pyrimidine has been researched along with uridine in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (15.91) | 18.7374 |
| 1990's | 8 (18.18) | 18.2507 |
| 2000's | 14 (31.82) | 29.6817 |
| 2010's | 15 (34.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kraal, I; Peters, GJ; Pinedo, HM | 1 |
| Etheredge, JL; Howell, BA; Ringer, DP | 1 |
| Fauler, J; Gasser, T; Holstege, A; Keppler, D; Weckbecker, G | 1 |
| Blonski, WJ; Brennan, RG; Hruska, FE; Privé, GG; Sundaralingam, M | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Hiroshige, K; Kuroiwa, A; Takasugi, M; Yuu, K | 1 |
| Bakri, MT; Tamura, K; Thomson, AW; Woo, J | 1 |
| Bailly, C; Colson, P; Dassonneville, L; Hamy, F; Houssier, C | 1 |
| Higashino, K; Moriwaki, Y; Takahashi, S; Tsutsumi, Z; Yamakita, J; Yamamoto, T | 1 |
| Hofsteenge, J; Jarai-Kote, Z; Moldow, C; Neumann, U; Vicentini, AM; Zelenko, O | 1 |
| Cappiello, M; Giorgelli, F; Ipata, PL; Mascia, L; Scolozzi, C | 1 |
| Fairbanks, LD; Hawrlowicz, CM; Kirschbaum, B; Qiu, Y; Richards, DF; Rückermann, K; Simmonds, HA | 1 |
| Sumi, S | 1 |
| Evans, VJ; Price, FM; Rotherham, J | 1 |
| Cao, D; Leffert, JJ; Pizzorno, G; Russell, RL; Zhang, D | 1 |
| Flao, KL; Francesconi, E; Hidden, H; Meakin, C; Millet, S; Ruuth, E; Spinella-Jaegle, S; Thomson, TA | 1 |
| Cromsigt, J; Flodell, S; Ippel, H; Kidd-Ljunggren, K; Schleucher, J; Wijmenga, S | 1 |
| Begué-Pastor, N; Benavent, S; Burger, D; Chicheportiche, R; Dayer, JM; Gruaz, L; Kaufmann, MT | 1 |
| HASHIMOTO, K; KUMAKURA, S; TANEMURA, I | 1 |
| LAWRENCE, NL; TSAN, YC | 1 |
| Cao, D; Kim, B; Leffert, JJ; McCabe, J; Pizzorno, G | 1 |
| Stuhlmeier, KM | 1 |
| Baglioni, P; Berti, D; Bombelli, FB; Dante, S; Hauss, T; Milani, S | 1 |
| Auclair, M; Capeau, J; Caron, M; Kornprobst, M; Lebrecht, D; Walker, UA | 1 |
| Cordero, MD; DiMauro, S; Hirano, M; López-Martín, JM; Montini, G; Navas, P; Quinzii, C; Rodriguez-Hernandez, A; Salviati, L; Sánchez-Alcázar, JA; Santos-Ocaña, C; Trevisson, E | 1 |
| Degano, M; Fornili, A; Sironi, M | 1 |
| LORING, HS; ORDWAY, GL; PIERCE, JG | 1 |
| Akerlund, HE; Andersen, G; Björnberg, O; Compagno, C; Gojković, Z; Hofer, A; Merico, AM; Moritz, T; Møller, K; Piskur, J; Polakova, S; Pynyaha, Y; Rasmussen, A; Sandrini, MP | 1 |
| Johnson, TC; Mann, RK; Martin, TP; Pobanz, MA | 1 |
| Brady, BS; Hyman, BC; Lovatt, CJ | 1 |
| Hu, P; Liang, QL; Luo, GA; Wang, YM; Xia, JF; Zou, TT | 1 |
| Bushman, LR; Chen, P; Hail, N; Rower, J | 1 |
| Chen, C; Kierzek, R; Yu, YT; Zhao, X | 1 |
| Boitz, JM; Gilroy, CA; Ullman, B; Wilson, ZN; Yates, PA | 1 |
| Brotman, S; Hayes, E; Le, TT; Pizzorno, G; Urasaki, Y; Ziemba, A | 1 |
| Fey, V; Haapa-Paananen, S; He, T; Kallioniemi, O; Kaminskyy, VO; Kohonen, P; Perälä, M; Zhivotovsky, B | 1 |
| Pawar, MG; Srivatsan, SG | 1 |
| Bartolotti, L; Delley, B; Franzen, S; Skalski, B | 1 |
| Chen, M; Herde, M; Witte, CP | 1 |
| Helm, M; Tserovski, L | 1 |
| Alhaddad, B; Botto, LD; Chen, MA; Colombo, R; Coughlin, CR; Descartes, M; Grűnewald, S; Kluijtmans, LA; Maranda, B; Mills, PB; Pai, EF; Pitt, J; Pontoglio, A; Potente, C; Rodenburg, R; Sampath, S; Tiller, GE; Wevers, RA; Wortmann, SB; Yuzyuk, T | 1 |
| Cao, Z; Chen, N; Fan, F; Wang, Y; Wu, R | 1 |
| Chen, CS; Chen, SY; Gopula, B; Lee, YL; Li, JK; Liang, JJ; Lin, YL; Yang, CF | 1 |
| Andrés-Benito, P; Bayona-Bafaluy, MP; Ferrer, I; Garrido-Pérez, N; Gaudó, P; Iglesias, E; Jiménez-Salvador, I; Meade, P; Montoya, J; Pesini, A; Pesini, P; Ruiz-Pesini, E | 1 |
1 review(s) available for pyrimidine and uridine
| Article | Year |
|---|---|
[Hereditary orotic aciduria].
Topics: Administration, Oral; Diagnosis, Differential; Humans; Immune System Diseases; Multienzyme Complexes; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Prognosis; Pyrimidines; Uridine | 2000 |
1 trial(s) available for pyrimidine and uridine
| Article | Year |
|---|---|
Effect of allopurinol and benzbromarone on the concentration of uridine in plasma.
Topics: Adult; Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Gout; Gout Suppressants; Humans; Male; Middle Aged; Purines; Pyrimidines; Time Factors; Uric Acid; Uricosuric Agents; Uridine; Xanthine Oxidase | 1997 |
42 other study(ies) available for pyrimidine and uridine
| Article | Year |
|---|---|
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis.
Topics: Amides; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Concanavalin A; DNA; Guinea Pigs; Intracellular Fluid; Lymphocyte Activation; Lymphocytes; Male; Nucleotides; Orotidine-5'-Phosphate Decarboxylase; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Uridine | 1991 |
Potentiation of antimetabolite action by uridylate trapping.
Topics: Amino Sugars; Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Galactose; Glucose; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Pyrimidines; Rats; Rats, Inbred Strains; Uracil Nucleotides; Uridine | 1985 |
Crystal structure of O4-methyl uridine: stacking induced changes in the geometry of the pyrimidine ring and its mutagenic role.
Topics: Electrochemistry; Methylation; Molecular Conformation; Molecular Structure; Mutagens; Pyrimidines; Structure-Activity Relationship; Uridine | 1983 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
Studies on the purine-pyrimidine metabolism (2)--Effects of sample preparation and diet on the concentrations of oxypurines in blood and urine.
Topics: Chromatography, High Pressure Liquid; Diet; Humans; Hypoxanthine; Hypoxanthines; Male; Pseudouridine; Purines; Pyrimidines; Specimen Handling; Uric Acid; Uridine; Xanthine; Xanthines | 1994 |
Brequinar sodium inhibits interleukin-6-induced differentiation of a human B-cell line into IgM-secreting plasma cells.
Topics: B-Lymphocytes; Biphenyl Compounds; Cell Differentiation; Cell Line; Concanavalin A; Cytidine; DNA; Humans; Immunoglobulin M; Immunosuppressive Agents; Interleukin-6; Pyrimidines; Uridine | 1993 |
Binding of Hoechst 33258 to the TAR RNA of HIV-1. Recognition of a pyrimidine bulge-dependent structure.
Topics: Absorption; Binding Sites; Bisbenzimidazole; Circular Dichroism; DNA Footprinting; Heating; HIV Long Terminal Repeat; HIV-1; Humans; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Pyrimidines; RNA, Viral; Sequence Deletion; Structure-Activity Relationship; Uridine | 1997 |
A single amino acid substitution changes ribonuclease 4 from a uridine-specific to a cytidine-specific enzyme.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cattle; Cytidine; Hydrolysis; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Pyrimidines; Ribonuclease, Pancreatic; Ribonucleases; Substrate Specificity; Swine; Uridine | 1998 |
In vitro assessment of salvage pathways for pyrimidine bases in rat liver and brain.
Topics: Animals; Brain; Liver; Phosphoribosyl Pyrophosphate; Purine Nucleosides; Purines; Pyrimidines; Rats; Ribosemonophosphates; Time Factors; Tissue Extracts; Uracil Nucleotides; Uridine | 1998 |
Mycophenolic acid-induced GTP depletion also affects ATP and pyrimidine synthesis in mitogen-stimulated primary human T-lymphocytes.
Topics: Adenosine Triphosphate; Bicarbonates; Cells, Cultured; Enzyme Inhibitors; Glycine; Guanosine Triphosphate; Humans; Hypoxanthine; Mitogens; Mycophenolic Acid; Osmolar Concentration; Phytohemagglutinins; Pilot Projects; Purine Nucleotides; Purines; Pyrimidines; Ribonucleotides; T-Lymphocytes; Uridine | 2000 |
Some aspects of the role of vitamin B12 in nucleic acid synthesis in a neoplastic C3H mouse cell strain. I. Growth studies.
Topics: Adenine; Adenosine; Animals; Cell Division; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Folic Acid; Guanine; Mice; Nucleic Acid Precursors; Nucleosides; Pyrimidines; Thymidine; Tumor Cells, Cultured; Uridine; Vitamin B 12 | 1970 |
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cells, Cultured; Embryo, Mammalian; Fluorouracil; Mice; Mice, Knockout; Proteins; Pyrimidines; Stem Cells; Uridine; Uridine Phosphorylase | 2002 |
In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
Topics: Aniline Compounds; Animals; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Crotonates; Dihydroorotate Dehydrogenase; Drug Antagonism; Enzyme Inhibitors; Erythrocytes; Hydroxybutyrates; Immunoglobulin G; Immunoglobulin kappa-Chains; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Sheep; Spleen; Toluidines; Uridine | 2002 |
The apical stem-loop of the hepatitis B virus encapsidation signal folds into a stable tri-loop with two underlying pyrimidine bulges.
Topics: Base Pairing; Base Sequence; Genome, Viral; Genotype; Hepatitis B virus; Humans; Mutation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pyrimidines; RNA-Directed DNA Polymerase; RNA, Viral; Substrate Specificity; Uridine | 2002 |
The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes.
Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Rheumatoid; Cells, Cultured; Crotonates; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydroxybutyrates; Interleukin-6; Isoenzymes; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Nitriles; Prostaglandin-Endoperoxide Synthases; Pyrimidines; RNA, Messenger; Synovial Membrane; Toluidines; Uridine | 2003 |
MODE OF ACTION OF ADENINE, URIDINE AND CYTIDINE NUCLEOTIDES AND 2,6-BIS(DIETHANOLAMINO)-4,8-DIPIPERIDINO-PYRIMIDINO(5,4-D)PYRIMIDINE ON THE CORONARY, RENAL AND FEMORAL ARTERIES.
Topics: Adenine; Adenine Nucleotides; Animals; Coronary Vessels; Cytidine; Cytosine Nucleotides; Dipyridamole; Dogs; Femoral Artery; Heart; Kidney; Nucleotides; Pharmacology; Pyrimidines; Renal Artery; Research; Uracil Nucleotides; Uridine | 1964 |
Reactions of spores and cells of Bacillus cereus with pyrimidine ribosides.
Topics: Bacillus; Bacillus cereus; Cytidine; Nucleosides; Nucleotides; Pyrimidines; Spores, Bacterial; Uracil; Uridine | 1962 |
Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.
Topics: Adenosine; Animals; Antimetabolites, Antineoplastic; Blotting, Southern; Cytidine; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Fluorouracil; Gene Deletion; Guanosine; Intestinal Mucosa; Kidney; Kinetics; Liver; Lung; Mice; Mice, Transgenic; Nucleotides; Pentobarbital; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Thymine Nucleotides; Time Factors; Tissue Distribution; Uridine; Uridine Phosphorylase | 2005 |
Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Enzyme Repression; Fibroblasts; Glucuronosyltransferase; Humans; Hyaluronan Synthases; Hyaluronic Acid; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; NF-kappa B; Protein Transport; Pyrimidines; RNA, Messenger; Synovial Membrane; Transcription, Genetic; Uridine | 2005 |
Structural investigation of bilayers formed by 1-palmitoyl-2-oleoylphosphatidylnucleosides.
Topics: Adenosine; Glycerophospholipids; Lipid Bilayers; Neutron Diffraction; Phase Transition; Phosphatidic Acids; Purines; Pyrimidines; Spectroscopy, Fourier Transform Infrared; Uridine; Water | 2006 |
Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions.
Topics: 3T3 Cells; Adipocytes; Animals; Anti-HIV Agents; Apoptosis; Cell Differentiation; DNA, Mitochondrial; Lipids; Membrane Potentials; Mice; Mitochondria; Pyrimidines; Reverse Transcriptase Inhibitors; Uridine | 2006 |
Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Base Sequence; Cell Division; Cells, Cultured; Coenzymes; Energy Metabolism; Enzyme Activation; Fibroblasts; Genetic Complementation Test; HeLa Cells; Humans; Immunoblotting; Mitochondria; Molecular Sequence Data; Mutation, Missense; Prohibitins; Pyrimidines; Saccharomyces cerevisiae; Sequence Alignment; Ubiquinone; Uridine | 2007 |
Accurate description of nitrogenous base flexibility in classical molecular dynamics simulations of nucleotides bound to proteins.
Topics: Binding Sites; Computer Simulation; Escherichia coli Proteins; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Conformation; Pyrimidines; Thermodynamics; Uridine | 2007 |
A method of assay for cytidine and uridine by means of a pyrimidine-deficient strain of Neurospora.
Topics: Cytidine; Neurospora; Pyrimidines; Uridine | 1948 |
A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes.
Topics: Eukaryotic Cells; Fungal Proteins; Lactic Acid; Molecular Structure; Mutagenesis, Site-Directed; Nucleic Acid Precursors; Oxygen; Pentosyltransferases; Pyrimidines; Saccharomyces; Uracil; Urea; Uridine | 2008 |
Penoxsulam--structure-activity relationships of triazolopyrimidine sulfonamides.
Topics: Acetolactate Synthase; Crops, Agricultural; Drug Discovery; Herbicides; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Uridine | 2009 |
Regulation of CPSase, ACTase, and OCTase genes in Medicago truncatula: Implications for carbamoylphosphate synthesis and allocation to pyrimidine and arginine de novo biosynthesis.
Topics: Arginine; Aspartate Carbamoyltransferase; Down-Regulation; Eukaryota; Genes, Fungal; Genes, Regulator; Medicago truncatula; Plants; Prokaryotic Cells; Pyrimidines; Uridine | 2010 |
Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients.
Topics: Aged; Chromatography, High Pressure Liquid; Creatine; Cytidine; Cytosine; Deoxyuridine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Male; Middle Aged; Pyrimidines; Tandem Mass Spectrometry; Thymidine; Thymine; Uridine | 2010 |
Teriflunomide encourages cytostatic and apoptotic effects in premalignant and malignant cutaneous keratinocytes.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Crotonates; Cytostatic Agents; Energy Metabolism; Epithelial Cells; Flow Cytometry; Humans; Hydroxybutyrates; Keratinocytes; Mitochondria; Nitriles; Oxygen Consumption; Precancerous Conditions; Pyrimidines; Reactive Oxygen Species; S Phase; Skin Neoplasms; Toluidines; Uridine | 2010 |
A flexible RNA backbone within the polypyrimidine tract is required for U2AF65 binding and pre-mRNA splicing in vivo.
Topics: Animals; Base Sequence; Molecular Sequence Data; Nuclear Proteins; Nucleic Acid Conformation; Oocytes; Protein Binding; Pyrimidines; Ribonucleoproteins; RNA Precursors; RNA Splicing; Splicing Factor U2AF; Uridine; Xenopus | 2010 |
Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Female; Homeostasis; Leishmania donovani; Leishmaniasis Vaccines; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Pentosyltransferases; Phosphorylation; Pyrimidines; Uracil; Uridine | 2012 |
Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation.
Topics: Animals; Cells, Cultured; Fatty Acids; Lipid Metabolism; Liver; Male; Mice; Mice, Transgenic; Pyrimidines; Triglycerides; Uridine; Uridine Phosphorylase | 2013 |
Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Computational Biology; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Silencing; Humans; Mitochondria; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Uridine | 2014 |
Environment-responsive fluorescent nucleoside analogue probe for studying oligonucleotide dynamics in a model cell-like compartment.
Topics: Fluorescent Dyes; Micelles; Models, Molecular; Nucleic Acid Hybridization; Oligonucleotides; Pyrimidines; Quantum Theory; Solvents; Spectrometry, Fluorescence; Uridine | 2013 |
The coupling of tautomerization to hydration in the transition state on the pyrimidine photohydration reaction path.
Topics: Cytosine; Pyrimidines; Quantum Theory; Thermodynamics; Thymine; Uridine; Water | 2014 |
Of the Nine Cytidine Deaminase-Like Genes in Arabidopsis, Eight Are Pseudogenes and Only One Is Required to Maintain Pyrimidine Homeostasis in Vivo.
Topics: Ammonia; Arabidopsis; Arabidopsis Proteins; Computational Biology; Cytidine; Cytidine Deaminase; Genes, Reporter; Glycine max; Homeostasis; Mutation; N-Glycosyl Hydrolases; Phosphotransferases; Plant Leaves; Pseudogenes; Pyrimidines; Uridine | 2016 |
Diastereoselectivity of 5-Methyluridine Osmylation Is Inverted inside an RNA Chain.
Topics: Organometallic Compounds; Pyridines; Pyrimidines; RNA; Stereoisomerism; Uridine | 2016 |
Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.
Topics: Anemia, Megaloblastic; Child; Child, Preschool; Female; Heterozygote; Humans; Infant; Intellectual Disability; Male; Multienzyme Complexes; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Urea Cycle Disorders, Inborn; Uridine | 2017 |
QM/MM and MM MD Simulations on the Pyrimidine-Specific Nucleoside Hydrolase: A Comprehensive Understanding of Enzymatic Hydrolysis of Uridine.
Topics: Biocatalysis; Hydrolysis; Molecular Dynamics Simulation; N-Glycosyl Hydrolases; Pyrimidines; Quantum Theory; Uridine | 2018 |
Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis.
Topics: A549 Cells; Animals; Antiviral Agents; Biosynthetic Pathways; Cell Line; Dengue Virus; Dihydroorotate Dehydrogenase; Flavivirus; Host-Pathogen Interactions; Humans; Mice; Oxidoreductases Acting on CH-CH Group Donors; Pyrazoles; Pyrimidines; Sulfonamides; Uridine; Virus Replication; Zika Virus | 2018 |
Brain pyrimidine nucleotide synthesis and Alzheimer disease.
Topics: Alzheimer Disease; Brain; Cell Differentiation; Drug Design; Electron Transport Complex IV; Humans; Mitochondria; Neurons; Neuroprotective Agents; Oxidative Phosphorylation; Pyrimidines; Signal Transduction; Uridine | 2019 |