pyrroles has been researched along with brostallicin in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (76.47) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Battaglia, R; Broggini, M; Colombo, T; Cozzi, P; D'Incalci, M; Galliera, E; Geroni, C; Howard, M; Marchini, S; Ragg, E | 1 |
| Calderoli, S; Colombo, E; Frigerio, E; James, CA; Sibum, M | 1 |
| Antonellini, A; De Jonge, MJ; Fiorentini, F; Fowst, C; Hartman, CM; Mantel, M; Planting, AS; Sparreboom, A; Stoter, G; Ten Tije, AJ; Tursi, J; Van Der Gaast, A; Verweij, J | 1 |
| Fedier, A; Fink, D; Fowst, C; Geroni, C; Haller, U; Marchini, S; Tursi, J | 1 |
| Broggini, M; Colombo, T; Geroni, C; Marchini, S; Sabatino, MA | 1 |
| Berlin, JD; Campbell, A; Fiorentini, F; Fontana, E; Fowst, C; Hande, KR; Howard, M; Lankford, O; Lockhart, AC; Paty, VA; Roth, BJ; Rothenberg, ML; Vreeland, F | 1 |
| Broggini, M; Fontana, E; Fowst, C; Geroni, C; Marchini, S; Moneta, D | 1 |
| Baraldi, PG; Beria, I; Caldarelli, M; Cozzi, P; Geroni, C; Marchini, S; Mongelli, N; Romagnoli, R | 1 |
| Mahendran, R; Pook, SH; Toh, CK | 1 |
| Blay, JY; de Balincourt, C; di Paola, ED; Duffaud, F; Fowst, C; Hogendoorn, PC; Judson, I; Le Cesne, A; Leahy, M; Ray-Coquard, I; van Glabbeke, M; Verweij, J | 1 |
| Baraldi, PG; Cruz-Lopez, O; Lopez-Cara, C; Preti, D; Romagnoli, R | 1 |
| Guirouilh-Barbat, J; Pommier, Y; Zhang, YW | 1 |
| Ferrandina, G; Foco, G; Lorusso, D; Mainenti, S; Masciullo, V; Pietragalla, A; Scambia, G | 1 |
| Antonini, G; Beria, I; Broggini, M; Caccuri, AM; Colombo, M; Federici, G; Geroni, C; Leboffe, L; MacArthur, R; Marchini, S; Mongelli, N; Mozzi, AF; Pezzola, S | 1 |
| Airoldi, M; Barone, C; Caponigro, F; Comis, S; Crippa, S; Fiorentini, F; Fornari, G; Jannuzzo, MG; Lorusso, D; MacArthur, R; Merlano, M; Petroccione, A; Schena, M; Weitman, S | 1 |
| Broggini, M; Ceruti, R; Ganzinelli, M; Geroni, C; Sabatino, MA | 1 |
| Bauer, S; Blay, JY; Gelderblom, H; Guchelaar, HJ; Hogendoorn, PC; Hohenberger, P; Kerst, JM; Leahy, M; Marreaud, S; Ouali, M; Ray-Coquard, I; Rutkowski, P; Seddon, BM; Sleijfer, S; van der Straaten, RJ; Weitman, SD | 1 |
2 review(s) available for pyrroles and brostallicin
| Article | Year |
|---|---|
Brostallicin: a new concept in minor groove DNA binder development.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Distamycins; DNA; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Glutathione; Glutathione Transferase; Guanidines; Humans; Molecular Structure; Neoplasms; Pyrroles | 2004 |
alpha-halogenoacrylic derivatives of antitumor agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Distamycins; Guanidines; Humans; Mice; Pyrroles; Pyrroloiminoquinones | 2009 |
5 trial(s) available for pyrroles and brostallicin
| Article | Year |
|---|---|
Phase I and pharmacokinetic study of brostallicin (PNU-166196), a new DNA minor-groove binder, administered intravenously every 3 weeks to adult patients with metastatic cancer.
Topics: Adult; Aged; Area Under Curve; DNA-Binding Proteins; Female; Guanidines; Humans; Infusions, Intravenous; Intercalating Agents; Male; Maximum Tolerated Dose; Middle Aged; Models, Chemical; Neoplasms; Pyrroles | 2003 |
A phase I dose-escalation and pharmacokinetic study of brostallicin (PNU-166196A), a novel DNA minor groove binder, in adult patients with advanced solid tumors.
Topics: Aged; Antineoplastic Agents; Area Under Curve; Calibration; DNA Damage; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Models, Chemical; Neoplasms; Pyrroles; Time Factors | 2004 |
Brostallicin, an agent with potential activity in metastatic soft tissue sarcoma: a phase II study from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.
Topics: Adult; Aged; Antineoplastic Agents; Disease Progression; Female; Gastrointestinal Stromal Tumors; Guanidines; Humans; Infusions, Intravenous; Male; Middle Aged; Pyrroles; Sarcoma; Soft Tissue Neoplasms; Survival Analysis; Treatment Outcome | 2007 |
Phase I dose-escalation study of brostallicin, a minor groove binder, in combination with cisplatin in patients with advanced solid tumors.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Female; Guanidines; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Pyrroles; Sex Characteristics | 2010 |
Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogeneti
Topics: Adult; Antibiotics, Antineoplastic; Bone Neoplasms; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Europe; Gene Frequency; Genotype; Glutathione Transferase; Guanidines; Humans; Isoenzymes; Kaplan-Meier Estimate; Middle Aged; Neoplasm Metastasis; Pharmacogenetics; Polymorphism, Genetic; Pyrroles; Sarcoma; Treatment Outcome | 2014 |
10 other study(ies) available for pyrroles and brostallicin
| Article | Year |
|---|---|
Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Female; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Guanidines; Humans; Isoenzymes; Leukemia L1210; Mice; Mice, Nude; Ovarian Neoplasms; Plasmids; Pyrroles; Transfection; Tumor Cells, Cultured | 2002 |
LC-MS-MS determination of brostallicin in human plasma following automated on-line SPE.
Topics: Chromatography, Liquid; Guanidines; Humans; Mass Spectrometry; Pyrroles; Technology, Pharmaceutical | 2003 |
Brostallicin (PNU-166196)--a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Animals; Antineoplastic Agents; Base Pair Mismatch; Carrier Proteins; Cell Death; Colonic Neoplasms; Distamycins; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Fibroblasts; Guanidines; Humans; Mice; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nitrogen Mustard Compounds; Nuclear Proteins; Proto-Oncogene Proteins; Pyrroles; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Colonic Neoplasms; DNA; Doxorubicin; Female; Glutathione; Glutathione Transferase; Guanidines; Irinotecan; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred DBA; Mice, Nude; Pyrroles; Transplantation, Heterologous | 2003 |
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Distamycins; Drug Screening Assays, Antitumor; Female; Glutathione; Guanidines; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Structure-Activity Relationship; Transplantation, Heterologous | 2004 |
Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Line, Tumor; Down-Regulation; Drug Antagonism; Drug Screening Assays, Antitumor; Enzyme Activation; Guanidines; Humans; Nasopharyngeal Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Silybin; Silymarin; Sulfhydryl Compounds; Up-Regulation | 2006 |
Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Chromosomal Proteins, Non-Histone; Dioxoles; DNA Breaks, Double-Stranded; DNA Replication; DNA-Binding Proteins; Glutathione; Guanidines; HCT116 Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; MRE11 Homologue Protein; Phosphoproteins; Pyrroles; Tetrahydroisoquinolines; Trabectedin; Tumor Suppressor p53-Binding Protein 1 | 2009 |
Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; DNA; Drug Screening Assays, Antitumor; Guanidines; Humans; Models, Chemical; Pyrroles | 2009 |
Role of glutathione transferases in the mechanism of brostallicin activation.
Topics: Antineoplastic Agents; Breast Neoplasms; Catalysis; Cell Line, Tumor; DNA; Female; Glutathione S-Transferase pi; Glutathione Transferase; Guanidines; Humans; Kinetics; Pyrroles | 2010 |
Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cytidine; DNA Methylation; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Guanidines; Humans; Male; Mice; Prostatic Neoplasms; Pyrroles; Random Allocation; Xenograft Model Antitumor Assays | 2013 |