pyrimethamine has been researched along with fluorouracil in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (42.86) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levin, VA | 1 |
| Fujiwara, H; Kai, J; Masuda, T; Nakamura, K; Ueda, I | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Araujo, FG; Huskinson-Mark, J; Remington, JS | 1 |
| Harris, C; Salgo, MP; Tanowitz, HB; Wittner, M | 1 |
| Cheng, CC | 1 |
| Carlisle, H; Spector, RG | 1 |
| Herbert, V; Waxman, S | 1 |
| Frick, PG | 1 |
| Scott, JM; Weir, DG | 1 |
| Baden, HP; Clendenning, W; Cornell, RC; Deneau, DD; Eaglstein, WH; Golub, A; King, L; Kulp, KR; Maibach, H; McCullough, JL; Stoughton, RB; Taylor, JS; Weinstein, GD; Zackheim, H | 1 |
| NEWELL, FW | 1 |
| Hyde, JE; Nirmalan, N; Sims, PF | 1 |
| Assaraf, YG; Berman, B; Bram, E; Ifergan, I; Jansen, G; Shafran, A | 1 |
3 review(s) available for pyrimethamine and fluorouracil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Some pyrimidines of biological and medicinal interest. I.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antimetabolites; Antithyroid Agents; Bacteria; Bromine; Chlorine; Floxuridine; Fluorine; Fluorouracil; Humans; Iodine; Pyrimethamine; Pyrimidines; Rodenticides; Sulfonamides | 1969 |
Drug-induced megaloblastic change.
Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim | 1980 |
1 trial(s) available for pyrimethamine and fluorouracil
| Article | Year |
|---|---|
A clinical screening program for topical chemotherapeutic drugs in psoriasis.
Topics: Adult; Animals; Clinical Trials as Topic; Cycloheximide; Dermatologic Agents; Double-Blind Method; Drug Evaluation, Preclinical; Emetine; Fluorouracil; Humans; Mitoguazone; Psoriasis; Pyrimethamine; Rabbits; Skin; Thiotepa | 1981 |
17 other study(ies) available for pyrimethamine and fluorouracil
| Article | Year |
|---|---|
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship | 1980 |
Thermodynamic aspects of hydrophobicity and the blood-brain barrier permeability studied with a gel filtration chromatography.
Topics: Blood-Brain Barrier; Chromatography, Gel; Hydrogen Bonding; Micelles; Permeability; Solubility; Thermodynamics | 1996 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.
Topics: Adenine; Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Brain; Clindamycin; Coccidiostats; Erythromycin; Fluorouracil; Mice; Mice, Inbred CBA; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma | 1991 |
In vitro assessment of antimicrobial agents against Toxoplasma gondii.
Topics: Animals; Anti-Infective Agents; Cell Line; Clindamycin; Drug Resistance; Eflornithine; Fluorouracil; Leucomycins; Methotrexate; Organometallic Compounds; Pyrimethamine; Rats; Spiro Compounds; Sulfadiazine; Toxoplasma | 1988 |
The effect of anti-metabolites on leptazol induced fits in rats.
Topics: Animals; Antimetabolites; Azathioprine; Brain; Cytarabine; Daunorubicin; Fluorouracil; Folic Acid; Folic Acid Antagonists; Methotrexate; Pentylenetetrazole; Pyrimethamine; Rats; Seizures | 1971 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
[Possible applications of antivitamins and antimetabolites in therapy].
Topics: Aminopterin; Antimetabolites; Azaserine; Child; Child, Preschool; Choriocarcinoma; Diazooxonorleucine; Female; Fluorouracil; Folic Acid Antagonists; Humans; Leukemia; Mercaptopurine; Methotrexate; Pregnancy; Pyrimethamine; Toxoplasmosis; Vitamin K; Vitamins | 1966 |
ANTICANCER AGENTS.
Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Corneal Transplantation; Drug Therapy; Eye Neoplasms; Female; Fluorouracil; Humans; Maternal-Fetal Exchange; Neoplasms; Nitrogen Mustard Compounds; Ophthalmology; Pregnancy; Pyrimethamine; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular; Transplantation Immunology; Uveitis | 1964 |
Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors.
Topics: Animals; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Plasmodium falciparum; Protein Biosynthesis; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Triazines; Up-Regulation | 2004 |
Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Lipids; Molecular Structure; Mutation; Neoplasm Proteins; Paclitaxel; Pyrimethamine; Pyrimidines; Quinazolines; Rhodamines; Transfection; Trimetrexate | 2006 |