pyrroles has been researched along with arachidonic acid in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.65) | 18.7374 |
| 1990's | 17 (39.53) | 18.2507 |
| 2000's | 20 (46.51) | 29.6817 |
| 2010's | 4 (9.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adeagbo, AS; Malik, KU | 1 |
| Chertock, H; Hamdan, A; Kimble, E; Kowalski, T; Lee, W; Neale, R; Pastor, G; Raychauduri, A; Wasley, J; White, D | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 1 |
| Carty, TJ; Moore, PF; Mylari, BL; Zembrowski, WJ | 1 |
| Burdisso, M; Leali, M; Panzone, G; Schiatti, P; Selva, D; Tarzia, G | 1 |
| Matsushima, T; Mimura, S; Muramatsu, S; Sawa, T; Takeuchi, T; Umezawa, K | 1 |
| Bouchard, JF; Dumont, E; Lamontagne, D | 1 |
| Morita, I; Murota, S; Nakahama, K | 1 |
| Oda, M; Yamashita, A; Yokota, K | 1 |
| Augustin, J; Dannhardt, G; Laufer, S; Tries, S | 1 |
| Morimoto, Y; Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 1 |
| Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 1 |
| Matsuo, K; Oda, M; Yamashita, A; Yokota, K | 1 |
| Fulton, D; Kaminski, P; McGiff, JC; Quilley, J; Wolin, MS | 1 |
| Akagi, M; Akagi, R; Fukuishi, N; Matsuura, S; Nakagawa, C; Sakaguchi, M | 1 |
| Lehr, M | 1 |
| Hoff, HF; Kaur, K; O'Neil, J; Salomon, RG | 1 |
| Allen, LF; Fatima, S; Kan, H; Malik, KU; Parmentier, JH; Ruan, Y | 1 |
| Capasso, A | 1 |
| Dannhardt, G; Fiebich, B; Kiefer, W; Krämer, G; Maehrlein, S; Nowe, U | 1 |
| Elfringhoff, AS; Lehr, M | 1 |
| Barrett, CF; Liu, L; Rittenhouse, AR | 1 |
| Hirata, M; Murakami, Y; Okada, S; Yokotani, K | 1 |
| Berezin, V; Bock, E; Jessen, U; Novitskaya, V; Pedersen, N; Serup, P | 1 |
| Caccese, D; Lauro, R; Lenti, L; Magnaterra, R; Martini, F; Pignatelli, P; Pulcinelli, FM; Sanguigni, V; Violi, F | 1 |
| Bełtowski, J; Górny, D; Marciniak, A; Wójcicka, G | 1 |
| Chang, FR; Chen, IJ; Kuo, RY; Wu, CC; Wu, YC; Yeh, JL | 1 |
| Hawkey, CJ; Skelly, MM | 1 |
| Cerletti, C; Evangelista, V; Krauze-Brzósko, K; Manarini, S; Rotondo, S | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Naveau, B | 1 |
| Arderiu, G; Escolar, G; Hernandez, MR; Pedreño, J; Pino, M; Salas, E; Serradell, M; Tonda, R | 1 |
| Kulkarni, SK; Singh, VP | 1 |
| Dodt, G; Fischer, L; Franke, L; Hornig, M; Meindl, N; Pergola, C; Schneider, G; Steinhilber, D; Tanrikulu, Y; Werz, O | 1 |
| Bartolini, G; Bonafè, M; Brighenti, E; Ferreri, C; Guarnieri, T; Laufer, S; Manara, S; Marini, M; Tavolari, S; Tomasi, V | 1 |
| Klein, T; Pushkareva, MA; Shephard, P; Sud'ina, GF | 1 |
| Gluck, N; Krimsky, M; Schwob, O; Yedgar, S | 1 |
| Bibonne, A; Leclerc, C; Lee, KW; Moreau, M; Néant, I | 1 |
| Alonso, S; Alvarez, Y; Fernández, N; Municio, C; San Román, JA; Sánchez Crespo, M | 1 |
| Barnés, CM; Butterfield, C; Cassiola, F; Chaponis, D; Christison-Lagay, EA; Fallon, EM; Folkman, J; Kieran, M; Le, HD; Nehra, D; Panigrahy, D; Prox, D; Puder, M; Short, S | 1 |
| Hofmann, B; Steinhilber, D | 1 |
| Meirer, K; Proschak, E; Steinhilber, D | 1 |
| Brewer, M; Cruz-Monserrate, Z; Houchen, CW; Janakiram, NB; Kumar, G; Lightfoot, S; Madka, V; May, R; Mohammed, A; Patlolla, JM; Rao, CV; Ritchie, RL; Sadeghi, M; Steele, VE; Yamada, HY | 1 |
4 review(s) available for pyrroles and arachidonic acid
| Article | Year |
|---|---|
COX-LOX inhibition: current evidence for an emerging new therapy.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Dogs; Humans; Intestinal Mucosa; Leukotrienes; Lipoxygenase Inhibitors; Models, Animal; Peptic Ulcer; Prostaglandins; Pyrroles; Rats; Sheep | 2003 |
Licofelone--a novel analgesic and anti-inflammatory agent.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cyclooxygenase Inhibitors; Humans; Lipoxygenase Inhibitors; Pyrroles | 2007 |
Recent advances in the search for novel 5-lipoxygenase inhibitors.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Computational Biology; Drug Design; Humans; Leukotrienes; Lipoxygenase Inhibitors; Pyrroles; Rhinitis, Allergic; Rhinitis, Allergic, Perennial | 2014 |
Inhibitors of the arachidonic acid cascade: interfering with multiple pathways.
Topics: Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Humans; Inflammation; Lipoxygenase Inhibitors; Pain; Pyrroles | 2014 |
39 other study(ies) available for pyrroles and arachidonic acid
| Article | Year |
|---|---|
Contribution of K+ channels to arachidonic acid-induced endothelium-dependent vasodilation in rat isolated perfused mesenteric arteries.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Cromakalim; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Lipoxygenase; Male; Mesenteric Arteries; Norepinephrine; Ouabain; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Vasodilation | 1991 |
CGS 22745: a selective orally active inhibitor of 5-lipoxygenase.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biological Availability; Blood Platelets; Calcimycin; Dogs; Guinea Pigs; Half-Life; Humans; Hydroxamic Acids; In Vitro Techniques; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Pleurisy; Pyrroles; Rats; Sheep | 1991 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Line; Cyclooxygenase Inhibitors; Edema; Indicators and Reagents; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Molecular; Molecular Structure; Prostaglandin Antagonists; Pyrroles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazines | 1990 |
Synthesis and pharmacological evaluation of a series of analgesic and antiinflammatory 4-aminopyrroles.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimental; Carrageenan; Chemical Phenomena; Chemistry; Diarrhea; Edema; Lethal Dose 50; Male; Pyrroles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Ulcer | 1984 |
Enhancement of haemolysis and cellular arachidonic acid release by pyrrolomycins.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Biological Transport, Active; Cells, Cultured; Deoxyglucose; Erythrocytes; Hemolysis; Horses; Kinetics; Mice; Mice, Inbred C3H; Pyrroles | 1982 |
Evidence that prostaglandins I2, E2, and D2 may activate ATP sensitive potassium channels in the isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprostone; Dose-Response Relationship, Drug; Glyburide; Iloprost; In Vitro Techniques; Ion Channel Gating; Male; Myocardium; Perfusion; Potassium Channels; Pressure; Prostaglandin D2; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Effects of endogenously produced arachidonic acid metabolites on rat mesangial cell proliferation.
Topics: 1-Methyl-3-isobutylxanthine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Benzeneacetamides; Bucladesine; Carbazoles; Cell Division; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Dinoprostone; DNA Replication; Flavanones; Flavonoids; Glomerular Mesangium; Hydroxamic Acids; Hydroxyeicosatetraenoic Acids; Indoles; Indomethacin; Lipoxygenase Inhibitors; Male; Platelet-Derived Growth Factor; Pyrroles; Rats; Rats, Sprague-Dawley; Umbelliferones | 1994 |
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Extracorporeal Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Silver Nitrate; Thiazoles; Thrombosis; Ticlopidine | 1995 |
Pharmacological profile of a new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase.
Topics: Acetates; Animals; Arachidonic Acid; Arthritis, Experimental; Benzoquinones; Blood Coagulation; Bronchoconstriction; Carrageenan; Cyclooxygenase Inhibitors; Edema; Female; Guinea Pigs; In Vitro Techniques; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Pain Measurement; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Yeast, Dried | 1994 |
Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Edema; Erythema; Gastric Mucosa; Guinea Pigs; Humans; Mice; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Serotonin; Species Specificity; Thiazoles; Thrombin; Ultraviolet Rays | 1995 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles | 1996 |
The mechanism of action of KBT-3022, a new antiplatelet agent.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arachidonic Acid; Blood Platelets; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Guinea Pigs; In Vitro Techniques; Intramolecular Oxidoreductases; Isomerases; Male; Phosphatidic Acids; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Pyrroles; Rabbits; Thiazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1997 |
Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat.
Topics: Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cromakalim; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Free Radical Scavengers; Heart; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; Indomethacin; Kidney Cortex; Luminescent Measurements; Male; Microsomes; Nitric Oxide; Nitroarginine; Parasympatholytics; Perfusion; Pyrazines; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Vasodilator Agents | 1997 |
The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Bucladesine; Carbazoles; Colforsin; Cyclic AMP-Dependent Protein Kinases; Granulomatous Disease, Chronic; Immunohistochemistry; Indoles; Isoproterenol; Male; Mast Cells; NADPH Oxidases; p-Methoxy-N-methylphenethylamine; Phosphoproteins; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Recombinant Proteins; Superoxides; Terpenes | 1997 |
Structure-activity relationships of (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: variation of the substituents in positions 1, 3, and 5.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Caproates; Cattle; Cytosol; Enzyme Inhibitors; Fatty Acids; Ionophores; Molecular Structure; Phospholipases A; Phospholipases A2; Pyrroles; Structure-Activity Relationship | 1997 |
(Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins.
Topics: Adjuvants, Immunologic; Animals; Antibody Specificity; Arachidonic Acid; Arteriosclerosis; Binding, Competitive; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitopes; Hemocyanins; Humans; Kidney Failure, Chronic; Linoleic Acid; Lipoproteins, LDL; Oxidation-Reduction; Pyrroles; Rabbits; Serum Albumin | 1997 |
Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: inhibition by protein kinase A.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Arachidonic Acid; Calcimycin; Carbazoles; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Glycerides; GTP-Binding Proteins; Indoles; Lipase; Phenylephrine; Phospholipase D; Phospholipases A; Phospholipases A2; Prazosin; Pyrroles; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Transfection; Virulence Factors, Bordetella | 1998 |
Further studies on the involvement of the arachidonic acid cascade in the acute dependence produced by mu, kappa and delta opioid agonists in isolated tissues.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Benzeneacetamides; Cyclooxygenase 1; Cyclooxygenase 2; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Isoenzymes; Jejunum; Male; Oligopeptides; Opioid-Related Disorders; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrroles; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1999 |
The pyrrole moiety as a template for COX-1/COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Isoenzymes; Leukocytes, Mononuclear; Membrane Proteins; Molecular Structure; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Pyrroles; Sulfones; Thiophenes | 2000 |
Comparison of the inhibition of the cytosolic phospholipase A2-mediated arachidonic acid release by several indole-2-carboxylic acids and 3-(pyrrol-2-yl)propionic acids in bovine and in human platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Carboxylic Acids; Cattle; Cytosol; Humans; Indoles; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Propionates; Pyrroles | 2000 |
Arachidonic acid reversibly enhances N-type calcium current at an extracellular site.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Calcium Channel Agonists; Cell Membrane; Cells, Cultured; Guanosine Diphosphate; Kinetics; Membrane Potentials; Neurons; omega-Conotoxin GVIA; Pyrroles; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Superior Cervical Ganglion; Tetrodotoxin; Thionucleotides | 2001 |
Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Brain; Corticotropin-Releasing Hormone; Epinephrine; Injections, Intraventricular; Male; Norepinephrine; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Urocortins | 2001 |
The transcription factors CREB and c-Fos play key roles in NCAM-mediated neuritogenesis in PC12-E2 cells.
Topics: Animals; Arachidonic Acid; Axons; Bucladesine; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Genes, fos; Genes, Reporter; Hippocampus; Indoles; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Neoplasm Proteins; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Neurites; PC12 Cells; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Pyrroles; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thionucleotides; Transcription, Genetic; Transfection | 2001 |
Increased superoxide anion production by platelets in hypercholesterolemic patients.
Topics: Anticholesteremic Agents; Arachidonic Acid; Atorvastatin; Blood Platelets; Cholesterol; Cholesterol, LDL; Cross-Sectional Studies; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Pyrroles; Superoxides; Triglycerides | 2002 |
The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Bucladesine; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Indoles; Kidney Cortex; Kidney Medulla; Male; Okadaic Acid; Phosphodiesterase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2002 |
Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
Topics: Adrenergic Antagonists; Animals; Arachidonic Acid; Aspirin; Benzyl Compounds; Collagen; Guinea Pigs; Humans; Inhibitory Concentration 50; Isoquinolines; Platelet Aggregation; Platelet Aggregation Inhibitors; Propanolamines; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
Topics: Acetates; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Humans; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinolines; Thrombin; Thromboxane B2 | 2004 |
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |
Dual inhibition of cyclo-oxygenases and 5-lipoxygenase: a novel therapeutic approach to inflammation?
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Inflammation; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2005 |
Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hemostasis; Humans; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrroles; Rabbits | 2006 |
The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products.
Topics: 5-Lipoxygenase-Activating Proteins; Acetates; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arsenites; Bridged Bicyclo Compounds; Calcimycin; Calcium; Carrier Proteins; Cell-Free System; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; HeLa Cells; Humans; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Molecular Structure; Neutrophils; Nuclear Envelope; Pyrroles; Quinolines; Sodium Compounds; Transfection | 2007 |
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Topics: Acetates; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytosol; Gene Expression Regulation, Neoplastic; Humans; Lipoxygenase Inhibitors; Membrane Potential, Mitochondrial; Mitochondria; Prostaglandin-Endoperoxide Synthases; Pyrroles | 2008 |
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blood; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Humans; Indoles; Isoenzymes; Lipoxygenase Inhibitors; Molecular Structure; Neutrophils; Pyrazoles; Pyrroles; Random Allocation; Sulfonamides | 2008 |
Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
Topics: Acyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Fatty Acids; Group IV Phospholipases A2; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phospholipids; Pyrroles; Quinazolines; Receptor, PAR-1; RNA, Messenger; Thimerosal; Thrombin; Time Factors | 2008 |
FGF-activated calcium channels control neural gene expression in Xenopus.
Topics: Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Carrier Proteins; Embryo, Nonmammalian; Embryonic Induction; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Pyrroles; Signal Transduction; Xenopus laevis | 2009 |
Cyclooxygenase-2 induced by zymosan in human monocyte-derived dendritic cells shows high stability, and its expression is enhanced by atorvastatin.
Topics: Antigens, CD; Arachidonic Acid; Atorvastatin; Cycloheximide; Cyclooxygenase 1; Cyclooxygenase 2; Dendritic Cells; Dinoprostone; Gene Expression; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Mevalonic Acid; Peptidoglycan; Phospholipases A2, Cytosolic; Pyrroles; Zymosan | 2009 |
Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib.
Topics: Angiogenesis Inhibitors; Animals; Arachidonic Acid; Cell Line, Tumor; Cell Proliferation; Diet; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Fish Oils; Humans; Indoles; Lipid Metabolism; Male; Mice; Mice, SCID; Microvessels; Mitochondria; Neuroblastoma; Protein Kinase Inhibitors; Pyrroles; Sunitinib; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arachidonic Acid; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Cell Proliferation; Ceruletide; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Doublecortin-Like Kinases; Lipoxygenase Inhibitors; Mice; Mice, Knockout; MicroRNAs; Neoplastic Stem Cells; Pancreatic Neoplasms; Pancreatitis; Protein Serine-Threonine Kinases; Pyrroles | 2015 |