pyrimidinones and indium-trichloride

pyrimidinones has been researched along with indium-trichloride* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and indium-trichloride

Article	Year
InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents. Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15 A convenient and practical methodology for the synthesis of 2-aryl quinazolin-4(3H)-ones by the condensation of o-aminobenzamides with aromatic aldehydes under mild conditions using catalytic InCl(3) with good yields and high selectivities. This method has been extended for the synthesis of 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones which have potential applications in medicinal chemistry. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules. Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Catalysis; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Drug Screening Assays, Antitumor; Humans; Indium; K562 Cells; Pyrimidinones; Quinazolinones; Sirtuin 1	2012

Article

Year

InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents.

Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15

A convenient and practical methodology for the synthesis of 2-aryl quinazolin-4(3H)-ones by the condensation of o-aminobenzamides with aromatic aldehydes under mild conditions using catalytic InCl(3) with good yields and high selectivities. This method has been extended for the synthesis of 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones which have potential applications in medicinal chemistry. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules.

Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Catalysis; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Drug Screening Assays, Antitumor; Humans; Indium; K562 Cells; Pyrimidinones; Quinazolinones; Sirtuin 1

2012