pyrilamine has been researched along with ovalbumin in 85 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (35.29) | 18.7374 |
| 1990's | 40 (47.06) | 18.2507 |
| 2000's | 11 (12.94) | 29.6817 |
| 2010's | 4 (4.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleisch, JH; Hooker, CS; Schmidt, MJ; Spaethe, SM; Truex, LL | 1 |
| Barrett-Bee, KJ; Green, LR | 1 |
| Chand, N | 1 |
| Buckner, CK; Hand, JM | 1 |
| Broder, I; Chamberlain, DW; Milne, EN; Rogers, S | 1 |
| Bernauer, W | 1 |
| Fidler, SF; Griffin, RL; Reid, MS; Richards, IM; Shields, SK | 1 |
| Chand, N; Diamantis, W; Nolan, K; Pillar, J; Sofia, RD; Zomask, M | 1 |
| Howell, RE; Sickels, BD; Weichman, BM | 1 |
| Hibi, M; Iwama, T; Sakashita, M; Shikada, K; Tanaka, S; Yamamoto, A | 1 |
| Chan, CC; Foster, A | 1 |
| Ahmad, Z; Baumann, G; Blömer, H; Felix, SB; Hashemi, T; Niemczyk, M; Ochsenfeld, G; Shirani, S | 1 |
| Ahmad, Z; Baumann, G; Berdel, WE; Felix, SB; Hashemi, T; Niemczyk, M | 1 |
| Kontny, M; LaPlante, AM; Lazer, ES; Letts, LG; Wegner, CD; Wolyniec, WW | 1 |
| Harada, K; Katayama, K; Katayama, S; Muramoto, K; Sakuma, Y; Tsunoda, H | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T; Uchida, M | 1 |
| Heuer, HO | 2 |
| Ishii, A; Miyamoto, T; Mizushima, Y; Motoishi, M; Nakagawa, T; Nambu, F; Shida, T; Yui, Y | 1 |
| Aliaga, M; Barbara, M; Tarayre, JP; Tisne-Versailles, J; Tisseyre, N; Vieu, S | 1 |
| Andersson, RG; Granérus, G; Grundström, N; Lindström, EG | 1 |
| Fernandes, LB; Goldie, RG | 1 |
| Lefort, J; Lellouch-Tubiana, A; Terlain, B; Vannier, E; Vargaftig, BB | 1 |
| Calonge, MC; González, JL; Herreras, JM; Pastor, JC | 1 |
| Barnes, PJ; Ichinose, M | 1 |
| Conklyn, M; Showell, HJ; Watson, JW | 1 |
| Montaño, LM; Segura, P; Selman, M; Vanda, B; Vargas, MH | 1 |
| Chand, N; Diamantis, W; Hess, FG; McGee, J; Nolan, K; Sofia, RD | 1 |
| Creese, BR; Temple, DM | 1 |
| Charette, L; Denis, D; Jones, TR | 1 |
| Dahlén, SE; Hedqvist, P; Raud, J; Smedegård, G | 1 |
| Bertrand, C; Landry, Y; Tschirhart, E | 1 |
| Casals-Stenzel, J; Heuer, H | 1 |
| Abdullah, NA; Assem, ES | 1 |
| Gary, RK; Gleason, JG; Nieves, AL; Wasserman, MA; Williams, LS; Woodward, DF | 1 |
| Aharony, D; Redkar-Brown, DG | 1 |
| Gleason, JG; Hall, RF; Hay, DW; Muccitelli, RM; Torphy, TJ; Tucker, SS; Vickery-Clark, LM; Wasserman, MA; Wilson, KA | 1 |
| Malo, PE; Muccitelli, R; Tucker, SS; Wasserman, MA | 1 |
| Cordeiro, R; Garcez Do Carmo, L; Lagente, V; Lefort, J; Randon, J; Vargaftig, BB | 1 |
| Cirino, M; Desquand, S; Lagente, V; Lefort, J; Vargaftig, BB | 1 |
| de Nucci, G; Payne, AN | 1 |
| Casals-Stenzel, J | 1 |
| Baird, AW; Cuthbert, AW; MacVinish, LJ | 1 |
| Kitamura, S; Shimizu, K; Takaku, F; Uchida, Y | 1 |
| Nijkamp, FP; Ramakers, AG | 1 |
| Carethers, ME; Janik, GM; Robichaud, LJ; Unangst, PC; Webster, K | 1 |
| Wasserman, MA; Weichman, BM; Woodward, DF | 1 |
| Alphin, RS; Callaham, EM; Foxwell, MH; Smith, WL; Yanni, JM | 1 |
| Burka, JF; Paterson, NA | 1 |
| Anderson, WH; O'Donnell, M; Simko, BA; Welton, AF | 1 |
| Andersson, RG; Hedman, SE | 1 |
| Antonissen, LA; Bergen, J; Kepron, W; Kroeger, EA; Mitchell, RW; Stephens, NL | 1 |
| Myers, AC; Undem, BJ | 1 |
| Krasnopolsky, L; Lee, JG; Levin, RM; Longhurst, PA; Wein, AJ | 1 |
| Buckner, CK; Conklin, R; Doran, O; Fishleder, RI; Graziano, FM; Will, JA | 1 |
| Dahlén, SE; Jonsson, EW | 1 |
| Asakura, K; Narita, S | 1 |
| Meurs, H; Olymulder, CG; Santing, RE; Schraa, EO; Wachters, A; Zaagsma, J | 1 |
| Aishita, H; Furuya, T; Kobayashi, T; Muryobayashi, K; Nakagawa, N; Nambu, F; Obata, T; Okada, Y; Sawada, M; Terawaki, T | 1 |
| Adams, GK; Kelly, LJ; Undem, BJ | 1 |
| Heuer, HO; Jennewein, HM; Urich, K; Wenz, B | 1 |
| Arakawa, H; Lötvall, J; Mochizuki, H; Morikawa, A; Tokuyama, K | 1 |
| Amann, R; Donnerer, J; Peskar, BA; Schuligoi, R | 1 |
| Iwahisa, Y; Kagoshima, M; Kawakami, Y; Matsuura, M; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 1 |
| Fuchigami, J; Hata, H; Ikegami, K; Kohjimoto, Y; Tanaka, K; Tasaka, K; Uchida, S | 1 |
| Andersson, RG; Lindström, EG | 1 |
| Fujita, M; Kawabata, K; Nakagawa, N; Ohno, H; Takeda, H; Yonetomi, Y | 1 |
| Esteve, H; Hsieh, L; Knippenberg, R; Kudlacz, E; Logan, D; Maynard, G; Olsen, K; Shatzer, S | 1 |
| Kohno, S; Nabe, T; Tomioka, H; Yamashita, K | 1 |
| Kohno, S; Miyake, I; Nabe, T; Yamamura, H | 1 |
| Akar, F | 1 |
| Glatzle, J; Grundy, D; Kreis, ME; Müller, M; Zittel, TT | 1 |
| Belvisi, MG; Birrell, MA; Foster, ML; Hele, DJ; Webber, SE | 1 |
| Hardwick, JC; Peterson, BA; Powers, MJ | 1 |
| Liu, T; Wang, B; Yang, P | 1 |
| Broadley, KJ; Martin, TJ | 1 |
| Endo, Y; Fujita, T; Matsushita, M; Ohtaki, Y; Takada, H; Yamaguchi, K; Yokochi, T; Zhao, L | 1 |
| Dahlén, SE; Låstbom, L; Ryrfeldt, A; Sundström, E | 1 |
| Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y | 1 |
| Boswell-Smith, V; Keir, S; Page, C; Spina, D | 1 |
| Al Suleimani, YM; Dong, Y; Walker, MJ | 1 |
| Browning, C; Clark, KL; Connor, HE; Ford, AJ; Hall, DA; Hodgson, ST; Luttmann, MA; Russell, LJ; Saunders, KA; Slack, RJ | 1 |
| Beermann, S; Glage, S; Jonigk, D; Neumann, D; Seifert, R | 1 |
| Adner, M; Dahlén, SE; Fuchs, B; Karlsson, L; Nilsson, GP; Rao, NL; Riley, JP; Sjöberg, L | 1 |
| Bäumer, W; Gutzmer, R; Kietzmann, M; Köchling, H; Rossbach, K; Schaper, K; Werfel, T; Wilzopolski, J | 1 |
1 trial(s) available for pyrilamine and ovalbumin
| Article | Year |
|---|---|
Effect of leukotriene antagonist on experimental and clinical bronchial asthma.
Topics: Allergens; Anaphylaxis; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Chromones; Drug Evaluation; Drug Evaluation, Preclinical; Dust; Guinea Pigs; Histamine; Humans; Immunization, Passive; Indomethacin; Male; Ovalbumin; Pyrilamine; SRS-A | 1991 |
84 other study(ies) available for pyrilamine and ovalbumin
| Article | Year |
|---|---|
Ethanol inhibition of antigen-induced histamine release from guinea pig lung: correlation with intracellular levels of cyclic nucleotides.
Topics: Animals; Antigens; Cyclic AMP; Cyclic GMP; Ethanol; Guinea Pigs; Histamine Release; In Vitro Techniques; Isoproterenol; Lung; Male; Metiamide; Ovalbumin; Pyrilamine; Time Factors | 1979 |
The relationship between prostaglandin release and lung c-AMP levels during anaphylaxis in the guinea-pig.
Topics: Anaphylaxis; Animals; Burimamide; Cyclic AMP; Guinea Pigs; Histamine; Immunization; Indomethacin; Isoproterenol; Lung; Ovalbumin; Polyphloretin Phosphate; Propranolol; Prostaglandins E; Prostaglandins F; Pyrilamine; Serotonin | 1975 |
In vitro anaphylaxis in guinea-pig lung: evidence for the protective role of histamine H2-receptors.
Topics: Anaphylaxis; Animals; Female; In Vitro Techniques; Lung; Male; Metiamide; Mice; Ovalbumin; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2 | 1979 |
Effects of selected antagonists on ovalbumin-induced contraction of tracheal strips isolated from the actively sensitized guinea-pig.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Airway Resistance; Animals; Barium; Guinea Pigs; In Vitro Techniques; Indomethacin; Ovalbumin; p-Methoxy-N-methylphenethylamine; Phenoxybenzamine; Pyrilamine; Trachea | 1979 |
Model of allergic bronchoconstriction in the guinea pig. I. Characteristics of the system.
Topics: Administration, Intranasal; Aerosols; Animals; Antibodies; Antigens; Bronchi; Bronchography; Cattle; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Immunologic; Guinea Pigs; Hypersensitivity; Lung; Lung Compliance; Lung Volume Measurements; Ovalbumin; Pyrilamine; Respiration; Serum Albumin, Bovine; Tracheotomy | 1978 |
Release of creatine kinase by antigen, histamine, and catecholamines.
Topics: Anaphylaxis; Animals; Antigens; Catecholamines; Creatine Kinase; Dibenzylchlorethamine; Epinephrine; Female; Guinea Pigs; Histamine; Male; Myocardium; Norepinephrine; Ovalbumin; Pyrilamine | 1976 |
Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats.
Topics: Animals; Ascaris; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Dogs; Guinea Pigs; Metyrapone; Neutrophils; Ovalbumin; Pulmonary Eosinophilia; Pyrilamine; Rats; Respiratory Function Tests | 1992 |
Characterization of aeroallergen-induced dyspnea in unrestrained guinea pigs by bias-flow-ventilated whole body plethysmography.
Topics: Aerosols; Allergens; Animals; Dyspnea; Guinea Pigs; Male; Ovalbumin; Plethysmography, Whole Body; Pyrilamine; Respiratory Function Tests | 1992 |
Comparison of the airway hyperreactivity produced by single and multiple antigen exposures in sensitized guinea pigs.
Topics: Animals; Antigens; Bronchial Hyperreactivity; Dexamethasone; Guinea Pigs; Ketotifen; Male; Methacholine Compounds; Ovalbumin; Pyrilamine; SRS-A | 1992 |
Inhibitory effect of NZ-107 on anaphylactic bronchoconstriction in guinea pigs and rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Anaphylaxis; Animals; Bronchoconstriction; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Indomethacin; Injections, Intravenous; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Prostaglandin Endoperoxides, Synthetic; Pyridazines; Pyrilamine; Rats; Rats, Inbred Strains; Regression Analysis; SRS-A | 1992 |
Peptide leukotriene involvement in pulmonary eosinophil migration upon antigen challenge in the actively sensitized guinea pig.
Topics: Animals; Bronchial Hyperreactivity; Cell Movement; Cimetidine; Eosinophils; Guinea Pigs; Indomethacin; Leukotrienes; Male; Ovalbumin; Propionates; Pyrilamine; Quinolines; Receptors, Immunologic; Receptors, Leukotriene | 1991 |
Effects of histamine H1-receptor blockade on respiratory and cardiac manifestation of systemic anaphylaxis.
Topics: Anaphylaxis; Animals; Blood Gas Analysis; Electrocardiography; Female; Guinea Pigs; Heart; Heart Ventricles; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Ovalbumin; Pyrilamine; Respiration | 1991 |
Characterization of cardiovascular events mediated by platelet activating factor during systemic anaphylaxis.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Azepines; Blood Pressure; Cardiac Output; Cimetidine; Electrocardiography; Female; Guinea Pigs; Heart Rate; Hemodynamics; Histamine; Male; Myocardial Contraction; Ovalbumin; Platelet Activating Factor; Pyrilamine; Triazoles | 1990 |
BI-L-239, a 5-lipoxygenase inhibitor, blocks inhaled antigen-induced airway hyperresponsiveness in conscious guinea pigs.
Topics: Administration, Inhalation; Airway Resistance; Animals; Antigens; Bronchoconstriction; Guinea Pigs; Indomethacin; Lipoxygenase Inhibitors; Male; Methacholine Compounds; Ovalbumin; Phenols; Pyrilamine; Respiratory Hypersensitivity | 1991 |
Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Asthma; Azepines; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; Triazoles | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; SRS-A; Thiazoles; Thiazolidines | 1991 |
Effect of the hetrazepinoic platelet-activating factor antagonist Bepafant (WEB 2170) in models of active and passive anaphylaxis in mice and guinea pigs.
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Lung; Male; Mice; Mice, Inbred Strains; Ovalbumin; Passive Cutaneous Anaphylaxis; Platelet Activating Factor; Propranolol; Pyrilamine; Respiration; Triazoles | 1991 |
Pharmacological modulation of a model of bronchial inflammation after aerosol-induced active anaphylactic shock in conscious guinea pigs.
Topics: Albuterol; Anaphylaxis; Animals; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Dexamethasone; Disease Models, Animal; Guinea Pigs; Male; Ovalbumin; Pyrilamine | 1991 |
Is the airway epithelium responsible for histamine metabolism in the trachea of guinea pigs?
Topics: Amine Oxidase (Copper-Containing); Animals; Antigens; Epithelium; Female; Guanidines; Guinea Pigs; Histamine; Methylhistamines; Muscle Contraction; Ovalbumin; Pyrilamine; Trachea | 1991 |
Inhibition of active anaphylaxis in mice and guinea pigs by the new hetrazepinoic PAF antagonist bepafant (WEB 2170).
Topics: Anaphylaxis; Animals; Azepines; Blood Pressure; Bronchoconstriction; Guinea Pigs; Immunization; Male; Mice; Ovalbumin; Platelet Activating Factor; Propranolol; Pulmonary Ventilation; Pyrilamine; Triazoles | 1991 |
Antigen-induced release of airway epithelium-derived inhibitory factor.
Topics: Animals; Antigens; Biological Factors; Dose-Response Relationship, Immunologic; Endothelium, Vascular; Epithelium; Guinea Pigs; Histamine; Immunization; Leukotrienes; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; p-Methoxy-N-methylphenethylamine; Pyrilamine; Rats; Rats, Inbred Strains; SRS-A; Trachea | 1991 |
Lipopolysaccharide from Escherichia coli reduces antigen-induced bronchoconstriction in actively sensitized guinea pigs.
Topics: Animals; Antigens; Aspirin; Bronchoconstriction; Cell Degranulation; Endotoxins; Escherichia coli; Guinea Pigs; Hemodynamics; Histamine; Hypersensitivity; Leukopenia; Lipopolysaccharides; Mast Cells; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Ovalbumin; Platelet Activating Factor; Pyrilamine; Thromboxane B2 | 1991 |
Pharmacologic modulation of vascular permeability in ocular allergy in the rat.
Topics: Animals; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Cromolyn Sodium; Dexamethasone; Disease Models, Animal; Dithiothreitol; Evans Blue; Male; Ovalbumin; Pyrilamine; Rats; Rats, Inbred Strains | 1990 |
Histamine H3 receptors modulate antigen-induced bronchoconstriction in guinea pigs.
Topics: Animals; Antigens; Bronchoconstriction; Cimetidine; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Guinea Pigs; Histamine; Immunization; Male; Ovalbumin; Piperidines; Pyrilamine; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Skin Tests | 1990 |
IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.
Topics: Acute Disease; Animals; Azepines; Bronchoconstriction; Dicarboxylic Acids; Dose-Response Relationship, Drug; Furans; Guinea Pigs; Immunization; Immunoglobulin G; Indoles; Lipids; Lung; Male; Ovalbumin; Phenylcarbamates; Piroxicam; Platelet Activating Factor; Propranolol; Pyrilamine; Respiratory Hypersensitivity; SRS-A; Sulfonamides; Tosyl Compounds; Triazoles | 1990 |
Pharmacological characterization of mediators and vagal influence in the acute allergic bronchoconstriction in guinea pigs.
Topics: Adenosine; Animals; Bronchoconstriction; Dexamethasone; Diethylcarbamazine; Dipyridamole; Eicosanoic Acids; Female; Guinea Pigs; Histamine; Indomethacin; Male; Neural Pathways; Ovalbumin; Pyrilamine; Respiratory Hypersensitivity; Vagotomy; Vagus Nerve | 1990 |
Aeroallergen-induced immediate asthmatic responses and late-phase associated pulmonary eosinophilia in the guinea pig: effect of methylprednisolone and mepyramine.
Topics: Administration, Oral; Aerosols; Aminopyridines; Animals; Asthma; Drug Administration Schedule; Guinea Pigs; Methylprednisolone; Ovalbumin; Premedication; Pulmonary Eosinophilia; Pyrilamine | 1990 |
Anaphylactic responses of guinea-pig lung parenchymal strips: antigen concentration dependence and pharmacological modification.
Topics: Anaphylaxis; Animals; Antigens; Chromones; Female; Guinea Pigs; Histamine Release; In Vitro Techniques; Lung; Ovalbumin; Pyrilamine | 1986 |
Antigen-induced contraction of guinea-pig isolated trachea: studies with novel inhibitors and antagonists of arachidonic acid metabolites.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acids; Cyclooxygenase Inhibitors; Guinea Pigs; In Vitro Techniques; Isoproterenol; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Pyrilamine; Theophylline; Thromboxane-A Synthase; Trachea | 1988 |
An intravital microscopic model for mast cell-dependent inflammation in the hamster cheek pouch.
Topics: Acute-Phase Reaction; Allergens; Animals; Antigens; Cheek; Cricetinae; Inflammation; Male; Mast Cells; Mesocricetus; Microcirculation; Models, Biological; Ovalbumin; p-Methoxy-N-methylphenethylamine; Pyrilamine | 1989 |
Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea.
Topics: Airway Resistance; Anaphylaxis; Animals; Benzoquinones; Chromones; Cromolyn Sodium; Flavonols; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Male; Nedocromil; Ovalbumin; Pyrilamine; Quercetin; Quinolones; Quinones; Trachea | 1989 |
The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Disease Models, Animal; Endotoxins; Escherichia coli; Guinea Pigs; Lung Diseases; Ovalbumin; Platelet Activating Factor; Pyrilamine; Shock, Septic; Triazines; Triazoles | 1989 |
Role of thromboxane A2, leukotriene C4 and histamine in the antigen-induced vasoconstriction in perfused, sensitized guinea-pig kidney.
Topics: Animals; Antigens; Guinea Pigs; Histamine; Immunization; In Vitro Techniques; Kidney; Ovalbumin; Perfusion; Pyrilamine; SRS-A; Thromboxane A2; Vasoconstriction | 1989 |
Interactive effects of peptidoleukotrienes and histamine on microvascular permeability and their involvement in experimental cutaneous and conjunctival immediate hypersensitivity.
Topics: Animals; Capillary Permeability; Chromium Radioisotopes; Cimetidine; Conjunctiva; Dicarboxylic Acids; Guinea Pigs; Histamine; Hypersensitivity, Immediate; Iodine Radioisotopes; Leukotrienes; Male; Ovalbumin; Pyrilamine; Skin | 1989 |
Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615.
Topics: Animals; Antigens; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Leukotrienes; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Phospholipid Ethers; Platelet Activating Factor; Pyrazoles; Pyrilamine; SRS-A; Trachea | 1989 |
Pharmacologic profile of SK&F 104353: a novel, potent and selective peptidoleukotriene receptor antagonist in guinea pig and human airways.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adult; Animals; Borates; Bronchi; Child; Dicarboxylic Acids; Female; Guinea Pigs; Humans; Immunoglobulin E; In Vitro Techniques; Male; Muscle Contraction; Ovalbumin; Pyrilamine; Receptors, Leukotriene; Receptors, Prostaglandin; Serine; SRS-A; Trachea | 1987 |
Effects of SK&F 93944 (Temelastine), a potent histamine H1-receptor antagonist in pharmacologic and antigen-induced bronchoconstriction.
Topics: Animals; Antigens; Bronchi; Dogs; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Ovalbumin; Pyrilamine; Pyrimidinones; Trachea | 1986 |
Failure of a combined anti-histamine and anti-leukotriene treatment to suppress passive anaphylaxis in the guinea-pig.
Topics: Anaphylaxis; Animals; Aspirin; Chromones; Female; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Lung; Male; Muscle Contraction; Ovalbumin; Propranolol; Pyrilamine; SRS-A | 1986 |
Involvement of PAF-acether in anaphylactic bronchoconstriction induced in guinea pigs by aerosolized antigen.
Topics: Aerosols; Anaphylaxis; Animals; Antigens; Bronchial Spasm; Chromones; Desensitization, Immunologic; Female; Guinea Pigs; Histamine; Male; Ovalbumin; Platelet Activating Factor; Pyrilamine; Time Factors | 1988 |
Anaphylaxis in guinea pigs induced by ovalbumin aerosol in vivo and in vitro methods.
Topics: Aerosols; Anaphylaxis; Animals; Guinea Pigs; Hemodynamics; Male; Ovalbumin; Pyrilamine; Respiratory Function Tests | 1987 |
Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis.
Topics: Administration, Oral; Anaphylaxis; Animals; Azepines; Blood Pressure; Guinea Pigs; Immunization; Immunization, Passive; Injections, Intravenous; Male; Mice; Ovalbumin; Platelet Activating Factor; Pyrilamine; Respiration; Triazines; Triazoles | 1987 |
Type 1 hypersensitivity reactions in reconstructed tissues using syngeneic cell types.
Topics: Animals; Cells, Cultured; Electrophysiology; Epithelium; Guinea Pigs; Histamine; Hypersensitivity, Immediate; In Vitro Techniques; Kinins; Lactoglobulins; Mast Cells; Ovalbumin; Peritoneal Cavity; Pyrilamine; Rats; Rats, Inbred Strains; Tetrodotoxin | 1987 |
[Effects of various drugs on antigen-induced contractile responses in guinea pig tracheal and lung parenchymal strips].
Topics: Animals; Antigen-Antibody Reactions; Benzoquinones; Guinea Pigs; In Vitro Techniques; Lung; Methysergide; Muscle Contraction; Ovalbumin; Pyrilamine; Quinones; Trachea | 1985 |
Prevention of anaphylactic bronchoconstriction by a lipoxygenase inhibitor.
Topics: Anaphylaxis; Animals; Autacoids; Bronchial Spasm; Drug Interactions; Guinea Pigs; Lipoxygenase Inhibitors; Male; Ovalbumin; Pyrilamine; SRS-A | 1980 |
Acidic furo[3,2-b]indoles. A new series of potent antiallergy agents.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Furans; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Indicators and Reagents; Indoles; Lung; Magnetic Resonance Spectroscopy; Male; Ovalbumin; Pyrilamine; Structure-Activity Relationship | 1984 |
Investigation of leukotriene involvement in the vasopermeability response associated with guinea pig tracheal anaphylaxis: comparison with cutaneous anaphylaxis.
Topics: Anaphylaxis; Animals; Capillary Permeability; Chromium Radioisotopes; Chromones; Female; Guinea Pigs; Histamine; In Vitro Techniques; Leukotriene E4; Ovalbumin; Passive Cutaneous Anaphylaxis; Pyrilamine; SRS-A; Time Factors; Trachea | 1983 |
A method for measuring changes in tracheal mucus gel layer thickness as an indication of an immediate hypersensitivity response.
Topics: Acetylcysteine; Aluminum Hydroxide; Animals; Atropine; Chromones; Cimetidine; Cromolyn Sodium; Dose-Response Relationship, Immunologic; Expectorants; Hypersensitivity, Immediate; Immune Sera; Methods; Methysergide; Mucus; Ovalbumin; Pyrilamine; Rats; Rats, Inbred Strains; Trachea | 1984 |
A comparison of antigen-induced and calcium ionophore A23187 induced contraction of isolated guinea pig trachea.
Topics: Animals; Anti-Bacterial Agents; Antigens; Calcimycin; Calcium; Contracture; Guinea Pigs; Indomethacin; Male; Ovalbumin; Pyrazoles; Pyrilamine; Time Factors; Trachea | 1981 |
An in vivo model for measuring antigen-induced SRS-A-mediated bronchoconstriction and plasma SRS-A levels in the guinea-pig.
Topics: Animals; Antigens; Bronchial Spasm; Guinea Pigs; Male; Ovalbumin; Pyrilamine; Respiration; SRS-A; Time Factors | 1983 |
Decreased Schultz-Dale reaction in airways from sensitized guinea pigs treated with threshold concentrations of egg albumin in vivo.
Topics: Animals; Female; Guinea Pigs; Histamine; Hypersensitivity, Immediate; Lung; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Pyrilamine; Receptors, Histamine H1; SRS-A | 1982 |
Histamine pharmacology in airway smooth muscle from a canine model of asthma.
Topics: Airway Resistance; Anaphylaxis; Animals; Asthma; Dogs; Histamine; In Vitro Techniques; Methylhistamines; Metiamide; Muscle Contraction; Muscle, Smooth; Ovalbumin; Pyrilamine; Receptors, Histamine H2; Trachea | 1980 |
Antigen depolarizes guinea pig bronchial parasympathetic ganglion neurons by activation of histamine H1 receptors.
Topics: Animals; Antibodies; Bronchi; Chickens; Ganglia, Parasympathetic; Guinea Pigs; Histamine; Humans; Immunization, Passive; Male; Membrane Potentials; Neurons; Ovalbumin; Pyrilamine; Receptors, Histamine H1; Serum Albumin | 1995 |
Effects of the peptide leukotriene receptor antagonist ICI 198,615 on the in vivo and in vitro changes in guinea pig bladder function which occur after sensitization with ovalbumin.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Indazoles; Indomethacin; Leukotriene Antagonists; Muscle Contraction; Ovalbumin; Pyrilamine; SRS-A; Urinary Bladder; Urodynamics | 1995 |
Pharmacologic modulation of the influence of the epithelium on immunologic- and nonimmunologic-induced histamine release and contraction in guinea pig superfused tracheal strips.
Topics: Animals; Epithelium; Female; Guinea Pigs; Histamine Release; Hydroxyurea; In Vitro Techniques; Indazoles; Indomethacin; Muscle Contraction; Ovalbumin; Pyrilamine; Trachea; Tubocurarine | 1993 |
Leukotrienes and other mediators of the Schultz-Dale reaction in guinea-pig lung parenchyma.
Topics: Animals; Guinea Pigs; Inflammation; Leukotriene B4; Leukotrienes; Lung; Male; Metiamide; Ovalbumin; Pyrilamine; Quinolines | 1995 |
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
Topics: Airway Resistance; Animals; Azepines; Chromones; Guinea Pigs; Histamine H1 Antagonists; Immunization; Lipoxygenase Inhibitors; Male; Ovalbumin; Phthalazines; Platelet Activating Factor; Pyrilamine; Rhinitis, Allergic, Perennial; Sneezing; SRS-A; Thiazoles; Thiazolidines; Triazoles | 1993 |
Role of histamine in allergen-induced asthmatic reactions, bronchial hyperreactivity and inflammation in unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoalveolar Lavage Fluid; Guinea Pigs; Histamine; Male; Methacholine Compounds; Ovalbumin; Pyrilamine; Respiratory Function Tests | 1994 |
Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma.
Topics: Acetylcholine; Acute-Phase Reaction; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Chromones; Disease Models, Animal; Guinea Pigs; Hypersensitivity; Immunization; Male; Ovalbumin; Phthalazines; Pulmonary Eosinophilia; Pyrilamine; SRS-A | 1993 |
Antigen-induced contraction of guinea pig isolated pulmonary arteries and lung parenchyma.
Topics: Animals; Antigens; Dicarboxylic Acids; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Male; Metiamide; Muscle Contraction; Ovalbumin; Pulmonary Artery; Pyrilamine; SRS-A; Vasoconstriction | 1993 |
Pharmacological characterisation of a new model of antigen-induced pulmonary late-phase reaction in the conscious guinea pig which uses additional polymyxin B inhalation.
Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Antigens; Asthma; Azepines; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Delayed; Male; Ovalbumin; Polymyxin B; Pyrilamine; Triazoles | 1996 |
Effect of maturation on allergen-induced airflow obstruction and airway plasma exudation in sensitized guinea pigs.
Topics: Age Factors; Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Exudates and Transudates; Guinea Pigs; Histamine; Histamine H1 Antagonists; Humans; Immunization, Passive; Male; Ovalbumin; Pyrilamine; Respiratory System | 1997 |
Release of calcitonin gene-related peptide in cardiac anaphylaxis.
Topics: 6-Ketoprostaglandin F1 alpha; Anaphylaxis; Animals; Calcitonin Gene-Related Peptide; Cimetidine; Coronary Circulation; Cyclooxygenase Inhibitors; Guinea Pigs; Heart; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Leukotriene C4; Lipoxygenase Inhibitors; Myocardium; Ovalbumin; Pyrilamine; Quinolines; Thromboxane B2 | 1997 |
Suppressive effects of Y-24180, a receptor antagonist to platelet activating factor (PAF), on antigen-induced asthmatic responses in guinea pigs.
Topics: Administration, Oral; Aerosols; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Chromones; Enzyme Inhibitors; Guinea Pigs; Heptanoic Acids; Histamine Antagonists; Leukotriene Antagonists; Male; Methacrylates; Ovalbumin; Platelet Membrane Glycoproteins; Pyrilamine; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine Proteinase Inhibitors; Signal Transduction; Theophylline; Thromboxane-A Synthase; Triazoles | 1997 |
Apafant (a PAF receptor antagonist) suppresses the early and late airway responses in guinea pigs: a comparison with antiasthmatic drugs.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Airway Resistance; Albuterol; Animals; Anti-Asthmatic Agents; Azepines; Bronchodilator Agents; Cromolyn Sodium; Dexamethasone; Drug Interactions; Glucocorticoids; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; Methacrylates; Metyrapone; Ovalbumin; Platelet Aggregation Inhibitors; Plethysmography; Pyrilamine; Theophylline; Thromboxane-A Synthase; Triazoles; Vaccination | 1997 |
Neurokinin A-LI release after antigen challenge in guinea-pig bronchial tubes: influence of histamine and bradykinin.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Bronchi; Capsaicin; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Ovalbumin; Pyrilamine; Substance P; Trachea | 1997 |
Effects of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs.
Topics: Airway Resistance; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Chromones; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Indomethacin; Leukotriene Antagonists; Nasal Mucosa; Ovalbumin; Phthalazines; Pyrilamine; Rhinitis, Allergic, Perennial; SRS-A; Thromboxane B2 | 1997 |
A role for histamine and substance P in immediate allergic responses in guinea pig airways: characterization of MDL 108,207DA, a dual H1/NK-1 receptor antagonist.
Topics: Animals; Benzimidazoles; Bronchi; Capillary Permeability; CHO Cells; Cricetinae; Dipeptides; Drug Combinations; Guinea Pigs; Histamine; Histamine H1 Antagonists; Indoles; Inositol Phosphates; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Ovalbumin; Pyrilamine; Pyrrolidines; Radioligand Assay; Receptors, Histamine H1; Receptors, Neurokinin-1; Respiratory Hypersensitivity; Skin Tests; Substance P; Trachea; Tumor Cells, Cultured | 1998 |
Repeated antigen inhalations alter chemical mediators that cause asthmatic obstruction in guinea pigs.
Topics: Administration, Inhalation; Airway Obstruction; Aluminum Hydroxide; Animals; Antigens; Asthma; Benzoquinones; Chromones; Eosinophilia; Guinea Pigs; Heptanoic Acids; Histamine H1 Antagonists; Leukotriene Antagonists; Lung; Male; Ovalbumin; Prostaglandin Antagonists; Pyrilamine; Thromboxane A2 | 1999 |
Reproducible biphasic cutaneous edema induced by topical and repeated application of antigen in sensitized mice.
Topics: Animals; Antigens; Benzoquinones; Cyclooxygenase Inhibitors; Dermatitis, Allergic Contact; Histamine H1 Antagonists; Indomethacin; Lipoxygenase Inhibitors; Male; Mice; Ovalbumin; Pyrilamine; Reproducibility of Results | 2000 |
Endothelial reactivity to the immediate hypersensitivity reaction of guinea pig pulmonary artery.
Topics: Animals; Dicarboxylic Acids; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Female; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Immediate; In Vitro Techniques; Leukotriene Antagonists; Male; Nitric Oxide Synthase; Nitroarginine; Ovalbumin; Pulmonary Artery; Pyrilamine; Vasoconstriction; Vasodilation | 2000 |
Mediators of neuronal activation in the rat brainstem following intestinal anaphylaxis.
Topics: Anaphylaxis; Animals; Brain Stem; Chickens; Histamine H1 Antagonists; Immunohistochemistry; Indomethacin; Intestinal Mucosa; Intestines; Male; Neurons, Afferent; Ovalbumin; Proto-Oncogene Proteins c-fos; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Histamine H1; Solitary Nucleus | 2000 |
Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Bronchi; Bronchial Spasm; Capillary Permeability; Cyclopropanes; Histamine; Histamine H1 Antagonists; Leukotriene D4; Male; Methysergide; Ovalbumin; Pyrilamine; Quinolines; Rats; Rats, Inbred BN; Respiratory Hypersensitivity; Serotonin; Serotonin Antagonists; Sulfides; Trachea | 2001 |
Regulation of parasympathetic neurons by mast cells and histamine in the guinea pig heart.
Topics: Action Potentials; Animals; Cimetidine; Female; Ganglia, Parasympathetic; Guinea Pigs; Heart; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Immunohistochemistry; Male; Mast Cells; Microtubule-Associated Proteins; Neurons; Ovalbumin; Pyrilamine; Receptors, Histamine; Vagus Nerve | 2001 |
[Effect of substance P on the short-circuit current of nasal mucosal epithelium].
Topics: Animals; Biphenyl Compounds; Electrophysiology; Epithelium; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Nasal Mucosa; Ovalbumin; Pyrilamine; Ranitidine; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Perennial; Substance P; Tetrodotoxin | 1998 |
Mediators of adenosine- and ovalbumen-induced bronchoconstriction of sensitized guinea-pig isolated airways.
Topics: Adenosine; Animals; Bronchoconstriction; Diclofenac; Guinea Pigs; Immunization; Lung; Male; Ovalbumin; Pyrilamine; Trachea | 2002 |
LPS-induced platelet response and rapid shock in mice: contribution of O-antigen region of LPS and involvement of the lectin pathway of the complement system.
Topics: Anaphylaxis; Animals; Blood Platelets; Complement Activation; Complement C4; Complement C5; Endotoxins; Escherichia coli; Histamine; Humans; Injections, Intravenous; Lectins; Lipopolysaccharides; Liver; Lung; Male; Mannose; Mannose-Binding Lectin; Mannose-Binding Protein-Associated Serine Proteases; Mast Cells; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred DBA; O Antigens; Ovalbumin; Pyrilamine; Serine Endopeptidases; Serotonin; Sesquiterpenes; Shock, Septic; Structure-Activity Relationship | 2002 |
Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bronchoconstriction; Cysteine; Drug Interactions; Guinea Pigs; Histamine; Histamine Antagonists; Leukotriene D4; Leukotrienes; Lung; Male; Ovalbumin; Perfusion; Pyrilamine; Thromboxanes | 2003 |
Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
Topics: Airway Resistance; Animals; Anti-Allergic Agents; Area Under Curve; Carbazoles; Disease Models, Animal; Guinea Pigs; Indoles; Leukotrienes; Male; Ovalbumin; Phenylcarbamates; Pyrilamine; Rhinitis; Sulfonamides; Terfenadine; Thromboxanes; Tosyl Compounds | 2005 |
Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Airway Obstruction; Airway Resistance; Anesthesia; Animals; Bronchoalveolar Lavage Fluid; Capsaicin; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; Lung; Male; Neural Pathways; Ovalbumin; Pyrilamine; Respiratory Function Tests; Respiratory Hypersensitivity; Vagotomy; Xanthines | 2006 |
Differential responses to various classes of drugs in a model of allergic rhinitis in guinea pigs.
Topics: Acetates; Acute Disease; Animals; Cetirizine; Cyclopropanes; Dexamethasone; Disease Models, Animal; Guinea Pigs; Heparin; Histamine H1 Antagonists; Male; Nasal Obstruction; NG-Nitroarginine Methyl Ester; Ovalbumin; Pyrilamine; Quinolines; Rhinitis, Allergic, Seasonal; Sneezing; Sulfides | 2008 |
Pharmacological characterization of GSK1004723, a novel, long-acting antagonist at histamine H(1) and H(3) receptors.
Topics: Allergens; Animals; Benzazepines; Binding, Competitive; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Carbachol; Cell Line; CHO Cells; Cricetinae; Cricetulus; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine H3 Antagonists; Humans; In Vitro Techniques; Niacinamide; Ovalbumin; Phthalazines; Piperidines; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H3; Recombinant Proteins; Rhinitis, Allergic, Perennial; Transfection | 2011 |
Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Drug Administration Schedule; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Histamine Antagonists; Histamine H2 Antagonists; Humans; Immunization; Immunoglobulin E; Indoles; Mice; Mice, Inbred BALB C; Ovalbumin; Piperazines; Pyrilamine; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Time Factors; Treatment Outcome | 2012 |
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disease Models, Animal; Guinea Pigs; Histamine Antagonists; Hypersensitivity; Indomethacin; Leukotriene Antagonists; Lung; Mast Cells; Ovalbumin; Prostaglandin Antagonists; Pyrilamine; Quinolines; Sulfides | 2013 |
Combined treatment with H1 and H4 receptor antagonists reduces inflammation in a mouse model of atopic dermatitis.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epidermis; Female; Histamine H1 Antagonists; Humans; Mice; Mice, Inbred BALB C; Ovalbumin; Pyrilamine; Pyrimidines; Pyrrolidines; Receptors, Histamine H4 | 2017 |