Page last updated: 2024-08-16

pyrimethamine and zidovudine

pyrimethamine has been researched along with zidovudine in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (19.05)	18.7374
1990's	10 (47.62)	18.2507
2000's	2 (9.52)	29.6817
2010's	5 (23.81)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Bouabdallah, R; Dhiver, C; Gamby, T; Gastaut, JA; Lafeuillade, A; Poizot-Martin, I; Xeri, L	1
Dannemann, BR; Remington, JS	1
Caumes, E; Feyeux, C; Garrouste, MT; Schlemmer, B; Wallach, D	1
Israelski, DM; Remington, JS; Tom, C	1
Davis, R; Ellis-Pegler, RB; Ingram, RJ	1
Bartlett, S; Bessesen, MT; Cohn, DL; Ellison, RT; Miller, LA	1
Alvaro, LC; Cortina, C; Fernandez, JM; Sadaba, F; Villaverde, FJ	1
Belda Mira, A; Díaz Sánchez, F; Michavila Gómez, J; Rovira Daudí, E	1
Joos, B; Lüthy, R; Opravil, M	1
Brown, GM; Hedriana, HL; Mitchell, JL; Williams, SB	1
Boué, F; Bouvet, E; Certain, A; Gaudebout, C; Girard, PM; Jelazko, P; Landman, R; Olivares, R; Saimot, AG	1
Childress, JF; DeMets, DL; Ellenberg, SS; Fleming, TR; Foulkes, M; Mayer, KH; O'Fallon, J; Pollard, RB; Rahal, JJ; Whitley, RJ	1
Davidian, M; Hafner, R; Jacobson, JM; Luft, BJ; Raasch, RH; Rainey, PM	1
Beijnen, JH; Burger, DM; Hoetelmans, RM; Koks, CH; Kraaijeveld, CL; Meenhorst, PL; Mulder, JW	1
Creek, MR; Dabbs, J; Freund, YR; MacGregor, JT; Phillips, SJ; Tyson, CA	1

Reviews

2 review(s) available for pyrimethamine and zidovudine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Cutaneo-mucosal hyperpigmentation in AIDS. 4 cases]. Presse medicale (Paris, France : 1983), 1991, Apr-13, Volume: 20, Issue:14 Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Ketoconazole; Male; Middle Aged; Nail Diseases; Pigmentation Disorders; Pyrimethamine; Zidovudine	1991

Trials

3 trial(s) available for pyrimethamine and zidovudine

Article	Year
Administration of pyrimethamine/sulfadoxine for prevention of Pneumocystis carinii pneumonia in patients with AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:3 Topics: Administration, Inhalation; Adolescent; Adult; AIDS-Related Opportunistic Infections; Drug Therapy, Combination; Humans; Male; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Sulfadoxine; Zidovudine	1995
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group. The New England journal of medicine, 1993, May-27, Volume: 328, Issue:21 Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Encephalitis; Female; HIV Infections; Humans; Male; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Toxoplasmosis, Cerebral; Zidovudine	1993
Pyrimethamine pharmacokinetics in human immunodeficiency virus-positive patients seropositive for Toxoplasma gondii. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:6 Topics: AIDS-Related Opportunistic Infections; Drug Interactions; Half-Life; HIV Infections; Humans; Male; Pyrimethamine; Toxoplasmosis; Zidovudine	1996

Other Studies

16 other study(ies) available for pyrimethamine and zidovudine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Toxoplasmic encephalitis in AIDS. Hospital practice (Office ed.), 1989, Mar-15, Volume: 24, Issue:3 Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antibodies, Protozoan; Brain; Diagnosis, Differential; Drug Therapy, Combination; Encephalitis; Humans; Magnetic Resonance Imaging; Male; Pyrimethamine; Recurrence; Sulfonamides; Tomography, X-Ray Computed; Toxoplasma; Toxoplasmosis; Zidovudine	1989
[Bullous toxic skin disease with fatal outcome in AIDS]. Presse medicale (Paris, France : 1983), 1989, Oct-21, Volume: 18, Issue:34 Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Johnson Syndrome; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Zidovudine	1989
Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:1 Topics: Animals; Cells, Cultured; Drug Interactions; Female; Fibroblasts; Humans; Male; Mice; Pyrimethamine; Skin; Toxoplasma; Toxoplasmosis, Animal; Zidovudine	1989
Experience with pneumocystis carinii pneumonia in patients with AIDS. The New Zealand medical journal, 1989, Sep-27, Volume: 102, Issue:876 Topics: Acquired Immunodeficiency Syndrome; Adult; Bronchoscopy; Drug Combinations; Follow-Up Studies; Homosexuality; Humans; Length of Stay; Male; Middle Aged; New Zealand; Pentamidine; Pneumonia, Pneumocystis; Pyrimethamine; Recurrence; Retrospective Studies; Sulfadoxine; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Zidovudine	1989
Cataplexy associated with midbrain lesion. Neurology, 1995, Volume: 45, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Cataplexy; HIV Seropositivity; Humans; Magnetic Resonance Imaging; Male; Mesencephalon; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Cerebral; Zidovudine	1995
[Porphyria cutanea tarda and human immunodeficiency virus infection. Apropos of 2 further cases]. Revista clinica espanola, 1994, Volume: 194, Issue:7 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Drug Therapy, Combination; HIV Infections; Humans; Male; Porphyria Cutanea Tarda; Pyrimethamine; Substance-Related Disorders; Zidovudine	1994
Levels of dapsone and pyrimethamine in serum during once-weekly dosing for prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:5 Topics: Adult; Aged; Dapsone; Drug Interactions; Female; HIV Infections; Humans; Male; Middle Aged; Phenotype; Pneumonia, Pneumocystis; Pyrimethamine; Toxoplasmosis, Cerebral; Zidovudine	1994
Normal fetal outcome in a pregnancy with central nervous system toxoplasmosis and human immunodeficiency virus infection. A case report. The Journal of reproductive medicine, 1993, Volume: 38, Issue:9 Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Antibodies, Protozoan; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Female; Humans; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Prognosis; Pyrimethamine; Recurrence; Sulfadiazine; Tomography, X-Ray Computed; Toxoplasma; Toxoplasmosis, Cerebral; Zidovudine	1993
The data and safety monitoring board and acquired immune deficiency syndrome (AIDS) clinical trials. Controlled clinical trials, 1995, Volume: 16, Issue:6 Topics: Advisory Committees; Anti-Infective Agents; Clinical Trials as Topic; Clinical Trials Data Monitoring Committees; Confidentiality; Conflict of Interest; Didanosine; Drug Evaluation; Federal Government; HIV Infections; Humans; National Institutes of Health (U.S.); Organizational Objectives; Professional Staff Committees; Pyrimethamine; Reverse Transcriptase Inhibitors; Risk Assessment; Toxoplasmosis, Cerebral; Treatment Outcome; United States; Zalcitabine; Zidovudine	1995
Penetration of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of zidovudine, into the cerebrospinal fluid of HIV-1-infected patients. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1997, Jun-01, Volume: 15, Issue:2 Topics: Administration, Oral; Adult; Anti-HIV Agents; Anti-Infective Agents; Antidotes; Dideoxynucleosides; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Leucovorin; Male; Middle Aged; Pyrimethamine; Spinal Puncture; Sulfadiazine; Time Factors; Toxoplasmosis, Cerebral; Zidovudine	1997
Synergistic bone marrow toxicity of pyrimethamine and zidovudine in murine in vivo and in vitro models: mechanism of toxicity. Toxicology and applied pharmacology, 2002, May-15, Volume: 181, Issue:1 Topics: Administration, Oral; Animals; Anti-HIV Agents; Antiprotozoal Agents; Cells, Cultured; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Hematopoietic Stem Cells; Humans; Longevity; Male; Mice; Mice, Inbred BALB C; Models, Animal; Pyrimethamine; Zidovudine	2002