Compounds > pyrroles
Page last updated: 2024-08-18

pyrroles and 2-pyrrolino-dox

pyrroles has been researched along with 2-pyrrolino-dox in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (39.29)18.2507
2000's15 (53.57)29.6817
2010's2 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Armatis, P; Nagy, A; Schally, AV1
Armatis, P; Groot, K; Halmos, G; Horvath, J; Jungwirth, A; Kovacs, M; Miyazaki, M; Nagy, A; Schally, AV; Szepeshazi, K; Zarandi, M1
Armatis, P; Cai, RZ; Halmos, G; Nagy, A; Schally, AV; Szepeshazi, K1
Groot, K; Koppan, M; Kovacs, M; Nagy, A; Schally, AV1
Groot, K; Halmos, G; Nagy, A; Schally, AV; Szepeshazi, K1
Armatis, P; Cai, RZ; Csernus, V; Halmos, G; Kahán, Z; Koppán, M; Kovács, M; Nagy, A; Schally, AV; Szepesházi, K1
Alexander, JM; Danila, DC; Nagy, A; Schally, AV1
Arencibia, JM; Groot, K; Halmos, G; Koppán, M; Nagy, A; Plonowski, A; Schally, AV1
Nagy, A; Plonowski, A; Schally, AV; Sun, B; Szepeshazi, K1
Groot, K; Halmos, G; Hebert, F; Kahán, Z; Nagy, A; Schally, AV; Sun, B1
Nagy, A; Schally, AV; Szepeshazi, K1
Nagy, A; Plonowski, A; Schally, AV1
Arencibia, JM; Groot, K; Halmos, G; Kahán, Z; Nagy, A; Schally, AV1
Groot, K; Halmos, G; Nagy, A; Plonowski, A; Schally, AV; Sun, B1
Halmos, G; Nagy, A; Plonowski, A; Schally, AV; Sun, B1
Arencibia, JM; Bajo, AM; Chatzistamou, I; Krupa, M; Nagy, A; Schally, AV1
Bajo, AM; Halmos, G; Hebert, F; Nagy, A; Schally, AV; Szepeshazi, K; Szereday, Z1
Blanc, E; Castex, C; Clair, P; Merida, P; Rees, AR; Temsamani, J1
Engel, JB; Halmos, G; Hammann, B; Keller, G; Nagy, A; Schally, AV1
Nagy, A; Schally, AV1
Baker, B; Engel, JB; Gaiser, T; Halmos, G; Keller, G; Nagy, A; Schally, AV1
Halmos, G; Kanashiro, CA; Nagy, A; Schally, AV; Stangelberger, A; Szepeshazi, K1
Baker, B; Engel, JB; Halmos, G; Keller, G; Nagy, A; Schally, AV1
Halmos, G; Schally, AV; Szepeshazi, K1
Halmos, G; Schally, AV; Seitz, S; Szepeshazi, K; Treszl, A1
Sun, Y; Wang, C1
Ibrahimova, M; Rihova, B; Studenovsky, M; Ulbrich, K1
Brabec, V; Kasparkova, J; Liskova, B; Malina, J; Novakova, O; Stepankova, J; Studenovsky, M; Ulbrich, K1

Reviews

2 review(s) available for pyrroles and 2-pyrrolino-dox

ArticleYear
Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers.
    Biology of reproduction, 2005, Volume: 73, Issue:5

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Endometrial Neoplasms; Epithelial Cells; Female; Gonadotropin-Releasing Hormone; Humans; Male; Ovarian Neoplasms; Prostatic Neoplasms; Pyrroles; Receptors, LHRH

2005
[Advances in the study of small peptides in targeted drug delivery system].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2008, Volume: 43, Issue:10

    Topics: Animals; Antineoplastic Agents; Doxorubicin; Drug Delivery Systems; Humans; Neoplasms; Oligopeptides; Pyrroles; Receptors, Bombesin; Receptors, LHRH; Receptors, Somatostatin

2008

Other Studies

26 other study(ies) available for pyrroles and 2-pyrrolino-dox

ArticleYear
High yield conversion of doxorubicin to 2-pyrrolinodoxorubicin, an analog 500-1000 times more potent: structure-activity relationship of daunosamine-modified derivatives of doxorubicin.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Mar-19, Volume: 93, Issue:6

    Topics: Aldehydes; Animals; Antibiotics, Antineoplastic; Doxorubicin; Drug Design; Humans; Mass Spectrometry; Mice; Pyrroles; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured

1996
Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-09, Volume: 93, Issue:14

    Topics: Amino Acid Sequence; Animals; Antibiotics, Antineoplastic; Binding, Competitive; Breast Neoplasms; Doxorubicin; Female; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormone; Molecular Sequence Data; Pituitary Gland; Pyrroles; Rats; Receptors, LHRH; Tumor Cells, Cultured

1996
Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Jan-21, Volume: 94, Issue:2

    Topics: Bombesin; Cell Survival; Cytotoxins; Doxorubicin; Humans; Molecular Structure; Pyrroles; Receptors, Bombesin; Structure-Activity Relationship; Tumor Cells, Cultured

1997
Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Feb-18, Volume: 94, Issue:4

    Topics: Animals; Antineoplastic Agents; Body Weight; Cytotoxins; Doxorubicin; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Luteinizing Hormone; Menstrual Cycle; Pituitary Function Tests; Pituitary Gland, Anterior; Pyrroles; Rats; Rats, Sprague-Dawley; Thyrotropin

1997
Targeted cytotoxic luteinizing hormone releasing hormone (LH-RH) anlalogs inhibit growth of estrogen independent MXT mouse mammary cancers in vivo by decreasing cell proliferation and inducing apoptosis.
    Anti-cancer drugs, 1997, Volume: 8, Issue:10

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Division; Cell Survival; DNA, Neoplasm; Doxorubicin; Estrogens; Female; Gonadotropin-Releasing Hormone; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Hormone-Dependent; Pyrroles; Receptors, LHRH

1997
Synthesis and biological evaluation of cytotoxic analogs of somatostatin containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-17, Volume: 95, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Membrane; Cytotoxins; Doxorubicin; Growth Inhibitors; Humans; Pituitary Gland; Pyrroles; Rats; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured

1998
Selective induction of apoptosis by the cytotoxic analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-19, Volume: 96, Issue:2

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; COS Cells; Cytotoxins; DNA Fragmentation; Doxorubicin; Genes, Reporter; Humans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Receptors, LHRH; Recombinant Proteins; Transfection

1999
Targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 inhibits the growth of PC-82 human prostate cancer in nude mice.
    The Prostate, 1999, Feb-01, Volume: 38, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Doxorubicin; Drug Delivery Systems; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Mice, Nude; Models, Chemical; Polymerase Chain Reaction; Prostatic Neoplasms; Pyrroles; Receptors, LHRH; Transplantation, Heterologous; Tumor Cells, Cultured

1999
Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238.
    Cancer research, 1999, Apr-15, Volume: 59, Issue:8

    Topics: Androgens; Animals; Antibiotics, Antineoplastic; Doxorubicin; Gene Expression; Humans; Lymphatic Metastasis; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Prostatic Neoplasms; Pyrroles; Receptors, Somatostatin; Somatostatin; Transplantation, Heterologous; Tumor Cells, Cultured

1999
Inhibition of growth of MX-1, MCF-7-MIII and MDA-MB-231 human breast cancer xenografts after administration of a targeted cytotoxic analog of somatostatin, AN-238.
    International journal of cancer, 1999, Aug-12, Volume: 82, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Division; Doxorubicin; Female; Growth Hormone; Humans; Immunotoxins; Luteinizing Hormone; Mice; Mice, Nude; Pyrroles; Receptors, Somatostatin; Transplantation, Heterologous

1999
Effective treatment of advanced estrogen-independent MXT mouse mammary cancers with targeted cytotoxic LH-RH analogs.
    Breast cancer research and treatment, 1999, Volume: 56, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Division; Doxorubicin; Drug Delivery Systems; Estrogens; Female; Gonadotropin-Releasing Hormone; Growth Inhibitors; Injections, Intravenous; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Hormone-Dependent; Pyrroles

1999
Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: implications for the design of preclinical studies.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Jan-18, Volume: 97, Issue:2

    Topics: Adult; Animals; Antineoplastic Agents; Bombesin; Carboxylesterase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Drug Interactions; Drug Stability; Gonadotropin-Releasing Hormone; Half-Life; Humans; Hydrolysis; Isoflurophate; Male; Mice; Mice, Nude; Nitrophenols; Paraoxon; Pyrroles; Weight Loss

2000
Administration of a targeted cytotoxic analog of luteinizing hormone-releasing hormone inhibits growth of estrogen-independent MDA-MB-231 human breast cancers in nude mice.
    Breast cancer research and treatment, 2000, Volume: 59, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Disease Models, Animal; DNA Primers; Doxorubicin; Drug Delivery Systems; Female; Gonadotropin-Releasing Hormone; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Radioligand Assay; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Specific Pathogen-Free Organisms; Tumor Cells, Cultured

2000
In vivo inhibition of PC-3 human androgen-independent prostate cancer by a targeted cytotoxic bombesin analogue, AN-215.
    International journal of cancer, 2000, Nov-15, Volume: 88, Issue:4

    Topics: Animals; Antibiotics, Antineoplastic; Bombesin; Carboxylic Ester Hydrolases; Doxorubicin; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Pyrroles; Receptors, Bombesin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238.
    International journal of oncology, 2002, Volume: 20, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cytotoxins; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Octreotide; Prostatic Neoplasms; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Treatment Outcome; Tumor Cells, Cultured

2002
Effective treatment of experimental ES-2 human ovarian cancers with a cytotoxic analog of luteinizing hormone-releasing hormone AN-207.
    Anti-cancer drugs, 2002, Volume: 13, Issue:9

    Topics: Animals; Antineoplastic Agents; Doxorubicin; Drug Evaluation, Preclinical; ErbB Receptors; Female; Gonadotropin-Releasing Hormone; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Pyrroles; Receptor, ErbB-2; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Treatment Outcome; Tumor Cells, Cultured

2002
Effective treatment of H838 human non-small cell lung carcinoma with a targeted cytotoxic somatostatin analog, AN-238.
    International journal of oncology, 2003, Volume: 22, Issue:5

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Division; Cytotoxins; Doxorubicin; Humans; Kinetics; Leukocyte Count; Lung Neoplasms; Mice; Mice, Nude; Pyrroles; Transplantation, Heterologous; Tumor Cells, Cultured

2003
2-Pyrrolinodoxorubicin and its peptide-vectorized form bypass multidrug resistance.
    Anti-cancer drugs, 2004, Volume: 15, Issue:6

    Topics: Adjuvants, Pharmaceutic; Biological Transport; Carrier Proteins; Cell Division; Cell Nucleus; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Delivery Systems; Drug Resistance, Multiple; Gene Expression; Genes, MDR; Humans; Intracellular Fluid; K562 Cells; Pyrroles; Tumor Cells, Cultured; Verapamil

2004
Growth inhibition of experimental non-Hodgkin's lymphomas with the targeted cytotoxic somatostatin analogue AN-238.
    International journal of cancer, 2005, May-01, Volume: 114, Issue:5

    Topics: Animals; Antineoplastic Agents; Body Weight; Doxorubicin; Humans; Kinetics; Leukocytes; Lymphoma, Non-Hodgkin; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Peptides; Pyrroles; Receptors, Somatostatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Time Factors

2005
Receptors for luteinizing hormone releasing hormone expressed on human renal cell carcinomas can be used for targeted chemotherapy with cytotoxic luteinizing hormone releasing hormone analogues.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Aug-01, Volume: 11, Issue:15

    Topics: Animals; Antineoplastic Agents; Binding Sites; Blotting, Western; Carcinoma, Renal Cell; Cell Differentiation; Cell Line, Tumor; DNA, Complementary; Doxorubicin; Humans; Immunohistochemistry; Kidney; Kidney Neoplasms; Kinetics; Male; Mice; Mice, Nude; Neoplasm Transplantation; Peptides; Protein Binding; Pyrroles; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2005
Inhibition of human experimental prostate cancers by a targeted cytotoxic luteinizing hormone-releasing hormone analog AN-207.
    The Prostate, 2006, Feb-01, Volume: 66, Issue:2

    Topics: Androgens; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Disease Progression; Doxorubicin; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Receptors, LHRH; RNA, Messenger; Transplantation, Heterologous; Triptorelin Pamoate

2006
Targeted chemotherapy with cytotoxic bombesin analogue AN-215 can overcome chemoresistance in experimental renal cell carcinomas.
    Cancer, 2005, Nov-15, Volume: 104, Issue:10

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bombesin; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Transplantation; Chemokines, CC; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Receptors, Bombesin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2005
LH-RH receptors in human colorectal cancers: unexpected molecular targets for experimental therapy.
    International journal of oncology, 2007, Volume: 30, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Colorectal Neoplasms; Doxorubicin; Gonadotropin-Releasing Hormone; Humans; Male; Mice; Mice, Nude; Pyrroles; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Therapy of experimental hepatic cancers with cytotoxic peptide analogs targeted to receptors for luteinizing hormone-releasing hormone, somatostatin or bombesin.
    Anti-cancer drugs, 2008, Volume: 19, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bombesin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Gonadotropin-Releasing Hormone; Humans; Immunohistochemistry; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Pyrroles; Radioligand Assay; Receptors, Bombesin; Receptors, LHRH; Receptors, Somatostatin; Transplantation, Heterologous

2008
Polymer conjugates of the highly potent cytostatic drug 2-pyrrolinodoxorubicin.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Jan-18, Volume: 42, Issue:1-2

    Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Carriers; Female; Humans; Lymphoma, T-Cell; Mice; Molecular Structure; Polymethacrylic Acids; Pyrroles; Solubility; Xenograft Model Antitumor Assays

2011
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
    Biochemical pharmacology, 2011, Aug-01, Volume: 82, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell-Free System; DNA; DNA Adducts; DNA Topoisomerases, Type II; Doxorubicin; Gene Expression Regulation, Neoplastic; Hexosamines; Humans; Mice; Molecular Structure; Pyrroles; Topoisomerase II Inhibitors; Transcription, Genetic

2011