pyrimidinones has been researched along with barbituric-acid* in 5 studies
5 other study(ies) available for pyrimidinones and barbituric-acid
| Article | Year |
|---|---|
An efficient one-pot organocatalyzed synthesis of spiro[chroman-3,6'- furo[2,3-d]pyrimidine]-tetraones.
An efficient synthesis of new spiro[chroman-3,6'-furo[2,3-d]pyrimidine]- tetraones by an organocatalyzed three-component condensation reaction of aldehydes, barbituric acids and 3-bromo-4-hydroxy-2H-chromen-2-one in refluxing acetic acid in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is reported. We are hopeful that the products will lead to a wider range pharmacological and physiological activity. Topics: Acetic Acid; Aldehydes; Barbiturates; Bridged Bicyclo Compounds, Heterocyclic; Catalysis; Chemistry Techniques, Synthetic; Molecular Structure; Pyrimidinones; Spiro Compounds | 2013 |
A new synthetic approach to functionalize pyrimido[4,5-b]quinoline-2,4(1H,3H)-diones via a three-component one-pot reaction.
Functionalized pyrimido[4,5-b]quinoline-2,4 (1H,3H)-diones were synthesized by a three-component one-pot reaction involving barbituric acid, aldehydes, and anilines. The use of commercially available anilines allowed the facile syntheses of pyrimido[4,5-b]quinolinediones substituted in all the positions on the benzene ring with electron donor or electron withdrawing groups. This straightforward method circumvents the preparation of unstable substituted 2-aminobenzaldehydes that limits the scope of previously described syntheses. Furthermore, access to the 5-substituted derivatives is now also possible starting from aliphatic or aromatic aldehydes. Our strategy and methodology offer significant and practical improvements over other methodologies. Topics: Acetic Acid; Aniline Compounds; Barbiturates; Chemical Phenomena; Pyrimidinones; Quinolines | 2010 |
Design, synthesis and anticancer activities of hybrids of indole and barbituric acids--identification of highly promising leads.
By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized. Evaluations of these molecules over 60 cell line panel of human cancer cells have identified two molecules with significant anticancer activities. Dockings of two active molecules in the active sites of COX-2, thymidylate synthase and ribonucleotide reductase indicate their strong interactions with these enzymes. Topics: Antineoplastic Agents; Barbiturates; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Cyclooxygenase 2; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Pyrimidinones; Ribonucleotide Reductases; Structure-Activity Relationship; Thymidylate Synthase | 2009 |
Shaken not stirred: a facile synthesis of 1,4-bis(furo[2,3-d]-pyrimidine-2,4(1H,3H)-dione-5-yl)benzenes by one-pot reaction of isocyanides, N,N'-dimethylbarbituric acid, and terephthaldialdehyde.
A simple and efficient synthesis of 1,4-bis(furo[2,3-d]pyrimidine-2,4(1H,3H)-dione-5-yl)benzene derivatives was achieved via a one-pot three-component reaction of isocyanides, N,N'-dimethylbarbituric acid, and terephthaldialdehyde in DMF at room temperature for 30 min. These improved reaction conditions allow the preparation of highly substituted furopyrimidinones in high yields and purity under mild reaction conditions. Topics: Aldehydes; Barbiturates; Benzene Derivatives; Cyanides; Furans; Magnetic Resonance Spectroscopy; Models, Chemical; Phthalic Acids; Pyrimidinones; Spectrophotometry, Ultraviolet | 2006 |
An NMR study of merocyanine-type dyes derived from barbituric acid.
The 13C NMR of two solvatochromic dyes derived from a barbituric acid acceptor and dimethylaminophenyl donor fragments, compound 1 and the related merocyanine 2, were recorded in various solvents. The observed chemical-shift variations were used to interpret their structural differences and solvatochromic behavior in solution. Topics: Barbiturates; Coloring Agents; Electrochemistry; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Solutions | 2004 |