pyrroles has been researched along with 2,5-hexanedione in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (36.11) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 5 (13.89) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Amarnath, V; Anthony, DC; Graham, DG; Pyle, SJ | 2 |
| Iwamoto, T; Ogata, M; Taguchi, T | 2 |
| Filser, JG; Filser, M; Heilmaier, H; Kessler, W; Kreuzer, P; Shen, JH | 1 |
| Autilio-Gambetti, L; Gambetti, P; Sayre, LM | 1 |
| Couri, D; Milks, MM | 1 |
| DeCaprio, AP; Jackowski, SJ; Regan, KA | 1 |
| Boekelheide, K | 1 |
| Briggs, RG; DeCaprio, AP; Jackowski, SJ; Kim, JC | 1 |
| Boekelheide, K; Eveleth, J | 1 |
| DeCaprio, AP | 2 |
| DeCaprio, AP; O'Neill, EA | 1 |
| Anderson, CW; Anthony, DC; Boekelheide, K; Graham, DG | 1 |
| Anthony, DC; Boekelheide, K; Graham, DG; Maschmann, NA; Richards, RG; Shaw, BR; Wolfram, JW | 1 |
| DeCaprio, AP; Strominger, NL; Weber, P | 1 |
| DeCaprio, AP; Olajos, EJ; Weber, P | 1 |
| Abdel-Rahman, SM; Abou-Donia, MB; Ibrahim, S; Johnson, DJ; Lack, L | 1 |
| Abou-Donia, MB; Lanning, CL; Wilmarth, KR | 1 |
| Csanády, GA; Dietz, W; Filser, JG; Kessler, W; Kreuzer, PE; Richter, M; Störmer, A | 1 |
| Bank, S; DeCaprio, AP; Yan, B; Zhu, M | 1 |
| DeCaprio, AP; Hauer, CR; Spink, DC; Zhu, M | 1 |
| Kansal, MM; Liu, Y; Sayre, LM; Xu, G | 1 |
| Gopal, D; Sayre, LM; Singh, MP; Xu, G | 1 |
| Batoréu, MC; dos Santos, AP; Mateus, ML | 2 |
| Nowak, I; Robins, MJ | 1 |
| Amarnath, K; Amarnath, V; Davies, S; Roberts, LJ | 1 |
| Xie, KQ; Yin, HY; Zhu, MX | 1 |
| Guo, Y; Song, FY; Xie, KQ; Yin, HY; Zeng, T | 1 |
| Guo, Y; Xie, K; Yin, H; Zeng, T; Zhao, X | 1 |
| Batoréu, MC; Bronze, MR; dos Santos, AP; Gonçalves, LL; Mateus, ML; Torres, ME | 1 |
| Andrade, V; Batoréu, MC; dos Santos, AP; Gonçalves, LL; Mateus, ML; Torres, ME | 1 |
| Li, M; Li, X; Wang, Q; Wang, S; Xie, K; Zhang, C | 1 |
| Li, M; Li, X; Liu, Z; Wang, Q; Wang, S; Xie, K; Yu, T | 1 |
2 review(s) available for pyrroles and 2,5-hexanedione
| Article | Year |
|---|---|
Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments.
Topics: Animals; Axonal Transport; Axons; Chickens; Cytoskeleton; Disease Models, Animal; Glyceraldehyde-3-Phosphate Dehydrogenases; Hexanones; Humans; In Vitro Techniques; Intermediate Filament Proteins; Intermediate Filaments; Mice; Nervous System Diseases; Neurofilament Proteins; Nitriles; Phosphorylation; Pyrroles; Rats | 1985 |
n-Hexane neurotoxicity: a mechanism involving pyrrole adduct formation in axonal cytoskeletal protein.
Topics: Animals; Axons; Central Nervous System; Cross-Linking Reagents; Cytoskeletal Proteins; Hexanes; Hexanones; Ketones; Oxidation-Reduction; Pyrroles; Solvents | 1987 |
1 trial(s) available for pyrroles and 2,5-hexanedione
| Article | Year |
|---|---|
Comparative estimation of the neurotoxic risks of N-hexane and N-heptane in rats and humans based on the formation of the metabolites 2,5-hexanedione and 2,5-heptanedione.
Topics: Administration, Inhalation; Adult; Animals; Body Burden; Cross-Linking Reagents; Half-Life; Heptanes; Hexanes; Hexanones; Humans; Ketones; Male; Nervous System Diseases; Pyrroles; Rats; Rats, Wistar; Risk Assessment | 1996 |
33 other study(ies) available for pyrroles and 2,5-hexanedione
| Article | Year |
|---|---|
The role of pyrrole formation in the alteration of neurofilament transport induced during exposure to 2,5-hexanedione.
Topics: Animals; Axons; Biological Transport; Brain; Hexanones; Male; Neurofilament Proteins; Pyrroles; Rats; Rats, Inbred Strains | 1992 |
Urinary 2,5-hexanedione assay involving its conversion to 2,5-dimethylpyrrole.
Topics: Benzaldehydes; Chromatography, Gas; Chromatography, High Pressure Liquid; Environmental Monitoring; Hexanes; Hexanones; Humans; Occupational Exposure; Pyrroles; Spectrophotometry | 1991 |
Spectrophotometric determination of pyrrole-like substances in urine of rat and man: an assay for the evaluation of 2,5-hexanedione formed from n-hexane.
Topics: Animals; Hexanes; Hexanones; Humans; Ketones; Kinetics; Male; Pyrroles; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Spectrophotometry | 1990 |
Determination of urinary 2,5-hexanedione by its conversion to 2,5-dimethylpyrrole.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Environmental Exposure; Hexanones; Humans; Hydrogen-Ion Concentration; Middle Aged; Pyrroles; Spectrophotometry | 1990 |
Hexacarbon neuropathy: tracking a toxin.
Topics: Animals; Biotransformation; Hexanes; Hexanones; Humans; Intermediate Filament Proteins; Isomerism; Ketones; Methyl n-Butyl Ketone; Neurofilament Proteins; Occupational Diseases; Peripheral Nervous System Diseases; Pyrroles; Rats; Textile Industry | 1985 |
Mechanism of formation and quantitation of imines, pyrroles, and stable nonpyrrole adducts in 2,5-hexanedione-treated protein.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Dithiothreitol; Hexanones; Imines; Ketones; Peptide Hydrolases; Proteins; Pyrroles; Sodium Dodecyl Sulfate; Urea | 1987 |
Rat testis during 2,5-hexanedione intoxication and recovery. II. Dynamics of pyrrole reactivity, tubulin content, and microtubule assembly.
Topics: Administration, Oral; Animals; Electrophoresis, Polyacrylamide Gel; Hexanones; Ketones; Male; Pyrroles; Rats; Sertoli Cells; Testis; Tubulin | 1988 |
Comparative neurotoxicity and pyrrole-forming potential of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat.
Topics: Animals; Ataxia; Axons; Body Weight; Cytoskeletal Proteins; Deuterium; Hexanones; Injections, Intraperitoneal; Ketones; Male; Pyrroles; Rats; Rats, Inbred Strains; Spinal Cord | 1988 |
The rate of 2,5-hexanedione intoxication, not total dose, determines the extent of testicular injury and altered microtubule assembly in the rat.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Hexanones; Ketones; Male; Microtubules; Organ Size; Pyrroles; Rats; Testis; Time Factors | 1988 |
Mechanisms of in vitro pyrrole adduct autoxidation in 2,5-hexanedione-treated protein.
Topics: Animals; Ascorbic Acid; Cattle; Free Radicals; Hexanones; Hydrogen-Ion Concentration; Intermediate Filaments; Ketones; Oxidation-Reduction; Pyrroles; Serum Albumin, Bovine | 1986 |
Alterations in rat axonal cytoskeletal proteins induced by in vitro and in vivo 2,5-hexanedione exposure.
Topics: Animals; Axons; Brain Stem; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Hexanones; In Vitro Techniques; Ketones; Lysine; Male; Pyrroles; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Hexanones; Ketones; Proteins; Pyrroles; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1983 |
Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking.
Topics: Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Hexanes; Hexanones; Lysine; Nervous System Diseases; Pyrroles | 1982 |
Neurotoxicity and protein binding of 2,5-hexanedione in the hen.
Topics: Animals; Chickens; Electrophoresis, Polyacrylamide Gel; Female; Hexanones; Ketones; Neuromuscular Diseases; Protein Binding; Pyrroles; Sciatic Nerve; Thoracic Nerves | 1983 |
Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione.
Topics: Amines; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chickens; Chromogenic Compounds; Female; Hexanes; Hexanones; Ketones; Nervous System Diseases; Proteins; Pyrroles | 1982 |
Protein-bound pyrroles in rat hair following subchronic intraperitoneal injections of 2,5-hexanedione.
Topics: Animals; Environmental Monitoring; Hair; Hexanes; Hexanones; Male; Methyl n-Butyl Ketone; Occupational Exposure; Pyrroles; Rats; Rats, Sprague-Dawley; Vibrissae | 1995 |
In vitro binding of [14C]2,5-hexanedione to rat neuronal cytoskeletal proteins.
Topics: Animals; Carbon Radioisotopes; Cytoskeletal Proteins; Hexanones; Immunoblotting; Male; Microtubule Proteins; Neurofilament Proteins; Neurons; Oxidation-Reduction; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley | 1994 |
Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione exposure.
Topics: Animals; Axons; Biological Transport; Hexanones; Male; Molecular Weight; Neurofibrils; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley | 1993 |
Solid-state 13C-NMR spectroscopy of adduction products of 2,5-hexanedione with ribonuclease, albumin, and rat neurofilament protein.
Topics: Animals; Carbon Isotopes; DNA Adducts; Hexanones; In Vitro Techniques; Magnetic Resonance Spectroscopy; Neurofilament Proteins; Pyrroles; Rats; Ribonucleases; Serum Albumin, Bovine | 1996 |
Characterization of glutathione conjugates of pyrrolylated amino acids and peptides by liquid chromatography-mass spectrometry and tandem mass spectrometry with electrospray ionization.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrochemistry; Glutathione; Hexanones; Lysine; Mass Spectrometry; Oligopeptides; Oxidation-Reduction; Pyrroles | 1997 |
Rapid cross-linking of proteins by 4-ketoaldehydes and 4-hydroxy-2-alkenals does not arise from the lysine-derived monoalkylpyrroles.
Topics: Aldehydes; Animals; Cattle; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Hexanones; Lysine; Proteins; Pyrroles; Ribonuclease, Pancreatic; Schiff Bases; Serum Albumin, Bovine | 1999 |
Novel 2,5-hexanedione analogues. Substituent-induced control of the protein cross-linking potential and oxidation susceptibility of the resulting primary amine-derived pyrroles.
Topics: Axons; Cross-Linking Reagents; Hexanones; Neurofilament Proteins; Neurotoxins; Oxidation-Reduction; Pyrroles | 2001 |
Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure.
Topics: Administration, Oral; Animals; Biomarkers; Dose-Response Relationship, Drug; Drug Interactions; Hexanones; Injections, Intraperitoneal; Male; Nervous System Diseases; Neurotoxins; Pyrroles; Rats; Rats, Wistar; Zinc Acetate | 2001 |
Evidence of zinc protection against 2,5-hexanedione neurotoxicity: correlation of neurobehavioral testing with biomarkers of excretion.
Topics: Animals; Biomarkers; Hexanones; Male; Motor Activity; Pyrroles; Rats; Rats, Wistar; Zinc Acetate | 2002 |
Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety.
Topics: Adenosine; Guanosine; Hexanones; Hot Temperature; Hydrolysis; Magnetic Resonance Spectroscopy; Nucleosides; Pyrroles; Spectrophotometry, Ultraviolet; Trifluoroacetic Acid; Water | 2003 |
Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls.
Topics: Aldehydes; Free Radical Scavengers; Hexanones; Ketones; Pyridoxamine; Pyrroles | 2004 |
[Formation of pyrrole adducts in 2,5-hexanedione-containing human serum cultured in vitro].
Topics: Hexanones; Humans; Oxidation-Reduction; Pyrroles; Serum | 2013 |
Toxicokinetic study of pyrrole adducts and its potential application for biological monitoring of 2,5-hexanedione subacute exposure.
Topics: Animals; Area Under Curve; Biomarkers; Environmental Monitoring; Hexanes; Hexanones; Male; Neurotoxins; Pyrroles; Rats; Rats, Wistar; Spectrophotometry; Toxicokinetics | 2014 |
Correlation between levels of 2, 5-hexanedione and pyrrole adducts in tissues of rats exposure to n-hexane for 5-days.
Topics: Animals; Benzaldehydes; Biomarkers; Chromatography, Gas; Dose-Response Relationship, Drug; Hexanes; Hexanones; Linear Models; Liver; Male; Pyrroles; Rats; Rats, Wistar | 2013 |
Alternative biomarkers of n-hexane exposure: characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-hexanedione.
Topics: Animals; Biomarkers; Colorimetry; Environmental Monitoring; Hexanes; Hexanones; Male; Pyrroles; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2014 |
Role of N-acetylcysteine in protecting against 2,5-hexanedione neurotoxicity in a rat model: changes in urinary pyrroles levels and motor activity performance.
Topics: Acetylcysteine; Animals; Chromatography, Liquid; Hexanones; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Norleucine; Pyrroles; Rats; Rats, Wistar; Tandem Mass Spectrometry | 2014 |
Hair pyrrole adducts serve as biomarkers for peripheral nerve impairment induced by 2,5-hexanedione and n-hexane in rats.
Topics: Animals; Biomarkers; Hair; Hexanes; Hexanones; Male; Peripheral Nervous System Diseases; Pyrroles; Rats; Rats, Wistar | 2018 |
Diallyl sulfide-induced attenuation of n-hexane-induced peripheral nerve impairment is associated with metabolic inhibition of n-hexane.
Topics: Allyl Compounds; Animals; Body Weight; Hair; Hexanes; Hexanones; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Pyrroles; Rats, Wistar; Sciatic Nerve; Sulfides | 2020 |