pyrimidine has been researched along with fluorouracil in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (20.41) | 18.7374 |
| 1990's | 10 (20.41) | 18.2507 |
| 2000's | 12 (24.49) | 29.6817 |
| 2010's | 13 (26.53) | 24.3611 |
| 2020's | 4 (8.16) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, T; Uchida, M; Ueda, T | 1 |
| Kraal, I; Peters, GJ; Pinedo, HM | 1 |
| de Montigny, J; Jund, R; Kern, L; Lacroute, F | 1 |
| Fujii, S | 1 |
| Kiang, DT; Mirkin, BL; O'Dea, RF; Ramnaraine, ML; Stoeckeler, JS; Tuchman, M | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Abe, K; Saitoh, Y; Usami, M; Wang, J; Yasuda, I; Yumisashi, T | 1 |
| Becker, D; Bittar, C; de Oliveria, JR; Ferreira Filho, A; Jung, FA; Machado, VL; Mans, DR; Pinheiro, CM; Ritt, JL; Scaletzky, A | 1 |
| Satou, T | 1 |
| Moore, JO; Pippas, AW; Robben, NC | 1 |
| Brennan, RG; Carter, D; Roos, DS; Schumacher, MA; Scott, DM; Ullman, B | 1 |
| Akamo, Y; Fukui, T; Kidouchi, K; Kobayashi, K; Manabe, T; Mizuno, I; Mohri, N; Sumi, S; Takeyama, H | 1 |
| Allen-Mersh, TG; Burke, D; Hedayati, B; Shousha, S | 1 |
| Kuhara, T; Ohdoi, C; Ohse, M | 1 |
| Cao, D; Leffert, JJ; Pizzorno, G; Russell, RL; Zhang, D | 1 |
| Aukett, A; Baaske, H; Dobritzsch, D; Duley, JA; Haasjes, J; Hein, G; Kalhoff, H; Kirk, JM; Lindqvist, Y; Maropoulos, GD; Meinsma, R; Nowaczyk, MJ; van Gennip, AH; van Kuilenburg, AB; Ward, KP; Waterham, HR | 1 |
| Fukushima, M; Honda, T; Inagawa, H; Moriyama, A; Soma, G | 1 |
| DEYSSON, G; TRUHAUT, R | 1 |
| KEMPNER, ES; MILLER, JH | 1 |
| HAHN, RG; MOERTEL, CG; REITEMEIER, RJ | 1 |
| BOLTON, CF; MOERTEL, CG; REITEMEIER, RJ; SHORTER, RG | 1 |
| LANGEN, P | 1 |
| BOWEN, JM; DMOCHOWSKI, L; ELLIOT, AY; SYKES, JA | 1 |
| MORSE, PA; POTTER, VR | 1 |
| Meinsma, R; van Gennip, AH; van Kuilenburg, AB | 1 |
| Cao, D; Kim, B; Leffert, JJ; McCabe, J; Pizzorno, G | 1 |
| Beijnen, JH; Bosch, TM; Jörger, M; Schellens, JH; Sparidans, RW | 1 |
| Chrenko, V; Frgala, T; Kocakova, I; Krejci, E; Kubosova, K; Roubalova, E; Sefr, R; Slampa, P; Svoboda, M; Zaloudik, J | 1 |
| Arakaki, TL; Buckner, FS; Detitta, GT; Gillespie, JR; Hol, WG; Kalyuzhniy, O; Luft, JR; Malmquist, NA; Merritt, EA; Phillips, MA; Van Voorhis, WC; Verlinde, CL | 1 |
| Campos, JM; Conejo-García, A; Cruz-López, O; Díaz-Gavilán, M; Espinosa, A; Gallo, MA; Núñez, MC | 1 |
| Ito, T | 1 |
| Hwang, M; Kim, S; Kim, TH; Park, DH; Shim, J | 1 |
| Burge, M; Clarke, S; Cordwell, C; Gibbs, P; Reece, W; Tebbutt, N | 1 |
| Elferich, J; Forquer, I; Riscoe, MK; Shinde, U; Soysa, R; Ullman, B; Wilson, ZN; Yates, PA | 1 |
| Corbeil, J; Légaré, D; Leprohon, P; Ouellette, M; Raymond, F; Ritt, JF | 1 |
| Bai, Y; Chu, YP; Gong, JF; Li, J; Li, Y; Shen, L; Zhang, XT | 1 |
| Dharmaraja, J; Narayan, A; Shobana, S; Subramaniam, P | 1 |
| Albrecht, P; Ford, JP; Kamerow, H; Mandetta, D; Thompson, JT; Vanden Heuvel, JP | 1 |
| Aliev, A; Beijnen, JH; Cats, A; Deenen, MJ; Jacobs, BA; Meulendijks, D; Pluim, D; Schellens, JH; van Werkhoven, E | 1 |
| Gao, X; Johnson, C; Li, S; Liu, X; Locasale, JW; Mehrmohamadi, M; Ser, Z | 1 |
| Abu-Remaileh, M; Cantor, JR; Freinkman, E; Gao, X; Kanarek, N; Lewis, CA; Louissaint, A; Sabatini, DM | 1 |
| Biankin, AV; Chantrill, L; Chin, V; Nagrial, A; O'Connor, CA; Scholten, RJ; Sjoquist, K; Yip, D | 1 |
| Bang, SM; Choi, IS; Kim, JH; Kim, JW; Kim, SH; Kim, YJ; Lee, JH; Lee, JO; Lee, JS; Lee, JY; Lee, KW; Suh, KJ | 1 |
| Taieb, J; Zaanan, A | 1 |
| Alisaraie, L; de Barros, ALB; Heale, K; Manto Chagas, C; Tozer, T | 1 |
| Deng, R; Jia, Y; Kong, F; Liao, D; Xie, H; Yao, Y; Zuo, J | 1 |
| Hafez, R; Moghazy, TF; Morsi, H; Ramadan, RA; Samir, M; Shamesya, M | 1 |
| Armisén, R; Bravo, ML; Cordova-Delgado, M; Corvalán, AH; Cumsille, E; Garrido, M; Hill, CN; Lavanderos, MA; Li, Z; Liao, Y; Miquel, JF; Muñoz-Medel, M; Owen, GI; Pinto, MP; Quiñones, LA; Retamal, IN; Rodriguez-Fernandez, M | 1 |
| Boku, N; Esaki, T; Izawa, N; Kawakami, K; Kawakami, T; Komoda, M; Makiyama, A; Masuishi, T; Mitani, S; Moriwaki, T; Nagashima, K; Nakajima, TE; Okuda, H; Tsuji, Y; Yamamoto, S; Yamamoto, Y; Yamazaki, K | 1 |
7 review(s) available for pyrimidine and fluorouracil
| Article | Year |
|---|---|
The syndrome of 5-fluorouracil cardiotoxicity. An elusive cardiopathy.
Topics: Female; Fluorouracil; Heart Diseases; Humans; Middle Aged; Pyrimidines; Syndrome | 1993 |
Pyrimidine degradation defects and severe 5-fluorouracil toxicity.
Topics: Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Exons; Fluorouracil; Genome; Humans; Models, Chemical; Models, Genetic; Pyrimidines | 2004 |
Design, synthesis and anticancer activity against the MCF-7 cell line of benzo-fused 1,4-dihetero seven- and six-membered tethered pyrimidines and purines.
Topics: Acetals; Antineoplastic Agents; Benzene Derivatives; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Drug Design; Fluorouracil; Heterocyclic Compounds; Humans; Inhibitory Concentration 50; Neoplasm Metastasis; Purines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.
Topics: Amidohydrolases; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carnitine; Cephalosporins; Child; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Intestinal Absorption; Pentanoic Acids; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Rats | 2009 |
Chemotherapy and radiotherapy for advanced pancreatic cancer.
Topics: Albumins; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Epirubicin; Fluorouracil; Gemcitabine; Humans; Paclitaxel; Pancreatic Neoplasms; Pyrimidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2018 |
[Predictive and prognostic value of MSI phenotype in adjuvant colon cancer: Who and how to treat?]
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Humans; Immunotherapy; Leucovorin; Lymphocytes, Tumor-Infiltrating; Microsatellite Instability; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Phenotype; Prognosis; Pyrimidines | 2019 |
Maintenance treatment in advanced HER2-negative gastric cancer.
Topics: Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Bevacizumab; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Fluorouracil; Humans; Maintenance Chemotherapy; Oxaliplatin; Pyrimidines; Ramucirumab; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Stomach Neoplasms | 2020 |
2 trial(s) available for pyrimidine and fluorouracil
| Article | Year |
|---|---|
An Australian translational study to evaluate the prognostic role of inflammatory markers in patients with metastatic ColorEctal caNcer Treated with bevacizumab (Avastin™) [ASCENT].
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease Progression; Female; Fluorouracil; Humans; Inflammation; Leucovorin; Lymphocytes; Male; Neutrophils; Organoplatinum Compounds; Oxaliplatin; Oxaloacetates; Prognosis; Proportional Hazards Models; Prospective Studies; Pyrimidines; Reproducibility of Results | 2013 |
A phase II study of triweekly paclitaxel and capecitabine combination therapy in patients with fluoropyrimidine-platinum-resistant metastatic gastric adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Male; Middle Aged; Paclitaxel; Platinum; Pyrimidines; Stomach Neoplasms | 2013 |
40 other study(ies) available for pyrimidine and fluorouracil
| Article | Year |
|---|---|
[Clinical pharmacology of anticancer agents (Part 4). Antimetabolites (1)].
Topics: Animals; Antimetabolites; Cytarabine; Fluorouracil; Leukemia, Experimental; Nucleotides; Permeability; Pyrimidines; Tumor Cells, Cultured | 1992 |
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Regulation of the pyrimidine salvage pathway by the FUR1 gene product of Saccharomyces cerevisiae.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Drug Resistance, Microbial; Fluorouracil; Gene Expression; Genes, Fungal; Molecular Sequence Data; Pentosyltransferases; Plasmids; Pyrimidines; RNA, Fungal; Saccharomyces cerevisiae; Transcription, Genetic | 1991 |
[BOF-A1 and BOF-A2, new 5-FU degradation-inhibitory agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Fluorouracil; Liver; Mice; Pyridines; Pyrimidines; Rats; Sarcoma 180; Sarcoma, Experimental; Sarcoma, Yoshida; Tegafur; Uracil | 1987 |
Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity.
Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Fluorouracil; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1985 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
[Effect of 5-FU on the utilization of purine and pyrimidine by human gastric cancer cells (KATO III)].
Topics: Cell Division; Culture Media; Drug Interactions; Fluorouracil; Humans; Purines; Pyrimidines; Stomach Neoplasms; Tumor Cells, Cultured | 1995 |
Two new cases of hyperpyrimidinuria associated with excessive 5-fluorouracil toxicity.
Topics: Adult; Aged; Female; Fluorouracil; Humans; Leukopenia; Mouth Mucosa; Pyrimidines; Stomatitis | 1994 |
[Importance of systemic administration of pyrimidine after thermochemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hyperthermia, Induced; Liver Neoplasms; Mitomycin; Neoplasm Metastasis; Norepinephrine; Pancreatic Neoplasms; Pyrimidines | 1993 |
Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
Topics: Amino Acid Sequence; Animals; Antimetabolites; Conserved Sequence; Crystallography, X-Ray; Dimerization; Drug Design; Fluorouracil; Models, Molecular; Molecular Sequence Data; Pentosyltransferases; Prodrugs; Protein Conformation; Protozoan Proteins; Pyrimidines; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Toxoplasma; Uridine Monophosphate | 1998 |
[A case of gastric cancer with decreased dihydropyrimidine dehydrogenase activity].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Oxidoreductases; Pyrimidines; Stomach Neoplasms; Thymine; Uracil | 1998 |
A cystic biliary tumour responding to regional fluorinated pyrimidine infusion.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Cysts; Floxuridine; Fluorouracil; Hamartoma; Humans; Infusions, Intra-Arterial; Male; Pyrimidines; Treatment Outcome | 1998 |
Simple gas chromatographic-mass spectrometric procedure for diagnosing pyrimidine degradation defects for prevention of severe anticancer side effects.
Topics: Antimetabolites, Antineoplastic; Fluorouracil; Gas Chromatography-Mass Spectrometry; Neoplasms; Pyrimidines | 2001 |
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cells, Cultured; Embryo, Mammalian; Fluorouracil; Mice; Mice, Knockout; Proteins; Pyrimidines; Stem Cells; Uridine; Uridine Phosphorylase | 2002 |
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.
Topics: Age of Onset; Amino Acids; Animals; Cells, Cultured; Child, Preschool; Crystallography, X-Ray; Dihydrouracil Dehydrogenase (NADP); Electron Transport; Exons; Fibroblasts; Fluorouracil; Gene Deletion; Genotype; Granulocytes; Humans; Infant; Infant, Newborn; Intellectual Disability; Leukocytes, Mononuclear; Models, Molecular; Motor Skills Disorders; Mutation; Mutation, Missense; Oxidoreductases; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Pyrimidines; Swine; Thymine; Uracil | 2002 |
Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Contraindications; Cross Reactions; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Hybridomas; Mice; Mice, Inbred BALB C; Oxidoreductases; Pyrimidines; Risk Factors; Thymine; Uracil | 2002 |
[Research on the antimitotic properties of antagonists of natural pyrimidine bases. I. 5-Fluorouracil and related compounds].
Topics: Antimitotic Agents; Antineoplastic Agents; Fluorouracil; Pyrimidines; Research; Uracil | 1962 |
THE MECHANISM OF ACTION OF PURINE AND PYRIMIDINE ANALOGS IN MICROORGANISMS.
Topics: Amino Acids; Antimetabolites; Azaguanine; Candida; Carbon Isotopes; Fluorouracil; Nucleoproteins; Phenylalanine; Proline; Proteins; Purines; Pyrimidines; Research; RNA | 1963 |
FLUORINATED PYRIMIDINE THERAPY OF ADVANCED GASTROINTESTINAL CANCER.
Topics: Alopecia; Colonic Neoplasms; Drug Eruptions; Esophagitis; Fluorouracil; Gallbladder Neoplasms; Humans; Leukopenia; Lymphatic Metastasis; Nausea; Neoplasm Metastasis; Pancreatic Neoplasms; Pharyngitis; Pyrimidines; Rectal Neoplasms; Stomach Neoplasms; Stomatitis; Toxicology; Vomiting | 1964 |
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Neoplasms; Pyrimidines; Toxicology | 1964 |
INFLUENCE OF PURINE AND PYRIMIDINE COMPOUNDS ON DNA-SYNTHESIS OF ASCITES-TUMOUR CELLS.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; DNA; DNA, Neoplasm; Fluorouracil; Metabolism; Neoplasms, Experimental; Nucleotides; Pharmacology; Phosphorus Isotopes; Purines; Pyrimidines; Research; Thymine; Uracil; Uracil Nucleotides | 1964 |
FLUORESCENCE MICROSCOPY OF POLYOMA-INFECTED CELLS TREATED WITH HALOGENATED PYRIMIDINE ANALOGUES.
Topics: Antimetabolites; Floxuridine; Fluorescence; Fluorouracil; Idoxuridine; Mice; Microscopy; Microscopy, Fluorescence; Nucleosides; Pharmacology; Polyomavirus; Pyrimidines; Research; Toxicology; Virus Diseases | 1964 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.
Topics: Adenosine; Animals; Antimetabolites, Antineoplastic; Blotting, Southern; Cytidine; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Fluorouracil; Gene Deletion; Guanosine; Intestinal Mucosa; Kidney; Kinetics; Liver; Lung; Mice; Mice, Transgenic; Nucleotides; Pentobarbital; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Thymine Nucleotides; Time Factors; Tissue Distribution; Uridine; Uridine Phosphorylase | 2005 |
Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.
Topics: beta-Alanine; Biological Assay; Calibration; Capecitabine; Case-Control Studies; Child; Child, Preschool; Chromatography, Liquid; Deoxycytidine; Enzymes; Female; Fluorouracil; Humans; Infant, Newborn; Male; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Uracil | 2006 |
Preoperative radiotherapy and concomitant capecitabine treatment induce thymidylate synthase and thymidine phosphorylase mRNAs in rectal carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoembryonic Antigen; Combined Modality Therapy; Deoxycytidine; Fluorouracil; Genetic Markers; Humans; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Pyrimidines; Rectal Neoplasms; RNA, Messenger; Thymidine Phosphorylase; Thymidylate Synthase | 2007 |
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Design; Fluorouracil; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Protozoan Proteins; Pyrimidines; RNA Interference; Sequence Homology, Amino Acid; Trypanosoma brucei brucei | 2008 |
Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.
Topics: Animals; Antimetabolites, Antineoplastic; Caenorhabditis elegans; Drug Resistance; Fluorouracil; Gene Knockdown Techniques; Multienzyme Complexes; Mutation; Nucleoside-Phosphate Kinase; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Polymorphism, Single Nucleotide; Pyrimidines; Uridine Phosphorylase | 2009 |
Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.
Topics: Cations, Divalent; Chromatography, Gel; Enzyme Stability; Feedback, Physiological; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Leishmania donovani; Mutation; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Protein Multimerization; Protozoan Proteins; Pyrimidines; Recombinant Proteins; Spectrophotometry; Substrate Specificity; Temperature; Thiouracil; Uracil | 2013 |
Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.
Topics: Antiprotozoal Agents; Biosynthetic Pathways; Comparative Genomic Hybridization; DNA Mutational Analysis; Drug Resistance; Fluorouracil; Leishmania infantum; Mutation; Protozoan Proteins; Pyrimidines; Sequence Analysis, DNA; Transfection | 2013 |
Morphological and pharmacological investigation on some biopotent materials derived from substituted pyrimidine and imidazole enzyme constituents.
Topics: Animals; Antimetabolites; Antioxidants; Bacteria; Bacterial Infections; Cattle; Coordination Complexes; Copper; DNA; DNA Cleavage; Fluorouracil; Fungi; Humans; Imidazoles; Ligands; Microbial Sensitivity Tests; Mycoses; Nickel; Pyrimidines; Zinc | 2014 |
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis.
Topics: Adenine; Carcinogenesis; Cell Line, Tumor; DNA Replication; Epithelial Cells; Esophagus; Fluorouracil; Gastric Mucosa; Gene Expression; Humans; Nucleobase Transport Proteins; Protective Agents; Pyrimidines; RNA, Messenger; Uracil | 2015 |
Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.
Topics: 5' Untranslated Regions; Adult; Aged; Aged, 80 and over; Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Expression; Genotype; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Polymorphism, Single Nucleotide; Pyrimidines; Tandem Repeat Sequences; Thymidylate Synthase; Young Adult | 2016 |
Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow.
Topics: Animals; Antimetabolites, Antineoplastic; Carbon; Cell Line, Tumor; Fluorouracil; Homeostasis; Male; Metabolic Networks and Pathways; Metabolome; Mice, Inbred NOD; Mice, SCID; Nucleotides; Pyrimidines | 2016 |
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
Topics: Aged; Animals; Cell Culture Techniques; Cell Line, Tumor; Culture Media; Fluorouracil; Glucose; Humans; Leukemia, Myeloid, Acute; Male; Mice; Middle Aged; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Protein Domains; Pyrimidines; Uric Acid | 2017 |
A population-based outcomes study of patients with metastatic gastric cancer receiving second-line chemotherapy: A nationwide health insurance database study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Databases, Factual; Disease-Free Survival; Female; Fluorides; Fluorouracil; Humans; Insurance, Health; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Outcome Assessment, Health Care; Oxaliplatin; Prognosis; Pyrimidines; Republic of Korea; Stomach Neoplasms; Taxoids | 2018 |
Interdomain twists of human thymidine phosphorylase and its active-inactive conformations: Binding of 5-FU and its analogues to human thymidine phosphorylase versus dihydropyrimidine dehydrogenase.
Topics: Antimetabolites, Antineoplastic; Binding Sites; Dihydrouracil Dehydrogenase (NADP); Drug Screening Assays, Antitumor; Fluorouracil; Humans; Ligands; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Engineering; Pyrimidines; Small Molecule Libraries; Structure-Activity Relationship; Thymidine Phosphorylase | 2019 |
Significance of expression of pyrimidine metabolizing genes in colon cancer.
Topics: Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Pyrimidines; Thymidylate Synthase | 2020 |
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Case-Control Studies; Confidence Intervals; Dihydrouracil Dehydrogenase (NADP); DNA-Binding Proteins; Endonucleases; Female; Fluorouracil; Gene Frequency; Genes, p53; Genotype; Glutathione S-Transferase pi; Glycine Hydroxymethyltransferase; Humans; Leucovorin; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Multienzyme Complexes; Nomograms; Odds Ratio; Organoplatinum Compounds; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Platinum Compounds; Polymorphism, Single Nucleotide; Pyrimidines; Quality of Life; Retrospective Studies; Stomach Neoplasms; Xeroderma Pigmentosum Group D Protein | 2021 |
Second-line chemotherapy after early disease progression during first-line chemotherapy containing bevacizumab for patients with metastatic colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Angiogenesis Inhibitors; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Female; Fluorouracil; Humans; Irinotecan; Japan; Leucovorin; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Progression-Free Survival; Pyrimidines; Retrospective Studies; Time Factors | 2021 |