pyrimidinones and alpha-aminopyridine

pyrimidinones has been researched along with alpha-aminopyridine* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and alpha-aminopyridine

Article	Year
Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2- a]pyrimidin-4-ones. Organic letters, 2019, 06-07, Volume: 21, Issue:11 Imines formed in situ from 2-aminopyridines and aldehydes undergo Rh(III)-catalyzed imidoyl C-H activation and coupling with diazo esters to give pyrido[1,2- a]pyrimidin-4-ones. Aromatic and enolizable aliphatic aldehydes were both effective substrates, and a broad range of functional groups were incorporated at different sites on the heterocyclic products. In addition, methoxy and dimethylamino functionalities could be directly installed on the pyrimidine ring by employing trimethyl orthoformate or N, N-dimethylformamide dimethyl acetal in place of the aldehyde, respectively. Topics: Aldehydes; Aminopyridines; Azo Compounds; Catalysis; Esters; Imides; Molecular Structure; Pyridines; Pyrimidinones; Rhodium	2019

Article

Year

Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2- a]pyrimidin-4-ones.

Organic letters, 2019, 06-07, Volume: 21, Issue:11

Imines formed in situ from 2-aminopyridines and aldehydes undergo Rh(III)-catalyzed imidoyl C-H activation and coupling with diazo esters to give pyrido[1,2- a]pyrimidin-4-ones. Aromatic and enolizable aliphatic aldehydes were both effective substrates, and a broad range of functional groups were incorporated at different sites on the heterocyclic products. In addition, methoxy and dimethylamino functionalities could be directly installed on the pyrimidine ring by employing trimethyl orthoformate or N, N-dimethylformamide dimethyl acetal in place of the aldehyde, respectively.

Topics: Aldehydes; Aminopyridines; Azo Compounds; Catalysis; Esters; Imides; Molecular Structure; Pyridines; Pyrimidinones; Rhodium

2019