pyrimidinones has been researched along with phenylbenzoquinone* in 2 studies
2 other study(ies) available for pyrimidinones and phenylbenzoquinone
| Article | Year |
|---|---|
Synthesis of 2,3-dihydro-3-amino-6-phenyl-2-thioxothieno [2,3-d] pyrimidin-4 (1H)-one and of potential antiinflammatory agents 2-aryl-7-phenyl-3H, 9H-pyrimido [2,1-b]thieno-[2',3':4,5]]1,3,4] thiadiazin-9-ones.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageenan; Edema; Magnetic Resonance Spectroscopy; Pain Measurement; Peritonitis; Pyrimidines; Pyrimidinones; Rats; Spectrophotometry, Infrared; Thiadiazines; Thiophenes | 1994 |
The pharmacological properties of 1,4-dihydro-1-ethyl-7-phenylpyrrol (1,2-a)-pyrimidine-4-one, a new antipyretic and analgesic drug.
The antipyretic, analgesic, antinflammatory and antiulcerogenic properties of a new compound 1,4 dihydro-1-ethyl-7-phenylpyrrol (1,2-a)-pyrimidine-4-one (V33) are described. V33 on a mg/kg basis possesses antipyretic and analgesic properties at doses lower than paracetamol and which do not produce hypothermia or motor impairment. V33 possesses antiinflammatory activity and decreases the production of LTB4 from inflammatory exudates without affecting PGE2 content. V33 is not only devoid of gastric ulcerogenic properties but exerts antiulcer activity toward various ulcerogenic stimuli. Lethal dose 50% (LD50) of V33 is higher that of paracetamol. Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Dose-Response Relationship, Drug; Fever; Humans; In Vitro Techniques; Leukotriene B4; Male; Mice; Oxygen Consumption; Pyrimidinones; Quinones; Rats; Rats, Inbred Strains; Reaction Time; Stomach Ulcer | 1987 |