pyrimidine has been researched along with pyridine in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.32) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 23 (56.10) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Fujii, S | 1 |
| Buxeraud, J; Comby, F; Lagorce, JF; Raby, C; Rousseau, A | 1 |
| Barclay, LR; Crowe, E; Edwards, CD | 1 |
| Kwong, P; Sasseville, D; Yu, K | 1 |
| Fujita, M; Kusukawa, T; Sun, WY; Yoshizawa, M | 1 |
| HANAI, K; MACHIDA, K; SASAKI, S; UEDA, M; UNO, T | 1 |
| Cai, D; Dormer, PG; Hoerrner, RS; Javadi, GJ; Jensen, MS; Larsen, RD; Li, W; Nelson, DP | 1 |
| Abdel-Hafez, NA; Amr, AG; Hammam, Ael-F; Mohamed, AM; Mohamed, SF | 1 |
| Kaur, P; Kaur, S; Kumar, S; Luxami, V; Singh, P | 1 |
| Agren, H; Alvarez Ruiz, J; Coreno, M; de Simone, M; Gao, B; Kivimäki, A; Rachlew, E; Vall-llosera, G | 1 |
| Gorobets, NY; Lipson, VV | 1 |
| Botek, E; Castet, F; Champagne, B; Méreau, R | 1 |
| El-Sayed Ali, T | 1 |
| Doytchinova, I; Geronikaki, A; Kapadia, K; Soković, M; Solankee, A | 1 |
| Hao, M; Li, G; Li, Y; Wang, Y; Yan, Y; Yang, L; Zhang, S | 1 |
| Kapavarapu, R; Kumar, KS; Kumar, PM; Mohakhud, PK; Mukkanti, K; Pal, M; Parsa, KV | 1 |
| Cai, ZL; Reimers, JR | 1 |
| Gangopadhyay, D; Popp, J; Singh, A; Singh, RK | 1 |
| Abadi, AH; Eissa, AA; Elsharif, SA; Gary, BD; Hany, MS; Piazza, GA; Tinsley, HN | 1 |
| Lippe, J; Mazik, M | 1 |
| Ding, LP; Kuang, XY; Shao, P | 1 |
| Aziz, SG; El-Shall, MS; Elroby, S; Hamid, AM; Hilal, R | 1 |
| Edwards, JP; Hack, MD; McGovern, P; Meduna, SP; Savall, BM; Smith, RC; Thurmond, RL; Venable, J; Wei, J | 1 |
| Batista, ER; Birnbaum, ER; John, KD; Martin, RL; Wilson, JJ | 1 |
| Ashihara, H; Deng, WW; Katahira, R | 1 |
| Barone, V; Cappelli, C; Carnimeo, I | 1 |
| Close, DM; Wardman, P | 1 |
| Blasberg, RG; Demoin, DW; Edwards, KJ; Lewis, JS; Pillarsetty, NV; Serganova, I; Shindo, M; Zhang, H | 1 |
| Almaz, Z; Camadan, Y; Gokcen, T; Gören, AC; Gülçin, İ; Kalin, R; Köksal, Z; Ozdemir, H; Usanmaz, H | 1 |
| Hansen, MDH; Hargiss, JB; Herron, SR; Hoj, JP; Hoj, TH; Payne, CJ; Quinn, C; Ritchie, CA; Schuler, JT; Siddiqui-Jain, A | 1 |
| Abdelgawad, MA; Azouz, AA; Bakr, RB | 1 |
| Cescon, DW; Hansen, MD; Hoj, JP; Siddiqui-Jain, A | 1 |
| de Orbe Izquierdo, ME; Gautam, R; Hart, JR; Hixon, MS; Jacob, NT; Janda, KD; Miranda, PO; Shirey, RJ; Ueno, L; Vogt, PK; Zhou, B | 1 |
| Abd Elhameid, MK; Al-Shorbagy, MY; El Meligie, S; Ismail, MM; Mohammed, MR; Ryad, N | 1 |
| Bharti, R; Kumari, P; Parvin, T; Yadav, R | 1 |
| Bikman, BT; Blomfield, MP; Evans, AT; Fox, JC; Hansen, MDH; Hill, JT; Livingstone, SK; Perry, K; Tenney, SR; Webster, JB | 1 |
| Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P | 1 |
| Hilty, C; Mandal, R; Pham, P | 1 |
| Athavale, SV; Denmark, SE; Houk, KN; Simon, A | 1 |
3 review(s) available for pyrimidine and pyridine
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Multicomponent metal-ligand self-assembly.
Topics: Alkanes; Alkenes; Crystallography, X-Ray; Dimerization; Ligands; Models, Molecular; Organometallic Compounds; Palladium; Photochemistry; Platinum; Pyridines; Pyrimidines; Silanes; Stereoisomerism | 2002 |
One hundred years of Meldrum's acid: advances in the synthesis of pyridine and pyrimidine derivatives.
Topics: Dioxanes; History, 19th Century; History, 20th Century; Pyridines; Pyrimidines | 2009 |
38 other study(ies) available for pyrimidine and pyridine
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Liver; Mice; Pyridines; Pyrimidines; Rats; Sarcoma 180; Sarcoma, Experimental; Sarcoma, Yoshida; Tegafur; Uracil | 1987 |
Synthesis and antithyroid activity of pyridine, pyrimidine and pyrazine derivatives of thiazole-2-thiol and 2-thiazoline-2-thiol.
Topics: Animals; Antithyroid Agents; Male; Pyrazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Thiazoles; Thyrotropin; Thyroxine | 1993 |
Photo-initiated peroxidation of lipids in micelles by azaaromatics.
Topics: Antioxidants; Chromans; Free Radicals; Kinetics; Linoleic Acid; Linoleic Acids; Lipid Peroxidation; Micelles; Models, Chemical; Nicotinic Acids; Photochemistry; Purines; Pyridines; Pyrimidines; Quinolines | 1997 |
Narrow spectrum of cross-sensitization with pyridine derivatives.
Topics: Dermatitis, Allergic Contact; Dermatitis, Occupational; Humans; Irritants; Occupational Exposure; Patch Tests; Pyridazines; Pyridines; Pyrimidines | 1998 |
INFRARED SPECTRA OF SULFONAMIDE DERIVATIVES. I. PYRIDINE, THIAZOLE, AND PYRIMIDINE DERIVATIVES.
Topics: Chemistry, Pharmaceutical; Deuterium; Pyridines; Pyrimidines; Research; Spectrum Analysis; Sulfathiazoles; Sulfonamides; Thiazoles | 1963 |
Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach.
Topics: Allosteric Regulation; Boronic Acids; Catalysis; GABA Agonists; Imidazoles; Molecular Structure; Oxidation-Reduction; Palladium; Propanols; Pyridines; Pyrimidines; Stereoisomerism | 2005 |
Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Inhibitory Concentration 50; Pyrans; Pyridines; Pyrimidines; Structure-Activity Relationship | 2006 |
Syntheses and anti-cancer activities of 2-[1-(indol-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylamino]-2-phenyl-ethanols.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Neoplasms; Pyridines; Pyrimidines; Quinolines; Structure-Activity Relationship; Tumor Cells, Cultured | 2007 |
The C 1s and N 1s near edge x-ray absorption fine structure spectra of five azabenzenes in the gas phase.
Topics: Absorption; Aza Compounds; Benzene Derivatives; Carbon; Electrons; Energy Transfer; Gases; Nitrogen; Photons; Pyrazines; Pyridines; Pyrimidines; Spectrum Analysis; Triazines; X-Rays | 2008 |
Effect of the dynamical disorder on the second-order nonlinear optical responses of helicity-encoded polymer strands.
Topics: Hydrazones; Models, Molecular; Molecular Structure; Nonlinear Dynamics; Polymers; Pyridines; Pyrimidines; Quantum Theory; Thermodynamics; Time Factors | 2009 |
Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Artemia; Biological Assay; Escherichia coli; Fungi; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Pyridines; Pyrimidines; Staphylococcus aureus; Staphylococcus epidermidis; Triazines | 2009 |
Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
Topics: Anti-Infective Agents; Bacteria; Chalcone; Microbial Sensitivity Tests; Pyrazoles; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Thermodynamics; Triazines | 2010 |
Combined 3D-QSAR, molecular docking, and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.
Topics: Biological Availability; Glutamic Acid; Heterocyclic Compounds, 1-Ring; Humans; Molecular Dynamics Simulation; Piperazine; Piperazines; Platelet Aggregation; Protein Conformation; Purinergic P2Y Receptor Antagonists; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Receptors, Purinergic P2Y12; Reproducibility of Results | 2011 |
Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridines.
Topics: Binding Sites; Catalysis; Computer Simulation; Cyclic Nucleotide Phosphodiesterases, Type 4; Heterocyclic Compounds; Mesylates; Oxygen; Phosphodiesterase 4 Inhibitors; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrimidines | 2012 |
Hydrogen bonding and reactivity of water to azines in their S1 (n,π*) electronic excited states in the gas phase and in solution.
Topics: Computer Simulation; Dimerization; Hydrogen Bonding; Models, Chemical; Photochemical Processes; Protons; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Water | 2012 |
Effect of deuteration on hydrogen bonding: a comparative concentration dependent Raman and DFT study of pyridine in CH₃OH and CD₃OD and pyrimidine in H₂O and D₂O.
Topics: Deuterium; Hydrogen Bonding; Methanol; Models, Molecular; Pyridines; Pyrimidines; Spectrum Analysis, Raman; Water | 2012 |
Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.
Topics: Binding Sites; Catalytic Domain; Cell Proliferation; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclization; HT29 Cells; Humans; Hydrolysis; Molecular Docking Simulation; Phosphodiesterase 3 Inhibitors; Protein Binding; Pyridines; Pyrimidines; Structure-Activity Relationship; Substrate Specificity | 2013 |
Artificial receptors inspired by crystal structures of complexes formed between acyclic receptors and monosaccharides: design, syntheses, and binding properties.
Topics: Hydrogen Bonding; Molecular Structure; Monosaccharides; Pyridines; Pyrimidines; Solubility | 2013 |
Probing the structural, bonding, and magnetic properties of cobalt coordination complexes: co-benzene, co-pyridine, and co-pyrimidine.
Topics: Benzene; Cobalt; Magnetic Fields; Molecular Structure; Organometallic Compounds; Pyridines; Pyrimidines; Quantum Theory | 2013 |
Unconventional hydrogen bonding to organic ions in the gas phase: stepwise association of hydrogen cyanide with the pyridine and pyrimidine radical cations and protonated pyridine.
Topics: Binding Sites; Cations; Computer Simulation; Free Radicals; Gases; Hydrogen Bonding; Hydrogen Cyanide; Models, Chemical; Models, Molecular; Organic Chemicals; Phase Transition; Protons; Pyridines; Pyrimidines; Spectrometry, Mass, Electrospray Ionization | 2014 |
The effect of pK(a) on pyrimidine/pyridine-derived histamine H4 ligands.
Topics: Histamine Antagonists; Humans; Ligands; Molecular Structure; Pyridines; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4 | 2014 |
Synthesis and characterization of nitrogen-rich macrocyclic ligands and an investigation of their coordination chemistry with lanthanum(III).
Topics: Coordination Complexes; Crystallography, X-Ray; Cyclams; Heterocyclic Compounds; Kinetics; Lanthanoid Series Elements; Macrocyclic Compounds; Mesylates; Molecular Conformation; Nitrogen; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Stereoisomerism; Thermodynamics | 2015 |
Short-term effect of caffeine on purine, pyrimidine and pyridine metabolism in rice (Oryza sativa) seedlings.
Topics: Caffeine; Oryza; Purines; Pyridines; Pyrimidines; Seedlings | 2015 |
Analytical gradients for MP2, double hybrid functionals, and TD-DFT with polarizable embedding described by fluctuating charges.
Topics: Acetone; Electrons; Formamides; Pyridines; Pyrimidines; Quantum Theory; Static Electricity; Water | 2015 |
Calculations of the Energetics of Oxidation of Aqueous Nucleosides and the Effects of Prototropic Equilibria.
Topics: DNA; Models, Molecular; Nucleic Acid Conformation; Nucleosides; Oxidation-Reduction; Pyridines; Pyrimidines; Quantum Theory; Thermodynamics; Water | 2016 |
Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas.
Topics: Amines; Animals; Biological Transport; Cell Line, Tumor; Chemistry Techniques, Synthetic; Drug Stability; Fluorine Radioisotopes; Glioma; Halogenation; Humans; Isotope Labeling; Male; Mice; Positron Emission Tomography Computed Tomography; Pyridines; Pyrimidines; Radiochemistry; Receptors, CXCR4 | 2016 |
Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors.
Topics: Anti-Bacterial Agents; Enzyme Inhibitors; Isoxazoles; Lactoperoxidase; Pyridines; Pyrimidines; Sulfonamides; Thiadiazoles | 2017 |
Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epithelial Cells; Hepatocyte Growth Factor; Humans; MCF-7 Cells; Molecular Structure; Pyridines; Pyrimidines; Structure-Activity Relationship | 2017 |
Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Male; Molecular Docking Simulation; Molecular Structure; Pyridines; Pyrimidines; Rats; Rats, Wistar; Structure-Activity Relationship; Ulcer | 2018 |
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.
Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Microtubules; Molecular Structure; Neoplasms, Experimental; Polymerization; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship | 2018 |
Synthetic molecules for disruption of the MYC protein-protein interface.
Topics: Dose-Response Relationship, Drug; Humans; Hydrophobic and Hydrophilic Interactions; Molecular Structure; Protein Binding; Proto-Oncogene Proteins c-myc; Pyridines; Pyrimidines; Solubility; Structure-Activity Relationship; Surface Plasmon Resonance | 2018 |
Design, Synthesis and Screening of 4,6-Diaryl Pyridine and Pyrimidine Derivatives as Potential Cytotoxic Molecules.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; HCT116 Cells; HL-60 Cells; Humans; MCF-7 Cells; Molecular Structure; Oxidative Stress; Polymerization; Pyridines; Pyrimidines; Structure-Activity Relationship; Tubulin | 2018 |
Regioselective synthesis of pyrimidine-fused tetrahydropyridines and pyridines by microwave-assisted one-pot reaction.
Topics: Chemistry Techniques, Synthetic; Microwaves; Molecular Structure; Pyridines; Pyrimidines; Pyrrolidines; Spectrum Analysis | 2020 |
Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization.
Topics: Amides; Humans; Microtubules; Polymerization; Pyridines; Pyrimidines | 2019 |
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication | 2020 |
Nuclear Spin Hyperpolarization of NH
Topics: Magnetic Resonance Spectroscopy; Pyridines; Pyrimidines; Temperature | 2020 |
Structural Contributions to Autocatalysis and Asymmetric Amplification in the Soai Reaction.
Topics: Aldehydes; Alkylation; Catalysis; Density Functional Theory; Molecular Conformation; Nitrogen; Pyridines; Pyrimidines; Structure-Activity Relationship; Zinc | 2020 |