pyrimidinones has been researched along with cercosporamide* in 1 studies
1 other study(ies) available for pyrimidinones and cercosporamide
| Article | Year |
|---|---|
Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.
In a context of growing resistance to classical antifungal therapy, the design of new drugs targeting alternative pathways is highly expected. Benzofuro[3,2-d]pyrimidine derivatives, derived from (-)-cercosporamide, were synthesized and evaluated as potential Candida albicans PKC inhibitors in the aim of restoring susceptibility to azole treatment. Co-administration assay of benzofuropyrimidinedione 23 and fluconazole highlighted a synergistic effect on inhibition of cell growth of a Candida albicans resistant strain. Topics: Antifungal Agents; Ascomycota; Benzofurans; Biofilms; Candida albicans; Drug Resistance, Fungal; Drug Synergism; Fluconazole; HeLa Cells; Humans; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidinones | 2018 |