pyrimethamine has been researched along with metoprine in 106 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (55.66) | 18.7374 |
| 1990's | 29 (27.36) | 18.2507 |
| 2000's | 16 (15.09) | 29.6817 |
| 2010's | 1 (0.94) | 24.3611 |
| 2020's | 1 (0.94) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, RJ; Meek, MA; Schwalbe, CH; Stevens, MF | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Levin, VA | 1 |
| Goldie, JH; Hill, BT; Price, LA | 3 |
| Brown, O; Fyfe, MJ; Laszlo, J; Lee, L; Swedwick, D | 1 |
| Cavallito, JC; Nichol, CA; Sigel, CW; Woolley, JL | 1 |
| Hansen, HH; Hansen, M; Lau, ME | 1 |
| Brown, OE; Frazer, T; Kutler, M; Laszlo, J; Sedwick, WD | 1 |
| Alberto, P; Beretta-Piccoli, M; Medenica, R; Peytremann, R | 1 |
| Hall, RR; Hindmarsh, JR; Kulatilake, AE | 1 |
| Bertino, JR; Horváth, C; Kalghatgi, KK; Moroson, BA | 1 |
| Brown, OE; Frazer, TA; Fyfe, MJ; Kutler, M; Laszlo, J; Sedwick, WD | 1 |
| Calvert, AH; Cridland, JS; Harrap, KR | 1 |
| Levin, EM; Levin, VA; Meyer, RB | 1 |
| Ganeshaguru, K; Hoffbrand, AV | 1 |
| Iinuma, K; Maeyama, K; Onodera, K; Tuomisto, L; Watanabe, T; Yanai, K; Yokoyama, H | 1 |
| Maeyama, K; Onodera, K; Sakai, N; Watanabe, T; Yanai, K | 1 |
| Frey, HH; Hashem, A; Scherkl, R | 1 |
| Baker, ND; Griffin, RJ; Irwin, WJ; Reichert, U; Schmidt, R | 1 |
| Scheulen, ME | 1 |
| Lecklin, A; Tuomisto, L | 4 |
| Cumming, P; Reiner, PB; Vincent, SR | 1 |
| Bunni, M; Dilwith, R; Galivan, J; Johnson, TB; Nair, MG; Priest, DG; Rhee, MS | 1 |
| Galivan, J; Nimec, Z; Rotundo, R | 1 |
| Mines, LS; Sirotnak, FM; Yang, CH | 1 |
| Cranford, SK; Fernandes, DJ | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Beardsley, GP; Erbe, RW; Wang, JC | 1 |
| Tacke, U; Tuomisto, L | 1 |
| Tacke, U; Tuomisto, L; Willman, A | 1 |
| Araki, Y; Fukuda, T; Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Roos, DS; Schimke, RT | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 3 |
| Iland, HJ; Laszlo, J; Sedwick, WD | 1 |
| Green, JP; Hough, LB; Khandelwal, JK | 1 |
| Itoh, Y; Oishi, R; Saeki, K; Yoshitomi, I | 1 |
| Friedlander, ML; Slowiaczek, P; Tattersall, MH; Taylor, IW | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Bigner, DD; Nichol, CA; Serano, RD; Sigel, CW | 1 |
| Hamrell, MR | 1 |
| Cody, V | 1 |
| Brown, OE; Fyfe, MJ; Laszlo, J; Sedwick, WD | 1 |
| Brown, OE; Kutler, M; Sedwick, WD | 1 |
| Browman, GP; Calvert, AH; Harrap, KR; Hart, LI; Taylor, GA | 1 |
| Alberto, P; Brugarolas, A; Cavalli, F; Hansen, HH; Klepp, O; Renard, J | 1 |
| de Jager, R; Dorlet, C; Dupont, D; Lagrange, G; Rodzynek, JJ | 1 |
| Brugarolas, A; de Jager, R; Hansen, M | 1 |
| Casper, ES; Golbey, RB; Gralla, RJ; Kelsen, DP; Lynch, GR; Stoopler, MB | 1 |
| Currie, V; Kemeny, N; Lynch, G | 1 |
| Hill, BT; Price, LA | 2 |
| Hill, BT | 1 |
| Goutas, LJ; Kelleher, LE; Moccio, DM; Montgomery, JA; Sirotnak, FM | 1 |
| Hamrell, MR; Laszlo, J; Sedwick, WD | 1 |
| Brown, OE; Hamrell, M; Laszlo, J; Sedwick, WD | 1 |
| Gordon, CS; Jones, BR; Reidenberg, MM; Umans, J; Young, CW | 1 |
| Laszlo, J; Sedwick, WD | 1 |
| Abelson, HT; Browman, GP; Gorka, C; Lazarus, H; Mehta, C | 1 |
| Mitsugi, K; Roy, K; Shane, B; Sirlin, S; Sirotnak, FM | 1 |
| Loiselle, J; Wollin, A | 1 |
| Gorrod, JW; Watkins, PJ | 1 |
| Bustamante, A; Henderson, GB; Patel, R; Rideout, DC | 1 |
| Järvikylä, M; Lecklin, A; Tuomisto, L | 1 |
| Bartolini, A; Ghelardini, C; Giotti, A; Lamberti, C; Malmberg-Aiello, P | 1 |
| Assaraf, YG; Borgnia, MJ | 1 |
| Assaraf, YG; Slotky, JI | 1 |
| Männistö, PT; Tuominen, RK; Tuomisto, L | 1 |
| Okubo, K; Yoshiki, Y | 1 |
| Igarashi, K; Okubo, K; Yoshiki, Y | 1 |
| Duoyon, E; Lee, WS; Morrishow, AM; Prell, GD | 1 |
| Buczko, W; Godlewski, G; Malinowska, B; Schlicker, E | 1 |
| Irman-Florjanc, T | 1 |
| Fukunaga, M; Ishizawa, K; Kakinoki, H; Kamei, C | 1 |
| Fujii, Y; Fukunaga, M; Ishizawa, K; Kakinoki, H; Kamei, C | 1 |
| Albino, AP; Devaney, K; Glantz, L; Healey, JH; Mak, S; Schwartz, GK; Terek, RM | 1 |
| Eriksson, L; Lecklin, A; Leppäluoto, J; Tarhanen, J; Tuomisto, L | 1 |
| Cody, V; Queener, SF; Rosowsky, A | 1 |
| Bartolini, A; Ipponi, A; Malmberg-Aiello, P; Schunack, W | 1 |
| Chen, Z | 1 |
| Christopherson, RI; Kamal, MA | 1 |
| Jochem, J | 5 |
| Murashima, YL; Nakagawa, Y; Nakano, K; Tanaka, K; Watanabe, Y; Yawata, I | 1 |
| Irman-Florjanc, T; Jochem, J; Zwirska-Korczala, K | 1 |
| Cheng, X; Horton, JR; Nishibori, M; Sawada, K | 1 |
| Adachi, N; Arai, T; Liu, K; Motoki, A; Semba, K | 1 |
| Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A | 1 |
| Shatskova, AB; Tuomisto, L; Vinogradova, LV | 1 |
| Chao, ZM; Li, LF; Liu, ZL; Song, ZQ; Wang, C; Zhang, L | 1 |
| Bazyan, AS; Birioukova, LM; Kuznetsova, GD; Midzyanovskaya, IS; Samotaeva, IS; Tuomisto, L | 1 |
| Hall, FS; Igarashi, K; Kitanaka, J; Kitanaka, N; Kobori, S; Kushihara, S; Nishiyama, N; Oyama, H; Sasaoka, Y; Sato, T; Takechi, M; Tanaka, KI; Tomita, K; Uhl, GR | 1 |
5 review(s) available for pyrimethamine and metoprine
| Article | Year |
|---|---|
Development of drug derivatives without cross-resistance to parent compounds.
Topics: Animals; Antineoplastic Agents; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Glutathione; Humans; Leukemia L1210; Methotrexate; Pyrimethamine; Tumor Cells, Cultured | 1990 |
Overcoming methotrexate resistance by a lipophilic antifolate (BW 301U): from theory to models to practice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Division; Cell Line; DNA; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia, Experimental; Methotrexate; Mice; Models, Biological; Phenotype; Pyrimethamine; Pyrimidines | 1985 |
DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-methylpyrimidine).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Diarrhea; Drug Administration Schedule; Drug Evaluation; Head and Neck Neoplasms; Humans; Lethal Dose 50; Leukopenia; Lung Neoplasms; Melanoma; Mice; Neoplasms, Experimental; Pyrimethamine; Rats; Seizures | 1980 |
Oxygen-radical-scavenging activity of DDMP-conjugated saponins and physiological role in leguminous plant.
Topics: Acetaldehyde; Free Radical Scavengers; Glycine max; Luminescent Measurements; Molecular Structure; Phenols; Pyrimethamine; Reactive Oxygen Species; Saponins | 1996 |
Chemiluminescence of oxygen radical scavengers such as DDMP saponins in the presence of radicals and aldehyde.
Topics: Aldehydes; Antioxidants; Free Radical Scavengers; Luminescent Measurements; Pyrimethamine | 1996 |
1 trial(s) available for pyrimethamine and metoprine
| Article | Year |
|---|---|
Initial clinical experience with a simultaneous combination of 2,4-diamino-5(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) with folinic acid.
Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Pyrimethamine | 1978 |
100 other study(ies) available for pyrimethamine and metoprine
| Article | Year |
|---|---|
Structural studies on bioactive compounds. 8. Synthesis, crystal structure, and biological properties of a new series of 2,4-diamino-5-aryl-6-ethylpyrimidine dihydrofolate reductase inhibitors with in vivo activity against a methotrexate-resistant tumor c
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Crystallization; Folic Acid Antagonists; Leukemia, Experimental; Liver; Methotrexate; Mice; Molecular Structure; Pyrimidines; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship | 1980 |
Methodichlorophen as anti-tumor drug.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Chlorobenzenes; Drug Therapy, Combination; Erythema; Headache; Humans; Kidney Neoplasms; Leucovorin; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pyrimethamine; Pyrimidines; Teratoma; Testicular Neoplasms | 1975 |
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Pyrimethamine; Time Factors | 1978 |
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
Topics: Administration, Oral; Animals; Brain; Brain Neoplasms; Dogs; Folic Acid; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Lipid Metabolism; Male; Models, Biological; Pyrimethamine; Pyrimidines; Rats; Solubility; Species Specificity | 1977 |
DDMP and selective folinic acid protection in the treatment of malignant disease: a further report.
Topics: Bone Marrow; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Neoplasms; Pyrimethamine; Remission, Spontaneous | 1977 |
Unpredictable hematologic toxicity of weekly ddmp.
Topics: Antineoplastic Agents; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Humans; Leucovorin; Middle Aged; Pyrimethamine | 1978 |
New dose-time relationships of folate antagonists to sustain inhibition of human lymphoblasts and leukemic cells in vitro.
Topics: Cell Line; Cell Survival; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Methotrexate; Pyrimethamine; Time Factors | 1979 |
Renal cell carcinoma: a preliminary clinical trial of methodichlorophen (D.D.M.P.).
Topics: Adenocarcinoma; Aged; Anorexia; Attention; Female; Headache; Humans; Kidney Neoplasms; Male; Middle Aged; Nausea; Neoplasm Metastasis; Pyrimethamine | 1979 |
Enhancement of antitumor activity of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine and Baker's antifol (triazinate) with carboxypeptidase G1.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Folic Acid Antagonists; Male; Pyrimethamine; Rats; Time Factors; Triazines | 1979 |
Deoxyuridine incorporation as a useful measure of methotrexate and metoprine uptake and metabolic effectiveness.
Topics: Deoxyuridine; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Pyrimethamine; Time Factors | 1979 |
An enzyme inhibition assay for 2,4-diamino-5-(3'4'-dichlorophenyl)-6-methylpyrimidine (DDMP,NSC 19494).
Topics: Folic Acid Antagonists; Humans; Methods; Pyrimethamine; Spectrophotometry | 1977 |
Quantitative high-pressure liquid chromatographic procedure for the determination of plasma and tissue levels of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (metoprine) and its application to the measurement of brain capillary permeability coeff
Topics: Animals; Antineoplastic Agents; Brain; Capillary Permeability; Chromatography, High Pressure Liquid; Pyrimethamine; Rats | 1978 |
Effects of DDMP and DDEP on the deoxyribonucleoside triphosphate concentrations in human cells.
Topics: Chlorobenzenes; Deoxyribonucleotides; Humans; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Pyrimethamine; Pyrimidines; Tetrahydrofolates | 1977 |
Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of alpha-fluoromethylhistidine and metoprine.
Topics: Animals; Brain Chemistry; Electroshock; Histamine; Histidine; Histidine Decarboxylase; Injections, Intraperitoneal; Male; Methylhistidines; Mice; Mice, Inbred Strains; Pyrimethamine | 1992 |
Effects of (S)-alpha -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice.
Topics: Animals; Behavior, Animal; Brain Chemistry; Histamine; Histamine N-Methyltransferase; Histidine Decarboxylase; Injections, Intraperitoneal; Male; Methylhistidines; Mice; Mice, Inbred ICR; Motor Activity; Pyrimethamine | 1992 |
Importance of histamine for seizure susceptibility.
Topics: Animals; Brain; Brocresine; Dimethindene; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histidine Decarboxylase; Male; Mice; Pentylenetetrazole; Promethazine; Pyrimethamine; Seizures | 1991 |
Uptake, cytotoxicity and metabolism of m-azidopyrimethamine and related lipophilic antifolates in SV-K14 human keratinocytes in vivo.
Topics: Animals; Anthralin; Azides; Cell Division; Cell Line, Transformed; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; In Vitro Techniques; Keratinocytes; Liver; Methotrexate; Mice; Mice, Hairless; Pyrimethamine; Regression Analysis; Skin | 1991 |
Histamine: a neurotransmitter that influences food intake?
Topics: Animals; Brain; Eating; Folic Acid Antagonists; Histamine; Male; Pyrimethamine; Rats; Rats, Inbred Strains | 1990 |
Feed intake after inhibition of histamine catabolism.
Topics: Animals; Brain Chemistry; Eating; Folic Acid Antagonists; Histamine; Histidine; Hypothalamus; Injections, Intraventricular; Male; Methylhistidines; Pyrimethamine; Rats; Rats, Inbred Strains | 1990 |
Inhibition of rat brain histamine-N-methyltransferase by 9-amino-1,2,3,4-tetrahydroacridine (THA).
Topics: 4-Aminopyridine; Aminoacridines; Animals; Antineoplastic Agents; Brain; Histamine; Histamine N-Methyltransferase; Injections, Intraperitoneal; Male; Methyltransferases; Physostigmine; Pyrimethamine; Rats; Tacrine | 1990 |
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Liver Neoplasms, Experimental; Pyrimethamine; Quinazolines; Rats; Thymidylate Synthase; Trimetrexate | 1989 |
The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate reductase.
Topics: Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Pyrimethamine; Tumor Cells, Cultured | 1989 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Cholic Acids; Chromatography; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Molecular Weight; Pyrimethamine; Receptors, Cell Surface; Succinimides | 1988 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Folic Acid Antagonists; Humans; Leukemia; Pyrimethamine; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides | 1986 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA by cells from patients with the fragile X syndrome.
Topics: Cells, Cultured; Deoxyuracil Nucleotides; DNA; DNA Glycosylases; Floxuridine; Folic Acid Antagonists; Fragile X Syndrome; Humans; Lymphocytes; Male; N-Glycosyl Hydrolases; Pyrimethamine; Pyrophosphatases; Sex Chromosome Aberrations; Uracil-DNA Glycosidase | 1985 |
Is histamine an anticonvulsive inhibitory transmitter?
Topics: Animals; Electroshock; Female; Histamine; Histamine N-Methyltransferase; Male; Neural Inhibition; Pyrimethamine; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1986 |
Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain; Histamine; Male; Neural Inhibition; Pyrimethamine; Rats; Seizures; Synaptic Transmission | 1987 |
Histamine turnover in the brain of morphine-dependent mice.
Topics: Animals; Brain; Folic Acid Antagonists; Histamine; Histidine; Male; Methylhistamines; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Pargyline; Pyrimethamine; Substance Withdrawal Syndrome | 1988 |
Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition.
Topics: Animals; Cell Division; Cell Line; Drug Interactions; Drug Resistance; Gene Amplification; Humans; Leucovorin; Methotrexate; Mice; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Xeroderma Pigmentosum | 1987 |
Mechanism of the central hyperglycemic action of histamine in mice.
Topics: Adrenalectomy; Animals; Blood Glucose; Chlorpheniramine; Chromatography, High Pressure Liquid; Corticosterone; Dose-Response Relationship, Drug; Epinephrine; Histamine; Hyperglycemia; Mice; Norepinephrine; Phentolamine; Promethazine; Propranolol; Pyrilamine; Pyrimethamine; Receptors, Histamine H1; Receptors, Histamine H2; Time Factors | 1987 |
Inhibition of brain histamine metabolism by metoprine.
Topics: Animals; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Histamine; Histamine N-Methyltransferase; Imidazoles; Male; Methylation; Methylhistamines; Pyrimethamine; Rats; Time Factors | 1986 |
Brain histamine turnover enhanced by footshock.
Topics: Animals; Brain; Electroshock; Foot; Histamine; Male; Methylhistamines; Methylhistidines; Mice; Pargyline; Pyrimethamine | 1986 |
Selective toxicity of a new lipophilic antifolate, BW301U, for methotrexate-resistant cells with reduced drug uptake.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Pyrimidines | 1985 |
Changes in histamine metabolism in the mouse hypothalamus induced by acute administration of ethanol.
Topics: Animals; Ethanol; Histamine; Hypothalamus; Male; Methylhistamines; Methylhistidines; Mice; Mice, Inbred Strains; Pargyline; Pyrimethamine; Time Factors | 1985 |
Phencyclidine and the dynamics of mouse brain histamine.
Topics: Animals; Brain Chemistry; Histamine; Male; Methylhistamines; Methylhistidines; Mice; Mice, Inbred Strains; Phencyclidine; Potassium; Pyrimethamine; Receptors, Histamine | 1985 |
Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.
Topics: Animals; Cell Line; Chlorobenzenes; Diamines; Folic Acid; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1973 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model.
Topics: Animals; Antineoplastic Agents; Avian Sarcoma Viruses; Carmustine; Drug Therapy, Combination; Glioma; Lipids; Neoplasms, Experimental; Pyrimethamine; Rats; Rats, Inbred F344; Solubility; Tissue Distribution | 1982 |
Inhibition of dihydrofolate reductase and cell growth by antifolates in a methotrexate-resistant cell line.
Topics: Adamantane; Animals; Aspartic Acid; Cell Division; Cell Line; Drug Resistance; Folic Acid Antagonists; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1984 |
Crystallographic studies of the antineoplastic antifolate 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) ethanesulfonate salt.
Topics: Antineoplastic Agents; Crystallography; Folic Acid Antagonists; Molecular Conformation; Pyrimethamine | 1983 |
Human plasma and amino acids as moderators of uptake and metabolic consequences of antifolates in WIL-2 and human leukemia cells.
Topics: Amino Acids; Blood; Cell Line; Culture Media; Deoxyuridine; Folic Acid Antagonists; Glutamine; Humans; Kinetics; Leukemia; Lymphocytes; Methotrexate; Pyrimethamine | 1981 |
Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA: inhibition of high molecular weight DNA synthesis in human lymphoblastoid cells.
Topics: Antineoplastic Agents; Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Humans; Kinetics; Pyrimethamine | 1981 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimethamine; Pyrimidines; Thymidine | 1980 |
Phase II study of diamino-dichlorophenyl-methylpyrimidine (DDMP) with folinic acid (CF) protection and rescue.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Child; Drug Evaluation; Drug Therapy, Combination; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leucovorin; Leukocyte Count; Melanoma; Neoplasms; Platelet Count; Pyrimethamine; Sarcoma | 1980 |
Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).
Topics: Antineoplastic Agents; Drug Evaluation; Humans; Kinetics; Leucovorin; Neoplasms; Protein Binding; Pyrimethamine | 1981 |
Phase II clinical trial of DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine) and folinic acid (CF) in solid tumors.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Drug Evaluation; Humans; Leucovorin; Neoplasms; Pyrimethamine | 1981 |
Phase II evaluation of metoprine in patients with non-small-cell lung carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Pyrimethamine | 1981 |
Phase II evaluation of metoprine with leucovorin rescue in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Pyrimethamine; Rectal Neoplasms | 1981 |
An experimentally designed high dose simultaneous combination of a diaminopyrimidine and folinic acid for the treatment of human malignancies.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leucovorin; Neoplasms; Pyrimethamine | 1981 |
Lethal and kinetic effects of DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine).
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cricetinae; Cytological Techniques; DNA; Dose-Response Relationship, Drug; Kinetics; Pyrimethamine; Time Factors | 1980 |
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
Topics: Animals; Biological Transport; Cell Line; Drug Resistance; Formyltetrahydrofolates; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 1982 |
Effect of DDMP (2, 4-diamino-5-3', 4'-dichlorophenyl-6-methylpyrimidine) on brain gliomas--a phase II study. E.O.R.T.C. Brain Tumor Group.
Topics: Adult; Brain Neoplasms; Drug Evaluation; Female; Glioma; Humans; Male; Middle Aged; Pyrimethamine | 1980 |
Transient induction of phenotypic resistance in human lymphoblastoid cells following sequential use of two antifolates.
Topics: Cell Line; Cell Survival; Drug Administration Schedule; Drug Resistance; Humans; Lymphocytes; Methotrexate; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Time Factors | 1981 |
Toxicity of methotrexate and metoprine in a dihydrofolate reductase gene-amplified mouse cell line.
Topics: Cell Line; Clone Cells; Deoxyuridine; Folic Acid Antagonists; Kinetics; Methotrexate; Phosphorus Radioisotopes; Pyrimethamine; Tetrahydrofolate Dehydrogenase | 1981 |
Kinetics of metoprine, a lipid-soluble antifolate.
Topics: Folic Acid Antagonists; Humans; Kinetics; Pyrimethamine; Solubility | 1981 |
An antifolate-induced lesion in newly synthesized DNA.
Topics: Cell Line; Cell Survival; Deoxyuridine; DNA; Folic Acid Antagonists; Humans; Methotrexate; Molecular Weight; Pyrimethamine; Thymidine | 1980 |
Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate.
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Pyrimethamine | 1980 |
Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
Topics: Amino Acid Sequence; Animals; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Gene Expression; Genetic Variation; Humans; Leukemia L1210; Mice; Molecular Sequence Data; Peptide Synthases; Pyrimethamine; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Mucosal histamine elimination and its effect on acid secretion in rabbit gastric mucosa.
Topics: Animals; Biological Transport; Gastric Acid; Gastric Mucosa; Histamine; Histamine N-Methyltransferase; Histamine Release; In Vitro Techniques; Kinetics; Methylation; Pyrimethamine; Rabbits | 1993 |
Determination of isomeric N-oxide metabolites of some substituted 2,4-diaminopyrimidines by reversed-phase ion-pair high-performance liquid chromatography.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Cricetinae; Dioctyl Sulfosuccinic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Indicators and Reagents; Isomerism; Microsomes, Liver; Oxides; Pyrimethamine; Pyrimidines; Surface-Active Agents; Trimethoprim | 1993 |
Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells.
Topics: Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Division; Drug Synergism; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Receptors, Cell Surface; Suramin; Tumor Cells, Cultured | 1995 |
The effect of metoprine on glucoprivic feeding induced by 2-deoxy-D-glucose.
Topics: Animals; Blood Glucose; Deoxyglucose; Drinking Behavior; Feeding Behavior; Folic Acid Antagonists; Glucose; Histamine; Hypothalamus; Male; Methylhistamines; Pyrimethamine; Rats; Rats, Wistar; Urodynamics; Water-Electrolyte Balance | 1994 |
Role of histamine in rodent antinociception.
Topics: Analgesics; Animals; Histamine; Histidine; Hyperalgesia; Male; Methylhistamines; Methylhistidines; Mice; Piperidines; Pyrimethamine; Rats; Rats, Wistar; Sensory Thresholds | 1994 |
Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; CHO Cells; Cricetinae; Drug Interactions; Drug Resistance; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimethamine; Pyrimidines; Quinidine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1993 |
Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
Topics: Animals; Cell Survival; CHO Cells; Cricetinae; Drug Resistance; Flow Cytometry; Folic Acid Antagonists; Leucovorin; Pyrimethamine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1993 |
Fluid balance in rats of three different strains after inhibition of histamine catabolism.
Topics: Animals; Arginine Vasopressin; Brain Chemistry; Drinking; Histamine; Male; Osmolar Concentration; Potassium; Pyrimethamine; Rats; Rats, Brattleboro; Rats, Inbred Strains; Rats, Wistar; Sodium; Species Specificity; Urination; Water-Electrolyte Balance | 1995 |
Effect of modified brain histamine contents on prolactin and thyrotropin secretion in male rats.
Topics: Animals; Brain; Cold Temperature; Enzyme Inhibitors; Histamine; Histamine N-Methyltransferase; Histidine; Hypothalamus; Male; Methylhistidines; Prolactin; Pyrimethamine; Rats; Rats, Wistar; Stress, Physiological; Thyrotropin | 1996 |
Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors.
Topics: Animals; Brain; Gas Chromatography-Mass Spectrometry; Histamine; Imidazoles; Male; Methylation; Physostigmine; Pyrimethamine; Rats; Rats, Sprague-Dawley; Receptors, GABA; Tacrine | 1997 |
Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats.
Topics: Adrenergic Fibers; Animals; Blood Pressure; Decerebrate State; Electric Stimulation; Histamine; Histamine Agonists; Histamine Antagonists; Hypertension; Imidazoles; Male; Methylhistamines; Piperidines; Pyrimethamine; Rats; Rats, Wistar; Receptors, Histamine H3; Thiourea; Vagotomy; Vascular Resistance | 1997 |
Effects of tele-methylhistamine and metoprine on plasma levels of histamine and on its elimination from cat plasma.
Topics: Animals; Cats; Enzyme Inhibitors; Female; Half-Life; Histamine; Histamine N-Methyltransferase; Kinetics; Male; Methylhistamines; Pyrimethamine | 1997 |
The blockade of H1 receptors attenuates the suppression of feeding and diuresis induced by inhibition of histamine catabolism.
Topics: Animals; Brain Chemistry; Diuresis; Enzyme Inhibitors; Feeding Behavior; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Piperidines; Pyrilamine; Pyrimethamine; Ranitidine; Rats; Rats, Wistar; Water-Electrolyte Balance | 1998 |
Histaminergic mechanisms in amygdaloid-kindled seizures in rats.
Topics: Amygdala; Animals; Brain; Histamine; Histamine Antagonists; Histidine; Kindling, Neurologic; Male; Pyrimethamine; Rats; Rats, Wistar; Seizures | 1998 |
The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.
Topics: Amygdala; Animals; Brain Chemistry; Enzyme Inhibitors; Histamine Antagonists; Histamine N-Methyltransferase; Imidazoles; Injections, Intraventricular; Kindling, Neurologic; Male; Piperidines; Pyrimethamine; Rats; Rats, Wistar; Receptors, Histamine H3; Seizures; Thiourea | 1998 |
Chemotherapy and P-glycoprotein expression in chondrosarcoma.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Chondrosarcoma; Cisplatin; Cohort Studies; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Ifosfamide; Male; Methotrexate; Middle Aged; Pyrimethamine; Retrospective Studies; Survival Analysis; Vinblastine | 1998 |
Metoprine-induced thirst and diuresis in Wistar rats.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Diuresis; Enzyme Inhibitors; Glomerular Filtration Rate; Histamine N-Methyltransferase; Kidney; Male; Pyrimethamine; Rats; Rats, Wistar; Renin-Angiotensin System; Thirst | 1999 |
Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine.
Topics: Animals; Binding Sites; Computer Simulation; Folic Acid; Folic Acid Antagonists; Liver; Molecular Structure; Oxidoreductases; Pneumocystis; Pyrimethamine; Rats; Serine; Threonine; Toxoplasma | 1999 |
Antiamnesic effect of metoprine and of selective histamine H(1) receptor agonists in a modified mouse passive avoidance test.
Topics: Amnesia; Animals; Avoidance Learning; Enzyme Inhibitors; Histamine; Histamine Agonists; Histamine H1 Antagonists; Histamine N-Methyltransferase; Male; Memory; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Nootropic Agents; Piracetam; Pyrilamine; Pyrimethamine; Receptors, Histamine H1; Scopolamine; Thiazoles | 2000 |
Effect of clobenpropit on regional cerebral blood flow in rat hippocampus.
Topics: Animals; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Hippocampus; Histamine Agonists; Histamine Antagonists; Imidazoles; Injections, Intraventricular; Male; Methylhistamines; Pyrimethamine; Rats; Rats, Wistar; Thiourea | 2001 |
Inhibition of histamine catabolism suppresses fat intake but not the intake of carbohydrates and protein.
Topics: Animals; Appetite; Caseins; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Eating; Energy Metabolism; Histamine; Male; Pyrimethamine; Rats; Rats, Wistar | 2002 |
Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates.
Topics: Amidophosphoribosyltransferase; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Leukemia; Molecular Structure; Phosphoribosyl Pyrophosphate; Pyrimethamine | 2004 |
Involvement of the sympathetic nervous system in the reversal of critical haemorrhagic hypotension by endogenous central histamine in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine Derivatives; Blood Pressure; Brain; Dose-Response Relationship, Drug; Epinephrine; Heart Rate; Hexamethonium; Histamine; Histamine N-Methyltransferase; Hypotension; Male; Muscarinic Antagonists; Nicotinic Antagonists; Pyrimethamine; Rats; Rats, Wistar; Regional Blood Flow; Shock, Hemorrhagic; Sympathetic Nervous System | 2004 |
Involvement of the renin-angiotensin system in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Blood Pressure; Brain Chemistry; Captopril; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Hindlimb; Histamine; Histamine N-Methyltransferase; Hypotension; Hypothalamus; Imidazoles; Injections, Intraperitoneal; Injections, Intravenous; Injections, Intraventricular; Male; Medulla Oblongata; Naphthyridines; Pyridines; Pyrimethamine; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Resuscitation; Shock, Hemorrhagic; Time Factors; Vascular Resistance | 2004 |
Involvement of proopiomenalocortin-derived peptides in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Topics: Adrenocorticotropic Hormone; alpha-MSH; Animals; Brain Chemistry; Disease Models, Animal; Heart Rate; Hemorrhage; Hindlimb; Histamine; Hypotension; Injections, Intraventricular; Injections, Subcutaneous; Male; Mifepristone; Peptides, Cyclic; Pro-Opiomelanocortin; Pyrimethamine; Rats; Rats, Wistar; Receptor, Melanocortin, Type 4; Regional Blood Flow; Renal Circulation; Shock, Hemorrhagic; Splanchnic Circulation; Time Factors | 2004 |
Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats.
Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Blood Pressure; Cardiovascular System; Epinephrine; Hemorrhage; Histamine; Hypotension; Immunoenzyme Techniques; Male; Pyrimethamine; Rats; Rats, Wistar; Receptors, Vasopressin; Time Factors | 2004 |
Cardiac and regional haemodynamic effects of histamine N-methyltransferase inhibitor metoprine in haemorrhage-shocked rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Heart Rate; Histamine; Histamine N-Methyltransferase; Hypotension; Hypothalamus; Inflammation; Ketamine; Male; Medulla Oblongata; Pyrimethamine; Rats; Rats, Wistar; Shock, Hemorrhagic; Time Factors | 2004 |
Role of histaminergic neurons in development of epileptic seizures in EL mice.
Topics: Animals; Brain; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epilepsy; Epilepsy, Temporal Lobe; Female; Genetic Predisposition to Disease; Histamine; Histamine H1 Antagonists; Histamine N-Methyltransferase; Histidine; Histidine Decarboxylase; Male; Mice; Mice, Neurologic Mutants; Neurons; Pyrimethamine; Receptors, Histamine H3; Up-Regulation | 2004 |
The role of peripherally acting histamine in metoprine-induced reversal of haemorrhagic hypotension in rats--skeletal muscle microcirculatory studies.
Topics: Animals; Hemorrhage; Histamine; Hypotension; Male; Microcirculation; Muscle, Skeletal; Pyrimethamine; Rats; Rats, Inbred WKY; Shock, Hemorrhagic; Survival Rate | 2005 |
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
Topics: Amodiaquine; Animals; Antimalarials; Cholinesterase Inhibitors; Crystallography, X-Ray; Diphenhydramine; Folic Acid Antagonists; Histamine H1 Antagonists; Histamine N-Methyltransferase; Humans; Models, Molecular; Molecular Structure; Protein Conformation; Pyrimethamine; Tacrine | 2005 |
Reduction in brain infarction by augmentation of central histaminergic activity in rats.
Topics: Animals; Cerebral Infarction; Extracellular Space; Histamine; Histamine Antagonists; Histidine; Male; Piperidines; Pyrimethamine; Rats; Rats, Wistar | 2005 |
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate | 2006 |
Histaminergic modulation of acoustically induced running behavior in rats.
Topics: Acoustic Stimulation; Animals; Brain; Brain Chemistry; Brain Stem; Enzyme Inhibitors; Epilepsy, Reflex; Epilepsy, Tonic-Clonic; Female; Histamine; Histamine N-Methyltransferase; Hyperkinesis; Injections, Intraperitoneal; Male; Nerve Net; Neural Pathways; Pyrimethamine; Rats; Rats, Mutant Strains; Rats, Wistar | 2007 |
[New chemical constituents from Radix Polygoni Multiflori after processing].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ethanol; Plant Roots; Plants, Medicinal; Polygonum; Pyrimethamine; Solvents; Technology, Pharmaceutical | 2007 |
Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Epilepsy; Epilepsy, Absence; Epilepsy, Reflex; Grooming; Histamine; Male; Motor Activity; Pyrimethamine; Rats; Rats, Wistar; Stereotyped Behavior | 2012 |
Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice.
Topics: Animals; Behavior, Animal; Dopamine; Enzyme Inhibitors; Feeding Behavior; Histamine; Histamine N-Methyltransferase; Hypothalamus; Locomotion; Male; Methamphetamine; Mice; Mice, Inbred ICR; Nucleus Accumbens; Pyrimethamine; Stereotyped Behavior; Synaptic Transmission | 2021 |