Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and alpha-synuclein

pyrroles has been researched along with alpha-synuclein in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eriksson, H; Georgievska, B; Poewe, W; Stefanova, N; Wenning, GK1
Abdelmotilib, HA; Chen, Y; Daher, JP; Fraser, KB; Galatsis, P; Hirst, WD; Hu, X; Moehle, MS; Needle, E; Steyn, SJ; Volpicelli-Daley, LA; West, AB1
Georgievska, B; Kaindlstorfer, C; Kugler, AR; Mather, RJ; Poewe, W; Sommer, P; Stefanova, N; Wenning, GK1
Bax, A; DuMond, JF; Levine, RL; Werner-Allen, JW1
Bax, A; Levine, RL; Werner-Allen, JW1
Henderson, MX; Lee, VMY; Peng, C; Trojanowski, JQ1

Other Studies

6 other study(ies) available for pyrroles and alpha-synuclein

ArticleYear
Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.
    Neurotoxicity research, 2012, Volume: 21, Issue:4

    Topics: Aged; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gliosis; Humans; Male; Mice; Mice, Transgenic; Microglia; Middle Aged; Motor Activity; Multiple System Atrophy; Nerve Degeneration; Peroxidase; Pyrimidinones; Pyrroles

2012
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.
    The Journal of biological chemistry, 2015, Aug-07, Volume: 290, Issue:32

    Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Dependovirus; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Vectors; Humans; Injections, Intraventricular; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Parkinson Disease; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Substantia Nigra

2015
Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.
    Neurotoxicity research, 2015, Volume: 28, Issue:3

    Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Mice, Transgenic; Microglia; Motor Activity; Multiple System Atrophy; Myelin Proteolipid Protein; Neurons; Neuroprotective Agents; Nitro Compounds; Peroxidase; Propionates; Pyrimidinones; Pyrroles; Severity of Illness Index; Treatment Outcome

2015
Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein.
    Angewandte Chemie (International ed. in English), 2016, 06-20, Volume: 55, Issue:26

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Cross-Linking Reagents; Humans; Limit of Detection; Pyrroles

2016
Superoxide is the critical driver of DOPAL autoxidation, lysyl adduct formation, and crosslinking of α-synuclein.
    Biochemical and biophysical research communications, 2017, May-27, Volume: 487, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Binding Sites; Cross-Linking Reagents; Enzyme Activation; Lysine; Oxidation-Reduction; Oxygen; Protein Binding; Pyrroles; Reactive Oxygen Species; Superoxide Dismutase

2017
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
    Acta neuropathologica communications, 2018, 05-31, Volume: 6, Issue:1

    Topics: alpha-Synuclein; Animals; Animals, Newborn; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Parkinson Disease; Pyrimidines; Pyrroles; Tyrosine 3-Monooxygenase

2018