pyrimethamine has been researched along with proguanil in 242 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 112 (46.28) | 18.7374 |
| 1990's | 44 (18.18) | 18.2507 |
| 2000's | 58 (23.97) | 29.6817 |
| 2010's | 23 (9.50) | 24.3611 |
| 2020's | 5 (2.07) | 2.80 |
| Authors | Studies |
|---|---|
| Diaz, DS; Jacobus, DP; Kozar, MP; Milhous, WK; O'Neil, MT; Schiehser, GA; Shearer, TW; Skillman, DR; Smith, PL; Yang, YS | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fidock, DA; Flannery, EL; Winzeler, EA | 1 |
| Cichero, E; Espinoza, S; Gainetdinov, RR; Tonelli, M | 1 |
| Cichero, E; Costi, MP; Gazzarrini, S; Loddo, R; Moroni, A; Naesens, L; Santucci, M; Tasso, B; Tonelli, M | 1 |
| Black, RH; Ray, AP | 1 |
| Copper, JR | 1 |
| Grey, D; Hamilton-Miller, JM | 1 |
| Ecker, A; Várnai, F | 1 |
| Clyde, DF; Hornick, RB; McCarthy, VC; Miller, RM | 1 |
| Agnes, E; Ferenc, V | 1 |
| Gon, F; Reid, FP | 1 |
| Gyang, FN; Peterson, DS; Wellems, TE | 1 |
| Edstein, MD; Shanks, GD; Suriyamongkol, V; Timsaad, S; Webster, HK | 1 |
| Karwacki, JJ; Shanks, GD; Suriyamongkol, V; Watanasook, C | 1 |
| Bjorkman, A; Flacks, H; Hanson, AP; Hogh, B; Petersen, E | 1 |
| Hopfenmüller, W; Janitschke, K; Schultes, U; Weber, G; Weinke, T | 1 |
| Cowman, AF; Foote, SJ; Galatis, D | 1 |
| Milhous, WK; Peterson, DS; Wellems, TE | 1 |
| Brandling-Bennett, AD; Hoogstrate, M; Keuter, M; Ngwawe, WA; Raasveld, M; van de Ree, M; van Eijk, A; Watkins, WM; Were, JB | 1 |
| Bates, CJ; Bradley, AK; Fuller, NJ; Greenwood, AM; Greenwood, BM; Hayes, RJ; Tulloch, S | 1 |
| Brandling-Bennett, AD; Gilles, HM; Howells, RE; Koech, DK; Oloo, AJ; Watkins, WM | 1 |
| Heap, BJ | 1 |
| Bygbjerg, IC; Fogh, S; Gøtzsche, PC; Jepsen, S; Kuijlen, K; Mordhorst, CH; Ravn, P; Rønn, A; Schapira, A | 1 |
| Booth, RG; Hansch, C; Neal, RA; Santi, DV; Sertsrivanich, R; Sirawaraporn, W | 1 |
| Bray, RS; Canning, EU; Huang, JC; Jiang, JB; Krotoski, WA; Krotowski, WA; Landau, I; Li, DS; Liang, DS; Liao, JY; Lun, ZR | 1 |
| Biddulph, J | 1 |
| Chiodini, PL | 1 |
| Barutwanayo, M; Coosemans, MH; Gryseels, B; Onori, E; Otoul, C; Wéry, M | 1 |
| Alestig, K; Bengtsson, E; Björkman, A; Brohult, J; Hanson, A; Hedman, P; Kollie, E; Pehrson, PO; Rombo, L; Willcox, M | 1 |
| Childs, GE; Lambros, C | 1 |
| Koech, DK; Sixsmith, DG; Spencer, HC; Watkins, WW | 1 |
| Howells, RE; Percy, M | 1 |
| Bygbjerg, IC; Flachs, H | 1 |
| Edstein, MD | 1 |
| Barber, AM; Campbell, CC; Collins, WE; Nguyen-Dinh, P; Teklehaimanot, A | 1 |
| Nguyen-Dinh, P | 1 |
| Chintana, T; Sucharit, F; Sucharit, S; Suphadtanaphongs, V; Tiewcharoen, S | 1 |
| Greenwood, BM; Panton, LJ | 1 |
| Spencer, HC | 1 |
| Danis, M; Gentilini, M | 1 |
| Salako, LA | 1 |
| Bent, NS; Gilles, HM; Howells, RE | 1 |
| Chaves-Carballo, E; Collins, WE; Glew, RH; Howard, WA; Miller, LH; Neva, FA; Wyler, DJ | 1 |
| Clyde, DF; DuPont, HL; Hornick, RB; McCarthy, VC | 1 |
| Collins, WE; Contacos, PG; Omar, MS | 1 |
| Olsen, VV | 1 |
| Olatunde, IA | 1 |
| Powell, RD | 1 |
| Osnes, M | 1 |
| Peters, W | 7 |
| Briesch, PE; Contacos, PG; Glew, RH; Krotoski, WA; Neva, FA | 1 |
| Weise, HJ | 1 |
| Botha, D | 1 |
| Collins, WE; Contacos, PG; Howard, WA; Jeffery, GM; Krotoski, WA | 1 |
| Gill, HS; Prakash, O | 1 |
| Brewer, GJ; Powell, RD | 1 |
| Laing, AB | 2 |
| Dawkins, AT; Stahler, N; Terzian, LA | 1 |
| Hunsicker, LG | 1 |
| Schmidt, LH | 1 |
| Clyde, DF; DuPont, HL; McCarthy, VC; Miller, RM | 1 |
| Clyde, DF; McCarthy, VC; Sangalang, RP; Shute, GT | 1 |
| Clyde, DF; McCarthy, VC; Miller, RM; Music, SI | 1 |
| Pinder, RM | 1 |
| Richards, WH; Williams, SG | 1 |
| Genther, CS; Smith, CC | 1 |
| Freisheim, JH; Guzy, PM; Smith, CC | 1 |
| Bruce-Chwatt, LJ | 1 |
| Chin, W; Coatney, GR; Contacos, PG; Lunn, JS | 1 |
| Diggens, SM; Gregory, KG | 1 |
| Gregory, KG; Peters, W | 1 |
| Bennike, T | 1 |
| Dann, O; Fink, E | 1 |
| Taylor, J | 1 |
| Drew, R | 1 |
| Akimova, IM; Dyban, AP; Udalova, LD | 1 |
| Aubert, B; Jaatinen, M; Kihamia, CH; Kumano, M; Magnuson, LW; McLarty, DG; Murru, M; Webber, RH | 1 |
| Doberstyn, EB | 1 |
| Spracklen, FH | 1 |
| Schapira, A | 1 |
| Bray, RS | 1 |
| Juma, FD | 1 |
| Chulay, JD; Sixsmith, DG; Spencer, HC; Watkins, WM | 1 |
| Chulay, JD; Sixsmith, DG; Watkins, WM | 1 |
| Rossan, RN; Schmidt, LH | 1 |
| Høiby, N; Kharazmi, A; Valerius, NH | 1 |
| Bell, D | 1 |
| Bengtsson, E; Björkman, A; Brohult, J; Sirleaf, V; Willcox, M | 1 |
| Coosemans, M; Wery, M | 1 |
| Howells, RE; Judge, BM | 1 |
| Graham, NB; Howells, RE; Judge, BM; McNeill, ME | 1 |
| Sweeney, TR | 1 |
| Gilles, HM | 1 |
| Bouare, M; Djimde, A; Doumbo, O; Plowe, CV; Wellems, TE | 1 |
| Bradley, DJ; Warhurst, DC | 1 |
| Basco, LK; Eldin de Pécoulas, P; Le Bras, J; Mazabraud, A; Wilson, CM | 1 |
| Abdallah, B; Basco, LK; Djé, MK; Eldin de Pécoulas, P; Le Bras, J; Mazabraud, A | 2 |
| Hughes, WT; Killmar, JT; Oz, HS | 1 |
| Basco, LK; Le Bras, J | 2 |
| Fuchs, E; Funk, M; Naef, U; Nevill, C; Phillips-Howard, P; Schildknecht, J; Schlagenhauf, P; Steffen, R; Stürchler, D | 1 |
| Basco, LK; Le Bras, J; Ramiliarisoa, O | 1 |
| Basco, LK; de Pecoulas, PE; Le Bras, J; Wilson, CM | 1 |
| Kager, PA; Wetsteyn, JC | 1 |
| Cowman, AF; Genton, B; Lorry, K; Reeder, JC; Rieckmann, KH; Wines, B | 1 |
| Bhasin, VK; Nair, L | 1 |
| Brun-Pascaud, M; Chau, F; Derouin, F; Garry, L; Girard, PM; Jacobus, D | 1 |
| Nguyen, DS; Nguyen, PD; Sköld, O; Swedberg, G; Zindrou, S | 1 |
| Diop, S; Djimde, A; Doumbo, OK; Kouriba, B; Plowe, CV; Wellems, TE | 1 |
| Ang, HH; Chan, KL; Mak, JW | 1 |
| Santi, DV; Sathitkul, T; Sirawaraporn, R; Sirawaraporn, W; Yuthavong, Y | 1 |
| Chambo, O; Curtis, CF; Hills, E; Mbwana, H; Trigg, JK; Watkins, W | 1 |
| Christopherson, RI; Rieckmann, KH; Seymour, KK; Yeo, AE | 1 |
| Amukoye, E; Hatcher, J; Lowe, B; Marsh, K; Minyiri, G; Mosobo, M; Ngumbao, E; Snow, RW; Ton, M; Watkins, WM; Winstanley, PA | 1 |
| Santi, DV; Sirawaraporn, R; Sirawaraporn, W; Yongkiettrakul, S; Yuthavong, Y | 1 |
| Mberu, EK; Nzila-Mounda, A; Plowe, CV; Sibley, CH; Watkins, WM; Winstanley, PA | 1 |
| Reynolds, MG; Roos, DS | 1 |
| Curtis, J; Duraisingh, MT; Warhurst, DC | 1 |
| Blanco García, A; de Górgolas Hernández-Mora, M; Fernández Guerrero, ML; Martín Torres, MP | 1 |
| Dicko, A; Diop, S; Djimde, A; Doumbo, O; Plowe, CV; Wellems, TE | 1 |
| Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B | 1 |
| Davis, TM | 1 |
| Bourgeade, A; Delmont, J | 1 |
| Bustos, DG; Canete-Miguel, E; Canfield, CJ; Hutchinson, DB | 1 |
| Canfield, CJ; Hutchinson, DB; Mulenga, M; Sukwa, TY | 1 |
| Griffin, JP | 1 |
| Howard, V; Mookherjee, S; Nzila-Mouanda, A; Sibley, CH; Watkins, W | 1 |
| Watt, G | 1 |
| Curtis, J; Maxwell, CA; Ortelli, F; Watkins, WM | 1 |
| Auparakkitanon, S; Chavalitshewinkoon-Petmitr, P; Pongvilairat, G; Wilairat, P | 1 |
| Fusai, T; Mosnier, J; Parzy, D; Pradines, B; Rogier, C; Spiegel, A; Tall, A; Trape, JF | 1 |
| Basco, LK; Ringwald, P | 1 |
| Hopkins Sibley, C; Mberu, EK; Monks, SA; Nduati, E; Nzila, AM; Watkins, WM; Winstanley, PA | 1 |
| Kamchonwongpaisan, S; Lowe, G; Quarrell, R; Rastelli, G; Sirawaraporn, W; Sompornpisut, P; Thebtaranonth, Y; Vilaivan, T; Yuthavong, Y | 1 |
| Bhasin, V; Nair, L; Toteja, R | 1 |
| Campos, P; Canfield, CJ; Clendenes, M; Hutchinson, DB; Llanos-Cuentas, A | 1 |
| de Alencastro, RB; Figueroa-Villar, JD; Santos-Filho, OA | 1 |
| Hankins, EG; Sibley, CH; Warhurst, DC | 1 |
| Hills, E; Mberu, E; Mutabingwa, T; Nduati, E; Nzila, A; Watkins, W; Winstanley, P | 1 |
| Chimpeni, P; Cortese, JF; Dzinjalamala, FK; Kamwendo, DD; Kublin, JG; Lescano, AG; Malkin, EM; Martino, LM; Molyneux, ME; Mukadam, RA; Plowe, CV; Rogerson, SJ; Taylor, TE; Winstanley, PA | 1 |
| Delfino, RT; Figueroa-Villar, JD; Santos-Filho, OA | 1 |
| Hastings, MD; Sibley, CH | 1 |
| Bedos, JP; Bruneel, F; Danis, M; Gachot, B; Regnier, B; Vachon, F; Wolff, M | 1 |
| Chimpeni, P; Hatcher, J; Kublin, JG; Marsh, K; Molyneux, ME; Plowe, CV; Sulo, J; Taylor, TE; Watkins, WM; Winstanley, PA | 1 |
| Dosekun, E; Ladhani, S; Patel, V; Shingadia, D | 1 |
| Liu, H; Yang, YM; Zhang, ZX | 1 |
| Durand, R; Le Bras, J | 1 |
| Ariey, F; Duchemin, JB; Harisoa, JL; Mauclere, P; Pietra, V; Rabarijaona, LP; Raharimalala, LA; Rakotomanana, F; Ranaivo, L; Randrianarivelojosia, M; Robert, V | 1 |
| Charlieu, JP; Imwong, M; Leartsakulpanich, U; Letourneur, F; Looareesuwan, S; Pukrittayakamee, S; Rénia, L; Snounou, G; White, NJ | 1 |
| Pfeifer, C; Strauss, R | 1 |
| Aubouy, A; Bakary, M; Deloron, P; Durand, R; Huart, V; Jafari, S; Le Bras, J; Mayombo, J; Migot-Nabias, F | 1 |
| Schubert, C | 1 |
| JONES, SA | 1 |
| NAIR, CP; RAY, AP; SINGH, J | 2 |
| DA MOURAO, MC | 1 |
| CHARLES, LJ | 1 |
| MEUWISSEN, JH | 1 |
| BASU, PC; RAMAKRISHNAN, SP; SINGH, H; SINGH, N | 1 |
| AMMA, MK; GUJRAL, ML; MISRA, N; SAREEN, K; VARMA, DR; VIJAYAMMA, N | 1 |
| CONTACOS, PG; MILLAR, JW; STITCHER, JE; YOUNG, MD | 1 |
| COATNEY, GR; CONTACOS, PG; LUNN, JS | 1 |
| SULLI, G; VARRONE, F | 1 |
| COLLINS, WE; JEFFERY, GM; SKINNER, JC | 1 |
| ALVING, AS; BREWER, GJ; MILLAR, JW; POWELL, RD | 1 |
| EYLES, DE; MONTGOMERY, R; SANDOSHAM, AA | 1 |
| AUDU, IS; COLLIS, WR | 1 |
| DAVID, HL | 1 |
| ROLLO, IM | 1 |
| Fischer, PR; Stauffer, W | 1 |
| Zimmerman, PA | 1 |
| Charoensetakul, N; Kamchonwongpaisan, S; Lowe, G; Ponsinet, R; Quarrell, R; Sirawaraporn, W; Tarnchompoo, B; Vanichtanankul, J; Vilaivan, T; Yuthavong, Y | 1 |
| Bienzle, U; Ehrhardt, S; Jelinek, T; Mockenhaupt, FP; Muehlen, M; Otchwemah, R; Schreiber, J | 1 |
| Imwong, M; Looareesuwan, S; Wilairatana, P | 1 |
| Alloueche, A; Bailey, W; Barton, S; Bwika, J; Chimpeni, P; Falade, CO; Fehintola, FA; Horton, J; Jaffar, S; Kanyok, T; Kremsner, PG; Kublin, JG; Lang, T; Missinou, MA; Mkandala, C; Oduola, AM; Premji, Z; Robertson, L; Sowunmi, A; Ward, SA; Winstanley, PA | 1 |
| Guiguemdé, TR; Kengne, P; Ouédraogo, JB; Veas, F; Zampan, H | 1 |
| Alloueche, A; Bates, SJ; Bwika, J; Happi, TC; Kremsner, PG; Kublin, JG; Premji, Z; Sibley, CH; Watkins, WM; Winstanley, PA | 1 |
| Hunt, SY; Rezvani, BB; Sibley, CH | 1 |
| Kamchonwongpaisan, S; Tarnchompoo, B; Taweechai, S; Vanichtanankul, J; Yuthavong, Y; Yuvaniyama, J | 1 |
| Afonso, R; Cancela, ML; Elandalloussi, LM; Leite, RB; Nunes, PA; Rodrigues, PM | 1 |
| Chusacultanachai, S; Japrung, D; Wilairat, P; Yuthavong, Y; Yuvaniyama, J | 1 |
| Alker, AP; Chaluluka, E; Kamwendo, DD; Meshnick, SR; Molyneux, ME; Mwapasa, V; Purfield, A; Rogerson, SJ; Tadesse, E | 1 |
| Garner, P; Jones, K; Taylor-Robinson, D | 1 |
| Jiang, S; McConkey, GA; McRobert, L; Stead, A | 1 |
| Ang, HH; Cheang, HS; Mak, JW | 1 |
| Bennett, S; Fielding, K; Greenwood, B; Malunga, P; Mulenga, M; Shulman, C; Thuma, P | 1 |
| Anh, le N; Auliff, A; Bell, D; Chen, N; Cheng, Q; Gao, Q; Maguire, J; O'Neil, MT; Russell, B; Wilson, DW | 1 |
| Alloueche, A; Bennett, S; Fielding, K; Greenwood, BM; Malunga, F; Mulenga, M; Shulman, C; Thuma, PE | 1 |
| Chitnumsub, P; Kamchonwongpaisan, S; Taweechai, S; Vanichtanankul, J; Yuthavong, Y | 1 |
| Atemnkeng, MA; Chimanuka, B; Plaizier-Vercammen, J | 1 |
| Hasan, MA; Klinkenberg, E; Leslie, T; Mayan, MI; Rowland, M; Safi, MH; Whitty, CJ | 1 |
| Chusacultanachai, S; Japrung, D; Leartsakulpanich, U; Yuthavong, Y | 1 |
| Nyunt, MM; Plowe, CV | 1 |
| Diriye, A; Kiara, S; Kokwaro, G; Masseno, V; Mwai, L; Nduati, E; Nzila, A; Ommeh, S | 1 |
| Chishimba, S; Mharakurwa, S; Mkulama, MA; Rouse, P; Sikalima, J; Thuma, PE | 1 |
| Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A | 1 |
| Dankyau, M; Madaki, AJ; Ogunfowokan, O; Thacher, TD | 1 |
| Briceño, M; Drakeley, C; Greenwood, BM; Mutabingwa, TK; Muze, K; Ord, R; Whitty, CJ | 1 |
| bin Reza, F; Chiodini, PL; Doherty, JF; Fifer, H; Gothard, P; Haustein, T; Nicholas, M; Njimgye-Tekumafor, NE; Pearce, RJ; Polley, SD; Sutherland, CJ | 1 |
| Borrmann, S; Kiara, SM; Masseno, V; Mwai, L; Nzila, A; Ochola, I; Okombo, J | 1 |
| Bell, DJ; Chimpeni, P; Hughes, DA; Kayange, N; Lalloo, DG; Molyneux, ME; Montgomery, J; Mukaka, M; Ward, SA; Winstanley, PA; Wootton, D | 1 |
| Carneiro, I; Chandramohan, D; Gesase, S; Gosling, RD; Greenwood, B; Hashim, R; Lemnge, M; Mosha, FW; Mosha, JF | 1 |
| Adane, L; Bharatam, PV; Patel, DS | 1 |
| Cairns, M; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Greenwood, B; Hashim, R; Kaur, H; Lemnge, M; Mosha, FW; Mosha, JF | 1 |
| Hamel, MJ; Kariuki, S; Lindblade, K; Newman, RD; Odhiambo, FO; Otieno, P; Peterson, E; Slutsker, L; ter Kuile, FO; Vulule, J; Williamson, J | 1 |
| Balu, L; Chevret, L; Habes, D; Orostegui, L; Pussard, E | 1 |
| Terlouw, DJ; van Eijk, AM | 1 |
| Brown, KM; Costanzo, MS; Hartl, DL | 1 |
| Ensom, MH; Wilby, KJ | 1 |
| Imwong, M; Kongsaeree, P; Leartsakulpanich, U; Riangrungroj, P; Tirakarn, S; Yuthavong, Y | 1 |
| Barnwell, JW; Collins, WE; Galland, GG; Jeffery, GM; Nace, D; Sullivan, JS; Williams, A; Williams, T | 1 |
| Adams, JH; Auliff, AM; Balu, B; Chen, N; Cheng, Q; O'Neil, MT | 1 |
| Blundell, TL; Dias, MV; Domingues, RR; Paes Leme, AF; Tyrakis, P | 1 |
| Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E | 1 |
| Diakite, I; Hartl, DL; Ogbunugafor, CB; Weinreich, DM; Wylie, CS | 1 |
| Gauye, F; Greub, G; Hauser, PM; Mueller, L | 1 |
| Björkman, A; Jovel, IT; Mårtensson, A; Roper, C; Ursing, J | 1 |
| Corral, MG; Leroux, J; Mylne, JS; Stubbs, KA | 1 |
| Blasco, B; Moon, RW; Sutherland, CJ; van Schalkwyk, DA | 1 |
| Ittarat, W; Kongkasuriyachai, D; Leartsakulpanich, U; Leelayoova, S; Mungthin, M; Pornthanakasem, W; Suwandittakul, N; Tarnchompoo, B; Yuthavong, Y | 1 |
| Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J | 1 |
| Hoarau, M; Kamchonwongpaisan, S; Srimongkolpithak, N; Vanichtanankul, J; Vitsupakorn, D; Yuthavong, Y | 1 |
| Aydemir, O; Bailey, JA; Byaruhanga, O; Conrad, MD; Cooper, RA; Duffey, M; Katairo, T; Kreutzfeld, O; Legac, J; Nsobya, SL; Okitwi, M; Orena, S; Rasmussen, SA; Rosenthal, PJ; Tumwebaze, PK | 1 |
| Enato, IG; Ibadin, OM; Odunvbun, ME; Sadoh, AE | 1 |
| Clapp, S; Freedman, B; Green, CL; Kirui, JK; Korwa, S; Njuguna, FM; O'Meara, WP; Taylor, SM; Wu, A | 1 |
26 review(s) available for pyrimethamine and proguanil
| Article | Year |
|---|---|
Using genetic methods to define the targets of compounds with antimalarial activity.
Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum | 2013 |
Malaria chemoprophylaxis: an update.
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Female; Humans; Malaria; Proguanil; Pyrimethamine; Sulfadoxine | 1987 |
The chemoprophylaxis of malaria.
Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 1987 |
Pharmacokinetics of antimalarial drugs: their therapeutic and toxicological implications.
Topics: Adult; Amodiaquine; Animals; Antimalarials; Child; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Half-Life; Humans; Kinetics; Male; Mefloquine; Mice; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine; Sulfalene | 1985 |
The present status of chloroquine in the drug treatment of malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfonamides; Sulfones; Triazines | 1972 |
Development of new antimalarial drugs.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Humans; Malaria; Methanol; Phenanthrenes; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinolines; Research; Sulfadiazine; Sulfonamides; Sulfones; United States | 1972 |
[Importation of malaria into the Federal Republic of Germany including Berlin (West) in the last ten years (1963-1972)].
Topics: Africa; Age Factors; Aircraft; Amodiaquine; Antimalarials; Asia; Berlin; Chloroquine; Disease Outbreaks; Epidemiologic Methods; Europe; Female; Germany, West; Humans; Malaria; Male; Proguanil; Pyrimethamine; Recurrence; Retrospective Studies; Sex Factors; Travel; World Health Organization | 1974 |
The pharmacology of the antimalarials. A rational approach to the therapy of resistant falciparum malaria.
Topics: Amodiaquine; Antimalarials; Chemical Phenomena; Chemistry; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Sulfadimethoxine; Sulfisoxazole | 1969 |
Drug resistance in malaria--a perspective.
Topics: Adult; Africa; Animals; Antimalarials; Asia, Southeastern; Child; Chloroquine; Drug Resistance, Microbial; Female; Humans; Immunity; Insect Control; Malaria; Male; Mice; Mutation; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; South America | 1969 |
Chemotherapy of the drug-resistant malarias.
Topics: Chloroquine; Cinchona; Drug Resistance, Microbial; Malaria; Mutation; Phytotherapy; Plants, Medicinal; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Quinolines; Sulfonamides; Sulfones | 1969 |
Malaria. Chemoprophylaxis and chemotherapy.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Drug Synergism; Humans; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Pyrimidines; Quinine; Sulfonamides; Triazines | 1971 |
Recent advances in the chemotherapy of malaria.
Topics: Acridines; Animals; Anti-Bacterial Agents; Antimalarials; Antineoplastic Agents; Cinchona; Culture Media; Humans; Malaria; Microbial Sensitivity Tests; Naphthoquinones; Phytotherapy; Plants, Medicinal; Plasmodium; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Quinacrine; Quinolines; Sulfonamides; Sulfones | 1971 |
Resistance of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Asia; Chloroquine; DNA; Drug Resistance; Drug Synergism; Hemin; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Quinolines; Research; RNA; South America | 1984 |
Malaria 1984. Part I. Malaria prophylaxis.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Malaria; Mosquito Control; Plasmodium falciparum; Plasmodium vivax; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; South Africa; Sulfadoxine | 1984 |
Practical therapeutics malaria chemoprophylaxis.
Topics: Adult; Africa, Eastern; Aminoquinolines; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Sulfadoxine | 1984 |
[Drug resistance in malaria].
Topics: Africa; Amodiaquine; Animals; Asia; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; South America; Sulfanilamides | 1980 |
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; Clinical Trials as Topic; Dogs; Drug Therapy, Combination; Erythrocytes; Female; Humans; Lethal Dose 50; Macaca mulatta; Malaria; Male; Mefloquine; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Primaquine; Proguanil; Protein Conformation; Pyrimethamine; Quinolines; Rats; Stereoisomerism; Swine | 1981 |
[Malaria and drug resistance].
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria; Microbial Sensitivity Tests; Plasmodium; Proguanil; Pyrimethamine | 1996 |
Drug interactions with antimalarial agents.
Topics: Antimalarials; Dapsone; Drug Interactions; Humans; Malaria; Proguanil; Pyrimethamine; Quinolines; Sulfadoxine; Tetracycline | 1999 |
Studies on anti-folate antimalarials in east Africa.
Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 1999 |
The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Antimetabolites; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 2003 |
[EXTRAMALARIAL THERAPUETIC APPLICATIONS OF ANTIMALARIAL DRUGS. 1. CLINICAL UTILIZATIONS].
Topics: Amodiaquine; Antimalarials; Chloroquine; Collagen Diseases; Dermatology; Drug Utilization; Epilepsy; Female; Heart Diseases; Hematology; Humans; Hydroxychloroquine; Hypersensitivity; Multiple Sclerosis; Muscular Diseases; Neurology; Parasitic Diseases; Pharmacology; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Toxicology; Uterus | 1963 |
Malaria: uncomplicated, caused by Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Proguanil; Pyrimethamine; Sesquiterpenes; Sulfadoxine | 2005 |
Azithromycin for treating uncomplicated malaria.
Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Atovaquone; Azithromycin; Chloroquine; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Proguanil; Pyrimethamine; Randomized Controlled Trials as Topic; Sulfadoxine; Treatment Failure | 2011 |
Pharmacokinetics of antimalarials in pregnancy: a systematic review.
Topics: Anti-Bacterial Agents; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Sulfadoxine | 2011 |
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine | 2020 |
32 trial(s) available for pyrimethamine and proguanil
| Article | Year |
|---|---|
Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border.
Topics: Blood Cells; Cambodia; Dapsone; Doxycycline; Drug Therapy, Combination; Drug Tolerance; Glucosephosphate Dehydrogenase Deficiency; Humans; Leukocyte Count; Malaria, Falciparum; Malaria, Vivax; Male; Military Personnel; Patient Compliance; Proguanil; Pyrimethamine; Thailand | 1992 |
Proguanil/sulfamethoxazole malaria chemoprophy-laxis on the Thai-Cambodian border.
Topics: Adult; Animals; Cambodia; Dapsone; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Male; Military Personnel; Patient Compliance; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfamethoxazole; Thailand | 1991 |
Comparison of chloroquine, pyrimethamine and sulfadoxine, and chlorproguanil and dapsone as treatment for falciparum malaria in pregnant and non-pregnant women, Kakamega District, Kenya.
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Dapsone; Drug Therapy, Combination; Female; Humans; Malaria; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Prospective Studies; Pyrimethamine; Sulfadoxine | 1990 |
The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children.
Topics: Antimalarials; Child, Preschool; Dapsone; Drug Combinations; Erythrocyte Indices; Erythrocytes; Folic Acid; Gambia; Hematocrit; Humans; Infant; Leukocyte Count; Placebos; Proguanil; Pyrimethamine | 1988 |
Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya.
Topics: Adolescent; Child; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; In Vitro Techniques; Kenya; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Random Allocation; Sulfadoxine | 1987 |
Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine.
Topics: Adult; Animals; Chloroquine; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Proguanil; Prospective Studies; Pyrimethamine; Random Allocation; Sulfadoxine; Sulfanilamides; Travel | 1988 |
Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil.
Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1987 |
Monthly antimalarial chemotherapy to children in a holoendemic area of Liberia.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Hematocrit; Humans; Immunoglobulin G; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Spleen; Time Factors | 1986 |
Prophylactic and sporontocidal treatment of chloroquine resistant Plasmodium falciparum from Malaya.
Topics: Adult; Amodiaquine; Anopheles; Antimalarials; Blood; Chloroquine; Clinical Trials as Topic; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Male; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine | 1970 |
Characterization of a drug resistant strain of Plasmodium falciparum from the Philippines.
Topics: Adult; Anopheles; Chloroquine; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; Malaria; Male; Philippines; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine | 1971 |
Prophylactic and sporontocidal treatment of chloroquine-resistant Plasmodium falciparum from Vietnam.
Topics: Adult; Antimalarials; Chloroquine; Clinical Trials as Topic; Dapsone; Humans; Malaria; Male; Methemoglobin; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine; Sulfonamides; United States; Vietnam | 1971 |
The present status of malaria chemotherapy: mefloquine, a novel antimalarial.
Topics: Amodiaquine; Animals; Antimalarials; Aotus trivirgatus; Chemical Phenomena; Chemistry; Chloroquine; Clinical Trials as Topic; Dogs; Drug Therapy, Combination; Erythrocytes; Female; Humans; Lethal Dose 50; Macaca mulatta; Malaria; Male; Mefloquine; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Primaquine; Proguanil; Protein Conformation; Pyrimethamine; Quinolines; Rats; Stereoisomerism; Swine | 1981 |
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria.
Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine | 1997 |
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.
Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Genes, Protozoan; Genetic Variation; Genotype; Humans; Isoleucine; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sulfadoxine | 1998 |
Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines.
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Malaria, Falciparum; Naphthoquinones; Philippines; Proguanil; Pyrimethamine; Sulfadoxine | 1999 |
Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute falciparum malaria in Zambia.
Topics: Adolescent; Adult; Animals; Blood Cells; Blood Chemical Analysis; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Polypharmacy; Proguanil; Pyrimethamine; Sulfadoxine; Zambia | 1999 |
Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Middle Aged; Naphthoquinones; Peru; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2001 |
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind Method; Drug Combinations; Drug Resistance, Bacterial; Humans; Infant; Malaria, Falciparum; Mutation; Proguanil; Prospective Studies; Pyrimethamine; Sensitivity and Specificity; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure | 2002 |
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.
Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; Drug Therapy, Combination; Female; Hemoglobinometry; Humans; Infant; Kenya; Malaria, Falciparum; Malawi; Male; Proguanil; Pyrimethamine; Recurrence; Retreatment; Sulfadoxine; Survival Rate | 2002 |
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.
Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Methemoglobin; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2004 |
Folic acid treatment of Zambian children with moderate to severe malaria anemia.
Topics: Anemia; Animals; Antimalarials; Atovaquone; Child; Child, Preschool; Drug Combinations; Folic Acid; Hematinics; Humans; Infant; Malaria, Falciparum; Naphthoquinones; Parasitemia; Population Density; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Failure; Zambia | 2006 |
A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children.
Topics: Anemia; Antimalarials; Atovaquone; Child; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Humans; Infant; Malaria, Falciparum; Male; Parasitemia; Prevalence; Proguanil; Pyrimethamine; Sulfadoxine; Time Factors; Treatment Failure; Zambia | 2006 |
Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial.
Topics: Adolescent; Adult; Afghanistan; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance; Female; Folic Acid Antagonists; Humans; Malaria, Vivax; Male; Middle Aged; Pakistan; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2007 |
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Oxidants; Polymorphism, Genetic; Proguanil; Pyrimethamine; Sulfadoxine | 2008 |
Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.
Topics: Animals; Antimalarials; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Nigeria; Parasitemia; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2009 |
Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.
Topics: Adult; Amodiaquine; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Young Adult | 2009 |
Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
Topics: Adolescent; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Child, Preschool; Dapsone; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Infant; Malaria; Malawi; Male; Medication Adherence; Plasma; Proguanil; Pyrimethamine; Sulfadoxine; Surveys and Questionnaires; Treatment Outcome; Young Adult | 2009 |
Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Topics: Antimalarials; Dapsone; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Resistance; Female; Follow-Up Studies; Half-Life; Humans; Immunization Schedule; Incidence; Infant; Infant Mortality; Logistic Models; Malaria, Falciparum; Male; Mefloquine; Multivariate Analysis; Proguanil; Pyrimethamine; Safety; Sulfadoxine; Tanzania; Treatment Outcome | 2009 |
Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants.
Topics: Antimalarials; Dapsone; Drug Administration Schedule; Drug Combinations; Drug Resistance; Humans; Immunization Schedule; Infant; Infant, Newborn; Malaria; Mefloquine; Pediatrics; Placebos; Proguanil; Pyrimethamine; Research Design; Sulfadoxine; Tanzania; Time Factors; Treatment Outcome | 2010 |
Intermittent preventive treatment in infants for the prevention of malaria in rural Western kenya: a randomized, double-blind placebo-controlled trial.
Topics: Anemia; Antimalarials; Artemisinins; Artesunate; Dapsone; Double-Blind Method; Drug Combinations; Humans; Incidence; Infant; Kenya; Malaria; Premedication; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome | 2010 |
Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants.
Topics: Antimalarials; Cohort Studies; Dapsone; Double-Blind Method; Drug Combinations; Female; Genotype; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemolysis; Humans; Infant; Logistic Models; Malaria; Male; Mefloquine; Multivariate Analysis; Odds Ratio; Poisson Distribution; Polymorphism, Single Nucleotide; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania | 2015 |
Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial.
Topics: Amodiaquine; Anemia, Sickle Cell; Antimalarials; Artemisinins; Chemoprevention; Child; Child, Preschool; Drug Combinations; Female; Humans; Hydroxyurea; Infant; Kenya; Malaria; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine | 2022 |
185 other study(ies) available for pyrimethamine and proguanil
| Article | Year |
|---|---|
In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.
Topics: Animals; Antimalarials; Biguanides; Chromatography, Liquid; Drug Resistance; Folic Acid Antagonists; Humans; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Triazines | 2005 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies.
Topics: Absorption, Physicochemical; Animals; Biguanides; Chemistry Techniques, Synthetic; Computer Simulation; Drug Design; Humans; Mice; Molecular Docking Simulation; Protein Conformation; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2017 |
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus.
Topics: Antiviral Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Influenza A Virus, H1N1 Subtype; Influenza B virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Proguanil; Respiratory Syncytial Viruses; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |
Experimental studies of the potentiation of proguanil and pyrimethamine by dapsone using Plasmodium berghei in white mice.
Topics: Animals; Chloroquine; Dapsone; Drug Synergism; Mice; Plasmodium berghei; Proguanil; Pyrimethamine | 1977 |
Which prophylactic drugs for malaria?
Topics: Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Proguanil; Pyrimethamine | 1979 |
Trimethoprim-resistant bacteria: cross-resistance patterns.
Topics: Aspartic Acid; Bacteria; Bacterial Infections; Cross Reactions; Drug Resistance, Microbial; Humans; Methotrexate; Proguanil; Pyrimethamine; R Factors; Species Specificity; Trimethoprim; Urine | 1977 |
Chemoprophylaxis of malaria.
Topics: Chloroquine; Drug Evaluation; Drug Resistance, Microbial; Malaria; Proguanil; Pyrimethamine | 1977 |
Chloroquine-resistant falciparum malaria from Irian Jaya (Indonesian New Guinea).
Topics: Amodiaquine; Chloroquine; Drug Resistance; Humans; Malaria; Male; Piperidines; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Quinolines | 1976 |
Chemoprophylaxis of malaria.
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Travel | 1976 |
[Chemoprophylaxis of malaria].
Topics: Africa; Asia; Chloroquine; Humans; Hungary; Malaria; Proguanil; Pyrimethamine; South America | 1976 |
A case of recurrent subacute disseminated intravascular coagulation associated with malarial prophylaxis.
Topics: Anemia, Hemolytic; Autopsy; Disseminated Intravascular Coagulation; Heparin; Humans; Malaria; Male; Middle Aged; Proguanil; Pyrimethamine; Recurrence | 1975 |
Plasmodium falciparum: rapid detection of dihydrofolate reductase mutations that confer resistance to cycloguanil and pyrimethamine.
Topics: Animals; Base Sequence; Drug Resistance; Molecular Sequence Data; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 1992 |
In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1990 |
Malaria prophylaxis in travellers to tropical Africa.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Travel | 1990 |
Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA; Drug Resistance; Genes; Molecular Sequence Data; Oligonucleotide Probes; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines | 1990 |
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
Topics: Amino Acid Sequence; Animals; Binding Sites; DNA; Drug Resistance; Humans; Malaria; Models, Structural; Molecular Structure; Mutation; Plasmodium falciparum; Proguanil; Protein Conformation; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 1990 |
Malaria chemoprophylaxis with a proguanil-chloroquine-maloprim combination in Papua New Guinea.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Military Personnel; Papua New Guinea; Plasmodium falciparum; Plasmodium vivax; Proguanil; Pyrimethamine | 1988 |
Agranulocytosis associated with the use of amodiaquine for malaria prophylaxis.
Topics: Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguanil; Pyrimethamine; Sulfadoxine; Travel | 1986 |
Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Leishmania tropica; Proguanil; Pyrimethamine; Pyrimidines; Triazines; Trimethoprim | 1988 |
Observations on early and late post-sporozoite tissue stages in primate malaria. V. The effect of pyrimethamine and proguanil upon tissue hypnozoites and schizonts of Plasmodium cynomolgi bastianellii.
Topics: Animals; Liver; Macaca mulatta; Malaria; Plasmodium; Proguanil; Pyrimethamine | 1988 |
Analogues of N-benzyloxydihydrotriazines: in vitro antimalarial activity against Plasmodium falciparum.
Topics: Antimalarials; Chloroquine; Drug Resistance, Microbial; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1986 |
Response of Plasmodium falciparum to dihydrofolate reductase inhibitors in Malindi, Kenya.
Topics: Child; Drug Resistance, Microbial; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Kenya; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Sulfanilamides; Triazines | 1986 |
The interaction of the naphthoquinone derivative menoctone and dihydrofolate reductase inhibitors on Plasmodium falciparum in vitro.
Topics: Animals; Antiprotozoal Agents; Drug Interactions; Folic Acid Antagonists; Hypoxanthines; Naphthoquinones; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1986 |
Effect of oral proguanil on human lymphocyte proliferation.
Topics: Adult; Humans; Leukocyte Count; Leukocytes; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Proguanil; Pyrimethamine; Thymidine; Time Factors; Triazines | 1986 |
Simultaneous measurement of proguanil and cycloguanil in human plasma by high-performance liquid chromatography.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Proguanil; Pyrimethamine; Spectrophotometry, Ultraviolet; Triazines | 1986 |
Evaluation of sporontocidal compounds using Plasmodium falciparum gametocytes produced in vitro.
Topics: Anopheles; Antimalarials; Drug Resistance, Microbial; Humans; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Triazines | 1985 |
Malaria prophylaxis for Canadian travellers.
Topics: Amodiaquine; Canada; Chloroquine; Dapsone; Doxycycline; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Infant; Infant, Newborn; Malaria; Plasmodium; Plasmodium falciparum; Pregnancy; Premedication; Proguanil; Pyrimethamine; Quinine; Sulfadoxine; Travel | 1985 |
[Studies on the chemoresistance of Plasmodium falciparum in Africa: current data].
Topics: Africa; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Mefloquine; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinolines | 1985 |
In vitro studies on the sensitivities of Plasmodium falciparum in Thailand to pyrimethamine and proguanil.
Topics: Animals; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Parasitology; Plasmodium falciparum; Proguanil; Pyrimethamine; Thailand | 1985 |
In vitro sensitivity of Plasmodium falciparum to chlorcycloguanil in The Gambia.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Gambia; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1985 |
Drug-resistant malaria--changing patterns mean difficult decisions.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Humans; Infant; Kenya; Malaria; Microbial Sensitivity Tests; Plasmodium; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Sulfadoxine | 1985 |
[Malaria chemoprophylaxis. Resistance problems].
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Combinations; Drug Resistance, Microbial; Humans; Infant; Malaria; Mefloquine; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine | 1985 |
A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii.
Topics: Animals; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Malaria; Male; Mice; Plasmodium; Proguanil; Pyrimethamine; Triazines | 1985 |
Drug-resistant malaria.
Topics: Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Quinine; Sulfonamides | 1969 |
Response to treatment in man of multi-drug resistant Plasmodium falciparum from Panama.
Topics: Adult; Amodiaquine; Animals; Anopheles; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; Haplorhini; Humans; Malaria; Male; Panama; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Recurrence; Sulfadiazine | 1974 |
Characterization of a drug resistant strain of Plasmodium falciparum from Burma.
Topics: Adult; Amodiaquine; Anopheles; Chloroquine; Drug Resistance, Microbial; Human Experimentation; Humans; Insect Vectors; Malaria; Male; Myanmar; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine | 1973 |
Gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. II. Action of the folic reductase inhibitors, chlorguanide, and pyrimethamine against Plasmodium cynomolgi.
Topics: Administration, Oral; Animals; Anopheles; Blood; Feeding Behavior; Folic Acid Antagonists; Macaca mulatta; Malaria; Plasmodium; Proguanil; Pyrimethamine; Salivary Glands; Time Factors | 1974 |
[Prevention of malaria].
Topics: Antimalarials; Chloroquine; Humans; Malaria; Proguanil; Pyrimethamine; World Health Organization | 1974 |
[Treatment of malaria].
Topics: Adolescent; Amodiaquine; Child; Child, Preschool; Humans; Infant; Malaria; Plasmodium; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Premedication; Proguanil; Pyrimethamine | 1972 |
The chemotherapy of rodent malaria. 18. The action of some sulphonamides alone or with folic reductase inhibitors against malaria vectors and parasites. 5. The blood schizontocidal action of some newer sulphonamides.
Topics: Animals; Drug Resistance, Microbial; Drug Synergism; Folic Acid Antagonists; Malaria; Mice; Plasmodium berghei; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfonamides | 1973 |
Multidrug-resistant strain of Plasmodium falciparum from eastern Colombia.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Colombia; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfadiazine | 1974 |
Editorial: Drugs for prevention of malaria.
Topics: Antimalarials; Drug Resistance, Microbial; Drug Synergism; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine | 1974 |
Some pharmacological aspects of antimalarial drugs.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfonamides; Trimethoprim | 1974 |
Studies on the characterization of plasmodium vivax strains from Central America.
Topics: Animals; Central America; Chloroquine; Haplorhini; Humans; Lincomycin; Malaria; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinine; Recurrence; Time Factors | 1972 |
Chemotherapy and chemoprophylaxis of experimental toxoplasmosis.
Topics: Acute Disease; Animals; Brain; Chronic Disease; Drug Combinations; Mice; Proguanil; Pyrimethamine; Pyrimidines; Sulfadiazine; Sulfonamides; Sulfones; Toxoplasma; Toxoplasmosis | 1972 |
Effects of pyrimethamine, chlorguanide, and primaquine against exoerythrocytic forms of a strain of chloroquine-resistant Plasmodium falciparum from Thailand.
Topics: Adult; Chloroquine; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Thailand | 1967 |
Antimalarial effects of sulphormethoxine, diaphenylsulphone and separate combinations of these with pyrimethamine: a review of preliminary investigations carried out in Tanzania.
Topics: Adolescent; Adult; Antimalarials; Child; Chloroquine; Dapsone; Drug Hypersensitivity; Drug Resistance, Microbial; Female; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Sulfonamides; Tanzania | 1968 |
The sporogonous of Plasmodium vivax in Anopheles mosquitoes as a system for evaluating the prophylactic and curative capabilities of potential antimalarial compounds.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Malaria; Naphthoquinones; Oxytetracycline; Penicillin G; Plasmodium vivax; Primaquine; Proguanil; Pyridines; Pyrimethamine; Quinacrine; Quinine; Quinolines; Sulfadiazine; Thiosemicarbazones | 1968 |
Studies on the chemotherapy of malaria. II. Pyrimethamine resistance in The Gambia.
Topics: Carrier State; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Erythrocytes; Female; Gambia; Humans; Infant; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfonamides | 1970 |
Action of some antimalaria compounds against Plasmodium berghei in vitro.
Topics: Animals; Antimalarials; Chloroquine; Haplorhini; Leucine; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinine; Triazines; Tritium | 1971 |
Confirmation of collateal sensitivity to pyrimethamine in Lactobacillus casei ATCC 7469 resistant to chlorguanide triazine.
Topics: Drug Resistance, Microbial; Folic Acid Antagonists; Lacticaseibacillus casei; Lactobacillus; Microbial Sensitivity Tests; Proguanil; Pyrimethamine; Triazines | 1971 |
Exotic holidays and malaria.
Topics: Holidays; Humans; Malaria; Proguanil; Protective Clothing; Pyrimethamine | 1972 |
Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.
Topics: Chromatography, Gel; Drug Resistance, Microbial; Folic Acid Antagonists; Genetics, Microbial; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Methyltransferases; Mutation; Proguanil; Pyrimethamine; Streptococcus; Tetrahydrofolate Dehydrogenase; Thymine Nucleotides; Triazines; Trimethoprim; Uracil Nucleotides | 1972 |
The role of drugs in a malaria program.
Topics: Amodiaquine; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Humans; Malaria; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Recurrence; Sulfonamides; Sulfones; Trimethoprim | 1972 |
The chemotherapy of rodent malaria. XIV. The action of some sulphonamides alone or with folic reductase inhibitors against malaria vectors and parasites. 4. The response of normal and drug-resistant strains of Plasmodium berghei.
Topics: Animals; Chloroquine; Drug Resistance, Microbial; Folic Acid Antagonists; Malaria; Male; Mice; Primaquine; Proguanil; Pyrimethamine; Pyrimidines; Sulfadimethoxine; Sulfonamides | 1971 |
Resistance to cycloguanil pamoate (CI-501) by falciparum malaria in West Pakistan.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Malaria; Male; Pakistan; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Quinine | 1965 |
Drug sensitivity of exo-erythrocytic stages in pyrimethamine-resistant Plasmodium berghei.
Topics: Animals; Antimalarials; Drug Resistance, Microbial; Malaria; Male; Mice; Microbial Sensitivity Tests; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Sulfadiazine; Triazines | 1970 |
The chemotherapy of rodent malaria. IX. Causal prophylaxis. I. A method for demonstrating drug action on exo-erythrocytic stages.
Topics: Animals; Antimalarials; Chloroquine; Dapsone; Malaria; Male; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Quinine; Sulfadiazine; Triazines | 1970 |
The action of sulphonamide-folic reductase inhibitor combinations against normal and drug-resistant strains of rodent malaria.
Topics: Animals; Folic Acid Antagonists; Malaria; Mice; Proguanil; Pyrimethamine; Pyrimidines; Sulfadimethoxine; Sulfonamides | 1971 |
[Prophylaxis versus suppression of malaria].
Topics: Chloroquine; Humans; Malaria; Proguanil; Pyrimethamine | 1967 |
[Further development of the Roehl test for testing antimalarial agents on Plasmodium cathemerium in the canary by intravenous administration].
Topics: Animals; Animals, Laboratory; Antimalarials; Canaries; Chloroquine; Injections, Intravenous; Malaria, Avian; Methods; Primaquine; Proguanil; Pyrimethamine; Quinine; Sulfadiazine; Sulfanilamides; Sulfonamides | 1967 |
Chemotherapy of malaria.
Topics: Drug Resistance, Microbial; Humans; Malaria; Proguanil; Pyrimethamine; Quinolines | 1968 |
Malaria--the British point of view.
Topics: Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Malaysia; Military Medicine; Proguanil; Pyrimethamine; Sulfadimethoxine; United Kingdom | 1969 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.
Topics: Amodiaquine; Animals; Chloroquine; Dapsone; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Quinacrine; Sulfadiazine; Triazines | 1965 |
Drug resistance in Plasmodium berghei Vincke and Lips, 1948. II. Triazine resistance.
Topics: Animals; Dapsone; In Vitro Techniques; Malaria; Mice; Plasmodium; Primaquine; Proguanil; Pyrimethamine; Sulfadiazine; Triazines | 1965 |
[Relationship between the teratogenic effect and the chemical structure of drugs. Experiments with chloridine and bigumal].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetus; Pregnancy; Proguanil; Pyrimethamine; Rats | 1966 |
Chemoprophylaxis of malaria in non-immune residents in Dar es Salaam, Tanzania.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Chloroquine; Dapsone; Drug Administration Schedule; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Infant; Malaria; Male; Middle Aged; Patient Compliance; Plasmodium falciparum; Proguanil; Pyrimethamine; Retrospective Studies; Sulfadoxine; Tanzania | 1984 |
Concomitant resistance to pyrimethamine and cycloguanil of chloroquine-resistant falciparum malaria from East Africa: an in vitro study of 12 isolates.
Topics: Africa, Eastern; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1984 |
The response of Plasmodium vivax to antifols.
Topics: Humans; Malaria; Plasmodium vivax; Proguanil; Pyrimethamine | 1984 |
In vitro antimalarial activity of tetrahydrofolate dehydrogenase inhibitors.
Topics: Animals; Culture Media; Folic Acid Antagonists; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1984 |
The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.
Topics: Animals; Biguanides; Chloroquine; Microbial Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1984 |
Activities of respository preparations of cycloguanil pamoate and 4,4'-diacetyldiaminodiphenylsulfone, alone and in combination, against infections with Plasmodium cynomolgi in rhesus monkeys.
Topics: Acedapsone; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance, Microbial; Macaca mulatta; Malaria; Particle Size; Plasmodium falciparum; Plasmodium vivax; Proguanil; Pyrimethamine; Time Factors; Triazines | 1984 |
Malaria prophylaxis for long term visitors.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguanil; Pyrimethamine; Sulfonamides; Sulfones; Time Factors; Travel | 1983 |
Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.
Topics: Antimalarials; Chemotaxis, Leukocyte; Chloroquine; Drug Combinations; Humans; Neutrophils; Proguanil; Pyrimethamine; Quinine; Sulfadoxine; Tetracycline; Triazines | 1983 |
Chemoprophylaxis in malaria.
Topics: Chloroquine; Drug Resistance, Microbial; Female; Humans; Malaria; Plasmodium falciparum; Pregnancy; Proguanil; Pyrimethamine | 1980 |
Plasmodium falciparum resistance to pyrimethamine and chlorproguanil -- host or parasite dependent?
Topics: Child; Child, Preschool; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine | 1980 |
Sustained-release implants in the chemotherapy of experimental rodent malaria I. A comparison of the effects of some antimalarials in polydimethylsiloxane matrices.
Topics: Animals; Antimalarials; Chloroquine; Dimethylpolysiloxanes; Drug Implants; Malaria; Male; Mefloquine; Mice; Mice, Inbred Strains; Naphthoquinones; Piperidines; Plasmodium berghei; Primaquine; Proguanil; Pyrimethamine; Quinolines; Silicone Elastomers; Sulfadiazine; Triazines | 1981 |
Sustained-release implants in the chemotherapy of experimental rodent malaria II. The effects of sulphadiazine, pyrimethamine and cycloguanil in biodegradable polymer matrices.
Topics: Animals; Biodegradation, Environmental; Drug Implants; Malaria; Male; Mice; Mice, Inbred Strains; Plasmodium berghei; Proguanil; Pyrimethamine; Sulfadiazine; Triazines | 1981 |
The management and treatment of malaria (a personal view).
Topics: Chloroquine; Female; Humans; Malaria; Male; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine | 1980 |
Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa.
Topics: Animals; Base Sequence; Child; DNA Primers; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Molecular Sequence Data; Parasitemia; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sensitivity and Specificity; Templates, Genetic; Tetrahydrofolate Dehydrogenase | 1995 |
Malaria prophylaxis: guidelines for travellers from Britain. Malaria Reference Laboratory of the Public Health Laboratory Service, London.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Culicidae; Dapsone; Doxycycline; Drug Administration Schedule; Drug Combinations; Humans; Infant; Infant, Newborn; Insect Bites and Stings; Malaria; Mefloquine; Proguanil; Pyrimethamine; Risk Factors; Travel | 1995 |
Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Base Sequence; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines | 1995 |
Plasmodium falciparum: detection of antifolate resistance by mutation-specific restriction enzyme digestion.
Topics: Animals; Base Sequence; Codon; DNA Primers; Drug Resistance; Genes, Protozoan; Humans; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Restriction Mapping; Tetrahydrofolate Dehydrogenase; Triazines | 1995 |
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.
Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Trials as Topic; Dapsone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Naphthoquinones; Pentamidine; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1994 |
In vitro susceptibility of Cambodian isolates of Plasmodium falciparum to halofantrine, pyronaridine and artemisinin derivatives.
Topics: Adult; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Mefloquine; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Triazines | 1994 |
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa.
Topics: Adult; Antimalarials; Chloroquine; Female; Humans; Kenya; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Proguanil; Pyrimethamine; Sulfadoxine; Travel | 1993 |
In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Triazines | 1994 |
Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates.
Topics: Alleles; Animals; Antimalarials; Blotting, Southern; Cambodia; Chloroquine; Codon; DNA Fingerprinting; DNA, Protozoan; Drug Resistance, Multiple; Folic Acid Antagonists; Genes, Protozoan; Genetic Variation; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Proguanil; Pyrimethamine; Triazines | 1996 |
Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea.
Topics: Animals; Antimalarials; Base Sequence; Dihydropteroate Synthase; DNA Primers; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Triazines | 1996 |
In vitro selection of Plasmodium falciparum lines resistant to dihydrofolate-reductase inhibitors and cross resistance studies.
Topics: Animals; Clone Cells; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1996 |
Use of a semi-nested PCR diagnosis test to evaluate antifolate resistance of Plasmodium falciparum isolates.
Topics: Animals; Antimalarials; Base Sequence; Codon; DNA Mutational Analysis; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Protozoan Proteins; Pyrimethamine; Sensitivity and Specificity; Tetrahydrofolate Dehydrogenase | 1995 |
Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model.
Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Immunosuppression Therapy; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Rats, Wistar; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim | 1996 |
Plasmodium falciparum: mutation pattern in the dihydrofolate reductase-thymidylate synthase genes of Vietnamese isolates, a novel mutation, and coexistence of two clones in a Thai patient.
Topics: Animals; Antimalarials; Base Sequence; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thailand; Thymidylate Synthase; Triazines; Vietnam | 1996 |
Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance.
Topics: Adolescent; Adult; Africa; Animals; Antimalarials; Cross-Sectional Studies; Drug Combinations; Drug Resistance, Microbial; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Prevalence; Proguanil; Pyrimethamine; Rural Population; Sequence Analysis, DNA; Sulfadoxine | 1996 |
Susceptibility studies of Plasmodium falciparum isolates and clones against cycloguanil and pyrimethamine using the modified in vitro microtechnique.
Topics: Animals; Antimalarials; Clone Cells; Drug Resistance; Folic Acid Antagonists; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 1996 |
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
Topics: Animals; Antimalarials; Biological Evolution; Drug Resistance; Folic Acid Antagonists; Models, Genetic; Mutagenesis, Site-Directed; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 1997 |
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone.
Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Infant; Malaria, Falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania | 1997 |
Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture.
Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Folic Acid; Humans; Leucovorin; Naphthoquinones; Plasmodium falciparum; Proguanil; Purine Nucleotides; Pyrimethamine; Pyrimidine Nucleotides; Triazines | 1997 |
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
Topics: Animals; Antimalarials; Confidence Intervals; Drug Resistance; Folic Acid Antagonists; Humans; Lethal Dose 50; Malaria, Falciparum; Nonlinear Dynamics; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1997 |
Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant.
Topics: Animals; Asparagine; Drug Resistance; Folic Acid Antagonists; Genes, Protozoan; Genes, Synthetic; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Triazines | 1997 |
Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.
Topics: Animals; Antimalarials; Humans; Kenya; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Proguanil; Protozoan Proteins; Pyrimethamine; Sensitivity and Specificity; Tetrahydrofolate Dehydrogenase; Triazines | 1998 |
A biochemical and genetic model for parasite resistance to antifolates. Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in Plasmodium falciparum.
Topics: Alleles; Animals; Binding Sites; Drug Resistance; Escherichia coli; Folic Acid; Folic Acid Antagonists; Genetic Complementation Test; Kinetics; Models, Genetic; Models, Molecular; Mutagenesis, Site-Directed; NAD; Plasmodium falciparum; Proguanil; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Toxoplasma; Triazines | 1998 |
[Chemoprophylaxis of malaria in travelers to endemic zones].
Topics: Antimalarials; Chloroquine; Dapsone; Doxycycline; Drug Resistance; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Proguanil; Pyrimethamine; Travel | 1998 |
Use of antimalarial drugs in Mali: policy versus reality.
Topics: Adolescent; Adult; Antimalarials; Chloroquine; Consumer Behavior; Data Collection; Drug Combinations; Drug Utilization; Female; Health Knowledge, Attitudes, Practice; Humans; Interviews as Topic; Malaria; Male; Mali; Medicine, Traditional; Middle Aged; Proguanil; Pyrimethamine; Quinine; Rural Population; Suburban Population; Sulfadoxine | 1998 |
Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Adverse Drug Reaction Reporting Systems; Antimalarials; Chloroquine; Databases, Factual; Drug Combinations; Drug Industry; Female; Humans; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Trimester, First; Proguanil; Prospective Studies; Pyrimethamine; Risk Factors; Safety; Sulfadoxine; Surveys and Questionnaires | 1998 |
Adverse effects of antimalarial prophylactic drugs: an important consideration in the risk-benefit equation.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Atovaquone; Azithromycin; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Naphthoquinones; Plasmodium falciparum; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Risk Assessment | 1998 |
[The proper use of antimalarial drugs currently available].
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Contraindications; Drug Combinations; Drug Resistance; Endemic Diseases; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Phenanthrenes; Plasmodium; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Quinine; Sulfadoxine; Travel | 1998 |
Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.
Topics: Alleles; Animals; Antimalarials; DNA Primers; DNA Restriction Enzymes; DNA, Protozoan; Humans; Inhibitory Concentration 50; Kenya; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase; Triazines | 1999 |
Atovaquone-proguanil for falciparum malaria in the Philippines.
Topics: Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Naphthoquinones; Philippines; Proguanil; Pyrimethamine; Sulfadoxine | 2000 |
Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro.
Topics: Amsacrine; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Enzyme Inhibitors; Etoposide; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Naphthyridines; Norfloxacin; Nucleic Acid Synthesis Inhibitors; Plasmodium falciparum; Primaquine; Proguanil; Pyrimethamine; Thailand; Topoisomerase II Inhibitors; Triazines | 2000 |
Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates.
Topics: Amodiaquine; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antimalarials; Artemether; Artemisinins; Chloroquine; Doxycycline; Drug Resistance; Erythrocytes; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Scintillation Counting; Senegal; Sesquiterpenes; Statistics, Nonparametric; Triazines | 2000 |
Molecular epidemiology of malaria in Yaounde, Cameroon. VI. Sequence variations in the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene and in vitro resistance to pyrimethamine and cycloguanil.
Topics: Animals; Antimalarials; Cameroon; DNA Primers; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Triazines | 2000 |
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.
Topics: Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Peptide Synthases; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 2000 |
Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance.
Topics: Amino Acid Sequence; Drug Resistance; Folic Acid Antagonists; Models, Molecular; Molecular Sequence Data; Molecular Structure; Proguanil; Pyrimethamine; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Triazines | 2000 |
Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone.
Topics: Animals; Antimalarials; DNA, Protozoan; Drug Resistance; Genome, Protozoan; Humans; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Restriction Fragment Length; Proguanil; Pyrimethamine; Sulfadoxine; Time Factors; Triazines | 2001 |
Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance.
Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Liver; Malaria; Models, Biological; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2001 |
Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210.
Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Drug Resistance; Genes, Protozoan; Inhibitory Concentration 50; Models, Molecular; Molecular Sequence Data; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Protein Conformation; Pyrimethamine; Saccharomyces cerevisiae; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Triazines | 2001 |
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania | 2001 |
Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.
Topics: Animals; Chickens; Drug Resistance; Folic Acid Antagonists; Humans; Liver; Malaria, Falciparum; Models, Chemical; Models, Genetic; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Triazines | 2002 |
Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.
Topics: Alleles; Amino Acid Sequence; Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Inhibitory Concentration 50; Malaria; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Plasmodium vivax; Point Mutation; Proguanil; Pyrimethamine; Recombinant Proteins; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase; Triazines | 2002 |
[Blackwater fever].
Topics: Adolescent; Adult; Aged; Antimalarials; Atovaquone; Blackwater Fever; Critical Care; Diagnosis, Differential; Drug Combinations; Humans; Mefloquine; Middle Aged; Naphthoquinones; Phenanthrenes; Prognosis; Proguanil; Pyrimethamine; Quinine; Sulfadoxine | 2002 |
Massive hepatosplenomegaly in a child with malaria.
Topics: Age Factors; Animals; Antimalarials; Child; Drug Combinations; Drug Therapy, Combination; Female; Ghana; Hepatomegaly; Humans; Liver; Malaria, Falciparum; Proguanil; Pyrimethamine; Quinine; Spleen; Splenomegaly; Sulfadoxine; Time Factors; Travel | 2002 |
[Gene point mutation in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum].
Topics: Animals; Drug Resistance; Multienzyme Complexes; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines | 2001 |
In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar.
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Madagascar; Malaria, Falciparum; Mefloquine; Parasitemia; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Triazines | 2002 |
Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure.
Topics: Animals; Drug Resistance; Folic Acid Antagonists; Plasmodium vivax; Point Mutation; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2003 |
Malaria in Austria 1990-2000.
Topics: Adolescent; Adult; Age Distribution; Animals; Austria; Chemoprevention; Child; Child, Preschool; Chloroquine; Disease Notification; Drug Combinations; Female; Humans; Infant; Infant, Newborn; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Patient Compliance; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Sex Distribution; Sulfadoxine | 2003 |
DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy.
Topics: Animals; Antimalarials; Dihydropteroate Synthase; DNA, Protozoan; Gabon; Genotype; Humans; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Triazines | 2003 |
New malaria drug to be unveiled in Africa.
Topics: Africa; Antimalarials; Dapsone; Drug Combinations; Drug Costs; Drug Industry; Drug Utilization; Humans; Proguanil; Pyrimethamine; Sulfadoxine | 2003 |
Experiment to determine if a proguanil-resistant strain of P. falciparum would respond to large doses of pyrimethamine.
Topics: Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Pyrimidines | 1953 |
Susceptibility of blood-induced P. cynomolgi infection to pyrimethamine (daraprim), proguanil and bromoguanide.
Topics: Antimalarials; Communicable Diseases; Disease Susceptibility; Humans; Malaria; Proguanil; Pyrimethamine | 1953 |
Studies on Nuri strain of P. knowlesi. II. Therapeutic effect of pyrimethamine, proguanil and quinine.
Topics: Antimalarials; Humans; Plasmodium; Proguanil; Pyrimethamine; Quinine | 1953 |
[Malaria prevention with paludrine and daraprim in school children of São Tomé].
Topics: Antimalarials; Child; Humans; Malaria; Proguanil; Pyrimethamine | 1956 |
Field trials with chlorproguanil in the prophylaxis of malaria in Ghana.
Topics: Africa; Antimalarials; Child; Drug Resistance; Ghana; Humans; Infant; Malaria; Malaria, Falciparum; Proguanil; Pyrimethamine | 1961 |
Resistance of Plasmodium falciparum to pyrimethamine and proguanil in Netherlands New Guinea.
Topics: Antimalarials; Humans; Netherlands; New Guinea; Plasmodium falciparum; Proguanil; Pyrimethamine | 1961 |
Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria.
Topics: Animals; Antimalarials; Birds; Chloroquine; Dapsone; Malaria; Malaria, Avian; Proguanil; Pyrimethamine; Quinine | 1962 |
Oral contraceptives. VII. Antimalarials as antifertility agents.
Topics: Amodiaquine; Antimalarials; Chloroquine; Contraceptive Agents; Contraceptives, Oral; Female; Humans; Proguanil; Pyrimethamine; Quinacrine | 1962 |
DRUG RESISTANCE IN PLASMODIUM FALCIPARUM FROM THAILAND.
Topics: Amodiaquine; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Humans; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Quinine; Thailand | 1963 |
DRUG-RESISTANT FALCIPARUM MALARIA FROM CAMBODIA AND MALAYA.
Topics: Animals; Cambodia; Chloroquine; Culicidae; Drug Resistance; Drug Resistance, Microbial; Humans; Malaria; Malaria, Falciparum; Malaysia; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Quinine | 1963 |
FLUORESCENT ANTIBODY STUDIES IN HUMAN MALARIA. II. DEVELOPMENT AND PERSISTENCE OF ANTIBODIES TO PLASMODIUM FALCIPARUM.
Topics: Amodiaquine; Antibodies; Antigen-Antibody Reactions; Chloroquine; Fluorescent Antibody Technique; Humans; Immune Sera; Malaria; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinine; Vaccination | 1964 |
STUDIES ON A STRAIN OF CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM FROM THAILAND.
Topics: Amodiaquine; Antimalarials; Asia, Southeastern; Biomedical Research; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Humans; Hydroxychloroquine; Malaria; Malaria, Falciparum; Pharmacology; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Quinine; Thailand | 1964 |
DRUG-RESISTANCE IN FALCIPARUM MALARIA IN SOUTH-EAST ASIA.
Topics: Adolescent; Asia, Southeastern; Child; Chloroquine; Drug Resistance; Drug Resistance, Microbial; Drug Therapy; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinacrine; Quinine; Statistics as Topic; Toxicology | 1964 |
MALARIA IN CHILDHOOD MODERN CONCEPTS OF IMMUNITY, TREATMENT, PROPHYLAXIS.
Topics: Amodiaquine; Child; Chloroquine; Diagnosis; Drug Therapy; Epidemiology; Humans; Infant; Infant, Newborn; Malaria; Proguanil; Pyrimethamine | 1965 |
SOME FEATURES OF MALARIA IN DILI, PORTUGUESE TIMOR, DURING 1963-64.
Topics: Amodiaquine; Anemia; Chloroquine; Clinical Laboratory Techniques; Drug Therapy; Epidemiology; Humans; Indonesia; Malaria; Proguanil; Pyrimethamine; Seasons | 1965 |
The mode of action of sulphonamides, proguanil and pyrimethamine on Plasmodium gallinaceum.
Topics: Antimalarials; Humans; Malaria; Plasmodium gallinaceum; Proguanil; Pyrimethamine; Sulfadiazine | 1955 |
Diagnosis and treatment of malaria in children.
Topics: Animals; Antimalarials; Atovaquone; Child; Chloroquine; Drug Combinations; Humans; Malaria; Malaria, Falciparum; Mefloquine; Naphthoquinones; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 2003 |
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets.
Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Insecticides; Malaria, Falciparum; Mosquito Control; Mutation; Plants; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 2003 |
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
Topics: Animals; Antimalarials; Cell Line; Chlorocebus aethiops; Drug Resistance; Folic Acid Antagonists; Humans; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2004 |
Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.
Topics: Animals; Antimalarials; Atovaquone; Child, Preschool; Cytochromes b; Drug Combinations; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid Antagonists; Ghana; Humans; Infant; Malaria, Falciparum; Male; Mutation; Naphthoquinones; Plasmodium falciparum; Polymorphism, Restriction Fragment Length; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Triazines | 2004 |
Chlorproguanil-dapsone for malaria in Africa.
Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine | 2004 |
Malaria: use of restriction endonuclease digestion and mutation-specific PCR for antifolate resistance isolate detection.
Topics: Amino Acid Substitution; Animals; Antimalarials; DNA Mutational Analysis; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Mutation, Missense; Parasitemia; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proguanil; Protozoan Proteins; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 2003 |
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.
Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Protozoan; Humans; Kenya; Malaria, Falciparum; Malawi; Molecular Epidemiology; Mutation, Missense; Nigeria; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Tetrahydrofolate Dehydrogenase | 2004 |
Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.
Topics: Alleles; Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Genes, Protozoan; Mutagenesis, Site-Directed; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2005 |
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Topics: Algorithms; Animals; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Folic Acid Antagonists; Humans; Kinetics; Mass Spectrometry; Molecular Structure; Mutation; Plasmodium falciparum; Proguanil; Protein Binding; Pyrimethamine; Recombinant Proteins; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 2005 |
Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni.
Topics: Animals; Antiprotozoal Agents; Bivalvia; Eukaryota; Folic Acid; Glycine; Glyphosate; Proguanil; Pyrimethamine; Shikimic Acid | 2005 |
A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Folic Acid Antagonists; Gene Library; Genes, Reporter; Genetic Complementation Test; Green Fluorescent Proteins; Hydrophobic and Hydrophilic Interactions; Kinetics; Mutagenesis, Site-Directed; Mutation; Plasmodium falciparum; Proguanil; Protein Engineering; Protein Structure, Quaternary; Pyrimethamine; Recombinant Fusion Proteins; Solubility; Tetrahydrofolate Dehydrogenase; Triazines | 2005 |
Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi.
Topics: Animals; Antimalarials; DNA Primers; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Malawi; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 2005 |
Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.
Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Naphthoquinones; Plasmodium falciparum; Proguanil; Pyrimethamine; Shikimic Acid; Triazines | 2005 |
Susceptibility studies of Malaysian Plasmodium falciparum clones to type II antifolate drugs after 3 years of continuous in vitro culture.
Topics: Animals; Antimalarials; Clone Cells; Drug Resistance; Folic Acid Antagonists; In Vitro Techniques; Malaysia; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 2005 |
Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs.
Topics: Amino Acid Sequence; Animals; Antimalarials; Asia, Southeastern; China; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Melanesia; Molecular Sequence Data; Plasmodium vivax; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Triazines | 2006 |
The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.
Topics: Animals; Catalysis; DNA, Protozoan; Enzyme Stability; Escherichia coli; Folic Acid Antagonists; Genetic Complementation Test; Kinetics; Mutagenesis, Insertional; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Tryptophan | 2007 |
Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DR.
Topics: Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Democratic Republic of the Congo; Drug Approval; Drug Combinations; Drug Industry; Pharmaceutical Preparations; Product Surveillance, Postmarketing; Proguanil; Pyrimethamine; Quality Control; Quinine; Sulfadoxine; Tablets | 2007 |
Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.
Topics: Animals; Antimalarials; Drug Resistance; Drug Resistance, Multiple; Kinetics; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2007 |
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.
Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Global Health; Half-Life; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine | 2007 |
Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.
Topics: Aminopterin; Animals; Antimalarials; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Inhibitory Concentration 50; Leucovorin; Methotrexate; Molecular Structure; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolates; Triazines; Trimetrexate | 2008 |
Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia.
Topics: Animals; Antimalarials; Child; Child, Preschool; DNA, Protozoan; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Mutation, Missense; Peptide Synthases; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proguanil; Protozoan Proteins; Pyrimethamine; Rural Population; Tetrahydrofolate Dehydrogenase; Triazines; Zambia | 2008 |
Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom.
Topics: Adult; Alleles; Amino Acid Sequence; Animals; Antimalarials; Atovaquone; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Haplotypes; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sequence Analysis, DNA; Sulfadoxine; Tetrahydrofolate Dehydrogenase; United Kingdom | 2009 |
In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.
Topics: Animals; Antimalarials; Folic Acid Antagonists; Genotype; Inhibitory Concentration 50; Kenya; Methotrexate; Mutation; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim; Trimetrexate | 2009 |
Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition.
Topics: Amino Acid Sequence; Animals; Antimalarials; DNA, Protozoan; Folic Acid Antagonists; Humans; Molecular Sequence Data; Plasmodium falciparum; Proguanil; Protein Binding; Pyrimethamine; Quantitative Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines; X-Rays | 2010 |
Community management of anti-malarials in Africa and iatrogenic risk.
Topics: Antimalarials; Atovaquone; Child; Community Health Services; Contraindications; Cote d'Ivoire; Diagnostic Errors; Drug Combinations; Female; Humans; Iatrogenic Disease; Liver Failure, Acute; Malaria; Proguanil; Pyrimethamine; Sulfadoxine | 2011 |
Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum.
Topics: Drug Resistance; Evolution, Molecular; Folic Acid Antagonists; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Triazines | 2011 |
Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene.
Topics: Amino Acid Sequence; Antimalarials; Cloning, Molecular; Escherichia coli; Folic Acid Antagonists; Genetic Complementation Test; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Plasmodium ovale; Proguanil; Protozoan Proteins; Pyrimethamine; Sequence Alignment; Sequence Analysis, DNA; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines | 2012 |
Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.
Topics: Animals; Anopheles; Antimalarials; Aotidae; Chloroquine; Disease Management; Disease Models, Animal; Host-Parasite Interactions; Humans; Malaria; Male; Monkey Diseases; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Quinine | 2012 |
Functional analysis of Plasmodium vivax dihydrofolate reductase-thymidylate synthase genes through stable transformation of Plasmodium falciparum.
Topics: Amino Acid Substitution; Antimalarials; Cells, Cultured; Drug Resistance; Erythrocytes; Folic Acid Antagonists; Gene Dosage; Humans; Inhibitory Concentration 50; Mutagenesis, Insertional; Plasmodium falciparum; Plasmodium vivax; Proguanil; Protozoan Proteins; Pyrimethamine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transfection; Triazines | 2012 |
Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs.
Topics: Bacterial Proteins; Calorimetry; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Ligands; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Proguanil; Protein Conformation; Pyrimethamine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 2014 |
Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.
Topics: Antimalarials; Computational Biology; Drug Resistance; Evolution, Molecular; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Models, Biological; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines | 2016 |
Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil.
Topics: DNA Viruses; Enzyme Activation; Folic Acid Antagonists; Humans; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimethoprim | 2017 |
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78.
Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Liberia; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Protozoan Proteins; Pyrimethamine; Selection, Genetic | 2017 |
Herbicidal properties of antimalarial drugs.
Topics: Antimalarials; Arabidopsis; Herbicides; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadiazine; Sulfadoxine; Triazines | 2017 |
Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents.
Topics: Antimalarials; Benzothiazoles; Colorimetry; Diamines; Dihydroorotate Dehydrogenase; Erythrocytes; Fluorescence; Humans; L-Lactate Dehydrogenase; Malaria; Organic Chemicals; Oxidoreductases Acting on CH-CH Group Donors; Parasitic Sensitivity Tests; Plasmodium falciparum; Plasmodium knowlesi; Proguanil; Pyrimethamine; Quinolines; Sensitivity and Specificity; Triazines | 2017 |
Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates.
Topics: Antimalarials; Base Sequence; Folic Acid Antagonists; Multienzyme Complexes; Plasmodium knowlesi; Proguanil; Protozoan Proteins; Pyrimethamine; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines | 2018 |
Discovery of new non-pyrimidine scaffolds as
Topics: Antimalarials; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Enzyme Inhibitors; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Plasmodium falciparum; Proguanil; Protozoan Proteins; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2021 |
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
Topics: Antimalarials; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Plasmodium falciparum; Polymorphism, Genetic; Proguanil; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Uganda | 2022 |
Prevalence of Molecular Markers of Plasmodium Falciparum Resistance to Proguanil and Pyrimethamine in Children with Haemoglobin Phenotypes SS and AA in Benin City, Nigeria.
Topics: Anemia, Sickle Cell; Antimalarials; Drug Combinations; Hemoglobin, Sickle; Humans; Malaria, Falciparum; Mutation; Nigeria; Phenotype; Plasmodium falciparum; Prevalence; Proguanil; Pyrimethamine; Sulfadoxine | 2021 |