pyrimidinones has been researched along with 8-hydroxyguanosine* in 3 studies
3 other study(ies) available for pyrimidinones and 8-hydroxyguanosine
| Article | Year |
|---|---|
Development of a specific fluorescent probe for 8-oxoguanosine.
8-Oxoguanosine (8-oxoG) is derived from the oxidation of guanosine (dG) and is known to induce transversion mutations (G:C to T:A) in DNA. We have already reported the fluorescent probe "8-oxoG-clamp", which shows a selective fluorescence quenching phenomenon toward 8-oxoG. In this study, attachment of an additional fluorophore to 8-oxoG-clamp was investigated as a strategy for the detection of 8-oxoG by a fluorescence color change attributed to the 8-oxoG-clamp. Topics: Base Pairing; Carbamates; Fluorescent Dyes; Guanosine; Pyrimidinones; Spectrometry, Fluorescence | 2007 |
Selective fluorescence detection of 8-oxoguanosine with 8-oxoG-clamp.
8-oxoguanosine, which is derived from the oxidation of guanosine (dG), is known to induce transversion mutations (G:C-->T:A) in DNA. The compounds with a small molecular weight for recognizing 8-oxoG were designed on the basis of the structure of the G-clamp, which is reported to have selective affinity toward guanosine. The G-clamp derivatives with the additional binding units toward 8-oxoG were effectively synthesized and named "8-oxoG-clamps." The 8-oxoG-clamp completely discriminated 8-oxoG from other nucleosides by fluorescence quenching. Topics: Carbamates; Fluorescence; Guanosine; Hydrogen-Ion Concentration; Kinetics; Pyrimidinones; Titrimetry | 2007 |
Fluorescence detection of 8-oxoguanosine by G-clamp derivatives.
8-Oxoguanosine, which is derived by the oxidation of guanosine (dG), is known to induce transversion mutations (G:C-->T:A) in DNA. The compounds with small molecular weight for recognizing 8-oxoG were designed on the basis of the structure of the G-clamp, which is reported to have selective affinity toward guanosine. The G-clamp derivatives with the additional binding units toward 8-oxoG were effectively synthesized and named "8-oxoG-clamps". Binding properties were measured by fluorescence quenching of 8-oxoG-clamps. Among the synthesized derivatives, 8-oxoG-clamp with N-benzyloxycarbonyl (Cbz) unit completely discriminated 8-oxoG from other nucleosides by fluorescence quenching. Topics: Carbamates; Fluorescent Dyes; Guanosine; Oxazines; Pyrimidinones; Spectrometry, Fluorescence | 2006 |