pyripyropene-a and beauverolides

pyripyropene-a has been researched along with beauverolides* in 1 studies

Other Studies

1 other study(ies) available for pyripyropene-a and beauverolides

Article	Year
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes. The Journal of antibiotics, 2007, Volume: 60, Issue:1 The selectivity of microbial inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) toward the two isozymes, ACAT1 and ACAT2, was assessed in cell-based assays. Purpactin A (IC50 values of ACAT1 vs. IC50 values of ACAT2; 2.5 microM vs. 1.5 microM), terpendole C (10 microM vs. 10 microM), glisoprenin A (4.3 microM vs. 10 microM), spylidone (25 microM vs. 5.0 microM) and synthetic CL-283,546 (0.1 microM vs. 0.09 microM) inhibited ACAT1 and ACAT2 to similar extents. Beauveriolides I (0.6 microM vs. 20 microM) and III (0.9 microM vs. >20 microM) inhibited ACAT1 rather selectively, while pyripyropenes A (>80 microM vs. 0.07 microM), B (48 microM vs. 2.0 microM), C (32 microM vs. 0.36 microM) and D (38 microM vs. 1.5 microM) showed selective inhibition against ACAT2. In particular, pyripyropene A was found to be the most selective ACAT2 inhibitor with a selective index of more than 1,000. Topics: Animals; CHO Cells; Cholesterol Esters; Cricetinae; Cricetulus; Depsipeptides; Diterpenes; Enzyme Inhibitors; Fatty Alcohols; Heterocyclic Compounds, 3-Ring; Indoles; Isoenzymes; Macrophages, Peritoneal; Mice; Molecular Structure; Phenanthrenes; Phenylurea Compounds; Pyridines; Sesquiterpenes; Spiro Compounds; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2	2007

Article

Year

Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes.

The Journal of antibiotics, 2007, Volume: 60, Issue:1

The selectivity of microbial inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) toward the two isozymes, ACAT1 and ACAT2, was assessed in cell-based assays. Purpactin A (IC50 values of ACAT1 vs. IC50 values of ACAT2; 2.5 microM vs. 1.5 microM), terpendole C (10 microM vs. 10 microM), glisoprenin A (4.3 microM vs. 10 microM), spylidone (25 microM vs. 5.0 microM) and synthetic CL-283,546 (0.1 microM vs. 0.09 microM) inhibited ACAT1 and ACAT2 to similar extents. Beauveriolides I (0.6 microM vs. 20 microM) and III (0.9 microM vs. >20 microM) inhibited ACAT1 rather selectively, while pyripyropenes A (>80 microM vs. 0.07 microM), B (48 microM vs. 2.0 microM), C (32 microM vs. 0.36 microM) and D (38 microM vs. 1.5 microM) showed selective inhibition against ACAT2. In particular, pyripyropene A was found to be the most selective ACAT2 inhibitor with a selective index of more than 1,000.

Topics: Animals; CHO Cells; Cholesterol Esters; Cricetinae; Cricetulus; Depsipeptides; Diterpenes; Enzyme Inhibitors; Fatty Alcohols; Heterocyclic Compounds, 3-Ring; Indoles; Isoenzymes; Macrophages, Peritoneal; Mice; Molecular Structure; Phenanthrenes; Phenylurea Compounds; Pyridines; Sesquiterpenes; Spiro Compounds; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2

2007