pyrimethamine has been researched along with etoprine in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levin, VA | 1 |
| Intaraudom, C; Kamchonwongpaisan, S; Phupong, W; Sirawaraporn, W; Sirichaiwat, C; Tarnchompoo, B; Thebtaranonth, Y; Vanichtanankul, J; Yuthavong, Y | 1 |
| Charoensetakul, N; Kamchonwongpaisan, S; Lowe, G; Ponsinet, R; Quarrell, R; Sirawaraporn, W; Tarnchompoo, B; Vanichtanankul, J; Vilaivan, T; Yuthavong, Y | 1 |
| Ferrari, AM; Pacchioni, S; Parenti, MD; Rastelli, G | 1 |
| Bunyarataphan, S; Kamchonwongpaisan, S; Leartsakulpanich, U; Tarnchompoo, B; Taweechai, S; Yuthavong, Y | 1 |
| Brown, O; Fyfe, MJ; Laszlo, J; Lee, L; Swedwick, D | 1 |
| Cavallito, JC; Nichol, CA; Sigel, CW; Woolley, JL | 1 |
| Levin, EM; Levin, VA; Meyer, RB | 1 |
| Ganeshaguru, K; Hoffbrand, AV | 1 |
| Hynes, JB; McCullough, JL; Weinstein, GD | 1 |
| Kennedy, CH; Mason, RP | 1 |
| Jacobsen, NE; Lee, JS; Ortiz de Montellano, PR | 1 |
| Chow, SA; Fischer, LJ; Rickert, DE | 1 |
| Correia, MA; Litman, DA; Lunetta, JM | 1 |
| Bigner, DD; Nichol, CA; Serano, RD; Sigel, CW | 1 |
| Jurima-Romet, M; Kobus, SM; Marks, GS; McNamee, JP | 1 |
| Correia, MA; Han, XM; Hefner, C; Lee, G; Maher, JJ | 1 |
17 other study(ies) available for pyrimethamine and etoprine
| Article | Year |
|---|---|
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Male; Models, Biological; Molecular Weight; Rats; Rats, Inbred F344; Solubility; Structure-Activity Relationship | 1980 |
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Binding, Competitive; Chlorocebus aethiops; Folic Acid Antagonists; Humans; KB Cells; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Vero Cells | 2002 |
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
Topics: Animals; Antimalarials; Cell Line; Chlorocebus aethiops; Drug Resistance; Folic Acid Antagonists; Humans; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Triazines | 2004 |
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.
Topics: Aldehyde Reductase; Animals; Antimalarials; Binding Sites; Folic Acid Antagonists; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2004 |
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
Topics: Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Genetic Complementation Test; Mutation; Plasmids; Plasmodium falciparum; Plasmodium vivax; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2006 |
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Pyrimethamine; Time Factors | 1978 |
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
Topics: Administration, Oral; Animals; Brain; Brain Neoplasms; Dogs; Folic Acid; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Lipid Metabolism; Male; Models, Biological; Pyrimethamine; Pyrimidines; Rats; Solubility; Species Specificity | 1977 |
Quantitative high-pressure liquid chromatographic procedure for the determination of plasma and tissue levels of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (metoprine) and its application to the measurement of brain capillary permeability coeff
Topics: Animals; Antineoplastic Agents; Brain; Capillary Permeability; Chromatography, High Pressure Liquid; Pyrimethamine; Rats | 1978 |
Effects of DDMP and DDEP on the deoxyribonucleoside triphosphate concentrations in human cells.
Topics: Chlorobenzenes; Deoxyribonucleotides; Humans; Kinetics; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Pyrimethamine; Pyrimidines; Tetrahydrofolates | 1977 |
In vitro screening of biochemical activity of folic acid antagonists in skin.
Topics: Animals; Animals, Newborn; Chlorobenzenes; Depression, Chemical; DNA; Folic Acid Antagonists; Methotrexate; Psoriasis; Pyrimethamine; Pyrimidines; Quinazolines; Rats; Skin; Tetrahydrofolate Dehydrogenase; Triazines; Trimethoprim | 1977 |
A reexamination of the cytochrome P-450-catalyzed free radical production from a dihydropyridine. Evidence of trace transition metal catalysis.
Topics: Animals; Cell Fractionation; Chelating Agents; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Male; Microsomes, Liver; Nitrogen Oxides; Pyridines; Pyrimethamine; Rats; Rats, Inbred Strains; Spin Labels | 1990 |
4-alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridines.
Topics: Animals; Cytochrome P-450 Enzyme System; Dihydropyridines; Free Radicals; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pyrimethamine; Rats; Rats, Inbred Strains | 1988 |
Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.
Topics: Animals; Cyproheptadine; Insulin; Liver; Lung; Male; Pancreas; Pyridines; Pyrimethamine; Rats; Rats, Inbred Strains | 1988 |
Drug-induced modulations of hepatic heme metabolism. Neurological consequences.
Topics: Animals; Brain; Gastric Emptying; Gluconeogenesis; Heme; Intestine, Small; Liver; Liver Diseases; Models, Biological; Porphyrias; Pyrimethamine; Rats; Serotonin; Tryptophan | 1987 |
Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model.
Topics: Animals; Antineoplastic Agents; Avian Sarcoma Viruses; Carmustine; Drug Therapy, Combination; Glioma; Lipids; Neoplasms, Experimental; Pyrimethamine; Rats; Rats, Inbred F344; Solubility; Tissue Distribution | 1982 |
cDNA-expressed human cytochrome P450 isozymes. Inactivation by porphyrinogenic xenobiotics.
Topics: Allylisopropylacetamide; Cell Line; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Isoenzymes; Lymphocytes; Microsomes; Pyrimethamine; Sydnones | 1997 |
Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase?
Topics: Aminolevulinic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2B1; eIF-2 Kinase; Enzyme Induction; Heat-Shock Proteins; Heme; Hepatocytes; Molecular Chaperones; Peptide Elongation Factor 2; Phenobarbital; Phosphorylation; Proteins; Protoporphyrins; Pyrimethamine; Rats; Steroid Hydroxylases; Transcriptional Activation | 2005 |