Topics: Amino Acid Sequence; Anti-HIV Agents; Ciprofloxacin; DNA, Viral; Gene Products, tat; HIV Long Terminal Repeat; HIV-1; Isoquinolines; Molecular Sequence Data; Mutation; Plasmids; Pyrroles; Quinolones; RNA, Viral; tat Gene Products, Human Immunodeficiency Virus | 2004 |
Effects of TAK-802, a novel acetylcholinesterase inhibitor, and various cholinomimetics on the urodynamic characteristics in anesthetized guinea pigs.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Pressure; Pyrroles; Quinolones; Urethane; Urethra; Urinary Bladder Neck Obstruction; Urodynamics | 2004 |
Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds.
Topics: Acetylcholinesterase; Animals; Bethanechol; Cholinesterase Inhibitors; Guinea Pigs; Inhibitory Concentration 50; Male; Molecular Structure; Muscle Contraction; Pyrroles; Quinolones; Rats; Structure-Activity Relationship; Urinary Bladder | 2005 |
Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Biological Availability; Blood Pressure; Cell Line; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Electric Stimulation; Erectile Dysfunction; Macaca mulatta; Male; Penis; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Solubility; Stereoisomerism; Structure-Activity Relationship | 2005 |
Effects of TAK-802, a novel acetylcholinesterase inhibitor, and tamsulosin, an alpha1-adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea-pig model of functional bladder outlet obstruction.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Animals; Cholinesterase Inhibitors; Drug Synergism; Drug Therapy, Combination; Guinea Pigs; Infusions, Intravenous; Male; Prostatic Hyperplasia; Pyrroles; Quinolones; Sulfonamides; Tamsulosin; Urinary Bladder Neck Obstruction; Urinary Retention; Urodynamics | 2005 |
Differential effects of TAK-802, a selective acetylcholinesterase inhibitor, and carbamate acetylcholinesterase inhibitors on contraction of the detrusor smooth muscle of the guinea pig.
Topics: Acetylcholinesterase; Animals; Carbamates; Cholinesterase Inhibitors; Guinea Pigs; Isometric Contraction; Male; Muscle, Smooth; Nicotine; Nicotinic Agonists; Pyrroles; Quinolones; Tissue Culture Techniques; Urinary Bladder | 2005 |
Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction.
Topics: Administration, Oral; Animals; Bethanechol; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mice; Muscarinic Agonists; Organ Size; Pyridinium Compounds; Pyrroles; Quinolones; Rats; Rats, Wistar; Urinary Bladder; Urinary Bladder Neck Obstruction; Urination; Urodynamics | 2005 |
Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity.
Topics: Animals; Antimitotic Agents; Aromatase; Biopolymers; Cell Line, Tumor; Cell Proliferation; Cytoskeleton; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Mice; Microscopy, Fluorescence; Neoplasm Transplantation; Pyrroles; Quinolones; Structure-Activity Relationship; Transplantation, Isogeneic; Tritium; Tubulin; Water | 2006 |
Asymmetric synthesis of intermediates for otamixaban and premafloxacin by the chiral ligand-controlled asymmetric conjugate addition of a lithium amide.
Topics: Amides; Cyclic N-Oxides; Fluoroquinolones; Ligands; Lithium; Pyridines; Pyrroles; Quinolones; Stereoisomerism | 2006 |
Solubility measurement of polymorphic compounds via the pH-metric titration technique.
Topics: Acetaminophen; Acetazolamide; Chlorpropamide; Crystallography, X-Ray; Fluoroquinolones; Furosemide; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Potentiometry; Pyrroles; Quinolones; Solubility; Sulfamethoxazole; Sulfathiazole; Sulfathiazoles; Thermodynamics; Titrimetry | 2007 |
Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity.
Topics: Alkaloids; Amsacrine; Animals; Antineoplastic Agents; Drug Design; Drug Screening Assays, Antitumor; Humans; Marine Biology; Molecular Structure; Pyrroles; Quinolones; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 2007 |
Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products.
Topics: Animals; Antineoplastic Agents; Biological Products; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Imidazoles; Marine Biology; Mice; Pyrroles; Quinolones; Quinoxalines; Structure-Activity Relationship; Toxicity Tests, Acute | 2007 |
Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.
Topics: Furans; HIV Integrase; HIV Integrase Inhibitors; Humans; Molecular Structure; Organic Chemicals; Pyrroles; Pyrrolidinones; Quinolones; Raltegravir Potassium; Triazoles | 2007 |
3-substituted 7-phenyl-pyrroloquinolinones show potent cytotoxic activity in human cancer cell lines.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Paclitaxel; Pyrroles; Quinolones; Structure-Activity Relationship | 2007 |
Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines.
Topics: Benzene; Cell Line, Tumor; Cell Proliferation; Humans; Molecular Structure; Pyrroles; Quinolones; Quinones; Structure-Activity Relationship | 2008 |
YSK2821, a newly synthesized indoledione derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating phosphatidylinositol-3 kinase cascade in vascular smooth muscle cells.
Topics: Apoptosis; Blotting, Western; Cell Count; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Proliferation; Humans; Magnetic Resonance Spectroscopy; Muscle, Smooth, Vascular; Necrosis; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Pyrroles; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thymidine | 2008 |
Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators.
Topics: Computer Simulation; Humans; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Isoxazoles; Models, Molecular; Multidrug Resistance-Associated Proteins; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; Quinolones; Quinoxalines; Silymarin; Sulfonamides; Thiophenes | 2008 |
Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats.
Topics: Absorptiometry, Photon; Androgen Antagonists; Animals; Biomechanical Phenomena; Body Weight; Bone Density; Bone Diseases, Metabolic; Diphosphonates; Drug Synergism; Drug Therapy, Combination; Estrogens; Female; Femur; Lumbar Vertebrae; Male; Orchiectomy; Organ Size; Osteocalcin; Ovariectomy; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 2009 |
Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator.
Topics: Administration, Oral; Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Animals; Drug Administration Routes; Male; Models, Animal; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley | 2009 |
FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrroles; Quinolones; Receptors, Androgen | 2010 |
In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Molecular Structure; Pyrroles; Quinolones; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2009 |
Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.
Topics: Acetoacetates; Anti-HIV Agents; Binding Sites; Computer Simulation; Drug Design; Furans; HIV Integrase; HIV Integrase Inhibitors; Humans; Mutation; Naphthyridines; Pyrroles; Pyrrolidinones; Quinolones; Raltegravir Potassium; Triazoles | 2009 |
Gold-catalyzed one-pot cascade construction of highly functionalized pyrrolo[1,2-a]quinolin-1(2H)-ones.
Topics: Catalysis; Gold Compounds; Molecular Structure; Organogold Compounds; Pyrroles; Quinolones; Stereoisomerism | 2009 |
A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Oligonucleotide Array Sequence Analysis; Pyrroles; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Xenograft Model Antitumor Assays | 2010 |
A selective androgen receptor modulator enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats.
Topics: Androgen Receptor Antagonists; Androgens; Animals; Dihydrotestosterone; Estradiol; Female; Flutamide; Male; Ovariectomy; Progesterone; Pyrroles; Quinolones; Random Allocation; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal | 2010 |
Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent.
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Female; Humans; Male; Mice; Neoplasms; Protein Binding; Pyrroles; Quinolones; Tissue Distribution; Xenograft Model Antitumor Assays | 2010 |
Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Least-Squares Analysis; Male; Mice; Pyrroles; Quinolones; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2011 |
Isolation and characterization of diastereomers of discorhabdins H and K and assignment of absolute configuration to discorhabdins D, N, Q, S, T, and U.
Topics: Alkaloids; Animals; Molecular Structure; New Zealand; Porifera; Pyrroles; Quinolones; Quinones; Spiro Compounds; Stereoisomerism; Thiazepines | 2010 |
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.
Topics: Animals; Apoptosis; Benzimidazoles; Blotting, Western; Carcinoma, Transitional Cell; Cell Cycle; Cell Proliferation; Cells, Cultured; Humans; Immunoenzyme Techniques; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mutation; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Quinolones; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 3; Urinary Bladder Neoplasms; Urothelium; Xenograft Model Antitumor Assays | 2011 |
Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes.
Topics: Catalysis; Cyclization; Enzyme Activation; Heterocyclic Compounds, 3-Ring; Humans; Metals, Heavy; Models, Molecular; Molecular Structure; Pyrroles; Quinolones; Sirtuin 1 | 2011 |
Pyrrolo[3,4-h]quinolinones a new class of photochemotherapeutic agents.
Topics: Cell Cycle; Cell Line, Tumor; DNA; Fluorometry; HL-60 Cells; Humans; Jurkat Cells; Lipid Peroxidation; Phosphatidylserines; Photochemical Processes; Photochemotherapy; Pyrroles; Quinolones; Structure-Activity Relationship; Subcellular Fractions | 2011 |
Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Humans; Membrane Potential, Mitochondrial; Mice; Ovarian Neoplasms; Pyrroles; Quinolones; Signal Transduction; Xenograft Model Antitumor Assays | 2011 |
Efficacy of re-challenging metastatic renal cell carcinoma with mTOR inhibitors.
Topics: Antineoplastic Agents; Benzimidazoles; Carcinoma, Renal Cell; Everolimus; Humans; Indoles; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pyrroles; Quinolones; Sirolimus; Sunitinib; TOR Serine-Threonine Kinases | 2011 |
Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors.
Topics: Animals; Brain; Carbon Radioisotopes; Positron-Emission Tomography; Pyrroles; Quinolones; Radiopharmaceuticals; Rats; Receptors, GABA-A; Receptors, GABA-B; Tissue Distribution | 2012 |
Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Protein Binding; Pyrroles; Quinolones; Tissue Distribution; Xenograft Model Antitumor Assays | 2012 |
A general intramolecular Friedel-Crafts approach to functionalized pyrrolo[3,2,1-ij]quinolin-4-ones.
Topics: Catalysis; Indium; Molecular Structure; Pyrroles; Quinolones; Stereoisomerism | 2012 |
Effect of solvents on the spectroscopic properties of LD-489 & LD-473: estimation of ground and excited state dipole moments by solvatochromic shift method.
Topics: Absorption; Electrons; Models, Chemical; Molecular Conformation; Naphthyridines; Pyrans; Pyrones; Pyrroles; Quinolones; Solvents; Spectrometry, Fluorescence | 2013 |
Disposition of the new potent acetylcholinesterase inhibitor 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidiny]-1-oxopropyl]-1, 2, 5, 6-tetrahydro-4H-pyrrolo [3, 2, 1-ij] quinolin-4-one (TAK-802) in rats, dogs and monkeys.
Topics: Animals; Bile; Cholinesterase Inhibitors; Dogs; Erythrocytes; Macaca fascicularis; Male; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2013 |
Identification of the ZAK-MKK4-JNK-TGFβ signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line; Cell Proliferation; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mammary Glands, Human; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; MCF-7 Cells; Neoplasm Proteins; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Stability; Pyrroles; Quinolones; Transforming Growth Factor beta2; Ubiquitination; Up-Regulation | 2013 |
New drugs 2013, part 2.
Topics: Acetanilides; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Retroviral Agents; Bronchodilator Agents; Citrates; Crotonates; Drug Approval; Humans; Hydroxybutyrates; Immunosuppressive Agents; Laxatives; Nitriles; Organometallic Compounds; Peptides; Picolines; Piperidines; Pyrimidines; Pyrroles; Quinolones; Receptors, Guanylate Cyclase-Coupled; Thiazoles; Toluidines; Tropanes | 2013 |
Antioxidant activity of zyzzyanones and makaluvamines from the marine sponge Zyzzya fuliginosa.
Topics: Animals; Antioxidants; Free Radical Scavengers; Porifera; Pyrroles; Quinolones; Quinones; Structure-Activity Relationship | 2013 |
Pyrroloquinolinone-based dual topoisomerase I/II inhibitor.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HL-60 Cells; Humans; Models, Molecular; Molecular Structure; Pyrroles; Quinolones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2014 |
A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Atorvastatin; Celecoxib; Cell Line, Tumor; Cell Proliferation; Female; Heptanoic Acids; Humans; Injections, Intraperitoneal; Mice; Mice, SCID; Neoplasms, Experimental; Pancreatic Neoplasms; Pyrazoles; Pyrroles; Quinolones; Sulfonamides; Xenograft Model Antitumor Assays | 2014 |
A new reactivity mode for the diazo group: diastereoselective 1,3-aminoalkylation reaction of β-amino-α-diazoesters to give triazolines.
Topics: Alkylation; Amines; Mass Spectrometry; Pyrroles; Quinolones; Stereoisomerism; Triazoles | 2014 |
Access to functionalized 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones and thieno[2,3-c]quinolin-4(5H)-ones via domino reaction of 4-alkynyl-3-bromoquinolin-2(1H)-ones.
Topics: Alkynes; Catalysis; Molecular Structure; Palladium; Pyrroles; Quinolones | 2014 |
Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.
Topics: Antineoplastic Agents; Caco-2 Cells; Cell Line, Tumor; Drug Design; HCT116 Cells; Humans; Molecular Structure; Pyrroles; Quinolones; Topoisomerase II Inhibitors | 2015 |
Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Pyrroles; Quinolones; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2015 |
Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Interactions; HeLa Cells; Humans; Protein Kinase Inhibitors; Pyrroles; Quinolones; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2015 |
Annulation Reaction of 3-Acylmethylidene Oxindoles with Huisgen Zwitterions and Its Applications in the Syntheses of Pyrrolo[4,3,2-de]quinolinones and Marine Alkaloids Ammosamides.
Topics: Alkaloids; Amides; Biological Products; Heterocyclic Compounds, 3-Ring; Indoles; Marine Biology; Molecular Structure; Oxindoles; Pyrroles; Quinolines; Quinolones; Structure-Activity Relationship | 2016 |
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds.
Topics: Bacterial Proteins; Benzoates; Carboxylic Acids; Crystallography, X-Ray; Drug Discovery; Fluorometry; Pseudomonas aeruginosa; Pyocyanine; Pyridines; Pyrroles; Quinolones; Quorum Sensing; Thiolester Hydrolases; Thiophenes; Virulence; Virulence Factors | 2016 |
The effects of the concentration-dependent erythrocyte distribution of TAK-802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Male; Protein Binding; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |
Evaluation of the Antioxidant Activity of the Marine Pyrroloiminoquinone Makaluvamines.
Topics: Animals; Antioxidants; Cell Line; Cell Line, Tumor; Female; Glutathione; Hydrogen Peroxide; Mice; Mitochondria; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Porifera; Pregnancy; Primary Cell Culture; Pyrroles; Pyrroloiminoquinones; Quinolones; Reactive Oxygen Species; Structure-Activity Relationship | 2016 |
Next generation of small molecules in inflammatory bowel disease.
Topics: Administration, Oral; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Humans; Immunologic Factors; Indans; Inflammatory Bowel Diseases; Oxadiazoles; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolones; Randomized Controlled Trials as Topic; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Iron-Catalyzed C-H Alkynylation through Triazole Assistance: Expedient Access to Bioactive Heterocycles.
Topics: Alkynes; Catalysis; Iron; Phthalimides; Pyridones; Pyrroles; Quinolones; Triazoles | 2017 |
Copper(II)-Catalyzed (3+2) Cycloaddition of 2
Topics: Azirines; Catalysis; Copper; Cycloaddition Reaction; Indoles; Pyrroles; Quinolones | 2022 |