pyrimidine has been researched along with orotic acid in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (52.27) | 18.7374 |
| 1990's | 6 (13.64) | 18.2507 |
| 2000's | 7 (15.91) | 29.6817 |
| 2010's | 5 (11.36) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Krungkrai, J; Krungkrai, SR; Phakanont, K | 1 |
| Visek, WJ | 1 |
| Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J | 1 |
| Fico, ME; Milner, JA; Motyl, T | 1 |
| Baker, KE; Ditullio, KP; Kelln, RA; Neuhard, J | 1 |
| Kidouchi, K; Morishita, H; Ohba, S; Suchi, M; Sumi, S; Wada, Y | 1 |
| Mizuno, H; Suchi, M; Wada, Y | 1 |
| Alvarez, MI; Eslava, AP; Iturriaga, EA; Velayos, A | 1 |
| Santoso, D; Thornburg, R | 1 |
| Asai, M; Imaeda, H; Kidouchi, K; Sumi, S; Togari, H; Wada, Y | 1 |
| Sumi, S | 1 |
| Ban, K; Fujimoto, S; Hamajima, N; Ito, T; Kidouchi, K; Sumi, S; Togari, H; Ueta, A; Wada, Y | 1 |
| Karatas, F | 1 |
| CARTER, CE; ROSE, IA | 1 |
| KORNBERG, A; LIEBERMAN, I | 2 |
| POTTER, VR; STONE, JE | 1 |
| ROGERS, S | 2 |
| AUSTRIAN, R; BECKWITH, JR; JACOB, F; PARDEE, AB | 1 |
| BROWN, GM; GOLDSTEIN, GA | 1 |
| TARR, HL | 1 |
| HANDSCHUMACHER, RE; REYNARD, A; RUBIN, RJ | 1 |
| TAYLOR, ML; TAYLOR, WH | 1 |
| NOVELLI, GD; TAYLOR, WH | 1 |
| COHEN, PP; LINDSAY, RH; NAKAGAWA, H | 2 |
| ROSS, CW | 1 |
| BIGGS, H; DOUMAS, B | 1 |
| Andrews, AW; Baugh, CL; Surgalla, MJ | 1 |
| HATFIELD, D; WYNGAARDEN, JB | 1 |
| SMITH, LH | 1 |
| BANCHI, G; LOMUTO, E | 1 |
| HUFF, JW; LIEBERT, KV; SPICER, DS; WRIGHT, LD | 1 |
| Alhazzazi, T; Capone, RF; Fenno, JC; Ning, Y; Pakulis, N | 1 |
| Defoor, E; Kryger, MB; Martinussen, J | 1 |
| Day, CW; Hurst, BL; Smee, DF | 1 |
| Hughes, LE; Niazy, A | 1 |
| Carrey, EA; Löffler, M; Zameitat, E | 1 |
| Dubey, VK; Kumar, R; Tiwari, K | 1 |
| Alhaddad, B; Botto, LD; Chen, MA; Colombo, R; Coughlin, CR; Descartes, M; Grűnewald, S; Kluijtmans, LA; Maranda, B; Mills, PB; Pai, EF; Pitt, J; Pontoglio, A; Potente, C; Rodenburg, R; Sampath, S; Tiller, GE; Wevers, RA; Wortmann, SB; Yuzyuk, T | 1 |
| Athineos, D; Blanco, GR; Blyth, K; Brunton, H; Dhayade, S; Fernandez-de-Cossio-Diaz, J; Lilla, S; Mackay, GM; Meiser, J; Oizel, K; Pietzke, M; Sumpton, D; Tait-Mulder, J; Vazquez, A; Zanivan, SR | 1 |
| Fischer, L; Hetzel, F; Klaiber, I; Pross, E; Seitl, I; Swietalski, P | 1 |
| Atzori, AS; Carboni, E; Gallo, A; Ghilardelli, F; Masoero, F; Rocchetti, G | 1 |
3 review(s) available for pyrimidine and orotic acid
| Article | Year |
|---|---|
[Hereditary orotic aciduria].
Topics: Biomarkers; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Prognosis; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines | 1998 |
[Hereditary orotic aciduria].
Topics: Administration, Oral; Diagnosis, Differential; Humans; Immune System Diseases; Multienzyme Complexes; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Prognosis; Pyrimidines; Uridine | 2000 |
Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis.
Topics: Animals; Central Nervous System; Enzymes; Humans; Milk; Orotic Acid; Pyrimidines | 2015 |
41 other study(ies) available for pyrimidine and orotic acid
| Article | Year |
|---|---|
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase.
Topics: Animals; Antimalarials; Chloroquine; Dihydroorotase; Dihydroorotate Dehydrogenase; Kinetics; Macrophages; Malaria; Mice; Orotic Acid; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Plasmodium falciparum; Pyrimidines | 1992 |
Nitrogen-stimulated orotic acid synthesis and nucleotide imbalance.
Topics: Ammonia; Animals; Carbamyl Phosphate; Cattle; Humans; Liver Neoplasms; Milk; Orotic Acid; Pyrimidines; Rats; Triglycerides; Urea | 1992 |
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea | 1985 |
Species comparison of the influence of ammonia on orotic acid and urea biosynthesis in liver.
Topics: Ammonia; Animals; Arginine; Cattle; Female; Liver; Male; Mice; Mice, Inbred ICR; Orotic Acid; Pyrimidines; Rats; Rats, Inbred Strains; Sheep; Species Specificity; Swine; Urea; Valine | 1984 |
Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichia coli requires the dicarboxylate transport protein encoded by dctA.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Carrier Proteins; Chromosome Mapping; Cloning, Molecular; Culture Media; Dicarboxylic Acid Transporters; Dicarboxylic Acids; DNA, Bacterial; Escherichia coli; Gene Deletion; Molecular Sequence Data; Orotic Acid; Peptide Chain Initiation, Translational; Phenotype; Pyrimidines; Salmonella typhimurium; Sequence Analysis, DNA; Transcription, Genetic | 1996 |
Pyrimidine metabolism in hereditary orotic aciduria.
Topics: Child; Follow-Up Studies; Humans; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines | 1997 |
Interallelic complementation at the pyrF locus and the homodimeric nature of orotate phosphoribosyltransferase (OPRTase) in Mucor circinelloides.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Dimerization; Fungal Proteins; Genetic Complementation Test; Models, Molecular; Molecular Sequence Data; Mucor; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Protein Conformation; Pyrimidines; Sequence Analysis; Transformation, Genetic | 1998 |
Fluoroorotic acid-selected Nicotiana plumbaginifolia cell lines with a stable thymine starvation phenotype have lost the thymine-regulated transcriptional program.
Topics: Aspartate Carbamoyltransferase; Blotting, Western; Cell Line; Chromatography, Thin Layer; Dihydroorotase; Dihydroorotate Dehydrogenase; Gene Expression Regulation, Plant; Multienzyme Complexes; Nicotiana; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; Plants, Toxic; Pyrimidines; RNA, Messenger; Thymine | 2000 |
Urinary pyrimidine analysis in healthy newborns, infants, children, adults and patients with congenital metabolic diseases.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Liquid; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Orotic Acid; Pyrimidines; Uracil | 2000 |
Intra-day variations in urinary pyrimidines in ornithine carbamoyltransferase deficiency and healthy individuals.
Topics: Adult; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; Male; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Pyrimidines; Uracil | 2001 |
An investigation of orotic acid levels in the breastmilk of smoking and non-smoking mothers.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Infant, Newborn; Milk, Human; Orotic Acid; Pyrimidines; Smoking; Uridine Monophosphate | 2002 |
Pyrimidine precursors for Lactobacillus bulgaricus 09.
Topics: Lactobacillus; Nucleotides; Orotic Acid; Pyrimidines | 1954 |
Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin.
Topics: Aspartic Acid; Hydantoins; Orotic Acid; Pyrimidines; Succinates | 1954 |
Biochemical screening of pyrimidine antimetabolites. I. Systems with oxidative energy source.
Topics: Antimetabolites; Orotic Acid; Oxidation-Reduction; Pyrimidines | 1956 |
Studies of the mechanism of action of urethane in initiating pulmonary adenomas in mice. II. Its relation to nucleic acid synthesis.
Topics: Adenine; Adenoma; Animals; DNA; Lung Neoplasms; Mice; Neoplasms; Nucleic Acids; Orotic Acid; Pyrimidines; RNA; Thymine; Urethane | 1957 |
Inhibitory influence of a normally occurring pyrimidine precursor upon methylcholanthrene carcinogenesis.
Topics: Carcinogenesis; Methylcholanthrene; Orotic Acid; Pyrimidines | 1957 |
Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli.
Topics: Amidohydrolases; Carboxy-Lyases; Escherichia coli; Glucosyltransferases; Nucleotides; Orotic Acid; Oxidoreductases; Pyrimidines | 1962 |
THE BIOSYNTHESIS OF THIAMINE. V. STUDIES CONCERNING PRECURSORS OF THE PYRIMIDINE MOIETY.
Topics: Acetates; Aspartic Acid; Carbon Isotopes; Chromatography; Escherichia coli; Formates; Glycine; Ion Exchange Resins; Metabolism; Methionine; Orotic Acid; Pyrimidines; Research; Serine; Sulfonic Acids; Thiamine; Uracil | 1963 |
FORMATION OF RIBOMONONUCLEOTIDES FROM PURINE AND PYRIMIDINE BASES AND 5'-PHOSPHORIBOSYLPYROPHOSPHATE BY A SALMON MILT EXTRACT.
Topics: Adenine; Adenine Nucleotides; Animals; Carbon Isotopes; Chromatography; Cytosine; Cytosine Nucleotides; Diphosphates; Fishes; Guanine; Guanine Nucleotides; Metabolism; Nucleotides; Orotic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Research; Salmon; Thymine; Tissue Extracts; Tritium; Uracil; Uracil Nucleotides; Xanthines | 1964 |
AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF DE NOVO PYRIMIDINE BIOSYNTHESIS.
Topics: Antimetabolites; Dogs; Drug Synergism; Enzyme Inhibitors; Leukocytes; Liver; Metabolism; Orotic Acid; Pharmacology; Pyrimidines; Rats; Research | 1964 |
ENZYMES OF THE PYRIMIDINE PATHWAY IN ESCHERICHIA COLI. II. INTRACELLULAR LOCALIZATION AND PROPERTIES OF DIHYDROOROTIC DEHYDROGENASE.
Topics: Carboxy-Lyases; Cholagogues and Choleretics; Cyanides; Cytochromes; Escherichia coli; Ferricyanides; Metabolism; Nucleotides; Orotic Acid; Oxidoreductases; Pharmacology; Pyrimidines; Research; Transferases | 1964 |
ENZYMES OF THE PYRIMIDINE PATHWAY IN ESCHERICHIA COLI. I. SYNTHESIS BY CELLS AND SPHEROPLASTS.
Topics: Amino Acids; Chloramphenicol; Edetic Acid; Escherichia coli; Nucleotides; Ornithine; Ornithine Carbamoyltransferase; Orotic Acid; Oxidoreductases; Pharmacology; Pyrimidines; Research; Spheroplasts; Sucrose; Transferases; Uracil | 1964 |
PATHWAY OF PYRIMIDINE BIOSYNTHESIS IN PREMETAMORPHIC TADPOLES.
Topics: Alanine; Animals; Anura; Aspartic Acid; Carbamates; Carbon Isotopes; Carboxy-Lyases; Glucose; Larva; Liver; Metabolism; Metamorphosis, Biological; Orotic Acid; Phosphates; Pyrimidines; Research; RNA; Succinates; Uracil | 1964 |
INFLUENCE OF 6-AZAURACIL ON PYRIMIDINE METABOLISM OF COCKLEBUR LEAF DISCS.
Topics: Carbon Dioxide; Metabolism; Nucleosides; Nucleotides; Orotic Acid; Plants; Pyrimidines; RNA; Uracil; Uracil Nucleotides; Xanthium | 1964 |
PYRIMIDINE INCORPORATION INTO NUCLEIC ACIDS OF CORYNEBACTERIA SPP.
Topics: Corynebacterium; DNA; DNA, Bacterial; Nucleic Acids; Orotic Acid; Proteins; Pyrimidines; Research; RNA; RNA, Bacterial; Thymine; Uracil | 1964 |
EFFECTS OF BICARBONATE ON GROWTH OF PASTEURELLA PESTIS. 3. REPLACEMENT OF BICARBONATE BY PYRIMIDINES.
Topics: Arginine; Bicarbonates; Carbamates; Carbon Dioxide; Citrulline; Culture Media; Cytosine; Metabolism; Orotic Acid; Pharmacology; Phosphates; Pyrimidines; Research; Uracil; Yersinia pestis | 1964 |
3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES.
Topics: Animals; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography; Erythrocytes; Glucosyltransferases; Metabolism; Nucleotides; Orotic Acid; Phosphates; Pterins; Purines; Pyrimidines; Research; Ribonucleosides; Ribonucleotides; Ribose; Spectrophotometry; Uracil; Uric Acid; Xanthines | 1964 |
HEREDITARY OROTIC ACIDURIA--PYRIMIDINE AUXOTROPHISM IN MAN.
Topics: Anemia; Anemia, Macrocytic; Genetics, Medical; Humans; Male; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Rare Diseases; Urine | 1965 |
THIOURACIL-PYRIMIDINE RELATIONSHIPS IN THYROID AND OTHER TISSUES.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Cattle; Liver; Metabolism; Organ Size; Orotic Acid; Pharmacology; Pyrimidines; Rats; Research; RNA; Thiouracil; Thymine; Thymus Gland; Thyroid Gland; Uracil; Uracil Nucleotides | 1965 |
Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. III. Ureidosuccinase.
Topics: Enzymes; Hydrolases; Orotic Acid; Pyrimidines | 1955 |
[Microbiological activity of orotic acid and of pyrimidine derivatives].
Topics: Orotic Acid; Pyrimidines | 1960 |
Study of ureidosuccinic acid and related compounds in pyrimidine synthesis by Lactobacillus bulgaricus 09.
Topics: Aspartic Acid; Lactobacillus; Orotic Acid; Pyrimidines; Urea | 1952 |
Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.
Topics: Bacterial Proteins; Culture Media; Drug Resistance, Bacterial; Genetic Complementation Test; Mutation; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pyrimidines; Treponema denticola; Uracil | 2007 |
The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker.
Topics: Amino Acid Sequence; Bacterial Proteins; Cloning, Molecular; DNA, Bacterial; Food Industry; Food Microbiology; Lactococcus lactis; Membrane Transport Proteins; Molecular Sequence Data; Open Reading Frames; Orotic Acid; Plasmids; Pyrimidines | 2007 |
D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis.
Topics: Anilides; Animals; Antiviral Agents; Butyric Acid; Dihydroorotate Dehydrogenase; Dogs; Female; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H5N1 Subtype; Liver; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Orotic Acid; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Succinates | 2012 |
Accumulation of Pyrimidine Intermediate Orotate Decreases Virulence Factor Production in Pseudomonas aeruginosa.
Topics: Bacterial Proteins; Gene Expression Regulation, Bacterial; Orotate Phosphoribosyltransferase; Orotic Acid; Pseudomonas aeruginosa; Pyrimidines; Virulence Factors | 2015 |
Biochemical characterization of dihydroorotase of Leishmania donovani: Understanding pyrimidine metabolism through its inhibition.
Topics: Biotin; Cytidine Deaminase; Dihydroorotase; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression Regulation, Enzymologic; Kaempferols; Kinetics; Leishmania donovani; Molecular Docking Simulation; Molecular Structure; Orotic Acid; Protein Domains; Protozoan Proteins; Pyrimidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Sulfones | 2016 |
Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.
Topics: Anemia, Megaloblastic; Child; Child, Preschool; Female; Heterozygote; Humans; Infant; Intellectual Disability; Male; Multienzyme Complexes; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Urea Cycle Disorders, Inborn; Uridine | 2017 |
Formate induces a metabolic switch in nucleotide and energy metabolism.
Topics: Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Energy Metabolism; Female; Formates; Humans; Mice, Inbred C57BL; Models, Biological; Models, Genetic; Nucleotides; Orotic Acid; Pyrimidines; Ribonucleotides | 2020 |
Orotic acid production by Yarrowia lipolytica under conditions of limited pyrimidine.
Topics: Metabolic Engineering; Orotic Acid; Pyrimidines; Yarrowia | 2022 |
Milk metabolome reveals pyrimidine and its degradation products as the discriminant markers of different corn silage-based nutritional strategies.
Topics: Animals; Aspartic Acid; Cattle; Diet; Female; Fermentation; Lactation; Medicago sativa; Metabolome; Milk; Nitrogen; Orotic Acid; Purines; Pyridoxal Phosphate; Pyridoxic Acid; Pyrimidines; Rumen; Silage; Vitamins; Zea mays | 2022 |