pyrimidinones and perchlorate

pyrimidinones has been researched along with perchlorate* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and perchlorate

Article	Year
In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes. Journal of inorganic biochemistry, 2011, Volume: 105, Issue:6 Conventional reactions of the versatile multidentate ligand 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one (HmtpO) with metallic(II) perchlorate salts lead to three novel multidimensional complexes [Cu(HmtpO)(2)(H(2)O)(3)](ClO(4))(2)·H(2)O (1), {[Cu(HmtpO)(2)(H(2)O)(2)](ClO(4))(2) ·2HmtpO}(n) (2) and {[Co(HmtpO)(H(2)O)(3)](ClO(4))(2)·2H(2)O}(n) (3). We have tested the antiparasital activity in vitro and in vivo of the three new complexes against Trypanosoma cruzi showing very promising results and overcoming clearly the reference drug commonly used for the Chagas disease treatment, benznidazole. Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells	2011

Article

Year

In vitro and in vivo antiparasital activity against Trypanosoma cruzi of three novel 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-based complexes.

Journal of inorganic biochemistry, 2011, Volume: 105, Issue:6

Conventional reactions of the versatile multidentate ligand 5-methyl-1,2,4-triazolo[1,5-a] pyrimidin-7(4H)-one (HmtpO) with metallic(II) perchlorate salts lead to three novel multidimensional complexes [Cu(HmtpO)(2)(H(2)O)(3)](ClO(4))(2)·H(2)O (1), {[Cu(HmtpO)(2)(H(2)O)(2)](ClO(4))(2) ·2HmtpO}(n) (2) and {[Co(HmtpO)(H(2)O)(3)](ClO(4))(2)·2H(2)O}(n) (3). We have tested the antiparasital activity in vitro and in vivo of the three new complexes against Trypanosoma cruzi showing very promising results and overcoming clearly the reference drug commonly used for the Chagas disease treatment, benznidazole.

Topics: Animals; Chagas Disease; Chlorocebus aethiops; Coordination Complexes; Crystallography, X-Ray; Female; Ligands; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Nitroimidazoles; Perchlorates; Pyrimidinones; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2011