pyrimidinones and artemisinin

Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. For decades, the research for novel antimalarials focused on the high-throughput screening of molecules that only targeted the asexual blood stages. In a search for new effective compounds presenting a triple action against erythrocytic and liver stages in addition to the ability to block the transmission of the disease

Topics: Animals; Antimalarials; Artemisinins; Cell Line, Tumor; Disease Models, Animal; Dogs; Drug Resistance; Female; Hep G2 Cells; Humans; Liver; Macaca fascicularis; Madin Darby Canine Kidney Cells; Malaria, Falciparum; Male; Mice; Mice, Inbred BALB C; Plasmodium cynomolgi; Plasmodium falciparum; Plasmodium yoelii; Pyrimidinones