Page last updated: 2024-08-16

pyrimethamine and etoprine

pyrimethamine has been researched along with etoprine in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199010 (58.82)18.7374
1990's2 (11.76)18.2507
2000's5 (29.41)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Levin, VA1
Intaraudom, C; Kamchonwongpaisan, S; Phupong, W; Sirawaraporn, W; Sirichaiwat, C; Tarnchompoo, B; Thebtaranonth, Y; Vanichtanankul, J; Yuthavong, Y1
Charoensetakul, N; Kamchonwongpaisan, S; Lowe, G; Ponsinet, R; Quarrell, R; Sirawaraporn, W; Tarnchompoo, B; Vanichtanankul, J; Vilaivan, T; Yuthavong, Y1
Ferrari, AM; Pacchioni, S; Parenti, MD; Rastelli, G1
Bunyarataphan, S; Kamchonwongpaisan, S; Leartsakulpanich, U; Tarnchompoo, B; Taweechai, S; Yuthavong, Y1
Brown, O; Fyfe, MJ; Laszlo, J; Lee, L; Swedwick, D1
Cavallito, JC; Nichol, CA; Sigel, CW; Woolley, JL1
Levin, EM; Levin, VA; Meyer, RB1
Ganeshaguru, K; Hoffbrand, AV1
Hynes, JB; McCullough, JL; Weinstein, GD1
Kennedy, CH; Mason, RP1
Jacobsen, NE; Lee, JS; Ortiz de Montellano, PR1
Chow, SA; Fischer, LJ; Rickert, DE1
Correia, MA; Litman, DA; Lunetta, JM1
Bigner, DD; Nichol, CA; Serano, RD; Sigel, CW1
Jurima-Romet, M; Kobus, SM; Marks, GS; McNamee, JP1
Correia, MA; Han, XM; Hefner, C; Lee, G; Maher, JJ1

Other Studies

17 other study(ies) available for pyrimethamine and etoprine

ArticleYear
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:6

    Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship

1980
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
    Journal of medicinal chemistry, 2002, Mar-14, Volume: 45, Issue:6

    Topics: Animals; Antimalarials; Binding, Competitive; Chlorocebus aethiops; Folic Acid Antagonists; Humans; KB Cells; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Vero Cells

2002
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
    Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3

    Topics: Animals; Antimalarials; Cell Line; Chlorocebus aethiops; Drug Resistance; Folic Acid Antagonists; Humans; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines

2004
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.
    Journal of medicinal chemistry, 2004, Aug-12, Volume: 47, Issue:17

    Topics: Aldehyde Reductase; Animals; Antimalarials; Binding Sites; Folic Acid Antagonists; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase

2004
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:11

    Topics: Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Genetic Complementation Test; Mutation; Plasmids; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2006
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
    Cancer treatment reports, 1978, Volume: 62, Issue:3

    Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Pyrimethamine; Time Factors

1978
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
    Cancer treatment reports, 1977, Volume: 61, Issue:4

    Topics: Administration, Oral; Animals; Brain; Brain Neoplasms; Dogs; Folic Acid; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Lipid Metabolism; Male; Models, Biological; Pyrimethamine; Pyrimidines; Rats; Solubility; Species Specificity

1977
Quantitative high-pressure liquid chromatographic procedure for the determination of plasma and tissue levels of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (metoprine) and its application to the measurement of brain capillary permeability coeff
    Journal of chromatography, 1978, Aug-21, Volume: 156, Issue:1

    Topics: Animals; Antineoplastic Agents; Brain; Capillary Permeability; Chromatography, High Pressure Liquid; Pyrimethamine; Rats

1978
Effects of DDMP and DDEP on the deoxyribonucleoside triphosphate concentrations in human cells.
    Biochemical pharmacology, 1977, Mar-15, Volume: 26, Issue:6

    Topics: Chlorobenzenes; Deoxyribonucleotides; Humans; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Pyrimethamine; Pyrimidines; Tetrahydrofolates

1977
In vitro screening of biochemical activity of folic acid antagonists in skin.
    The Journal of investigative dermatology, 1977, Volume: 68, Issue:6

    Topics: Animals; Animals, Newborn; Chlorobenzenes; Depression, Chemical; DNA; Folic Acid Antagonists; Methotrexate; Psoriasis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Skin; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim

1977
A reexamination of the cytochrome P-450-catalyzed free radical production from a dihydropyridine. Evidence of trace transition metal catalysis.
    The Journal of biological chemistry, 1990, Jul-15, Volume: 265, Issue:20

    Topics: Animals; Cell Fractionation; Chelating Agents; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Male; Microsomes, Liver; Nitrogen Oxides; Pyridines; Pyrimethamine; Rats; Rats, Inbred Strains; Spin Labels

1990
4-alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines.
    Biochemistry, 1988, Oct-04, Volume: 27, Issue:20

    Topics: Animals; Cytochrome P-450 Enzyme System; Dihydropyridines; Free Radicals; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pyrimethamine; Rats; Rats, Inbred Strains

1988
Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Animals; Cyproheptadine; Insulin; Liver; Lung; Male; Pancreas; Pyridines; Pyrimethamine; Rats; Rats, Inbred Strains

1988
Drug-induced modulations of hepatic heme metabolism. Neurological consequences.
    Annals of the New York Academy of Sciences, 1987, Volume: 514

    Topics: Animals; Brain; Gastric Emptying; Gluconeogenesis; Heme; Intestine, Small; Liver; Liver Diseases; Models, Biological; Porphyrias; Pyrimethamine; Rats; Serotonin; Tryptophan

1987
Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model.
    Cancer treatment reports, 1982, Volume: 66, Issue:1

    Topics: Animals; Antineoplastic Agents; Avian Sarcoma Viruses; Carmustine; Drug Therapy, Combination; Glioma; Lipids; Neoplasms, Experimental; Pyrimethamine; Rats; Rats, Inbred F344; Solubility; Tissue Distribution

1982
cDNA-expressed human cytochrome P450 isozymes. Inactivation by porphyrinogenic xenobiotics.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:4

    Topics: Allylisopropylacetamide; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Isoenzymes; Lymphocytes; Microsomes; Pyrimethamine; Sydnones

1997
Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase?
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Aminolevulinic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2B1; eIF-2 Kinase; Enzyme Induction; Heat-Shock Proteins; Heme; Hepatocytes; Molecular Chaperones; Peptide Elongation Factor 2; Phenobarbital; Phosphorylation; Proteins; Protoporphyrins; Pyrimethamine; Rats; Steroid Hydroxylases; Transcriptional Activation

2005