Compounds > pyrimidine
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pyrimidine and pyrrolidine

pyrimidine has been researched along with pyrrolidine in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Paul, K; Singh, P1
Chen, J; Cook, K; Evans, DC; Gopaul, V; Jackson, PF; Lim, HK; Preston, R; Rassnick, S; Rhodes, K; Salter, R; Sensenhauser, C; Shook, B; Silva, J; Thomas, T1
Dai, H; Doran, SD; Piotrowski, DW; Prakash, C; Ryder, TF; Sharma, R; Sun, H1
Cassera, MB; Clinch, K; Crump, DR; Evans, GB; Fröhlich, RF; Harris, LD; Hazleton, KZ; Schramm, VL; Tyler, PC; Zhang, Y1

Reviews

1 review(s) available for pyrimidine and pyrrolidine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

4 other study(ies) available for pyrimidine and pyrrolidine

ArticleYear
Anti-cancer activities of 5-acyl-6-[2-hydroxy/benzyloxy-3-(amino)-propylamino]-1,3-dialkyl-1H-pyrimidin-2,4-diones.
    Bioorganic & medicinal chemistry, 2006, Dec-15, Volume: 14, Issue:24

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Neoplasms; Piperidines; Propanolamines; Pyrimidines; Pyrimidinones; Pyrrolidines; Structure-Activity Relationship

2006
Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
    Chemical research in toxicology, 2011, Jul-18, Volume: 24, Issue:7

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Biotransformation; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Humans; Imines; Indenes; Ions; Mass Spectrometry; Mice; Mutagenicity Tests; Pyrimidines; Pyrrolidines; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A; Salmonella typhimurium

2011
Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:11

    Topics: Amides; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dogs; Feces; Female; Humans; Hydrolysis; Hydroxylation; Male; Metabolic Detoxication, Phase II; Microsomes, Liver; Molecular Docking Simulation; Piperazine; Piperazines; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley

2012
Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.
    The Journal of biological chemistry, 2013, Nov-29, Volume: 288, Issue:48

    Topics: Antimalarials; Binding Sites; Humans; Hydrogen Bonding; Kinetics; Malaria; Metabolic Networks and Pathways; Nucleosides; Orotate Phosphoribosyltransferase; Plasmodium falciparum; Protein Conformation; Pyrimidines; Pyrrolidines; Substrate Specificity

2013