pyrimidinones and hypericin

pyrimidinones has been researched along with hypericin* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and hypericin

Article	Year
Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells. Cancer letters, 2003, Jun-30, Volume: 196, Issue:1 The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlated with the accumulation of endogenous and exogenous photosensitizes. Reduced accumulation of the endogenous protoporphyrin IX and the exogenous hypericin and MC540 was detected in differentiated cells. In contrast, a differentiation-dependent increase was measured with TPPS4, TMPyP, the pheophorbides (C5, C6, C12), HypS4 and helianthrone. In conclusion, PpIX, Hypericin and MC540 show specific binding and accumulation in poorly differentiated tumors, giving these tumors tissue-specific advantage in photo-diagnostic PDT applications. Topics: Animals; Anthracenes; Butyrates; Carcinoma; Cell Cycle; Cell Differentiation; Colonic Neoplasms; Mice; Perylene; Photosensitizing Agents; Protoporphyrins; Pyrimidinones; Tumor Cells, Cultured	2003

Article

Year

Specificity of photosensitizer accumulation in undifferentiated versus differentiated colon carcinoma cells.

Cancer letters, 2003, Jun-30, Volume: 196, Issue:1

The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlated with the accumulation of endogenous and exogenous photosensitizes. Reduced accumulation of the endogenous protoporphyrin IX and the exogenous hypericin and MC540 was detected in differentiated cells. In contrast, a differentiation-dependent increase was measured with TPPS4, TMPyP, the pheophorbides (C5, C6, C12), HypS4 and helianthrone. In conclusion, PpIX, Hypericin and MC540 show specific binding and accumulation in poorly differentiated tumors, giving these tumors tissue-specific advantage in photo-diagnostic PDT applications.

Topics: Animals; Anthracenes; Butyrates; Carcinoma; Cell Cycle; Cell Differentiation; Colonic Neoplasms; Mice; Perylene; Photosensitizing Agents; Protoporphyrins; Pyrimidinones; Tumor Cells, Cultured

2003