pyrroles has been researched along with 8-(3-(1-((3-fluorophenyl)methyl)-4-piperidinyl)-1-oxopropyl)-1,2,5,6-tetrahydro-4h-pyrrolo(3,2,1-ij)quinolin-4-one in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doi, T; Nagabukuro, H; Okanishi, S | 1 |
| Doi, T; Imai, S; Ishichi, Y; Ishihara, Y; Miwatashi, S; Nagabukuro, H; Okanishi, S; Saikawa, R; Sasaki, M; Setoh, M; Tsukamoto, T | 1 |
| Doi, T; Hashimoto, T; Iwata, M; Nagabukuro, H | 1 |
| Doi, T; Nagabukuro, H | 1 |
| Doi, T; Hashimoto, T; Nagabukuro, H | 1 |
| Asahi, S; Kakehi, M; Kondo, T; Tagawa, Y | 1 |
| Asahi, S; Kondo, T; Mouri, K; Nishihara, M; Takahashi, J | 1 |
| Asahi, S; Goto, A; Kakehi, M; Kondo, T; Tagawa, Y | 1 |
1 trial(s) available for pyrroles and 8-(3-(1-((3-fluorophenyl)methyl)-4-piperidinyl)-1-oxopropyl)-1,2,5,6-tetrahydro-4h-pyrrolo(3,2,1-ij)quinolin-4-one
| Article | Year |
|---|---|
Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11β-hydroxysteroid dehydrogenase 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Dogs; Dose-Response Relationship, Drug; Glycyrrhetinic Acid; Haplorhini; Humans; Male; Microsomes, Liver; Pyrroles; Quinolones; Rats; Species Specificity | 2014 |
7 other study(ies) available for pyrroles and 8-(3-(1-((3-fluorophenyl)methyl)-4-piperidinyl)-1-oxopropyl)-1,2,5,6-tetrahydro-4h-pyrrolo(3,2,1-ij)quinolin-4-one
| Article | Year |
|---|---|
Effects of TAK-802, a novel acetylcholinesterase inhibitor, and various cholinomimetics on the urodynamic characteristics in anesthetized guinea pigs.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Pressure; Pyrroles; Quinolones; Urethane; Urethra; Urinary Bladder Neck Obstruction; Urodynamics | 2004 |
Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds.
Topics: Acetylcholinesterase; Animals; Bethanechol; Cholinesterase Inhibitors; Guinea Pigs; Inhibitory Concentration 50; Male; Molecular Structure; Muscle Contraction; Pyrroles; Quinolones; Rats; Structure-Activity Relationship; Urinary Bladder | 2005 |
Effects of TAK-802, a novel acetylcholinesterase inhibitor, and tamsulosin, an alpha1-adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea-pig model of functional bladder outlet obstruction.
Topics: Acetylcholinesterase; Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Animals; Cholinesterase Inhibitors; Drug Synergism; Drug Therapy, Combination; Guinea Pigs; Infusions, Intravenous; Male; Prostatic Hyperplasia; Pyrroles; Quinolones; Sulfonamides; Tamsulosin; Urinary Bladder Neck Obstruction; Urinary Retention; Urodynamics | 2005 |
Differential effects of TAK-802, a selective acetylcholinesterase inhibitor, and carbamate acetylcholinesterase inhibitors on contraction of the detrusor smooth muscle of the guinea pig.
Topics: Acetylcholinesterase; Animals; Carbamates; Cholinesterase Inhibitors; Guinea Pigs; Isometric Contraction; Male; Muscle, Smooth; Nicotine; Nicotinic Agonists; Pyrroles; Quinolones; Tissue Culture Techniques; Urinary Bladder | 2005 |
Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction.
Topics: Administration, Oral; Animals; Bethanechol; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mice; Muscarinic Agonists; Organ Size; Pyridinium Compounds; Pyrroles; Quinolones; Rats; Rats, Wistar; Urinary Bladder; Urinary Bladder Neck Obstruction; Urination; Urodynamics | 2005 |
Disposition of the new potent acetylcholinesterase inhibitor 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidiny]-1-oxopropyl]-1, 2, 5, 6-tetrahydro-4H-pyrrolo [3, 2, 1-ij] quinolin-4-one (TAK-802) in rats, dogs and monkeys.
Topics: Animals; Bile; Cholinesterase Inhibitors; Dogs; Erythrocytes; Macaca fascicularis; Male; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2013 |
The effects of the concentration-dependent erythrocyte distribution of TAK-802, a potent acetylcholinesterase inhibitor, on rat pharmacokinetics.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Erythrocytes; Male; Protein Binding; Pyrroles; Quinolones; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2016 |