Compounds > pyronaridine
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pyronaridine and mefloquine

pyronaridine has been researched along with mefloquine in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.55)18.7374
1990's6 (27.27)18.2507
2000's3 (13.64)29.6817
2010's10 (45.45)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Fidock, DA; Flannery, EL; Winzeler, EA1
Avery, VM; Sykes, ML1
Baum, J; Bridgford, JL; Charman, SA; Churchyard, A; Crespo, B; Deni, I; Fidock, DA; Gahalawat, S; Gamo, FJ; Laleu, B; Lawong, A; Mittal, N; Mok, S; Niederstrasser, H; Okombo, J; Palmer, MJ; Phillips, MA; Posner, B; Ready, JM; Striepen, J; Winzeler, E; Wittlin, S; Yeo, T; Zhou, A1
Avery, VM; Challis, MP; Creek, DJ; De Paoli, A; Devine, SM; Kigotho, JK; MacRaild, CA; Norton, RS; Scammells, PJ; Siddiqui, G1
Chu, YH; Shao, BR; Ye, XY2
Boudreau, EF; Chen, C; Childs, GE; Häusler, B; Milhous, W; Pooyindee, N; Wimonwattrawatee, T1
Yang, H; Yang, P; Yang, Y1
Basco, LK; Le Bras, J1
Fleck, SL; Peters, W; Robinson, BL1
Croft, SL; Elueze, EI; Warhurst, DC1
Auparakkitanon, S; Chavalitshewinkoon-Petmitr, P; Pongvilairat, G; Wilairat, P1
Ambroise-Thomas, P1
Gao, BH; Huang, KG; Yang, HL1
Abdulla, S; Binh, TQ; Borghini-Fuhrer, I; Duparc, S; Fleckenstein, L; Pénali, LK; Phyo, AP; Poravuth, Y; Rueangweerayut, R; Shin, CS; Tien, NT; Tinto, H; Uthaisin, C; Valecha, N1
Holtermann, MK1
Cremers, S; Fidock, DA; Henrich, PP; Kyle, DE; O'Brien, C; Sáenz, FE1
Bukirwa, H; Kramer, CV; Nair, S; Sinclair, D; Tharyan, P; Unnikrishnan, B1
Cui, L; Gupta, B; Miao, J; Sun, L; Wang, Z; Xu, S; Yang, Z1
Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Hine, P; Pryce, J1

Reviews

5 review(s) available for pyronaridine and mefloquine

ArticleYear
Using genetic methods to define the targets of compounds with antimalarial activity.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum

2013
Approaches to protozoan drug discovery: phenotypic screening.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2013
[Treatment of malaria: prevention of resistance by combinations of antimalarial agents].
    Medecine tropicale : revue du Corps de sante colonial, 2000, Volume: 60, Issue:3

    Topics: Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Naphthyridines; Plasmodium; Sesquiterpenes

2000
Artesunate plus pyronaridine for treating uncomplicated Plasmodium falciparum malaria.
    The Cochrane database of systematic reviews, 2014, Mar-04, Issue:3

    Topics: Adult; Antimalarials; Artemisinins; Artesunate; Child; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Liver; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Randomized Controlled Trials as Topic

2014
Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.
    The Cochrane database of systematic reviews, 2019, 01-08, Volume: 1

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Therapy, Combination; Humans; Liver; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Randomized Controlled Trials as Topic

2019

Trials

1 trial(s) available for pyronaridine and mefloquine

ArticleYear
Pyronaridine-artesunate versus mefloquine plus artesunate for malaria.
    The New England journal of medicine, 2012, Apr-05, Volume: 366, Issue:14

    Topics: Adolescent; Adult; Africa; Antimalarials; Artemisinins; Artesunate; Asia; Child; Child, Preschool; Drug Combinations; Drug Resistance; Female; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Naphthyridines; Proportional Hazards Models; Young Adult

2012

Other Studies

16 other study(ies) available for pyronaridine and mefloquine

ArticleYear
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in
    Journal of medicinal chemistry, 2021, 03-11, Volume: 64, Issue:5

    Topics: Amides; Antimalarials; Drug Resistance, Microbial; Hemeproteins; Hemoglobins; Hep G2 Cells; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Small Molecule Libraries; Structure-Activity Relationship; Tetrazoles

2021
Discovery and development of 2-aminobenzimidazoles as potent antimalarials.
    European journal of medicinal chemistry, 2021, Oct-05, Volume: 221

    Topics: Antimalarials; Benzimidazoles; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Malaria, Falciparum; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship

2021
[The blood schizontocidal effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on mice infected with Plasmodium berghei].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Resistance; Female; Malaria; Male; Mefloquine; Mice; Naphthyridines; Plasmodium berghei; Sesquiterpenes

1992
Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
    The Southeast Asian journal of tropical medicine and public health, 1992, Volume: 23, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance; Female; Malaria; Male; Mefloquine; Mice; Naphthyridines; Plasmodium berghei; Sesquiterpenes

1992
In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1988, Volume: 38, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Humans; Mefloquine; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Thailand

1988
[In vitro sensitivity of Plasmodium falciparum to mefloquine, quinine, amodiaquine, chloroquine, pyronaridine and sulfadoxine/pyrimethamine in south Yunnan].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1994, Volume: 12, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Mefloquine; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Quinine; Sulfadoxine

1994
In vitro susceptibility of Cambodian isolates of Plasmodium falciparum to halofantrine, pyronaridine and artemisinin derivatives.
    Annals of tropical medicine and parasitology, 1994, Volume: 88, Issue:2

    Topics: Adult; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Mefloquine; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Triazines

1994
The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites.
    Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1

    Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Antagonism; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Mefloquine; Mice; Naphthyridines; Parasitemia; Phenanthrenes; Phenylpropionates; Plasmodium berghei; Plasmodium yoelii

1997
Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Mefloquine; Naphthyridines; Plasmodium falciparum; Quinacrine; Quinine

1996
Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro.
    Parasitology international, 2000, Volume: 48, Issue:4

    Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Enzyme Inhibitors; Etoposide; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Naphthyridines; Norfloxacin; Nucleic Acid Synthesis Inhibitors; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Thailand; Topoisomerase II Inhibitors; Triazines

2000
[Effect of pyronaridine, mefloquine and quinine on artesunate-sensitive and artesunate-resistant Plasmodium falciparum].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2000, Volume: 18, Issue:1

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Drug Resistance; Drug Synergism; Mefloquine; Naphthyridines; Plasmodium falciparum; Quinine; Sesquiterpenes

2000
[New combination therapy against malaria].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2012, Aug-21, Volume: 132, Issue:15

    Topics: Africa; Antimalarials; Artemisinins; Artesunate; Asia; Drug Combinations; Drug Resistance; Global Health; Humans; Malaria, Falciparum; Mefloquine; Naphthyridines

2012
Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Drug Resistance; Female; Flow Cytometry; Malaria, Falciparum; Mefloquine; Mice; Naphthyridines

2014
Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:8

    Topics: Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Geography; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Multidrug Resistance-Associated Proteins; Mutation; Myanmar; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Single Nucleotide; Selection, Genetic; Sequence Analysis, DNA

2014
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8

    Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases

2016
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017