pyrimidinones and 6-amino-1-3-dimethyl-uracil

pyrimidinones has been researched along with 6-amino-1-3-dimethyl-uracil* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and 6-amino-1-3-dimethyl-uracil

ArticleYear
Biginelli and Hantzsch-type reactions leading to highly functionalized dihydropyrimidinone, thiocoumarin, and pyridopyrimidinone frameworks via ring annulation with β-oxodithioesters.
    The Journal of organic chemistry, 2010, Nov-19, Volume: 75, Issue:22

    An efficient and highly convergent route to dihydropyrimidinones (DHPMs) and hitherto unreported dihydropyridopyrimidinones has been developed by one-pot, three-component cyclocondensation of aromatic aldehydes, β-oxodithioesters, and urea/6-amino-1,3-dimethyluracil in the presence of recyclable SiO2-H2SO4. On the other hand, salicylaldehyde, β-oxodithioester, and urea reacted under similar conditions to afford the 3-aroyl/heteroaroyl-2H-chromen-2-thiones in high yields instead of Biginelli product. The attractive feature of this approach is the synthesis of three important bioactive heterocyclic frameworks from the same β-oxodithioester under the similar reaction conditions, making this new strategy highly useful in diversity-oriented synthesis (DOS).

    Topics: Catalysis; Coumarins; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrimidinones; Sulfhydryl Compounds; Uracil

2010