pyrroles and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

Topics: Androstadienes; Animals; Apoptosis; Bile Acids and Salts; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Indoles; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Solubility; Wortmannin

Topics: Animals; Carbazoles; Chromones; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Indole Alkaloids; Indoles; Interleukin-6; Isoquinolines; Macrophages, Peritoneal; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Sulfonamides; Time Factors

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin

Topics: Androgens; Apoptosis; Cell Division; Chromones; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ligands; Male; Morpholines; Prostatic Neoplasms; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Tumor Cells, Cultured

Topics: 1-Methyl-3-isobutylxanthine; Amphibian Proteins; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Chromatin; Chromones; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glycogen Synthase Kinase 3; Hippocampus; In Situ Nick-End Labeling; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Mitogen-Activated Protein Kinase Kinases; Morpholines; Neurons; Neuroprotective Agents; Peptide Fragments; Peptide Hormones; Peptides; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Thionucleotides; Time Factors; Urocortins; Urotensins; Vasodilator Agents

Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Cell Division; Cell Line, Tumor; Chromones; Deoxycytidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gemcitabine; Humans; Hypoxia; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Pathologic; NF-kappa B; Nitriles; Oxygen; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tyrosine

Topics: Animals; Axons; Carbazoles; Cell Survival; Chromones; Ciliary Neurotrophic Factor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Flavonoids; Indoles; MAP Kinase Signaling System; Morpholines; Nerve Regeneration; Optic Nerve Injuries; Peroneal Nerve; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Rats; Rats, Inbred F344; Receptor, Ciliary Neurotrophic Factor; Retinal Ganglion Cells; Signal Transduction; STAT3 Transcription Factor; Thionucleotides; Trans-Activators; Tyrphostins; Up-Regulation

Topics: Animals; Carbazoles; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hemocytes; Indoles; Lymnaea; Morpholines; Phagocytosis; Phosphatidylinositol 3-Kinases; Pyrroles

Topics: Acetophenones; Benzopyrans; Calcium; Calcium Channels; Calcium Signaling; Catalytic Domain; Cell Line, Tumor; Chemokine CCL17; Chemokine CCL22; Chemokines, CC; Chemotaxis; Chromones; Diglycerides; Estrenes; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Leukemia-Lymphoma, Adult T-Cell; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Protein Processing, Post-Translational; Pyrroles; Pyrrolidinones; Receptors, CCR4; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; T-Lymphocytes; Th2 Cells

Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gastrointestinal Stromal Tumors; Humans; Indoles; Morpholines; Phosphotransferases; Protein Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyrroles; Sirolimus; Sunitinib; TOR Serine-Threonine Kinases

Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Carcinoma, Hepatocellular; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Etoposide; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms; Morpholines; Phosphorylation; Pravastatin; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

Topics: Animals; Antigens, Differentiation; Butadienes; Carbazoles; Cell Differentiation; Cell Line; Cell Proliferation; Chondrocytes; Chromones; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Indoles; Insulin-Like Growth Factor I; Isoquinolines; Maleimides; MAP Kinase Signaling System; Mesoderm; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Sulfonamides

Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin

Topics: Animals; Apolipoproteins E; Astrocytes; Butadienes; Chromones; Fibroblast Growth Factor 1; Lipids; Lipoproteins, HDL; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Morpholines; Nitriles; Pyrroles; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Signal Transduction

Topics: Apoptosis; CD40 Antigens; CD40 Ligand; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chromones; Flow Cytometry; Humans; Indoles; Morpholines; Nuclear Proteins; Protein Kinase Inhibitors; Pyrroles; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Small Interfering; Stomach Neoplasms; Vascular Endothelial Growth Factor A

Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Cells, Cultured; Chromones; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolysin; Fibrinolytic Agents; Fibroblast Growth Factors; Flavonoids; Immunohistochemistry; Microglia; Morpholines; Nerve Growth Factors; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasminogen; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Rats; Receptor, PAR-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta3

Topics: Animals; Animals, Newborn; Brain Injuries; Cell Survival; Cells, Cultured; Chromones; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Glucose; Hypoxia; Hypoxia-Ischemia, Brain; Indoles; Injections, Intraventricular; Male; Morpholines; Neurons; Phosphorylation; Placenta Growth Factor; Platelet Endothelial Cell Adhesion Molecule-1; Pregnancy Proteins; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Time Factors; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Chromones; Humans; Indoles; Melanoma; Morpholines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor alpha; RNA, Small Interfering; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor Receptor-2

Topics: Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Endothelium, Vascular; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Myocytes, Smooth Muscle; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Pyrroles; Quinazolines; RNA, Small Interfering; Saphenous Vein; Thrombin

Topics: Animals; Chromones; Drug Therapy, Combination; Endothelial Cells; Haploinsufficiency; Hemangiosarcoma; Humans; Indoles; Morpholines; Mutation; Neovascularization, Pathologic; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-akt; Pseudopodia; Pyrroles; RNA, Messenger; Sunitinib; Up-Regulation; Vascular Endothelial Growth Factor A; Zebrafish; Zebrafish Proteins

Topics: Androstadienes; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Molecular Targeted Therapy; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptors, Androgen; RNA Splicing; RNA Stability; Transcription Initiation, Genetic; Wortmannin

Topics: Breast Neoplasms; Cell Line, Tumor; Chromones; Drug Synergism; Enzyme Inhibitors; Heterocyclic Compounds, 3-Ring; Humans; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles

Topics: Benzophenanthridines; Calcium; Carbazoles; Cell Line, Tumor; Cell Survival; Chromones; Cyclooxygenase 2; HSP70 Heat-Shock Proteins; Humans; Intracellular Space; Membrane Potential, Mitochondrial; Morpholines; Neuroblastoma; Neuroprotective Agents; Neurotoxins; NF-E2-Related Factor 2; Orexin Receptors; Orexins; Oxidopamine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Signal Transduction

Topics: Animals; Cell Line, Tumor; Chromones; Cisplatin; Drug Resistance, Neoplasm; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Morpholines; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrroles; Stomach Neoplasms; Xenograft Model Antitumor Assays

Topics: Animals; Butadienes; Chick Embryo; Chromones; Enzyme Inhibitors; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Hindlimb; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Morpholines; Muscle Development; Muscle, Skeletal; MyoD Protein; Myogenin; Nitriles; PAX3 Transcription Factor; Phosphoinositide-3 Kinase Inhibitors; Podophyllotoxin; Pyrroles; Receptor, IGF Type 1; Receptors, Vascular Endothelial Growth Factor

Topics: Animals; Chromones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Indoles; Kidney; Membrane Proteins; Morpholines; Podocytes; Pyrroles; Random Allocation; Rats; Rats, Sprague-Dawley; TRPC Cation Channels; Vascular Endothelial Growth Factor A

Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Case-Control Studies; Cell Line, Tumor; Chromones; Disease Progression; Dose-Response Relationship, Drug; Female; Flavonoids; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Morpholines; Myeloid Cells; Philadelphia Chromosome; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Treatment Outcome; Vascular Endothelial Growth Factor A

Topics: Animals; Cells, Cultured; Child, Preschool; Chromones; Female; Humans; Immunoglobulin G; Insulin-Like Growth Factor I; Male; Morpholines; Neuroblastoma; Neurons; Opsoclonus-Myoclonus Syndrome; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Pyrroles; Rats; Receptor, IGF Type 1; Signal Transduction