Compounds > pyrimidine
Page last updated: 2024-08-21

pyrimidine and quinazolines

pyrimidine has been researched along with quinazolines in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's10 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alanine, A; Blasco, F; Kolczewski, S; Lübbers, T; Peters, JU; Steward, L1
McLaughlin, ML; Talele, TT1
Bhatnagar, PK; Dastidar, SG; Kapoor, S; Nithya, D; Ray, A; Senthil, V; Sharma, A; Talwadkar, A; Tandon, R; Vali, S; Venkataramanan, R1
Encío, I; Font, M; Lamberto, I; Moreno, E; Palop, JA; Plano, D; Sanmartín, C1
Beckers, T; Böhmer, FD; Eichhorn, E; Fiebig, HH; Kelter, G; Krumbach, R; Mahboobi, S; Pongratz, H; Schächtele, C; Sellmer, A; Totzke, F1
Chang, CP; Chao, YS; Chen, CT; Chou, MC; Hsieh, CJ; Jan, JJ; Kao, TT; Shia, KS; Song, JS; Tseng, CT; Wong, YC; Wu, CH; Wu, SH; Wu, SY; Yeh, CF; Yeh, KC1
Bouloc, N; Buxton, RS; Chapman, TM; Chugh, J; Lougheed, KE; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL; Whalley, D1
Chauhan, PM; Sharma, M1
Chen, HJ; Chen, KF; Chou, YC; Huang, JW; Kim, I; Liu, CY; Pao, KC; Shiau, CW; Su, JC1
Ding, K; Han, C; Huang, Z; Ji, H; Lai, Y; Peng, S; Wan, L; Zhang, Y; Zheng, C1
Agarwal, SM; Gupta, M; Pal, D; Saini, R1
Abe, Y; Caaveiro, JMM; Fuchida, H; Hamachi, I; Hatsuyama, Y; Koyanagi, S; Kuwata, K; Matsunaga, N; Miura, C; Morimoto, S; Nakao, T; Ohdo, S; Ojida, A; Okamoto, K; Ono, M; Sakamoto, S; Sato, M; Shibata, T; Shindo, N; Shiroishi, M; Tamura, T; Tokunaga, K; Ueda, T; Watari, K; Yamaguchi, Y1

Reviews

2 review(s) available for pyrimidine and quinazolines

ArticleYear
Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.
    Future medicinal chemistry, 2012, Volume: 4, Issue:10

    Topics: Animals; Anti-Infective Agents; Antimalarials; Bacteria; Communicable Diseases; Drug Resistance, Microbial; Folic Acid Antagonists; Humans; Parasites; Pyrimidines; Quinazolines; Tetrahydrofolate Dehydrogenase

2012
Insight into Discovery of Next Generation Reversible TMLR Inhibitors Targeting EGFR Activating and Drug Resistant T790M Mutants.
    Current cancer drug targets, 2017, Volume: 17, Issue:7

    Topics: Antineoplastic Agents; Binding Sites; Carcinoma, Non-Small-Cell Lung; Drug Discovery; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Purines; Pyridones; Pyrimidines; Quinazolines; Structure-Activity Relationship

2017

Other Studies

10 other study(ies) available for pyrimidine and quinazolines

ArticleYear
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.
    Bioorganic & medicinal chemistry letters, 2008, Jan-01, Volume: 18, Issue:1

    Topics: Animals; Blood-Brain Barrier; Brain; Guanidines; Humans; Kinetics; Ligands; Models, Molecular; Pyrimidines; Quinazolines; Rats; Receptors, Serotonin; Structure-Activity Relationship

2008
Molecular docking/dynamics studies of Aurora A kinase inhibitors.
    Journal of molecular graphics & modelling, 2008, Volume: 26, Issue:8

    Topics: Aurora Kinases; Binding Sites; Computer Simulation; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Structure-Activity Relationship; Sulfonamides

2008
Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: a novel approach for overcoming resistance in anticancer treatment.
    European journal of pharmacology, 2011, Sep-30, Volume: 667, Issue:1-3

    Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Computational Biology; Cyclin D1; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Humans; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Receptor, IGF Type 1

2011
Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: synthesis and study of their potential cytotoxic activity in vitro.
    European journal of medicinal chemistry, 2012, Volume: 47, Issue:1

    Topics: Absorption; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Line, Tumor; Humans; Pyrimidines; Quinazolines; Selenium; Sulfur

2012
Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.
    Bioorganic & medicinal chemistry, 2012, Jan-01, Volume: 20, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Indoles; Phosphorylation; Pyrimidines; Quinazolines; Structure-Activity Relationship

2012
Discovery of novel stem cell mobilizers that target the CXCR4 receptor.
    ChemMedChem, 2012, Feb-06, Volume: 7, Issue:2

    Topics: Animals; Benzylamines; Cyclams; Drug Evaluation, Preclinical; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Heterocyclic Compounds; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Polyamines; Pyrimidines; Quinazolines; Receptors, CXCR4; Regenerative Medicine

2012
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
    Bioorganic & medicinal chemistry letters, 2012, May-01, Volume: 22, Issue:9

    Topics: Amines; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Structure-Activity Relationship

2012
Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity.
    Bioorganic & medicinal chemistry, 2012, Oct-15, Volume: 20, Issue:20

    Topics: Cell Line, Tumor; Cell Proliferation; Down-Regulation; ErbB Receptors; Erlotinib Hydrochloride; Humans; Protein Phosphatase 2; Pyrimidines; Quinazolines; Structure-Activity Relationship

2012
Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.
    European journal of medicinal chemistry, 2013, Volume: 66

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Resistance, Neoplasm; Enzyme Activation; ErbB Receptors; Free Radical Scavengers; Gefitinib; Humans; Nitric Oxide; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Signal Transduction

2013
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
    Nature chemical biology, 2019, Volume: 15, Issue:3

    Topics: Acetamides; Animals; Antineoplastic Agents; Cell Line; Cysteine; ErbB Receptors; Humans; Mice; Mice, Nude; Neoplasms; Phosphotransferases; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2019