Page last updated: 2024-08-21

pyrimidine and pyrroles

pyrimidine has been researched along with pyrroles in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (92.31)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
Abbate, I; Almerico, AM; Lauria, A; Martorana, A; Patella, C1
El-Gamal, MI; Oh, CH1
Avasthi, K; Kant, R; Ravikumar, K; Shukla, L1
Dommaraju, Y; Prajapati, D1
Cai, J; Huang, W; Jin, Q; Tang, F; Wang, Y; Xiang, H; Xin, M; Zhao, X; Zhao, Y1
Mei, H; Seela, F; Yang, H1
Tang, Q; Wang, J; Wang, W; Wu, C; Xu, S; Zhao, Y; Zheng, P; Zhu, W1
Chen, P; Gui, L; Huang, W; Liu, F; Tang, F; Wang, J; Wang, Y; Xin, M; Zhao, X1
Honma, T; Kikuzato, K; Koda, Y; Koyama, H; Kukimoto-Niino, M; Mikuni, J; Shirai, F; Shirouzu, M; Tanaka, A; Tomabechi, Y; Yuki, H1
Georg, GI; Hawkinson, JE; Herr, JC; Mudaliar, D; Shetty, J; Sinville, R; Ward, T1
Duan, Y; Jiang, L; Liu, X; Tang, Q; Wang, LX; Xiao, Z; Xu, S; Zheng, P; Zhi, J; Zhu, W1

Reviews

1 review(s) available for pyrimidine and pyrroles

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

12 other study(ies) available for pyrimidine and pyrroles

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
Lead optimization through VLAK protocol: new annelated pyrrolo-pyrimidine derivatives as antitumor agents.
    European journal of medicinal chemistry, 2012, Volume: 55

    Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Informatics; Pyrimidines; Pyrroles

2012
Diarylureas and diarylamides with pyrrolo[2,3-d]pyrimidine scaffold as broad-spectrum anticancer agents.
    Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Imatinib Mesylate; Niacinamide; Phenylurea Compounds; Piperazines; Pyrimidines; Pyrroles; Sorafenib

2014
Folded conformations due to arene interactions in dissymmetric and symmetric butylidene-linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine.
    Acta crystallographica. Section C, Structural chemistry, 2014, Volume: 70, Issue:Pt 6

    Topics: Crystallography, X-Ray; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Conformation; Purines; Pyrazoles; Pyrimidines; Pyrroles

2014
A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction.
    Molecular diversity, 2015, Volume: 19, Issue:1

    Topics: Chemistry Techniques, Synthetic; Chromatography; Green Chemistry Technology; Models, Molecular; Pyrimidines; Pyrroles

2015
Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold.
    Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4

    Topics: Agammaglobulinaemia Tyrosine Kinase; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Structure-Activity Relationship

2015
Pyrrolo-dC Metal-Mediated Base Pairs in the Reverse Watson-Crick Double Helix: Enhanced Stability of Parallel DNA and Impact of 6-Pyridinyl Residues on Fluorescence and Silver-Ion Binding.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Jul-06, Volume: 21, Issue:28

    Topics: Base Pairing; Circular Dichroism; DNA; Fluorescence; Heterocyclic Compounds; Ions; Nucleic Acid Conformation; Nucleosides; Pyrimidines; Pyrroles; Silver

2015
Synthesis, and docking studies of phenylpyrimidine-carboxamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship

2016
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors.
    Bioorganic & medicinal chemistry, 2017, 01-01, Volume: 25, Issue:1

    Topics: Amines; Cell Line; Humans; Janus Kinase 2; Janus Kinase 3; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles

2017
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
    Bioorganic & medicinal chemistry, 2017, 08-15, Volume: 25, Issue:16

    Topics: Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-hck; Pyrimidines; Pyrroles; Structure-Activity Relationship

2017
Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2).
    ChemMedChem, 2017, 11-22, Volume: 12, Issue:22

    Topics: Dose-Response Relationship, Drug; High-Throughput Screening Assays; Humans; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Structure-Activity Relationship

2017
Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors.
    European journal of medicinal chemistry, 2017, Dec-01, Volume: 141

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridazines; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship

2017