pyrimidinones and dioctanoyl-ethylene-glycol

pyrimidinones has been researched along with dioctanoyl-ethylene-glycol* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and dioctanoyl-ethylene-glycol

Article	Year
Diacylglycerol kinase inhibitors R59022 and dioctanoylethylene glycol potentiate the respiratory burst of neutrophils by raising cytosolic Ca2+. Biochemical and biophysical research communications, 1989, May-30, Volume: 161, Issue:1 The diacylglycerol kinase inhibitors, R59022 and dioctanoylethylene glycol (diC8-eg), potentiate stimulation of the respiratory burst by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) in human neutrophils. However, in contrast to the potentiation observed in intact cells, neither R59022 nor diC8-eg enhanced the effect of fMLP on O2 consumption in electropermeabilized neutrophils, under conditions where cytosolic [Ca2+] was held constant using EGTA. In unstimulated, intact cells treatment with the diacylglycerol kinase inhibitors elicited an increase in cytosolic Ca2+ ([Ca2+]i). The results suggest that enhancement of the respiratory burst by diC8-eg and R59022 is mediated by a rise in [Ca2+]i, rather than by inhibition of diacylglycerol kinase. Topics: Calcium; Cell Membrane Permeability; Cytosol; Diacylglycerol Kinase; Drug Synergism; Ethylene Glycols; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphotransferases; Pyrimidinones; Thiazoles	1989

Article

Year

Diacylglycerol kinase inhibitors R59022 and dioctanoylethylene glycol potentiate the respiratory burst of neutrophils by raising cytosolic Ca2+.

Biochemical and biophysical research communications, 1989, May-30, Volume: 161, Issue:1

The diacylglycerol kinase inhibitors, R59022 and dioctanoylethylene glycol (diC8-eg), potentiate stimulation of the respiratory burst by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) in human neutrophils. However, in contrast to the potentiation observed in intact cells, neither R59022 nor diC8-eg enhanced the effect of fMLP on O2 consumption in electropermeabilized neutrophils, under conditions where cytosolic [Ca2+] was held constant using EGTA. In unstimulated, intact cells treatment with the diacylglycerol kinase inhibitors elicited an increase in cytosolic Ca2+ ([Ca2+]i). The results suggest that enhancement of the respiratory burst by diC8-eg and R59022 is mediated by a rise in [Ca2+]i, rather than by inhibition of diacylglycerol kinase.

Topics: Calcium; Cell Membrane Permeability; Cytosol; Diacylglycerol Kinase; Drug Synergism; Ethylene Glycols; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphotransferases; Pyrimidinones; Thiazoles

1989