Compounds > pyrimidine
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pyrimidine and pyridazine

pyrimidine has been researched along with pyridazine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's2 (14.29)18.2507
2000's4 (28.57)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
Walker, MA1
Kwong, P; Sasseville, D; Yu, K1
Cho, MK; Kim, SG1
Gündisch, D; Kämpchen, T; Schwarz, S; Seitz, G; Siegl, J; Wegge, T1
OGATA, M; OTOMASU, H; TAKAHASHI, H1
Imahori, T1
Deepak, HS; Joy, A; Suryaprakash, N1
Chevallier, F; Mongin, F; Seggio, A; Vaultier, M1
Foote, DB; Scarborough, TD; Uiterwaal, CJ1
Cai, ZL; Reimers, JR1
Gorfinkiel, JD; Mašín, Z1
Batista, ER; Birnbaum, ER; John, KD; Martin, RL; Wilson, JJ1

Reviews

3 review(s) available for pyrimidine and pyridazine

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
Improvement in aqueous solubility achieved via small molecular changes.
    Bioorganic & medicinal chemistry letters, 2017, 12-01, Volume: 27, Issue:23

    Topics: Carbon; Drug Discovery; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Water

2017
[A novel deprotonative functionalization of aromatics with phosphazene base].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2004, Volume: 124, Issue:8

    Topics: Benzothiazoles; Chemistry, Organic; Hydrocarbons, Aromatic; Iodides; Organic Chemistry Phenomena; Organophosphorus Compounds; Protons; Pyridazines; Pyrimidines; Thiadiazoles; Thiazoles; Zinc Compounds

2004

Other Studies

11 other study(ies) available for pyrimidine and pyridazine

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
Narrow spectrum of cross-sensitization with pyridine derivatives.
    Contact dermatitis, 1998, Volume: 38, Issue:4

    Topics: Dermatitis, Allergic Contact; Dermatitis, Occupational; Humans; Irritants; Occupational Exposure; Patch Tests; Pyridazines; Pyridines; Pyrimidines

1998
Differential induction of rat hepatic microsomal epoxide hydrolase and rGSTA2 by diazines: the role of cytochrome P450 2E1-mediated metabolic activation.
    Chemico-biological interactions, 1998, Nov-27, Volume: 116, Issue:3

    Topics: Acetone; Animals; beta-Naphthoflavone; Biotransformation; Blotting, Northern; Cytochrome P-450 CYP2E1; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione Transferase; Isoenzymes; Male; Microsomes, Liver; Pyrazines; Pyridazines; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Starvation

1998
Syntheses and evaluation of pyridazine and pyrimidine containing bioisosteres of (+/-)-pyrido[3.4-b]homotropane and pyrido-[3.4-b]tropane as novel nAChR ligands.
    Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:1

    Topics: Ligands; Molecular Structure; Pyridazines; Pyridines; Pyrimidines; Receptors, Nicotinic; Spectrum Analysis; Tropanes

2002
STUDIES ON THE STRUCTURES OF DIAZINE N-OXIDES. II. DIPOLE MOMENTS OF SOME ALKOXY-DERIVATIVES OF PYRIMIDINE, PYRIDAZINE AND THEIR N-OXIDES.
    Chemical & pharmaceutical bulletin, 1964, Volume: 12

    Topics: Alcohols; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Heterocyclic Compounds; Oxides; Pyridazines; Pyrimidines; Research

1964
Determination of natural abundance 15N-1H and 13C-1H dipolar couplings of molecules in a strongly orienting media using two-dimensional inverse experiments.
    Magnetic resonance in chemistry : MRC, 2006, Volume: 44, Issue:5

    Topics: Carbon Isotopes; Deuterium; Liquid Crystals; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Pyrazines; Pyridazines; Pyrimidines

2006
Lithium-mediated zincation of pyrazine, pyridazine, pyrimidine, and quinoxaline.
    The Journal of organic chemistry, 2007, Aug-17, Volume: 72, Issue:17

    Topics: Lithium; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrazines; Pyridazines; Pyrimidines; Quinoxalines; Zinc

2007
Ultrafast resonance-enhanced multiphoton ionization in the azabenzenes: pyridine, pyridazine, pyrimidine, and pyrazine.
    The Journal of chemical physics, 2012, Feb-07, Volume: 136, Issue:5

    Topics: Ions; Light; Models, Molecular; Pyrazines; Pyridazines; Pyridines; Pyrimidines

2012
Hydrogen bonding and reactivity of water to azines in their S1 (n,π*) electronic excited states in the gas phase and in solution.
    Physical chemistry chemical physics : PCCP, 2012, Jul-07, Volume: 14, Issue:25

    Topics: Computer Simulation; Dimerization; Hydrogen Bonding; Models, Chemical; Photochemical Processes; Protons; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Water

2012
Shape and core excited resonances in electron collisions with diazines.
    The Journal of chemical physics, 2012, Nov-28, Volume: 137, Issue:20

    Topics: Electrons; Models, Molecular; Pyrazines; Pyridazines; Pyrimidines; Quantum Theory

2012
Synthesis and characterization of nitrogen-rich macrocyclic ligands and an investigation of their coordination chemistry with lanthanum(III).
    Inorganic chemistry, 2015, Jan-05, Volume: 54, Issue:1

    Topics: Coordination Complexes; Crystallography, X-Ray; Cyclams; Heterocyclic Compounds; Kinetics; Lanthanoid Series Elements; Macrocyclic Compounds; Mesylates; Molecular Conformation; Nitrogen; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Quantum Theory; Stereoisomerism; Thermodynamics

2015