Compounds > pyronaridine
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pyronaridine and amodiaquine

pyronaridine has been researched along with amodiaquine in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's11 (42.31)18.2507
2000's4 (15.38)29.6817
2010's7 (26.92)24.3611
2020's3 (11.54)2.80

Authors

AuthorsStudies
Baum, J; Bridgford, JL; Charman, SA; Churchyard, A; Crespo, B; Deni, I; Fidock, DA; Gahalawat, S; Gamo, FJ; Laleu, B; Lawong, A; Mittal, N; Mok, S; Niederstrasser, H; Okombo, J; Palmer, MJ; Phillips, MA; Posner, B; Ready, JM; Striepen, J; Winzeler, E; Wittlin, S; Yeo, T; Zhou, A1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Basco, LK; Le Bras, J1
Peters, W; Robinson, BL1
Chu, YH; Shao, BR; Ye, XY2
Boudreau, EF; Chen, C; Childs, GE; Häusler, B; Milhous, W; Pooyindee, N; Wimonwattrawatee, T1
Yang, H; Yang, P; Yang, Y1
Barlin, GB; Edstein, MD; Kotecka, BM; Rieckmann, KH1
Croft, SL; Elueze, EI; Warhurst, DC1
Dong, Y; Huang, KG; Liao, MZ; Liu, DQ; Yang, HL; Yang, PF; Yang, YM; Zhang, CY1
Doury, JC; Fusai, T; Hienne, R; Parzy, D; Pradines, B; Spiegel, A; Tall, A; Trape, JF1
Maggs, JL; Naisbitt, DJ; O'Neill, PM; Park, BK; Pirmohamed, M; Williams, DP; Willock, DJ1
Doury, JC; Kombila, M; Lebeau, C; Mabika Mamfoumbi, M; Mourou Mbina, JR; Owono Medang, M; Parzy, D; Pradines, B1
Björkman, A; Gupta, S; Mariga, ST; Thapar, MM; Wernsdorfer, WH1
Agnamey, P; Brasseur, P; Galega, PF; Moyou, SR1
Görlitzer, K; Jomaa, H; Meyer, H; Wiesner, J1
Enge, C; Görlitzer, K; Jomaa, H; Jones, PG; Wiesner, J1
Adjalley, SH; Eappen, AG; Eastman, RT; Ekland, EH; Fidock, DA; Hoffman, SL; Johnston, GL; Lee, MC; Li, T; Richman, A; Sim, BK1
Arzika, I; Fandeur, T; Guillebaud, J; Issaka, M; Maazou, A; Salissou, A; Specht, S; Zamanka, H1
Cremers, S; Fidock, DA; Henrich, PP; Kyle, DE; O'Brien, C; Sáenz, FE1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Clark, RL1
Hine, P; Pryce, J1
Tsanni, A1

Reviews

2 review(s) available for pyronaridine and amodiaquine

ArticleYear
Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester.
    Birth defects research, 2017, Aug-15, Volume: 109, Issue:14

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Combinations; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pregnancy; Pregnancy Trimester, First; Pyrimethamine; Quinine; Quinolines; Rabbits; Rats; Sulfadoxine; Teratogens

2017
Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria.
    The Cochrane database of systematic reviews, 2019, 01-08, Volume: 1

    Topics: Adult; Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Therapy, Combination; Humans; Liver; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Randomized Controlled Trials as Topic

2019

Trials

1 trial(s) available for pyronaridine and amodiaquine

ArticleYear
Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial.
    Lancet (London, England), 2018, 04-07, Volume: 391, Issue:10128

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Longitudinal Studies; Malaria; Male; Naphthyridines; Quinolines; Young Adult

2018

Other Studies

23 other study(ies) available for pyronaridine and amodiaquine

ArticleYear
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in
    Journal of medicinal chemistry, 2021, 03-11, Volume: 64, Issue:5

    Topics: Amides; Antimalarials; Drug Resistance, Microbial; Hemeproteins; Hemoglobins; Hep G2 Cells; Humans; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Small Molecule Libraries; Structure-Activity Relationship; Tetrazoles

2021
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
In vitro activity of pyronaridine against African strains of Plasmodium falciparum.
    Annals of tropical medicine and parasitology, 1992, Volume: 86, Issue:5

    Topics: Africa; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Naphthyridines; Plasmodium falciparum

1992
The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials.
    Annals of tropical medicine and parasitology, 1992, Volume: 86, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Drug Resistance; Malaria; Mannich Bases; Mice; Naphthyridines; Plasmodium berghei; Plasmodium yoelii

1992
[The blood schizontocidal effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on mice infected with Plasmodium berghei].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1992, Volume: 10, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Resistance; Female; Malaria; Male; Mefloquine; Mice; Naphthyridines; Plasmodium berghei; Sesquiterpenes

1992
Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
    The Southeast Asian journal of tropical medicine and public health, 1992, Volume: 23, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Resistance; Female; Malaria; Male; Mefloquine; Mice; Naphthyridines; Plasmodium berghei; Sesquiterpenes

1992
In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1988, Volume: 38, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Humans; Mefloquine; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Thailand

1988
[In vitro sensitivity of Plasmodium falciparum to mefloquine, quinine, amodiaquine, chloroquine, pyronaridine and sulfadoxine/pyrimethamine in south Yunnan].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1994, Volume: 12, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Mefloquine; Naphthyridines; Plasmodium falciparum; Pyrimethamine; Quinine; Sulfadoxine

1994
New quinoline di-Mannich base compounds with greater antimalarial activity than chloroquine, amodiaquine, or pyronaridine.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:6

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Mannich Bases; Microbial Sensitivity Tests; Naphthyridines; Plasmodium falciparum; Quinolines; Saimiri; Structure-Activity Relationship

1997
Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Mefloquine; Naphthyridines; Plasmodium falciparum; Quinacrine; Quinine

1996
In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas.
    The Southeast Asian journal of tropical medicine and public health, 1997, Volume: 28, Issue:3

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; China; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Laos; Microbial Sensitivity Tests; Myanmar; Naphthyridines; Plasmodium falciparum; Quinine; Sesquiterpenes

1997
In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents.
    The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:3

    Topics: Africa; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Naphthyridines; Plasmodium falciparum; Quinine

1998
Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.
    Chemical research in toxicology, 1998, Volume: 11, Issue:12

    Topics: Adult; Amodiaquine; Antimalarials; Biotransformation; Cell Survival; Glutathione; Horseradish Peroxidase; Humans; Hydrogen Peroxide; In Vitro Techniques; Naphthyridines; Neutrophils; Oxidation-Reduction

1998
In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine.
    The American journal of tropical medicine and hygiene, 1999, Volume: 60, Issue:1

    Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Gabon; Humans; Infant; Malaria, Falciparum; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Quinine

1999
Plasmodium falciparum: in vitro interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine.
    Experimental parasitology, 2002, Volume: 100, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Interactions; Drug Resistance; Naphthyridines; Parasitic Sensitivity Tests; Plasmodium falciparum; Sesquiterpenes

2002
[Center of multidrug-resistant malaria in a forest zone of Cameroon revisited after 14 years].
    Medecine tropicale : revue du Corps de sante colonial, 2002, Volume: 62, Issue:2

    Topics: Amodiaquine; Animals; Cameroon; Chloroquine; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Naphthyridines; Plasmodium falciparum; Quinine; Trees

2002
[[1]Benzofuro[3,2-b]pyridin-4-yl-amines - synthesis and investigation of activity against malaria].
    Die Pharmazie, 2004, Volume: 59, Issue:6

    Topics: Amines; Amodiaquine; Animals; Antimalarials; Benzofurans; Chemical Phenomena; Chemistry, Physical; Mannich Bases; Naphthyridines; Plasmodium falciparum

2004
[Benzo[c][2,7]naphthyridine-5-yl-arylamines-phenol Mannich bases of the amodiaquine-, cycloquine- and pyronaridine-type].
    Die Pharmazie, 2007, Volume: 62, Issue:2

    Topics: Amodiaquine; Animals; Antimalarials; Crystallography, X-Ray; Mannich Bases; Naphthyridines; Plasmodium falciparum; Quinones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

2007
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Nov-22, Volume: 108, Issue:47

    Topics: Amodiaquine; Animals; Anopheles; Antimalarials; Artemisinins; Blotting, Southern; Dose-Response Relationship, Drug; Ethanolamines; Fluorenes; Genetic Vectors; Germ Cells, Plant; Green Fluorescent Proteins; Luciferases; Lumefantrine; Malaria; Methylene Blue; Naphthyridines; Plasmodium falciparum; Quinolines; Sexual Development

2011
Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:7

    Topics: Amodiaquine; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Naphthyridines; Niger; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolines

2013
Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Drug Combinations; Drug Resistance; Female; Flow Cytometry; Malaria, Falciparum; Mefloquine; Mice; Naphthyridines

2014
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017
African scientists race to test COVID drugs - but face major hurdles.
    Nature, 2021, Volume: 599, Issue:7883

    Topics: Africa; Amides; Amodiaquine; Artesunate; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Approval; Drug Evaluation, Preclinical; Drug Repositioning; Drug Therapy, Combination; Humans; Hydroxylamines; Imidazoles; Ivermectin; Naphthyridines; Nitro Compounds; Pregnenediones; Pyrazines; Pyrrolidines; Ritonavir; Sample Size; Thiazoles; Valine; World Health Organization

2021