pyrimidinones has been researched along with tyloxapol* in 1 studies
1 other study(ies) available for pyrimidinones and tyloxapol
| Article | Year |
|---|---|
Design, synthesis, and antihyperlipidemic evaluation of novel 2-[1-(substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2,3-d]pyrimidin-4(3H)-ones.
Novel thienopyrimidine derivatives of azetidinone possessing the combined features of the cholesterol absorption inhibitor drug ezetimibe and potential antihyperlipidemic 2-substitutedthienopyrimidin-4-ones were synthesized and characterized by spectroscopic data and elemental analysis. These compounds were evaluated for their lipid-lowering activity in Wistar albino rats. Some of them showed significant lipid-lowering effects comparable to those of the standard drug, gemfibrozil, at the same dose levels. Topics: Animals; Azetidines; Biomarkers; Cholesterol; Disease Models, Animal; Drug Design; Gemfibrozil; Hyperlipidemias; Hypolipidemic Agents; Intestinal Absorption; Intestinal Mucosa; Intestines; Molecular Structure; Polyethylene Glycols; Pyrimidinones; Rats; Rats, Wistar; Structure-Activity Relationship; Triglycerides | 2013 |