pyrophosphate and 1-stearoyl-2-arachidonylphosphatidylcholine

pyrophosphate has been researched along with 1-stearoyl-2-arachidonylphosphatidylcholine* in 1 studies

Other Studies

1 other study(ies) available for pyrophosphate and 1-stearoyl-2-arachidonylphosphatidylcholine

Article	Year
Further studies on the antioxidant role of pyrophosphate in model membranes. Chemistry and physics of lipids, 1993, Volume: 66, Issue:1-2 Our previous studies (G. Cervato et al., Chem. Phys. Lipids 56 (1990), 91-99) demonstrated that 100 microM pyrophosphate (PPi) inhibits Fe2+/ascorbate-induced peroxidation of arachidonic acid (AA) inserted in unilamellar liposomes (SUVs) of dipalmitoylphosphatidylcholine (DPPC), by chelating ferrous ions in the aqueous phase. In this work we demonstrate that the kinetics of AA peroxidation in DPPC SUVs are strongly affected by PPi, also at very low concentration (1 microM). In fact at low PPi concentration there is a longer lag-phase, while the maximum of thiobarbituric acid reactive substances (TBARS) is similar in both the presence and absence of 1 microM PPi. The lag-phase of peroxidation of AA in lysophosphatidylcholine (palmitoyl) (LysoPC) micelles is also prolonged. The AA peroxidation in membrane models without choline as the polar headgroup (dipalmitoylphosphatidylethanolamine (DPPE) SUVs, or Triton X-100 micelles), or in which AA is not free but esterified with glycerol (stearoyl-arachidonyl-phosphatidylcholine (SAPC)), is unaffected by the presence of 1 microM PPi. Topics: 1,2-Dipalmitoylphosphatidylcholine; Antioxidants; Arachidonic Acid; Diphosphates; Iron; Kinetics; Lipid Peroxidation; Liposomes; Lysophosphatidylcholines; Micelles; Phosphatidylcholines; Phosphatidylethanolamines	1993

Article

Year

Further studies on the antioxidant role of pyrophosphate in model membranes.

Chemistry and physics of lipids, 1993, Volume: 66, Issue:1-2

Our previous studies (G. Cervato et al., Chem. Phys. Lipids 56 (1990), 91-99) demonstrated that 100 microM pyrophosphate (PPi) inhibits Fe2+/ascorbate-induced peroxidation of arachidonic acid (AA) inserted in unilamellar liposomes (SUVs) of dipalmitoylphosphatidylcholine (DPPC), by chelating ferrous ions in the aqueous phase. In this work we demonstrate that the kinetics of AA peroxidation in DPPC SUVs are strongly affected by PPi, also at very low concentration (1 microM). In fact at low PPi concentration there is a longer lag-phase, while the maximum of thiobarbituric acid reactive substances (TBARS) is similar in both the presence and absence of 1 microM PPi. The lag-phase of peroxidation of AA in lysophosphatidylcholine (palmitoyl) (LysoPC) micelles is also prolonged. The AA peroxidation in membrane models without choline as the polar headgroup (dipalmitoylphosphatidylethanolamine (DPPE) SUVs, or Triton X-100 micelles), or in which AA is not free but esterified with glycerol (stearoyl-arachidonyl-phosphatidylcholine (SAPC)), is unaffected by the presence of 1 microM PPi.

Topics: 1,2-Dipalmitoylphosphatidylcholine; Antioxidants; Arachidonic Acid; Diphosphates; Iron; Kinetics; Lipid Peroxidation; Liposomes; Lysophosphatidylcholines; Micelles; Phosphatidylcholines; Phosphatidylethanolamines

1993