Page last updated: 2024-08-21

pyrimidine and pyridine

pyrimidine has been researched along with pyridine in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.32)18.7374
1990's3 (7.32)18.2507
2000's8 (19.51)29.6817
2010's23 (56.10)24.3611
2020's4 (9.76)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
Fujii, S1
Buxeraud, J; Comby, F; Lagorce, JF; Raby, C; Rousseau, A1
Barclay, LR; Crowe, E; Edwards, CD1
Kwong, P; Sasseville, D; Yu, K1
Fujita, M; Kusukawa, T; Sun, WY; Yoshizawa, M1
HANAI, K; MACHIDA, K; SASAKI, S; UEDA, M; UNO, T1
Cai, D; Dormer, PG; Hoerrner, RS; Javadi, GJ; Jensen, MS; Larsen, RD; Li, W; Nelson, DP1
Abdel-Hafez, NA; Amr, AG; Hammam, Ael-F; Mohamed, AM; Mohamed, SF1
Kaur, P; Kaur, S; Kumar, S; Luxami, V; Singh, P1
Agren, H; Alvarez Ruiz, J; Coreno, M; de Simone, M; Gao, B; Kivimäki, A; Rachlew, E; Vall-llosera, G1
Gorobets, NY; Lipson, VV1
Botek, E; Castet, F; Champagne, B; Méreau, R1
El-Sayed Ali, T1
Doytchinova, I; Geronikaki, A; Kapadia, K; Soković, M; Solankee, A1
Hao, M; Li, G; Li, Y; Wang, Y; Yan, Y; Yang, L; Zhang, S1
Kapavarapu, R; Kumar, KS; Kumar, PM; Mohakhud, PK; Mukkanti, K; Pal, M; Parsa, KV1
Cai, ZL; Reimers, JR1
Gangopadhyay, D; Popp, J; Singh, A; Singh, RK1
Abadi, AH; Eissa, AA; Elsharif, SA; Gary, BD; Hany, MS; Piazza, GA; Tinsley, HN1
Lippe, J; Mazik, M1
Ding, LP; Kuang, XY; Shao, P1
Aziz, SG; El-Shall, MS; Elroby, S; Hamid, AM; Hilal, R1
Edwards, JP; Hack, MD; McGovern, P; Meduna, SP; Savall, BM; Smith, RC; Thurmond, RL; Venable, J; Wei, J1
Batista, ER; Birnbaum, ER; John, KD; Martin, RL; Wilson, JJ1
Ashihara, H; Deng, WW; Katahira, R1
Barone, V; Cappelli, C; Carnimeo, I1
Close, DM; Wardman, P1
Blasberg, RG; Demoin, DW; Edwards, KJ; Lewis, JS; Pillarsetty, NV; Serganova, I; Shindo, M; Zhang, H1
Almaz, Z; Camadan, Y; Gokcen, T; Gören, AC; Gülçin, İ; Kalin, R; Köksal, Z; Ozdemir, H; Usanmaz, H1
Hansen, MDH; Hargiss, JB; Herron, SR; Hoj, JP; Hoj, TH; Payne, CJ; Quinn, C; Ritchie, CA; Schuler, JT; Siddiqui-Jain, A1
Abdelgawad, MA; Azouz, AA; Bakr, RB1
Cescon, DW; Hansen, MD; Hoj, JP; Siddiqui-Jain, A1
de Orbe Izquierdo, ME; Gautam, R; Hart, JR; Hixon, MS; Jacob, NT; Janda, KD; Miranda, PO; Shirey, RJ; Ueno, L; Vogt, PK; Zhou, B1
Abd Elhameid, MK; Al-Shorbagy, MY; El Meligie, S; Ismail, MM; Mohammed, MR; Ryad, N1
Bharti, R; Kumari, P; Parvin, T; Yadav, R1
Bikman, BT; Blomfield, MP; Evans, AT; Fox, JC; Hansen, MDH; Hill, JT; Livingstone, SK; Perry, K; Tenney, SR; Webster, JB1
Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P1
Hilty, C; Mandal, R; Pham, P1
Athavale, SV; Denmark, SE; Houk, KN; Simon, A1

Reviews

3 review(s) available for pyrimidine and pyridine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
Multicomponent metal-ligand self-assembly.
    Current opinion in chemical biology, 2002, Volume: 6, Issue:6

    Topics: Alkanes; Alkenes; Crystallography, X-Ray; Dimerization; Ligands; Models, Molecular; Organometallic Compounds; Palladium; Photochemistry; Platinum; Pyridines; Pyrimidines; Silanes; Stereoisomerism

2002
One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.
    Molecular diversity, 2009, Volume: 13, Issue:4

    Topics: Dioxanes; History, 19th Century; History, 20th Century; Pyridines; Pyrimidines

2009

Other Studies

38 other study(ies) available for pyrimidine and pyridine

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Liver; Mice; Pyridines; Pyrimidines; Rats; Sarcoma 180; Sarcoma, Experimental; Sarcoma, Yoshida; Tegafur; Uracil

1987
Synthesis and antithyroid activity of pyridine, pyrimidine and pyrazine derivatives of thiazole-2-thiol and 2-thiazoline-2-thiol.
    Chemical & pharmaceutical bulletin, 1993, Volume: 41, Issue:7

    Topics: Animals; Antithyroid Agents; Male; Pyrazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Thiazoles; Thyrotropin; Thyroxine

1993
Photo-initiated peroxidation of lipids in micelles by azaaromatics.
    Lipids, 1997, Volume: 32, Issue:3

    Topics: Antioxidants; Chromans; Free Radicals; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxidation; Micelles; Models, Chemical; Nicotinic Acids; Photochemistry; Purines; Pyridines; Pyrimidines; Quinolines

1997
Narrow spectrum of cross-sensitization with pyridine derivatives.
    Contact dermatitis, 1998, Volume: 38, Issue:4

    Topics: Dermatitis, Allergic Contact; Dermatitis, Occupational; Humans; Irritants; Occupational Exposure; Patch Tests; Pyridazines; Pyridines; Pyrimidines

1998
INFRARED SPECTRA OF SULFONAMIDE DERIVATIVES. I. PYRIDINE, THIAZOLE, AND PYRIMIDINE DERIVATIVES.
    Chemical & pharmaceutical bulletin, 1963, Volume: 11

    Topics: Chemistry, Pharmaceutical; Deuterium; Pyridines; Pyrimidines; Research; Spectrum Analysis; Sulfathiazoles; Sulfonamides; Thiazoles

1963
Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach.
    The Journal of organic chemistry, 2005, Jul-22, Volume: 70, Issue:15

    Topics: Allosteric Regulation; Boronic Acids; Catalysis; GABA Agonists; Imidazoles; Molecular Structure; Oxidation-Reduction; Palladium; Propanols; Pyridines; Pyrimidines; Stereoisomerism

2005
Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives.
    Bioorganic & medicinal chemistry, 2006, Aug-15, Volume: 14, Issue:16

    Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Inhibitory Concentration 50; Pyrans; Pyridines; Pyrimidines; Structure-Activity Relationship

2006
Syntheses and anti-cancer activities of 2-[1-(indol-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylamino]-2-phenyl-ethanols.
    Bioorganic & medicinal chemistry, 2007, Mar-15, Volume: 15, Issue:6

    Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Neoplasms; Pyridines; Pyrimidines; Quinolines; Structure-Activity Relationship; Tumor Cells, Cultured

2007
The C 1s and N 1s near edge x-ray absorption fine structure spectra of five azabenzenes in the gas phase.
    The Journal of chemical physics, 2008, Jan-28, Volume: 128, Issue:4

    Topics: Absorption; Aza Compounds; Benzene Derivatives; Carbon; Electrons; Energy Transfer; Gases; Nitrogen; Photons; Pyrazines; Pyridines; Pyrimidines; Spectrum Analysis; Triazines; X-Rays

2008
Effect of the dynamical disorder on the second-order nonlinear optical responses of helicity-encoded polymer strands.
    The journal of physical chemistry. A, 2009, Jun-18, Volume: 113, Issue:24

    Topics: Hydrazones; Models, Molecular; Molecular Structure; Nonlinear Dynamics; Polymers; Pyridines; Pyrimidines; Quantum Theory; Thermodynamics; Time Factors

2009
Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Animals; Anti-Infective Agents; Artemia; Biological Assay; Escherichia coli; Fungi; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Pyridines; Pyrimidines; Staphylococcus aureus; Staphylococcus epidermidis; Triazines

2009
Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Anti-Infective Agents; Bacteria; Chalcone; Microbial Sensitivity Tests; Pyrazoles; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Thermodynamics; Triazines

2010
Combined 3D-QSAR, molecular docking, and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
    Journal of chemical information and modeling, 2011, Oct-24, Volume: 51, Issue:10

    Topics: Biological Availability; Glutamic Acid; Heterocyclic Compounds, 1-Ring; Humans; Molecular Dynamics Simulation; Piperazine; Piperazines; Platelet Aggregation; Protein Conformation; Purinergic P2Y Receptor Antagonists; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Receptors, Purinergic P2Y12; Reproducibility of Results

2011
Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridines.
    Chemical communications (Cambridge, England), 2012, Jan-11, Volume: 48, Issue:3

    Topics: Binding Sites; Catalysis; Computer Simulation; Cyclic Nucleotide Phosphodiesterases, Type 4; Heterocyclic Compounds; Mesylates; Oxygen; Phosphodiesterase 4 Inhibitors; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrimidines

2012
Hydrogen bonding and reactivity of water to azines in their S1 (n,π*) electronic excited states in the gas phase and in solution.
    Physical chemistry chemical physics : PCCP, 2012, Jul-07, Volume: 14, Issue:25

    Topics: Computer Simulation; Dimerization; Hydrogen Bonding; Models, Chemical; Photochemical Processes; Protons; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Water

2012
Effect of deuteration on hydrogen bonding: a comparative concentration dependent Raman and DFT study of pyridine in CH₃OH and CD₃OD and pyrimidine in H₂O and D₂O.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2012, Volume: 99

    Topics: Deuterium; Hydrogen Bonding; Methanol; Models, Molecular; Pyridines; Pyrimidines; Spectrum Analysis, Raman; Water

2012
Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.
    Chemical & pharmaceutical bulletin, 2013, Volume: 61, Issue:4

    Topics: Binding Sites; Catalytic Domain; Cell Proliferation; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclization; HT29 Cells; Humans; Hydrolysis; Molecular Docking Simulation; Phosphodiesterase 3 Inhibitors; Protein Binding; Pyridines; Pyrimidines; Structure-Activity Relationship; Substrate Specificity

2013
Artificial receptors inspired by crystal structures of complexes formed between acyclic receptors and monosaccharides: design, syntheses, and binding properties.
    The Journal of organic chemistry, 2013, Sep-20, Volume: 78, Issue:18

    Topics: Hydrogen Bonding; Molecular Structure; Monosaccharides; Pyridines; Pyrimidines; Solubility

2013
Probing the structural, bonding, and magnetic properties of cobalt coordination complexes: co-benzene, co-pyridine, and co-pyrimidine.
    The journal of physical chemistry. A, 2013, Dec-05, Volume: 117, Issue:48

    Topics: Benzene; Cobalt; Magnetic Fields; Molecular Structure; Organometallic Compounds; Pyridines; Pyrimidines; Quantum Theory

2013
Unconventional hydrogen bonding to organic ions in the gas phase: stepwise association of hydrogen cyanide with the pyridine and pyrimidine radical cations and protonated pyridine.
    The Journal of chemical physics, 2014, Aug-07, Volume: 141, Issue:5

    Topics: Binding Sites; Cations; Computer Simulation; Free Radicals; Gases; Hydrogen Bonding; Hydrogen Cyanide; Models, Chemical; Models, Molecular; Organic Chemicals; Phase Transition; Protons; Pyridines; Pyrimidines; Spectrometry, Mass, Electrospray Ionization

2014
The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands.
    Bioorganic & medicinal chemistry letters, 2014, Dec-01, Volume: 24, Issue:23

    Topics: Histamine Antagonists; Humans; Ligands; Molecular Structure; Pyridines; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4

2014
Synthesis and characterization of nitrogen-rich macrocyclic ligands and an investigation of their coordination chemistry with lanthanum(III).
    Inorganic chemistry, 2015, Jan-05, Volume: 54, Issue:1

    Topics: Coordination Complexes; Crystallography, X-Ray; Cyclams; Heterocyclic Compounds; Kinetics; Lanthanoid Series Elements; Macrocyclic Compounds; Mesylates; Molecular Conformation; Nitrogen; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Stereoisomerism; Thermodynamics

2015
Short-term effect of caffeine on purine, pyrimidine and pyridine metabolism in rice (Oryza sativa) seedlings.
    Natural product communications, 2015, Volume: 10, Issue:5

    Topics: Caffeine; Oryza; Purines; Pyridines; Pyrimidines; Seedlings

2015
Analytical gradients for MP2, double hybrid functionals, and TD-DFT with polarizable embedding described by fluctuating charges.
    Journal of computational chemistry, 2015, Dec-05, Volume: 36, Issue:31

    Topics: Acetone; Electrons; Formamides; Pyridines; Pyrimidines; Quantum Theory; Static Electricity; Water

2015
Calculations of the Energetics of Oxidation of Aqueous Nucleosides and the Effects of Prototropic Equilibria.
    The journal of physical chemistry. A, 2016, Jun-16, Volume: 120, Issue:23

    Topics: DNA; Models, Molecular; Nucleic Acid Conformation; Nucleosides; Oxidation-Reduction; Pyridines; Pyrimidines; Quantum Theory; Thermodynamics; Water

2016
Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas.
    Nuclear medicine and biology, 2016, Volume: 43, Issue:10

    Topics: Amines; Animals; Biological Transport; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Stability; Fluorine Radioisotopes; Glioma; Halogenation; Humans; Isotope Labeling; Male; Mice; Positron Emission Tomography Computed Tomography; Pyridines; Pyrimidines; Radiochemistry; Receptors, CXCR4

2016
Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors.
    Molecules (Basel, Switzerland), 2017, May-24, Volume: 22, Issue:6

    Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Isoxazoles; Lactoperoxidase; Pyridines; Pyrimidines; Sulfonamides; Thiadiazoles

2017
Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms.
    Bioorganic & medicinal chemistry letters, 2017, 09-01, Volume: 27, Issue:17

    Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial Cells; Hepatocyte Growth Factor; Humans; MCF-7 Cells; Molecular Structure; Pyridines; Pyrimidines; Structure-Activity Relationship

2017
Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability.
    Bioorganic chemistry, 2018, Volume: 77

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Male; Molecular Docking Simulation; Molecular Structure; Pyridines; Pyrimidines; Rats; Rats, Wistar; Structure-Activity Relationship; Ulcer

2018
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.
    Bioorganic & medicinal chemistry letters, 2018, 03-01, Volume: 28, Issue:5

    Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Microtubules; Molecular Structure; Neoplasms, Experimental; Polymerization; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship

2018
Synthetic molecules for disruption of the MYC protein-protein interface.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Dose-Response Relationship, Drug; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Protein Binding; Proto-Oncogene Proteins c-myc; Pyridines; Pyrimidines; Solubility; Structure-Activity Relationship; Surface Plasmon Resonance

2018
Design, Synthesis and Screening of 4,6-Diaryl Pyridine and Pyrimidine Derivatives as Potential Cytotoxic Molecules.
    Chemical & pharmaceutical bulletin, 2018, 10-01, Volume: 66, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; HCT116 Cells; HL-60 Cells; Humans; MCF-7 Cells; Molecular Structure; Oxidative Stress; Polymerization; Pyridines; Pyrimidines; Structure-Activity Relationship; Tubulin

2018
Regioselective synthesis of pyrimidine-fused tetrahydropyridines and pyridines by microwave-assisted one-pot reaction.
    Molecular diversity, 2020, Volume: 24, Issue:1

    Topics: Chemistry Techniques, Synthetic; Microwaves; Molecular Structure; Pyridines; Pyrimidines; Pyrrolidines; Spectrum Analysis

2020
Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization.
    Bioorganic & medicinal chemistry letters, 2019, 07-01, Volume: 29, Issue:13

    Topics: Amides; Humans; Microtubules; Polymerization; Pyridines; Pyrimidines

2019
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication

2020
Nuclear Spin Hyperpolarization of NH
    Chemphyschem : a European journal of chemical physics and physical chemistry, 2020, 10-02, Volume: 21, Issue:19

    Topics: Magnetic Resonance Spectroscopy; Pyridines; Pyrimidines; Temperature

2020
Structural Contributions to Autocatalysis and Asymmetric Amplification in the Soai Reaction.
    Journal of the American Chemical Society, 2020, 10-28, Volume: 142, Issue:43

    Topics: Aldehydes; Alkylation; Catalysis; Density Functional Theory; Molecular Conformation; Nitrogen; Pyridines; Pyrimidines; Structure-Activity Relationship; Zinc

2020