Compounds > pyrimidine
Page last updated: 2024-08-21

pyrimidine and pyrazole

pyrimidine has been researched along with pyrazole in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.11)18.7374
1990's0 (0.00)18.2507
2000's4 (14.81)29.6817
2010's16 (59.26)24.3611
2020's4 (14.81)2.80

Authors

AuthorsStudies
Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T1
Fotsch, C; St Jean, DJ1
BOVERINI, A; BUZZI, A; LISSARRAGUE, V1
HAMASHIMA, Y; HAYASHI, S; KIDO, R; TAKAMIZAWA, A1
Brust, P; Deuther-Conrad, W; Diekers, M; Fischer, S; Hiller, A; Hoepping, A; Scheunemann, M; Steinbach, J; Wegner, F1
McLaughlin, ML; Talele, TT1
Botta, M; Dreassi, E; Falchi, F; Maga, G; Santucci, A; Schenone, S; Zizzari, AT1
El-Sayed Ali, T1
Doytchinova, I; Geronikaki, A; Kapadia, K; Soković, M; Solankee, A1
Akaho, E; Ali, HI; Fujita, T; Nagamatsu, T1
Golovina, ES; Ivachtchenko, AV; Kadieva, MG; Kysil, VM; Mitkin, OD; Okun, I; Tkachenko, SE1
Brenk, R; Cleghorn, LA; Collie, IT; Frearson, JA; Gilbert, IH; Luksch, T; Mottram, JC; Mpamhanga, C; Norcross, N; Torrie, LS; Walker, RG; Woodland, A; Wyatt, PG1
Kumar, RA; Rajendra Prasad, KJ; Yamuna, E; Zeller, M1
Aoki, T; Arai, T; Hayashi, S; Hirokawa, H; Inoue, H; Kainoh, M; Kawai, H; Koga, Y; Meguro, H; Ohno, M; Oshida, K; Suyama, K1
Atwal, K; Blanar, M; Caringal, Y; Conder, ML; Finlay, HJ; Harper, T; Hsueh, MM; Jiang, J; Kover, A; Levesque, P; Lloyd, J; Wexler, R; Xing, D1
Ahmetaj, S; Dahmann, G; Golobič, A; Grošelj, U; Kočar, D; Prek, B; Stanovnik, B; Šterbal, I; Svete, J; Velikanje, N1
Ahsan, MJ; Govindasamy, J; Jadav, SS; Khalilullah, H; Yasmin, S1
Deese, A; Hop, CE; Hunt, KW; Kallan, NC; Khojasteh, SC; Kim-Kang, H; Liu, X; Ma, S; Siu, M; Takahashi, R; Yi, Y; Yue, Q1
Ballester, P; Barceló-Oliver, M; Bauzá, A; Cabra, MI; Cánaves, MM; Cañellas, P; Fiol, JJ; Frontera, A; García-Raso, A; Hussain, F; Mata, I; Molins, E; Orvay, F; Sánchez, K; Terrón, A1
Alcaro, S; Amato, R; Artese, A; Bianco, C; Botta, L; Costa, G; D'antona, L; Gigliotti, F; Musumeci, F; Ortuso, F; Perrotti, N; Schenone, S; Talarico, C; Trapasso, F1
Cacciari, B; Ciancetta, A; Federico, S; Kachler, S; Klotz, KN; Moro, S; Redenti, S; Spalluto, G; Sturlese, M1
Ceulemans, H; Cougnaud, L; De Bondt, A; De Wolf, H; Göhlmann, H; Van Hoorde, K; Wegner, JK1
Abbas, HS; Ahmed, EH; Alfaifi, MY; Elbehairi, SEI; Fouda, AM; Shati, AA1
El-Dash, Y; Gedawy, EM; Kassab, AE1
Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P1
Ceusters, S; Cobbaut, M; Daelemans, D; De Borggraeve, WM; De Jonghe, S; Freitas, MJ; Gilles, P; Janssens, A; Kashyap, RS; Persoons, L; Van Asch, K; Van Lint, J; Voet, ARD1
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL1

Reviews

1 review(s) available for pyrimidine and pyrazole

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012

Other Studies

26 other study(ies) available for pyrimidine and pyrazole

ArticleYear
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:10

    Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase

1981
[Action of pyrazole-pyrimidine preparation (Ciba 24:650-Ba) on anginose pain].
    El Dia medico, 1962, Jun-28, Volume: 34

    Topics: Angina Pectoris; Azoles; Humans; Pyrazoles; Pyrimidines

1962
[SYNTHESES OF PYRAZOLE DERIVATIVES. VI. 7-AMINO-PYRAZOLO(1,5-ALPHA)PYRIMIDINE AND ITS METHYL SUBSTITUTED DERIVATIVES].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1963, Volume: 83

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Chemistry, Pharmaceutical; Pyrazoles; Pyrimidines; Research

1963
Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors.
    Bioorganic & medicinal chemistry, 2008, Feb-01, Volume: 16, Issue:3

    Topics: Animals; Female; Fluorine; Inhibitory Concentration 50; Molecular Structure; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship

2008
Molecular docking/dynamics studies of Aurora A kinase inhibitors.
    Journal of molecular graphics & modelling, 2008, Volume: 26, Issue:8

    Topics: Aurora Kinases; Binding Sites; Computer Simulation; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Structure-Activity Relationship; Sulfonamides

2008
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Humans; Lipids; Membranes, Artificial; Permeability; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrazoles; Pyrimidines

2009
Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Animals; Anti-Infective Agents; Artemia; Biological Assay; Escherichia coli; Fungi; Microbial Sensitivity Tests; Molecular Structure; Pyrazoles; Pyridines; Pyrimidines; Staphylococcus aureus; Staphylococcus epidermidis; Triazines

2009
Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Anti-Infective Agents; Bacteria; Chalcone; Microbial Sensitivity Tests; Pyrazoles; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Thermodynamics; Triazines

2010
A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitors.
    Journal of computer-aided molecular design, 2010, Volume: 24, Issue:1

    Topics: Animals; Catalytic Domain; Cattle; Enzyme Inhibitors; Models, Molecular; Protein Binding; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Xanthine Oxidase

2010
Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.
    Bioorganic & medicinal chemistry, 2011, Feb-15, Volume: 19, Issue:4

    Topics: Cell Line; Heterocyclic Compounds, 3-Ring; Humans; Models, Molecular; Molecular Structure; Pyrazoles; Pyrimidines; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfur Compounds

2011
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
    ChemMedChem, 2011, Dec-09, Volume: 6, Issue:12

    Topics: Binding Sites; CDC2 Protein Kinase; Computer Simulation; Drug Evaluation, Preclinical; Humans; Leishmania; Leishmaniasis; Protein Kinase Inhibitors; Protein Structure, Tertiary; Protozoan Proteins; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Urea

2011
Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles.
    European journal of medicinal chemistry, 2012, Volume: 47, Issue:1

    Topics: Anti-Bacterial Agents; Hydrogen Bonding; Indoles; Isoxazoles; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; Pyrazoles; Pyrimidines; Software; Structure-Activity Relationship

2012
Design and synthesis of novel p38α MAP kinase inhibitors: discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety.
    Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15

    Topics: Administration, Oral; Animals; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Drug Design; Drug Evaluation, Preclinical; Humans; Imidazoles; Lipopolysaccharides; Liver; Mice; Mitogen-Activated Protein Kinase 14; Naphthalenes; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrazoles; Pyridines; Pyrimidines; Tumor Necrosis Factor-alpha; Urea

2012
Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.
    Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6

    Topics: Animals; Cell Line; Imidazoles; Isomerism; Kv1.5 Potassium Channel; Mice; Potassium Channel Blockers; Potassium Channels; Protein Binding; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Triazoles

2013
Parallel synthesis of 7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamides.
    Molecular diversity, 2013, Volume: 17, Issue:4

    Topics: Combinatorial Chemistry Techniques; Cyclization; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrazoles; Pyrimidines

2013
Synthesis, characterisation, and in vitro anticancer activity of curcumin analogues bearing pyrazole/pyrimidine ring targeting EGFR tyrosine kinase.
    BioMed research international, 2013, Volume: 2013

    Topics: Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Curcumin; ErbB Receptors; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines

2013
Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:5

    Topics: Amyloid Precursor Protein Secretases; Animals; Aryl Hydrocarbon Hydroxylases; Aspartic Acid Endopeptidases; Bile; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Feces; Hepatocytes; Imidazoles; Male; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Spiro Compounds; Tandem Mass Spectrometry

2014
Crystal structures and DFT calculations of new chlorido-dimethylsulfoxide-M(III) (M = Ir, Ru, Rh) complexes with the N-pyrazolyl pyrimidine donor ligand: kinetic vs. thermodynamic isomers.
    Dalton transactions (Cambridge, England : 2003), 2014, May-07, Volume: 43, Issue:17

    Topics: Coordination Complexes; Crystallography, X-Ray; Dimethyl Sulfoxide; Iridium; Isomerism; Kinetics; Ligands; Molecular Conformation; Pyrazoles; Pyrimidines; Rhodium; Ruthenium; Thermodynamics

2014
In silico identification and biological evaluation of novel selective serum/glucocorticoid-inducible kinase 1 inhibitors based on the pyrazolo-pyrimidine scaffold.
    Journal of chemical information and modeling, 2014, Jul-28, Volume: 54, Issue:7

    Topics: Cell Line, Tumor; Computer Simulation; Drug Discovery; Humans; Molecular Docking Simulation; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines

2014
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Models, Molecular; Protein Binding; Protein Conformation; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyrimidines; Receptors, Purinergic P1; Structure-Activity Relationship

2015
High-Throughput Gene Expression Profiles to Define Drug Similarity and Predict Compound Activity.
    Assay and drug development technologies, 2018, Volume: 16, Issue:3

    Topics: High-Throughput Screening Assays; HSP90 Heat-Shock Proteins; Humans; Pyrazoles; Pyrimidines; Receptors, Glucocorticoid; Support Vector Machine; Transcriptome

2018
Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-
    Molecules (Basel, Switzerland), 2019, Mar-19, Volume: 24, Issue:6

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; HCT116 Cells; Hep G2 Cells; Humans; MCF-7 Cells; Microbial Sensitivity Tests; Microwaves; Pyrazoles; Pyrimidines

2019
Novel pyrazolopyrimidine urea derivatives: Synthesis, antiproliferative activity, VEGFR-2 inhibition, and effects on the cell cycle profile.
    Archiv der Pharmazie, 2020, Volume: 353, Issue:4

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Urea; Vascular Endothelial Growth Factor Receptor-2

2020
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
    European journal of medicinal chemistry, 2020, Sep-15, Volume: 202

    Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication

2020
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors.
    European journal of medicinal chemistry, 2020, Nov-01, Volume: 205

    Topics: Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Humans; Inhibitory Concentration 50; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines

2020
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship

2021