pyrimidinones has been researched along with ardeemin* in 1 studies
1 other study(ies) available for pyrimidinones and ardeemin
Article | Year |
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Ardeemins and cytochalasins from Aspergillus terreus residing in Artemisia annua.
Three new alkaloids, 15b-dehydro-5- N-acetylardeemin ( 3), 10-phenyl-[12]-cytochalasins Z16 ( 6) and Z17 ( 7), were characterized from the liquid culture of the endophytic fungus ASPERGILLUS TERREUS IFB-E030 along with six known derivatives, 5- N-acetylardeemin ( 1), 15b- β-hydroxyl-5- N-acetylardeemin ( 2), cytochalasin E ( 4), rosellichalasin ( 5), cytochalasins Z11 ( 8), and Z13 ( 9). The structures of the new metabolites were established mainly by a combination of their 1D- and 2D-NMR spectra, single crystal X-ray diffraction, and the modified Mosher reaction. Biological assays indicated that cytochalasin Z17 ( 7) had moderate cytotoxicity against human nasopharyngeal epidermoid tumor KB cell line with an IC (50) value of 26.2 µM. Topics: Artemisia annua; Aspergillus; Chemical Fractionation; Cytochalasins; Cytotoxins; Humans; Indole Alkaloids; KB Cells; Nuclear Magnetic Resonance, Biomolecular; Pyrimidinones; X-Ray Diffraction | 2010 |