pyrimethamine has been researched along with aminopterin in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (79.17) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M | 1 |
| Bera, S; Mondal, D | 1 |
| Filler, J; Humphrey, GB; Krous, HF; Maxwell, JD; VanHoutte, JJ | 1 |
| Dyban, AP | 1 |
| Girdwood, RH | 1 |
| Mines, LS; Sirotnak, FM; Yang, CH | 1 |
| Sirotnak, FM | 1 |
| Jaffe, JJ; McCormack, JJ | 1 |
| McCullough, JL; Weinstein, GD | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Morrison, NE | 1 |
| Heischkeil, R | 1 |
| Baker, BR | 1 |
| Frenkel, JK; Good, JT; Shultz, JA | 1 |
| Lund, E; Lycke, E | 1 |
| Gerzeli, G; Polver, Pde P | 1 |
| Baugh, CM; Gaut, ZN; Solomon, HM | 1 |
| Frick, PG | 1 |
| Dixon, NE; Elvin, CM; Kemp, DH; Liyou, NE; Pearson, R | 1 |
| HITCHINGS, GH; WOOD, RC | 1 |
| JACOBS, RL | 1 |
| NEWELL, FW | 1 |
| WISE, MF; WOOD, RC | 1 |
| Diriye, A; Kiara, S; Kokwaro, G; Masseno, V; Mwai, L; Nduati, E; Nzila, A; Ommeh, S | 1 |
| Irungu, B; Kiboi, D; Langat, B; Nzila, A; Rukunga, G; Wittlin, S | 1 |
4 review(s) available for pyrimethamine and aminopterin
| Article | Year |
|---|---|
Insights of synthetic analogues of anti-leprosy agents.
Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship | 2019 |
Treatment of overt CNS leukemia.
Topics: Adrenal Cortex Hormones; Aminopterin; Antineoplastic Agents; Asparaginase; Blood-Brain Barrier; Carmustine; Child; Cytarabine; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia; Meningeal Neoplasms; Methotrexate; Pyrimethamine | 1979 |
[Theoretical and applied aspects of experimental teratology].
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dactinomycin; DNA Replication; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Fetal Death; Folic Acid Antagonists; Gestational Age; Haplorhini; Humans; Mutation; Pregnancy; Pyrimethamine; Rats; Risk; Species Specificity; Teratogens; Thalidomide; Time Factors | 1977 |
Active-site directed irreversible inhibitors of dihydrofolate reductase.
Topics: Aminopterin; Animals; Binding Sites; Biological Transport, Active; Carcinoma 256, Walker; Folic Acid Antagonists; Intestines; Kidney; Leukemia L1210; Liver; Methotrexate; Mice; Pyrimethamine; Rats; Spleen; Structure-Activity Relationship; Time Factors; Triazines | 1971 |
20 other study(ies) available for pyrimethamine and aminopterin
| Article | Year |
|---|---|
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma | 1995 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12 | 1976 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Cholic Acids; Chromatography; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Molecular Weight; Pyrimethamine; Receptors, Cell Surface; Succinimides | 1988 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
Dihydrofolate reductase from Trypanosoma equiperdum. I. Isolation, partial purification, and properties.
Topics: Aminopterin; Animals; Folic Acid; Folic Acid Antagonists; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methotrexate; NAD; NADP; Pyrimethamine; Rats; Tetrahydrofolate Dehydrogenase; Trypanosoma | 1967 |
Effect of lipid-soluble esters of methotrexate on DNA synthesis in human skin.
Topics: Aminopterin; Depression, Chemical; DNA; Esters; Humans; Lipids; Methotrexate; Pyrimethamine; Skin; Solubility; Temperature; Time Factors; Trimethoprim; Tritium; Uridine | 1974 |
Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
Topics: Aminopterin; Folic Acid Antagonists; Kinetics; Leprosy; Methotrexate; Mycobacterium leprae; Protein Binding; Pteridines; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1974 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene | 1973 |
Latent Pneumocystis infection of rats, relapse, and chemotherapy.
Topics: Aminopterin; Animals; Antiprotozoal Agents; Chlorambucil; Chlortetracycline; Cortisone; Cricetinae; Cyclophosphamide; Drug Synergism; Mice; Pneumonia, Pneumocystis; Pyrimethamine; Rats; Stilbamidines; Sulfadiazine | 1966 |
Studies on the reproduction of Toxoplasma gondii in a cell culture system. Inhibition or stimulation of growth by changes in the p-aminobenzoic acid and the folic acid metabolism.
Topics: Aminobenzoates; Aminopterin; Culture Techniques; Folic Acid; HeLa Cells; Leucovorin; Pyrimethamine; Sulfonamides; Toxoplasma | 1966 |
[A new cytochemical method for the study of the tetrahydrofolatereductase activity in Plasmodium berghei: analysis of the effect of specific inhibitors].
Topics: Aminopterin; Folic Acid Antagonists; Plasmodium; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase | 1969 |
Accumulation of (3',5'-3H2)folic acid by human blood platelets. Effect of dihydrofolic acid reductase inhibitors.
Topics: Aminopterin; Biological Transport, Active; Blood Platelets; Diffusion; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Pyrimethamine; Triamterene; Tritium | 1970 |
[Possible applications of antivitamins and antimetabolites in therapy].
Topics: Aminopterin; Antimetabolites; Azaserine; Child; Child, Preschool; Choriocarcinoma; Diazooxonorleucine; Female; Fluorouracil; Folic Acid Antagonists; Humans; Leukemia; Mercaptopurine; Methotrexate; Pregnancy; Pyrimethamine; Toxoplasmosis; Vitamin K; Vitamins | 1966 |
Molecular cloning and expression of the dihydrofolate reductase (DHFR) gene from adult buffalo fly (Haematobia irritans exigua): effects of antifolates.
Topics: Amino Acid Sequence; Aminopterin; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary; Escherichia coli; Folic Acid Antagonists; Genetic Vectors; Methotrexate; Molecular Sequence Data; Muscidae; Phylogeny; Polymerase Chain Reaction; Pyrimethamine; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tetrahydrofolate Dehydrogenase | 2003 |
A study of the uptake and degradation of folic acid, citrovorum factor, aminopterin, and pyrimethamine by bacteria.
Topics: Aminopterin; Antimalarials; Bacteria; Folic Acid; Leucovorin; Pyrimethamine | 1959 |
ROLE OF P-AMINOBENZOIC ACID IN PLASMODIUM BERGHEI INFECTION IN THE MOUSE.
Topics: 4-Aminobenzoic Acid; Aminopterin; Animals; Chloroquine; Folic Acid; Folic Acid Deficiency; Leucovorin; Malaria; Mice; Pharmacology; Plasmodium berghei; Pyrimethamine; Research | 1964 |
ANTICANCER AGENTS.
Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Corneal Transplantation; Drug Therapy; Eye Neoplasms; Female; Fluorouracil; Humans; Maternal-Fetal Exchange; Neoplasms; Nitrogen Mustard Compounds; Ophthalmology; Pregnancy; Pyrimethamine; Toxicology; Toxoplasmosis; Toxoplasmosis, Ocular; Transplantation Immunology; Uveitis | 1964 |
CONVERSION OF FOLIC ACID DERIVATIVES TO THEIR CONJUGATED FORMS BY CELLS OF STREPTOCOCCUS FAECALIS.
Topics: Amino Acids; Aminopterin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimetabolites; Bacteriological Techniques; Dermatologic Agents; Enterococcus faecalis; Folic Acid; Formates; Glutamates; Hydrogen-Ion Concentration; Leucovorin; Metabolism; Methotrexate; Pharmacology; Pigments, Biological; Pyrimethamine; Research | 1965 |
Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.
Topics: Aminopterin; Animals; Antimalarials; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Inhibitory Concentration 50; Leucovorin; Methotrexate; Molecular Structure; Plasmodium falciparum; Proguanil; Pyrimethamine; Tetrahydrofolates; Triazines; Trimetrexate | 2008 |
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species.
Topics: Administration, Oral; Aminopterin; Animals; Biological Availability; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Malaria; Methotrexate; Mice; Plasmodium; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Pyrimethamine | 2009 |