pyrroles has been researched along with adenosine in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (24.00) | 18.7374 |
| 1990's | 17 (22.67) | 18.2507 |
| 2000's | 14 (18.67) | 29.6817 |
| 2010's | 11 (14.67) | 24.3611 |
| 2020's | 15 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Birch, GM; Coleman, LA; Drach, JC; Hudson, JL; Nassiri, MR; Pudlo, JS; Townsend, LB; Turk, SR | 1 |
| Alzheimer, C; Sutor, B; ten Bruggencate, G | 1 |
| Daly, J; Huang, M; Shimizu, H | 1 |
| Brdar, B; Reich, E | 1 |
| Daly, JW; Shimizu, H | 1 |
| Jaffe, JJ; Ross, AF | 1 |
| Baxter, CS; Byvoet, P | 2 |
| Bussolotti, DL; Chang, CD; Coward, JK | 1 |
| Brown, PR; Parks, RE | 1 |
| Roy-Burman, S; Visser, DW | 1 |
| Komatsu, Y; Tanaka, K | 1 |
| Muzik, H; Paterson, AR; Warnick, CT | 1 |
| Reinert, KE | 1 |
| Ng, MH; Vilcek, J | 1 |
| Caldwell, IC; Chu, SY; Henderson, JF; Mikoshiba, A | 1 |
| Hecht, SM | 1 |
| Khimenko, PL; Moore, TM; Taylor, AE | 1 |
| Broadley, KJ; Ford, WR; Urquhart, RA | 1 |
| Marquardt, DL; Walker, LL | 1 |
| Chiba, S; Furukawa, Y; Murakami, M | 1 |
| Bender, AS; White, HS; Woodbury, DM | 1 |
| Griffith, TM; Randall, MD; Ujiie, H | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Kasai, H; Ogawa, N | 1 |
| McGrath, JC; Smith, GC | 1 |
| Shen, YT; Vatner, SF | 1 |
| Chiba, S; Furukawa, Y; Inoue, Y; Sawaki, S; Takayama, S | 1 |
| Cronstein, BN; Landau, S; Montesinos, MC; Naime, D; Revan, S | 1 |
| Randall, MD | 1 |
| Carper, HT; Mandell, GL; Sullivan, GW | 1 |
| Gidday, JM; Maceren, RG; Meier, JA; Shah, AR; Zhu, Y | 1 |
| Broussas, M; Cornillet-Lefèbvre, P; Nguyen, P; Potron, G | 1 |
| Hirsch, JR; Hohendahl, A; Saleh, H; Schlatter, E; Schulte, EA; Stegemann, H | 1 |
| Agematsu, K; Hokibara, S; Komiyama, A; Nagumo, H; Nakazawa, T; Shinozaki, K; Yasui, K | 1 |
| Bellon, G; Fawzi, A; Kefalides, NA; Monboisse, JC; Robinet, A; Ziaie, Z | 1 |
| Nowak, I; Robins, MJ | 1 |
| POST, RL; SEN, AK | 1 |
| COTTERILL, J; PERRY, SV | 1 |
| Francis, K; Ham, J; Lewis, BM; Lewis, MD; Rees, DA; Scanlon, MF | 1 |
| Diniz, C; Fresco, P; Gonçalves, J | 1 |
| Domenici, MR; Martire, A; Pepponi, R; Popoli, P; Potenza, RL; Tebano, MT | 1 |
| Di Sciascio, G; Nusca, A; Pasceri, V; Patti, G | 1 |
| Amrani, M; Chester, AH; Osman, L; Smolenski, RT; Yacoub, MH | 1 |
| Amrani, M; Isley, C; Osman, L; Smolenski, RT; Yacoub, MH | 1 |
| Birnbaum, Y; Huang, MH; Hughes, MG; Lin, Y; Manickavasagam, S; McAdoo, DJ; Perez-Polo, R; Uretsky, BF; Ye, Y | 1 |
| Birnbaum, Y; Huang, MH; Lin, Y; Manickavasagam, S; Merla, R; Perez-Polo, RJ; Uretsky, BF; Ye, Y | 1 |
| Birnbaum, Y; Huang, MH; Hughes, MG; Lin, Y; Lui, CY; Manickavasagam, S; McAdoo, DJ; Perez-Polo, RJ; Uretsky, BF; Ye, Y | 1 |
| Delso, I; Merino, P; Tejero, T | 1 |
| Kamaike, K; Kawashima, E; Ohba, Y | 1 |
| Butler, KA; Mitchell, PD; Teng, R | 1 |
| Catar, R; Chaykovska, L; Dragun, D; Fuller, TF; Haller, M; Hoff, U; Kusch, A; Pützer, J; Troppmair, J | 1 |
| Li, X; Liu, D; Rong, Z; Xiang, D; Xu, Y; Zhang, C | 1 |
| Bray, JK; Chiu, GS; Darmody, PT; Freund, GG; Kwakwa, KA; McCusker, RH; Moon, ML; Walsh, JP | 1 |
| Bekerman, E; Einav, S | 1 |
| Clinch, K; Evans, GB; Freitas, EO; Guan, R; Meyer-Fernandes, JR; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC | 1 |
| Hashemian, Z; Khayamian, T; Saraji, M; Shirani, MP | 1 |
| Warren, RB; Yiu, ZZ | 1 |
| Fan, D; Liu, Y; Ma, H; Pang, X; Wei, Q; Wu, D; Zhang, Y | 1 |
| Cooper, S; Hussain, A; Maddock, H; Mee, C; Sandhu, H | 1 |
| Hong, J; Li, B; Li, X; Lu, Q; Wang, J; Weng, C; Yan, X; Zhou, X | 1 |
| Alvarez, JC; Annane, D; Etting, I; Larabi, IA; Moine, P | 1 |
| Bunel, V; Descamps, D; Jaquet, P; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH | 1 |
| Bunel, V; Descamps, D; Jaquet, P; Le Beller, C; Le Hingrat, Q; Lê, MP; Mal, H; Massias, L; Messika, J; Peytavin, G; Timsit, JF; Visseaux, B; Wicky, PH | 1 |
| Muller, FL; Yan, VC | 1 |
| Cies, JJ; Davis, MR; Pham, CU | 1 |
| Arnold, L; Chernobrovkin, A; Friman, T; Martinez Molina, D | 1 |
| Chen, YS; Chu, J; German, P; Humeniuk, R; John Ling, KH; Mathias, A; Tarnowski, T; van Ingen, E; Xiao, D | 1 |
| Brügel, M; Habler, K; Liebchen, U; Paal, M; Scharf, C; Schönermarck, U; Teupser, D; Vogeser, M | 1 |
| Bojkova, D; Buyck, C; Ciesek, S; Cinatl, J; De Jonghe, S; De Meyer, S; Jochmans, D; Leyssen, P; Neyts, J; Van Damme, E; Van Loock, M | 1 |
| Babusis, D; Cao, H; German, P; Humeniuk, R; Kirby, BJ; Ling, J; Lutz, JD; Mathias, A; Osinusi, A; Porter, D; Reddy, YS; Wei, X | 1 |
| Gandhi, M; Gerona, R; Metcalfe, J; Ong, CM; Reckers, A; Wu, AHB | 1 |
| Abe, T; Maekawa, M; Mano, N; Sato, T; Yamaguchi, H | 1 |
| Deb, S; Reeves, AA | 1 |
| Agrati, C; Ascoli Bartoli, T; Benvenuto, D; Marchioni, L; Nicastri, E; Stazi, GV; Tempestilli, M | 1 |
| Castillo, D; Cosaro, E; Murphy, BG; Pires, J; Reagan, KL | 1 |
4 review(s) available for pyrroles and adenosine
| Article | Year |
|---|---|
[Prevention of periprocedural myocardial damage in patients undergoing percutaneous coronary intervention].
Topics: Actuarial Analysis; Adenosine; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Biomarkers; Clopidogrel; Creatine Kinase, MB Form; Electrocardiography; Embolism; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Placebos; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Randomized Controlled Trials as Topic; Risk Factors; Stents; Ticlopidine; Time Factors; Vasodilator Agents | 2005 |
Current developments in the synthesis and biological activity of aza-C-nucleosides: immucillins and related compounds.
Topics: Adenine; Adenosine; Aza Compounds; Glycoside Hydrolases; N-Glycosyl Hydrolases; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines | 2008 |
Novel Oral Therapies for Psoriasis and Psoriatic Arthritis.
Topics: Adamantane; Adenosine; Adenosine A3 Receptor Antagonists; Administration, Oral; Arthritis, Psoriatic; Azetidines; Biological Factors; Biological Therapy; Clinical Trials as Topic; Humans; Isonicotinic Acids; Janus Kinases; Niacinamide; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; rho-Associated Kinases; Sulfonamides; Thalidomide; Thiazoles | 2016 |
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor.
Topics: Adenosine; Adenosine Monophosphate; Adult; Alanine; Animals; Antiviral Agents; Area Under Curve; COVID-19 Drug Treatment; Dose-Response Relationship, Drug; Drug Interactions; Furans; Half-Life; Humans; Metabolic Clearance Rate; Pyrroles; SARS-CoV-2; Triazines | 2021 |
2 trial(s) available for pyrroles and adenosine
| Article | Year |
|---|---|
Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteers.
Topics: Adenosine; Adult; Area Under Curve; Atorvastatin; Biotransformation; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Least-Squares Analysis; Linear Models; Male; Metabolic Clearance Rate; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Pyrroles; Simvastatin; Ticagrelor | 2013 |
Efficacy of Oral Remdesivir Compared to GS-441524 for Treatment of Cats with Naturally Occurring Effusive Feline Infectious Peritonitis: A Blinded, Non-Inferiority Study.
Topics: Adenosine; Animals; Antiviral Agents; Cats; Double-Blind Method; Equivalence Trials as Topic; Feline Infectious Peritonitis; Furans; Pyrroles; Triazines | 2023 |
69 other study(ies) available for pyrroles and adenosine
| Article | Year |
|---|---|
Activity of acyclic halogenated tubercidin analogs against human cytomegalovirus and in uninfected cells.
Topics: Adenosine; Antiviral Agents; Cell Division; Cells, Cultured; Cytomegalovirus; DNA, Viral; Dose-Response Relationship, Drug; Humans; KB Cells; Pyrimidines; Pyrroles; RNA, Viral; Tubercidin | 1991 |
Cromakalim (BRL 34915) acts on an inwardly rectifying neuronal K+ conductance, which is similar to that activated by adenosine.
Topics: Adenosine; Animals; Benzopyrans; Cromakalim; Electrophysiology; Guinea Pigs; Hippocampus; In Vitro Techniques; Potassium Channels; Pyrroles; Vasodilator Agents | 1989 |
Regulation of adenosine cyclic 3',5'-phosphate formation in cerebral cortical slices. Interaction among norepinephrine, histamine, serotonin.
Topics: Adenosine; Alkaloids; Amines; Animals; Autonomic Agents; Biogenic Amines; Carbon Isotopes; Cerebral Cortex; Cyclic AMP; Drug Interactions; Drug Synergism; Guinea Pigs; Histamine; In Vitro Techniques; Male; Norepinephrine; Ouabain; Potassium; Pregnanes; Pyrroles; Receptors, Drug; Serotonin; Time Factors; Toxins, Biological; Veratrine | 1971 |
7-Deazanebularin. Metabolism in cultures of mouse fibroblasts and incorporation into cellular and viral nucleic acids.
Topics: Adenosine; Animals; Carbon Isotopes; Chick Embryo; DNA; DNA, Viral; Encephalomyocarditis virus; Fibroblasts; L Cells; Mice; Nucleosides; Phenylalanine; Protein Biosynthesis; Pyrimidines; Pyrroles; Ribonucleosides; RNA; RNA, Transfer; RNA, Viral; Tritium; Vaccinia virus; Virus Replication | 1972 |
Effect of depolarizing agents on accumulation of cyclic adenosine 3',5'-monophosphate in cerebral cortical slices.
Topics: Adenosine; Alkaloids; Animals; Brain Chemistry; Carbon Isotopes; Cerebral Cortex; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Male; Neuromuscular Depolarizing Agents; Ouabain; Phosphoric Diester Hydrolases; Potassium; Pregnanes; Pyrroles; Quaternary Ammonium Compounds; Rabbits; Tetrodotoxin; Theophylline; Toxins, Biological; Veratrine | 1972 |
Effects of tubercidin and its ribonucleotides on various metabolic pathways in Schistosoma mansoni.
Topics: Adenosine; Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Creatine Kinase; Glucose; Glycogen; Lactates; NAD; Nucleotides; Phosphotransferases; Potassium; Purine Nucleotides; Pyrimidines; Pyrroles; Ribonucleosides; Ribonucleotides; Schistosoma mansoni; Sodium; Time Factors | 1972 |
Effects of carcinogens and other agents on histone methylation by a histone arginine methyltransferase purified from rat liver cytoplasm.
Topics: Acridines; Adenine; Adenosine; Animals; Arginine; Azo Compounds; Carbon Radioisotopes; Carcinogens; Cytoplasm; Dimethylformamide; Ethidium; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Male; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Effects of carcinogens and other agents on histone methylation in rat liver nuclei by endogenous histone lysine methyltransferase.
Topics: Adenosine; Animals; Azo Compounds; Benz(a)Anthracenes; Carbon Radioisotopes; Carcinogens; Cell Nucleus; Dimethylformamide; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Lysine; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Inhibition of several methylases by S-tubercidinylhomocysteine.
Topics: Adenosine; Animals; Anti-Bacterial Agents; Catechol O-Methyltransferase Inhibitors; Homocysteine; Indoles; Kinetics; Liver; Lung; Methyltransferases; Pyrimidines; Pyrroles; Rabbits; Rats; Ribonucleosides; S-Adenosylmethionine; tRNA Methyltransferases | 1974 |
Incorporation of nucleosides into the nucleotide pools of human erythrocytes. Adenosine and its analogs.
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminohydrolases; Antibiotics, Antineoplastic; Aza Compounds; Carbohydrate Metabolism; Deoxyadenosines; Erythrocytes; Fluorine; Humans; Inosine; Mercaptopurine; Nucleosides; Phosphotransferases; Pyrazoles; Pyrimidines; Pyrimidinones; Pyrroles; Ribonucleosides; Structure-Activity Relationship | 1973 |
Transport studies of showdomycin, nucleosides and sugars in Escherichia coli B and in showdomycin-resistant mutants.
Topics: Adenosine; Amino Acids; Antibiotics, Antineoplastic; Biological Transport; Carbon Isotopes; Cytidine; Drug Resistance, Microbial; Escherichia coli; Ethylmaleimide; Glucose; Guanosine; Maleimides; Mannose; Mutation; Nucleosides; Pyrroles; Ribose; Tritium; Uridine | 1972 |
A showdomycin-resistant mutant of Escherichia coli K-12 with altered nucleoside transport character.
Topics: Adenosine; Antibiotics, Antineoplastic; Biological Transport; Carbon Isotopes; Cytidine; Deamination; Deoxyribonucleosides; Drug Interactions; Drug Resistance, Microbial; Escherichia coli; Genetics, Microbial; Guanosine; Hypoxanthines; Maleimides; Mutation; Nucleosides; Osmosis; Pyrroles; Ribonucleotides | 1972 |
Interference with nucleoside transport in mouse lymphoma cells proliferating in culture.
Topics: Adenosine; Animals; Ascitic Fluid; Aza Compounds; Biological Transport; Bromodeoxyuridine; Carbon Isotopes; Cell Division; Cell-Free System; Cells, Cultured; Guanosine; Inosine; Lymphoma; Male; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Pyrimidinones; Pyrroles; Ribonucleosides; Thymidine; Time Factors; Transplantation, Homologous | 1972 |
Adenosine-thymidine cluster-specific elongation and stiffening of DNA induced by the oligopeptide antibiotic netropsin.
Topics: Adenosine; Animals; Anti-Bacterial Agents; Binding Sites; Cattle; DNA; Guanidines; Molecular Weight; Nucleic Acid Conformation; Peptide Chain Elongation, Translational; Pyrroles; Thymidine; Viscosity | 1972 |
Temperature-sensitive interferon production in rabbit kidney cell cultures treated with toyocamycin.
Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Drug Stability; Interferons; Kidney; Liver; Microsomes, Liver; Nitriles; Nucleosides; Poly I-C; Protein Biosynthesis; Pyrroles; Rabbits; RNA, Messenger; RNA, Ribosomal; Temperature; Time Factors; Translations; Tritium | 1973 |
Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Binding Sites; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Feedback; Kinetics; Mercaptopurine; Phosphotransferases; Protein Binding; Pyrimidines; Pyrroles; Ribonucleosides; Ribonucleotides; Structure-Activity Relationship | 1972 |
Mass spectra of some heterocycles related to N 6 -( 2 -isopentenyl)adenosine.
Topics: Adenine; Adenosine; Alkenes; Mass Spectrometry; Methylation; Nucleosides; Pyrazoles; Pyrimidines; Pyrroles; Sulfides | 1971 |
ATP-sensitive K+ channels are not involved in ischemia-reperfusion lung endothelial injury.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Capillary Permeability; Cromakalim; Endothelium; Glyburide; Hemodynamics; Hypoglycemic Agents; In Vitro Techniques; Ischemia; Lung; Male; Potassium Channels; Pulmonary Circulation; Pulmonary Wedge Pressure; Pyrroles; Rats; Reperfusion Injury; Vascular Resistance; Vasodilator Agents | 1995 |
Potassium channel blockade of atrial negative inotropic responses to P1-purinoceptor and muscarinic receptor agonists and to cromakalim.
Topics: 4-Aminopyridine; Adenosine; Animals; Benzopyrans; Carbachol; Cromakalim; Depression, Chemical; Glyburide; Guinea Pigs; Heart Atria; Hydrochloric Acid; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Phenylisopropyladenosine; Potassium Channels; Pyrroles; Receptors, Muscarinic; Receptors, Purinergic; Rubidium Radioisotopes | 1993 |
Inhibition of protein kinase A fails to alter mast cell adenosine responsiveness.
Topics: Adenosine; Adenylyl Cyclases; Animals; Bone Marrow Cells; Carbazoles; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Indoles; Mast Cells; Mice; Mice, Inbred BALB C; Pyrroles; Receptors, Purinergic P1; Type C Phospholipases | 1994 |
Effects of glibenclamide on negative cardiac responses to cholinergic and purinergic stimuli and cromakalim in the isolated dog heart.
Topics: Acetylcholine; Adenosine; Adenosine Triphosphate; Analysis of Variance; Animals; Benzopyrans; Cholinergic Agonists; Cromakalim; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; In Vitro Techniques; Myocardial Contraction; Parasympathetic Nervous System; Potassium Channels; Purinergic Agonists; Pyrroles; Receptors, Cholinergic; Receptors, Purinergic; Vasodilator Agents | 1994 |
Ionic dependence of adenosine uptake into cultured astrocytes.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Biological Transport; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Cortex; Cromakalim; Furosemide; Glyburide; Ionophores; Kinetics; Mice; Niacinamide; Nicorandil; Nigericin; Omeprazole; Potassium; Pyrroles; Sodium; Valinomycin; Vasodilator Agents | 1994 |
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pinacidil; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Xanthines | 1994 |
Comparison of the effects of KRN2391 and other coronary dilators on porcine isolated coronary arteries of different sizes.
Topics: Adenosine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Characterisation of the effect of oxygen tension on response of fetal rabbit ductus arteriosus to vasodilators.
Topics: Adenosine; Animals; Atrial Natriuretic Factor; Benzopyrans; Colforsin; Cromakalim; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus; Epoprostenol; Flurbiprofen; Indomethacin; Nifedipine; Nitroprusside; Norepinephrine; Oxygen; Pyrroles; Rabbits; Vasodilator Agents | 1993 |
Effects of a K+ATP channel opener, lemakalim, on systemic, coronary and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerin and acetylcholine.
Topics: Acetylcholine; Adenosine; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Hemodynamics; Nifedipine; Nitroglycerin; Potassium Channels; Pyrroles; Regional Blood Flow; Vascular Resistance; Vasodilator Agents | 1993 |
A bradycardic agent, UL-FS 49, increases atrial force and decreases ventricular force in isolated, perfused heart preparations of dogs.
Topics: Acetylcholine; Adenosine; Animals; Atrial Function; Benzazepines; Benzopyrans; Cardiovascular Agents; Cromakalim; Dogs; Heart Atria; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Perfusion; Potassium Channels; Pyrroles; Sinoatrial Node; Ventricular Function | 1993 |
Adenosine A2 receptor occupancy regulates stimulated neutrophil function via activation of a serine/threonine protein phosphatase.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Carbazoles; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Humans; In Vitro Techniques; Indoles; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Purinergic P1 Receptor Agonists; Pyrroles; Superoxides | 1996 |
The involvement of ATP-sensitive potassium channels and adenosine in the regulation of coronary flow in the isolated perfused rat heart.
Topics: Adenosine; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Glyburide; Heart; In Vitro Techniques; Male; Perfusion; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Theophylline; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
The specific type IV phosphodiesterase inhibitor rolipram combined with adenosine reduces tumor necrosis factor-alpha-primed neutrophil oxidative activity.
Topics: Adenosine; Carbazoles; Drug Synergism; Humans; In Vitro Techniques; Indoles; Neutrophils; Pentoxifylline; Phenethylamines; Phosphodiesterase Inhibitors; Pyrroles; Pyrrolidinones; Respiratory Burst; Rolipram; Superoxides; Tumor Necrosis Factor-alpha | 1995 |
KATP channels mediate adenosine-induced hyperemia in retina.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Cyclic AMP; Dose-Response Relationship, Drug; Fluorescein Angiography; Glyburide; Hyperemia; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Pyrroles; Regional Blood Flow; Retinal Vessels; Second Messenger Systems; Signal Transduction; Swine; Vasodilation; Vasodilator Agents | 1996 |
Inhibition of fMLP-triggered respiratory burst of human monocytes by adenosine: involvement of A3 adenosine receptor.
Topics: Adenosine; Bucladesine; Calcium; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochalasin B; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Humans; Indoles; Luminescent Measurements; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Oxygen Consumption; Pyrroles; Receptor, Adenosine A3; Receptors, Purinergic P1; Respiratory Burst; RNA, Messenger; Second Messenger Systems; Theobromine; Xanthines | 1999 |
Natriuretic peptides and diadenosine polyphosphates modulate pH regulation of rat mesangial cells.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Alkaloids; Animals; Atrial Natriuretic Factor; Carbazoles; Cells, Cultured; Dinucleoside Phosphates; Female; Gene Expression Regulation; Glomerular Mesangium; Guanidines; Hydrogen-Ion Concentration; Indoles; Platelet-Derived Growth Factor; Pyrroles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sodium-Hydrogen Exchangers; Sulfones | 1999 |
Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism.
Topics: Adenosine; Apoptosis; Carbazoles; Cells, Cultured; Humans; Indoles; Neutrophils; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyrroles; Receptor, Adenosine A2A; Signal Transduction; Theophylline; Xanthines | 2000 |
A peptide of the alpha 3(IV) chain of type IV collagen modulates stimulated neutrophil function via activation of cAMP-dependent protein kinase and Ser/Thr protein phosphatase.
Topics: Adenosine; Amino Acid Sequence; Autoantigens; Calcium; Carbazoles; Chelating Agents; Collagen; Collagen Type IV; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine Antagonists; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; Indoles; Marine Toxins; Molecular Sequence Data; Neutrophils; Okadaic Acid; Oxazoles; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Pyrroles; Pyrrolidinones; Respiratory Burst; Signal Transduction; Thapsigargin; Trifluoperazine | 2000 |
Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety.
Topics: Adenosine; Guanosine; Hexanones; Hot Temperature; Hydrolysis; Magnetic Resonance Spectroscopy; Nucleosides; Pyrroles; Spectrophotometry, Ultraviolet; Trifluoroacetic Acid; Water | 2003 |
STOICHIOMETRY AND LOCALIZATION OF ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT IN THE ERYTHROCYTE.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Antimetabolites; Chromatography; Erythrocytes; Hemolysis; Iodoacetates; Ion Transport; Keto Acids; Lactates; Metabolism; Pharmacology; Potassium; Purines; Pyrroles; Research; Sodium; Strophanthins | 1964 |
THE ACTION OF THIOL REAGENTS ON THE ADENOSINE-TRIPHOSPHATASE ACTIVITIES OF HEAVY MEROMYOSIN AND L-MYOSIN.
Topics: Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Biochemical Phenomena; Biochemistry; Calcium; Calcium Chloride; Catalysis; Chemical Phenomena; Chemistry, Physical; Ethylmaleimide; Ions; Mercury; Muscle Proteins; Myosin Subfragments; Myosins; Potassium Chloride; Pyrroles; Research; Sodium Chloride; Sulfhydryl Compounds; Sulfhydryl Reagents | 1965 |
Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Cells, Cultured; Dexamethasone; Estrenes; Indoles; Interleukin-6; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pituitary Gland, Anterior; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, Adenosine A2B; Type C Phospholipases; Vascular Endothelial Growth Factors; Wortmannin | 2003 |
Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylyl Cyclases; Animals; Arteries; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Indoles; Isoquinolines; Male; Norepinephrine; Phenethylamines; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptor, Adenosine A2A; Signal Transduction; Sulfonamides; Tail; Tetradecanoylphorbol Acetate; Triazoles; Tritium; Type C Phospholipases | 2004 |
Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum.
Topics: Adenosine; Animals; Carbazoles; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; In Vitro Techniques; Indoles; Male; Membrane Potentials; N-Methylaspartate; Phenethylamines; Phenylacetates; Pregnancy; Purinergic P1 Receptor Agonists; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Adenosine A2; Receptors, Metabotropic Glutamate; Triazines; Triazoles | 2004 |
A novel role of extracellular nucleotides in valve calcification: a potential target for atorvastatin.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Aged; Alkaline Phosphatase; Aortic Valve; Aortic Valve Stenosis; Apyrase; Atorvastatin; Biomarkers; Calcinosis; Cell Differentiation; Cells, Cultured; Drug Evaluation, Preclinical; Heptanoic Acids; Humans; Middle Aged; Osteoblasts; Pyrroles; Receptors, Purinergic P2; Second Messenger Systems | 2006 |
Stimulatory effects of atorvastatin on extracellular nucleotide degradation in human endothelial cells.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nucleotides; Pyrroles | 2006 |
Enhanced cardioprotection against ischemia-reperfusion injury with a dipyridamole and low-dose atorvastatin combination.
Topics: Adenosine; Administration, Oral; Animals; Atorvastatin; Cardiotonic Agents; Dipyridamole; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Heptanoic Acids; Male; Myocardial Reperfusion Injury; Pyrroles; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2007 |
The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation.
Topics: 5'-Nucleotidase; Adenosine; Animals; Atorvastatin; Butadienes; Enzyme Inhibitors; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Nitriles; Phosphodiesterase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Purinergic P1; Theophylline | 2007 |
The cardioprotective effect of a statin and cilostazol combination: relationship to Akt and endothelial nitric oxide synthase activation.
Topics: Adenosine; Administration, Oral; Animals; Atorvastatin; Body Weight; Cilostazol; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Heptanoic Acids; Immunoblotting; Male; Myocardium; Nitric Oxide Synthase Type III; Organ Culture Techniques; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Risk Factors; Tetrazoles; Treatment Outcome | 2007 |
Synthesis of oligonucleotide conjugated pyrrolepolyamide- and pyrrole-imidazole polyamide-2'-deoxyguanosine hybrids as novel gene expression control compounds.
Topics: Adenosine; Gene Expression Regulation; Genetic Therapy; Oligodeoxyribonucleotides; Pyrroles | 2008 |
Protein kinase C inhibition ameliorates posttransplantation preservation injury in rat renal transplants.
Topics: Adenosine; Allopurinol; Animals; Apoptosis; Biomarkers; Blotting, Western; Cell Proliferation; Cold Temperature; Creatinine; Cytokines; Cytoprotection; Delayed Graft Function; Glutathione; Immunohistochemistry; Inflammation Mediators; Insulin; Kidney; Kidney Transplantation; Male; Mycophenolic Acid; Organ Preservation; Organ Preservation Solutions; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Raffinose; Rats; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Signal Transduction; Time Factors | 2012 |
Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability.
Topics: Adenosine; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Diketopiperazines; Glycine; Heterocyclic Compounds, 4 or More Rings; Intestinal Absorption; Intestinal Mucosa; Leukotriene Antagonists; Male; Mice; Mice, Knockout; Propionates; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Tolmetin; Vasodilator Agents; Verapamil | 2013 |
Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety.
Topics: Adenosine; Amygdala; Animals; Anxiety; Brain; Carbazoles; Caspase 1; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exploratory Behavior; Feeding Behavior; Glyburide; Interleukin-1beta; Ion Transport; KATP Channels; Locomotion; Maze Learning; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Potassium; Pyrroles; Receptor, Adenosine A2A; Receptors, Interleukin-1 Type I | 2014 |
Infectious disease. Combating emerging viral threats.
Topics: Adenine; Adenosine; Antiviral Agents; Benzamides; Chloroquine; Communicable Diseases, Emerging; Cyclosporins; Cytosine; Dengue; Drug Approval; Drug Design; Erlotinib Hydrochloride; Hemorrhagic Fever, Ebola; Humans; Imatinib Mesylate; Indoles; Organophosphonates; Piperazines; Purine Nucleosides; Pyrimidines; Pyrroles; Pyrrolidines; Quinazolines; Sunitinib; Viruses | 2015 |
Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro.
Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Cell Proliferation; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Pyrrolidines | 2015 |
Aptasensor based on fluorescence resonance energy transfer for the analysis of adenosine in urine samples of lung cancer patients.
Topics: Adenosine; Aptamers, Nucleotide; Biosensing Techniques; Fluorescence; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Humans; Limit of Detection; Lung Neoplasms; Molecular Dynamics Simulation; Polymers; Pyrroles; Quantum Dots | 2016 |
Visible light photoelectrochemical aptasensor for adenosine detection based on CdS/PPy/g-C3N4 nanocomposites.
Topics: Adenosine; Aptamers, Nucleotide; Cadmium Compounds; Conductometry; Equipment Design; Equipment Failure Analysis; Light; Nanoconjugates; Nitriles; Photometry; Polymers; Pyrroles; Reproducibility of Results; Selenium Compounds; Sensitivity and Specificity | 2016 |
Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Cell Survival; Heart; Heart Rate; Hemodynamics; HL-60 Cells; Humans; Indoles; MicroRNAs; Protein Kinase C-alpha; Pyrroles; Receptor, Adenosine A3; Signal Transduction; Sunitinib; Ventricular Function, Left | 2017 |
A versatile fluorometric aptasensing scheme based on the use of a hybrid material composed of polypyrrole nanoparticles and DNA-silver nanoclusters: application to the determination of adenosine, thrombin, or interferon-gamma.
Topics: Adenosine; Aptamers, Nucleotide; Biosensing Techniques; DNA; Fluorometry; Interferon-gamma; Nanostructures; Polymers; Pyrroles; Silver; Thrombin | 2019 |
Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Chromatography, Liquid; Coronavirus Infections; COVID-19; Drug Monitoring; Drug Stability; Female; Furans; Humans; Limit of Detection; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pyrroles; Reproducibility of Results; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2020 |
Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; beta-Cyclodextrins; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Interactions; Furans; Humans; Intensive Care Units; Lung Transplantation; Multiple Organ Failure; Pandemics; Pneumonia, Viral; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines | 2020 |
Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity".
Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung Transplantation; Neuroglia; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines | 2020 |
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity.
Topics: Adenosine; Adenosine Monophosphate; Alanine; beta-Cyclodextrins; COVID-19; Furans; Humans; Lung; Pandemics; Pyrroles; Renal Dialysis; SARS-CoV-2; Transplant Recipients; Triazines | 2020 |
Remdesivir and GS-441524 plasma concentrations in patients with end-stage renal disease on haemodialysis.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Furans; Humans; Kidney Failure, Chronic; Pyrroles; Renal Dialysis; Triazines | 2021 |
CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; ATPases Associated with Diverse Cellular Activities; Cell Cycle Proteins; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; Furans; Hep G2 Cells; Humans; Mass Spectrometry; Proteomics; Pyrroles; Triazines; United States; United States Food and Drug Administration | 2021 |
Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, High Pressure Liquid; COVID-19 Drug Treatment; Drug Monitoring; Furans; Humans; Limit of Detection; Pyrroles; Tandem Mass Spectrometry; Triazines | 2021 |
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum
Topics: Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Azithromycin; Chloroquine; Chromatography, Liquid; COVID-19; COVID-19 Drug Treatment; Furans; Humans; Hydroxychloroquine; Isotopes; Lopinavir; Pandemics; Pyrazines; Pyrroles; Ritonavir; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2021 |
In vitro activity of itraconazole against SARS-CoV-2.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 Drug Treatment; Drug Repositioning; Furans; Humans; Itraconazole; Pyrroles; SARS-CoV-2; Triazines; Vero Cells; Virus Replication | 2021 |
A combined assay for quantifying remdesivir and its metabolite, along with dexamethasone, in serum.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Chromatography, Liquid; COVID-19 Drug Treatment; Dexamethasone; Furans; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Triazines | 2021 |
Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Dogs; Dose-Response Relationship, Drug; Drug Approval; Furans; Humans; Kidney; Kidney Tubules, Proximal; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Pyrroles; Triazines | 2021 |
Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; Computer Simulation; COVID-19; COVID-19 Drug Treatment; Databases, Chemical; Drug Interactions; Furans; Humans; Prodrugs; Pyrroles; Risk Assessment; Risk Factors; SARS-CoV-2; Triazines | 2021 |
Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects.
Topics: Adenosine; Adenosine Monophosphate; Alanine; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pyrroles; SARS-CoV-2; Tandem Mass Spectrometry; Transaminases; Triazines | 2022 |